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1. Fludarabine or cyclophosphamide in combination with total body irradiation as myeloablative conditioning prior to allogeneic hematopoietic cell transplantation for acute lymphoblastic leukemia: an analysis by the Acute Leukemia Working Party of the EBMT

Author

Giebel, Sebastian, Labopin, Myriam, Socié, Gerard, Aljurf, Mahmoud, Salmenniemi, Urpu, Labussière-Wallet, Hélène, Srour, Micha, Kröger, Nicolaus, Zahrani, Mohsen Al, Lioure, Bruno, Reményi, Péter, Arat, Mutlu, Bourhis, Jean Henri, Helbig, Grzegorz, Tbakhi, Abdelghani, Forcade, Edouard, Huynh, Anne, Brissot, Eolia, Spirydonidis, Alexandros, Savani, Bipin N., Peric, Zinaida, Nagler, Arnon, and Mohty, Mohamad

Published
2023
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2. Allogeneic hematopoietic cell transplantation in patients with therapy-related myeloid neoplasm after breast cancer: a study of the Chronic Malignancies Working Party of the EBMT

Author

Nabergoj, Mitja, Mauff, Katya, Beelen, Dietrich, Ganser, Arnold, Kröger, Nicolaus, Stölzel, Friedrich, Finke, Jürgen, Passweg, Jakob, Cornelissen, Jan, Schub, Natalie, Veelken, Joan Hendrik, Beguin, Yves, Wilson, Keith, Zuckerman, Tsila, Hunault-Berger, Mathilde, Lioure, Bruno, Porras, Rocio Parody, Turlure, Pascal, Kerre, Tessa, Koster, Linda, Hayden, Patrick J., Onida, Francesco, Scheid, Christof, Chalandon, Yves, Robin, Marie, and Yakoub-Agha, Ibrahim

Published
2022
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3. Prognostic value of a new clinically-based classification system in patients with CMML undergoing allogeneic HCT: a retrospective analysis of the EBMT-CMWP

Author

Onida, Francesco, Sbianchi, Giulia, Radujkovic, Aleksandar, Sockel, Katja, Kröger, Nicolaus, Sierra, Jorge, Socié, Gerard, Cornelissen, Jan, Poiré, Xavier, Raida, Luděk, Bourhis, Jean Henri, Finke, Jürgen, Passweg, Jakob, Salmenniemi, Urpu, Schouten, Harry C., Beguin, Yves, Martin, Sonja, Deconinck, Eric, Ganser, Arnold, Zver, Samo, Lioure, Bruno, Rohini, Radia, Koster, Linda, Hayden, Patrick, Iacobelli, Simona, Robin, Marie, and Yakoub-Agha, Ibrahim

Published
2022
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4. Autologous hematopoietic cell transplantation for relapsed multiple myeloma performed with cells procured after previous transplantation–study on behalf of CMWP of the EBMT

Author

Drozd-Sokołowska, Joanna, Gras, Luuk, Zinger, Nienke, Snowden, John A., Arat, Mutlu, Basak, Grzegorz, Pouli, Anastasia, Crawley, Charles, Wilson, Keith M. O., Tilly, Herve, Byrne, Jennifer, Bulabois, Claude Eric, Passweg, Jakob, Ozkurt, Zubeyde Nur, Schroyens, Wilfried, Lioure, Bruno, Colorado Araujo, Mercedes, Poiré, Xavier, Van Gorkom, Gwendolyn, Gurman, Gunhan, de Wreede, Liesbeth C., Hayden, Patrick J., Beksac, Meral, Schönland, Stefan O., and Yakoub-Agha, Ibrahim

Published
2022
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6. Haematological features of telomere biology disorders diagnosed in adulthood: A French nationwide study of 127 patients.

Author

Maillet, François, Galimard, Jacques‐Emmanuel, Borie, Raphaël, Lainey, Elodie, Larcher, Lise, Passet, Marie, Plessier, Aurélie, Leblanc, Thierry, Terriou, Louis, Lebon, Delphine, Alcazer, Vincent, Cathebras, Pascal, Loschi, Michael, Wadih, Abou‐Chahla, Marcais, Ambroise, Marceau‐Renaut, Alice, Couque, Nathalie, Lioure, Bruno, Soulier, Jean, and Ba, Ibrahima

Subjects
ACUTE myeloid leukemia, SOMATIC mutation, MYELODYSPLASTIC syndromes, BONE marrow, OVERALL survival
Abstract

Summary: Data on haematological features of telomere biology disorders (TBD) remain scarce. We describe haematological, extra‐haematological characteristics and prognosis of 127 genetically confirmed TBD patients diagnosed after the age of 15. Ninety‐three index cases and 34 affected relatives were included. At diagnosis of TBD, 76.3% of index cases had haematological features, half pulmonary features and a third liver features. At diagnosis, bone marrow failure (BMF) was present in 59 (46.5%), myelodysplastic syndrome (MDS) in 22 (17.3%) and acute myeloid leukaemia (AML) in 2 (1.6%) while 13 (10.2%) developed or worsened bone marrow involvement during follow‐up. At diagnosis, compared to MDS/AML patients, BMF patients were younger (median 23.1 years vs. 43.8, p = 0.007), and had a better outcome (4‐year overall survival 76.3% vs. 31.8%, p < 0.001). While frequencies and burden of cytogenetical and somatic mutations increased significantly in myeloid malignancies, some abnormalities were also observed in patients with normal blood counts and BMF, notably somatic spliceosome variants. Solid cancers developed in 8.7% patients, mainly human papillomavirus‐related cancers and hepatocellular carcinomas. TBD is a multiorgan progressive disease. While BMF is the main haematological disorder, high‐risk myeloid malignancies are common, and are, together with age, the only factors associated with a worse outcome. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Factors associated with coinfections in invasive aspergillosis: a retrospective cohort study

Author

Addeo, Pietro Francesco, Astruc, Dominique, Baldacini, Mathieu, Bilger, Karin, Chenard, Marie-Pierrette, Collange, Olivier, Degot, Tristan, Dhif, Nadia, Dicop, Elise, Fafi-Kremer, Samira, Fornecker, Luc-Matthieu, Fuseau, Charline, Guillot, Max, Harlay, Mary-Line, Janssen-Langenstein, Ralf, Jaulhac, Benoît, Kaeuffer, Charlotte, Kessler, Romain, Kummerlen, Christine, Laplace, Annegret, Launoy, Anne, Lioure, Bruno, Merdji, Hamid, Mertes, Paul-Michel, Natarajan-Ame, Shanti, Nisand, Gabriel, Porzio, Michele, Pottecher, Julien, Roche, Anne-Claude, Schenck-Dhif, Maleka, Sonntag, Cécile, Toussaint, Elise, Zilliox, Anne, Danion, François, Duval, Céline, Séverac, François, Bachellier, Philippe, Candolfi, Ermanno, Castelain, Vincent, Clere-Jehl, Raphaël, Denis, Julie, Dillenseger, Laurence, Epailly, Eric, Gantzer, Justine, Guffroy, Blandine, Hansmann, Yves, Herbrecht, Jean-Etienne, Letscher-Bru, Valérie, Leyendecker, Pierre, Le Van Quyen, Pauline, Ludes, Pierre-Olivier, Morel, Guillaume, Moulin, Bruno, Paillard, Catherine, Renaud-Picard, Benjamin, Sabou, Marcela, Schneider, Francis, Solis, Morgane, Talagrand-Reboul, Emilie, Veillon, Francis, Ledoux, Marie-Pierre, Simand, Célestine, and Herbrecht, Raoul

Published
2021
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8. Allogeneic hematopoietic stem cell transplantation from unmanipulated haploidentical donor and unrelated cord blood for T-cell lymphoma: a retrospective study from the Société Francophone de Greffe de Moelle et de Therapie Cellulaire

Author

Cornillon, Jerome, Daguenet, Elisabeth, Tournilhac, Olivier, Blaise, Didier, NGuyen, Stephanie, Wallet, Helene Labussiere, Chevallier, Patrice, Dulery, Rémy, Forcade, Edouard, Srour, Micha, Bazarbachi, Ali, Contentin, Nathalie, Lioure, Bruno, Tinquaut, Fabien, Bulabois, Claude-Eric, Rubio, Marie-Therese, Robin, Marie, and Bay, Jacques-Olivier

Published
2021
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10. Impact of early candidemia on the long-term outcome of allogeneic hematopoietic stem cell transplant in non-leukemic patients: an outcome analysis on behalf of IDWP–EBMT

Author

Cesaro, Simone, Tridello, Gloria, Knelange, Nina Simone, Blijlevens, Nicole, Martin, Murray, Snowden, John A., Malladi, Ram, Ljungman, Per, Deconinck, Eric, Gedde-Dahl, Tobias, Byrne, Jennifer, Xhaard, Alienor, Chevallier, Patrice, Maertens, Johan, Zuckerman, Tsila, Lioure, Bruno, Petersen, Eefke, Cornelissen, Jan J., Arcese, William, Blaise, Didier, Milpied, Noel, Cahn, Jean Yves, Aljurf, Mahmoud, de Wreede, Liesbeth, Mauro, Margherita, de la Camara, Rafael, Averbuch, Diana, Mikulska, Malgorzata, and Styczynski, Jan

Published
2021
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11. Use of letermovir in off-label indications: Infectious Diseases Working Party of European Society of Blood and Marrow Transplantation retrospective study

Author

Styczyński, Jan, Tridello, Gloria, Xhaard, Alienor, Medinger, Michael, Mielke, Stephan, Taskinen, Mervi, Blijlevens, Nicole, Rodriguez, M. Aranzazu Bermudez, Solano, Carlos, Nikolousis, Emmanouil, Biffi, Alessandra, Groll, Andreas H., Junghanss, Christian, Tsirigotis, Panagiotis, Lioure, Bruno, Šrámek, Jiří, Holler, Ernst, Galaverna, Federica, Fagioli, Franca, Knelange, Nina, Wendel, Lotus, Gil, Lidia, de la Camara, Rafael, Mikulska, Malgorzata, and Ljungman, Per

Published
2021
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12. Second- and third-generation tyrosine kinase inhibitors for Philadelphia-positive adult acute lymphoblastic leukemia relapsing post allogeneic stem cell transplantation—a registry study on behalf of the EBMT Acute Leukemia Working Party

Author

Hirschbühl, Klaus, Labopin, Myriam, Houhou, Mohamed, Gabellier, Ludovic, Labussière-Wallet, Hélène, Lioure, Bruno, Beelen, Dietrich, Cornelissen, Jan, Wulf, Gerald, Jindra, Pavel, Tilly, Hervé, Passweg, Jakob, Niittyvuopio, Riita, Bug, Gesine, Schmid, Christoph, Nagler, Arnon, Giebel, Sebastian, and Mohty, Mohamad

Published
2021
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13. Comparison of mycophenolate mofetil and calcineurin inhibitor versus calcineurin inhibitor-based graft-versus-host-disease prophylaxis for matched unrelated donor transplant in acute myeloid leukemia. A study from the ALWP of the EBMT

Author

Paviglianiti, Annalisa, Labopin, Myriam, Blaise, Didier, Socié, Gerard, Bulabois, Claude Eric, Lioure, Bruno, Ceballos, Patrice, Blau, Igor Wolfgang, Guillerm, Gaelle, Maertens, Johan, Chevallier, Patrice, Huynh, Anne, Turlure, Pascal, Deconinck, Eric, Forcade, Edouard, Nagler, Arnon, and Mohty, Mohamad

Published
2021
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14. A Phase II Study of Coltuximab Ravtansine (SAR3419) Monotherapy in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia

Author

Kantarjian, Hagop M, Lioure, Bruno, Kim, Stella K, Atallah, Ehab, Leguay, Thibaut, Kelly, Kevin, Marolleau, Jean-Pierre, Escoffre-Barbe, Martine, Thomas, Xavier G, Cortes, Jorge, Jabbour, Elias, O'Brien, Susan, Bories, Pierre, Oprea, Corina, Hatteville, Laurence, and Dombret, Hervé

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Vaccine Related, Cancer, Rare Diseases, Clinical Trials and Supportive Activities, Childhood Leukemia, Clinical Research, Pediatric, Hematology, Pediatric Cancer, Neurodegenerative, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, 6.2 Cellular and gene therapies, Aged, Aged, 80 and over, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Drug Resistance, Neoplasm, Female, Humans, Immunotoxins, Male, Maytansine, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Recurrence, Retreatment, Treatment Outcome, Adult, Antibody-drug conjugate, CD19, Maytansine derivatives, Safety, Cardiovascular medicine and haematology, Oncology and carcinogenesis
Abstract

BackgroundLong-term disease-free survival in adult patients with acute lymphoblastic leukemia (ALL) remains unsatisfactory, and the treatment options are limited for those patients with relapse or a failure to respond after initial therapy. We conducted a dose-escalation/expansion phase II, multicenter, single-arm study to determine the optimal dose of coltuximab ravtansine (SAR3419), an anti-CD19 antibody-drug conjugate, in this setting.Patients and methodsThe dose-escalation part of the study determined the selected dose of coltuximab ravtansine for the evaluation of efficacy and safety in the dose-expansion phase. Patients received coltuximab ravtansine induction therapy (≤ 8 weekly doses). The responding patients were eligible for maintenance therapy (biweekly administration for ≤ 24 weeks). Three dose levels of coltuximab ravtansine were examined: 55, 70, and 90 mg/m(2). The primary endpoint was the objective response rate (ORR). The secondary endpoints included the duration of response (DOR) and safety.ResultsA total of 36 patients were treated: 19 during dose escalation and 17 during dose expansion. One dose-limiting toxicity was observed at 90 mg/m(2) (grade 3 peripheral motor neuropathy); therefore, 70 mg/m(2) was selected for the dose-expansion phase. Five patients discontinued therapy because of adverse events (AEs). The most common AEs were pyrexia, diarrhea, and nausea. Of the 17 evaluable patients treated at the selected dose, 4 had a disease response (estimated ORR using the Bayesian method: 25.5% (80% confidence interval, 14.2%-39.6%). The DOR was 1.9 months (range, 1-5.6 months). Because of these results, the study was prematurely discontinued.ConclusionColtuximab ravtansine was well tolerated but was associated with a low clinical response rate in patients with relapsed or refractory ALL.

Published
2016

15. Late relapse after hematopoietic stem cell transplantation for acute leukemia: a retrospective study by SFGM-TC

Author

Kaphan, Eléonore, Bettega, François, Forcade, Edouard, Labussière-Wallet, Hélène, Fegueux, Nathalie, Robin, Marie, Peffault De Latour, Régis, Huynh, Anne, Lapierre, Léopoldine, Berceanu, Ana, Marcais, Ambroise, Debureaux, Pierre-Edouard, Vanlangendonck, Nicolas, Bulabois, Claude-Eric, Magro, Leonardo, Daniel, Adrien, Galtier, Jean, Lioure, Bruno, Chevallier, Patrice, Antier, Chloé, Loschi, Michael, Guillerm, Gaelle, Mear, Jean-Baptiste, Chantepie, Sylvain, Cornillon, Jérome, Rey, Gaelle, Poire, Xavier, Bazarbachi, Ali, Rubio, Marie-Thérèse, Contentin, Nathalie, Orvain, Corentin, Dulery, Rémy, Bay, Jacques Olivier, Croizier, Carolyne, Beguin, Yves, Charbonnier, Aude, Skrzypczak, Caroline, Desmier, Déborah, Villate, Alban, Carré, Martin, and Thiebaut-Bertrand, Anne

Published
2023
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16. Compatibility at amino acid position 98 of MICB reduces the incidence of graft-versus-host disease in conjunction with the CMV status

Author

Carapito, Raphael, Aouadi, Ismail, Pichot, Angélique, Spinnhirny, Perrine, Morlon, Aurore, Kotova, Irina, Macquin, Cécile, Rolli, Véronique, Cesbron, Anne, Gagne, Katia, Oudshoorn, Machteld, van der Holt, Bronno, Labalette, Myriam, Spierings, Eric, Picard, Christophe, Loiseau, Pascale, Tamouza, Ryad, Toubert, Antoine, Parissiadis, Anne, Dubois, Valérie, Paillard, Catherine, Maumy-Bertrand, Myriam, Bertrand, Frédéric, von dem Borne, Peter A., Kuball, Jürgen H. E., Michallet, Mauricette, Lioure, Bruno, Peffault de Latour, Régis, Blaise, Didier, Cornelissen, Jan J., Yakoub-Agha, Ibrahim, Claas, Frans, Moreau, Philippe, Charron, Dominique, Mohty, Mohamad, Morishima, Yasuo, Socié, Gérard, and Bahram, Seiamak

Published
2020
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17. Scoring System Based on Post-Transplant Complications in Patients after Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndrome: A Study from the SFGM-TC

Author

Caulier, Alexis, Drumez, Elodie, Gauthier, Jordan, Robin, Marie, Blaise, Didier, Beguin, Yves, Michallet, Mauricette, Chevallier, Patrice, Bay, Jacques-Olivier, Vigouroux, Stéphane, Desbrosses, Yohan, Cornillon, Jérôme, Nguyen, Stéphanie, Dauriac, Charles, de Latour, Régis Peffault, Lioure, Bruno, Rohrlich, Pierre-Simon, Carré, Martin, Bourhis, Jean-Henri, Huynh, Anne, Suarez, Felipe, Garnier, Federico, Duhamel, Alain, and Yakoub-Agha, Ibrahim

Published
2019
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19. Low non‐relapse mortality and good haematological and renal responses after autologous haematopoietic stem cell transplantation in multiple myeloma patients with renal insufficiency at transplant: A prospective Société Francophone de Greffe de Moelle‐Thérapie Cellulaire observational study

Author

Garderet, Laurent, Ouldjeriouat, Hafida, Bekadja, Mohamed‐Amine, Daguenet, Elisabeth, Bigot, Noemie, Vincent, Laure, Roos‐Weil, Damien, Vignon, Marguerite, Ikhlef, Souhila, Abraham, Julie, Escoffre‐Barbe, Martine, Lioure, Bruno, Nacer, Redhouane Ahmed, Lafon, Ingrid, Mariette, Clara, Karlin, Lionel, Morel, Pierre, Gilis, Lila, Le Ray, Emanuelle, and Blouet, Anaïse

Subjects
HEMATOPOIETIC stem cell transplantation, KIDNEY failure, KIDNEY transplantation, MULTIPLE myeloma, AUTOTRANSPLANTATION
Abstract

Summary: High‐dose melphalan followed by autologous haematopoietic stem cell transplantation is widely used in newly diagnosed multiple myeloma (MM) patients as upfront therapy. However, the safety and efficacy of transplantation in patients with renal insufficiency (RI) are controversial. We followed a multicentre (16 SFGM‐TC centres) prospective cohort of 50 newly diagnosed MM patients with a serum creatinine clearance of <40 mL/min at transplantation. Patients received a recommended dose of melphalan of 140 mg/m2. The primary end‐point was the non‐relapse mortality at Day 100. One death occurred during the first 100 days post‐transplant. The median time to neutrophil engraftment was 12 days and to platelet engraftment was 13 days. The haematological response improved in 69% of patients, with best responses from partial response (PR) to very good partial response (VGPR) (10%), from PR to complete response (CR)/stringent complete response (sCR) (16%), from VGPR to CR/sCR (39%) and from CR to sCR (2%). At 2 years, the overall survival was 84%, the progression‐free survival was 70% and the cumulative incidence of relapse was 20%. The renal response improved in 59% of patients, with the best renal responses post‐transplant being minimal (9%), partial (2%) and complete (48%). Autologous transplantation was safe and effective in myeloma patients with RI at transplant. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Low non‐relapse mortality and good haematological and renal responses after autologous haematopoietic stem cell transplantation in multiple myeloma patients with renal insufficiency at transplant: A prospective Société Francophone de Greffe de Moelle‐Thérapie Cellulaire observational study

Author

Garderet, Laurent, primary, Ouldjeriouat, Hafida, additional, Bekadja, Mohamed‐Amine, additional, Daguenet, Elisabeth, additional, Bigot, Noemie, additional, Vincent, Laure, additional, Roos‐Weil, Damien, additional, Vignon, Marguerite, additional, Ikhlef, Souhila, additional, Abraham, Julie, additional, Escoffre‐Barbe, Martine, additional, Lioure, Bruno, additional, Nacer, Redhouane Ahmed, additional, Lafon, Ingrid, additional, Mariette, Clara, additional, Karlin, Lionel, additional, Morel, Pierre, additional, Gilis, Lila, additional, Le Ray, Emanuelle, additional, Blouet, Anaïse, additional, Nguyen Quoc, Stéphanie, additional, Boffa, Jean Jacques, additional, Ronco, Pierre, additional, Lambert, Jerome, additional, and Cornillon, Jérôme, additional

Published
2023
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21. Posttransplant cyclophosphamide versus antithymocyte globulin in patients with acute lymphoblastic leukemia treated with allogeneic hematopoietic cell transplantation from matched unrelated donors: A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Giebel, Sebastian, primary, Labopin, Myriam, additional, Salmenniemi, Urpu, additional, Socié, Gerard, additional, Bondarenko, Sergey, additional, Blaise, Didier, additional, Kröger, Nicolaus, additional, Vydra, Jan, additional, Grassi, Anna, additional, Bonifazi, Francesca, additional, Czerw, Tomasz, additional, Anagnostopoulos, Achilles, additional, Lioure, Bruno, additional, Ruggeri, Annalisa, additional, Savani, Bipin, additional, Spyridonidis, Alexandros, additional, Sanz, Jaime, additional, Peric, Zinaida, additional, Nagler, Arnon, additional, Ciceri, Fabio, additional, and Mohty, Mohamad, additional

Published
2023
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22. Evaluation of infectious complications after haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide following reduced-intensity and myeloablative conditioning: a study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC)

Author

Fayard, Amandine, Daguenet, Elisabeth, Blaise, Didier, Chevallier, Patrice, Labussière, Hélène, Berceanu, Ana, Yakoub-Agha, Ibrahim, Socié, Gérard, Charbonnier, Amandine, Suarez, Felipe, Huynh, Anne, Mercier, Mélanie, Bulabois, Claude-Eric, Lioure, Bruno, Chantepie, Sylvain, Beguin, Yves, Bourhis, Jean-Henri, Malfuson, Jean-Valère, Clément, Laurence, Peffault de la Tour, Régis, and Cornillon, Jérôme

Published
2019
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23. Current use of androgens in bone marrow failure disorders: a report from the Severe Aplastic Anemia Working Party of the European Society of Blood and Marrow Transplantation

Author

Pagliuca, Simona, primary, Kulasekararaj, Austin G., additional, Eikema, Dirk-Jan, additional, Piepenbroek, Brian, additional, Iftikhar, Raheel, additional, Satti, Tariq Mahmood, additional, Griffin, Morag, additional, Laurino, Marica, additional, Kupesiz, Alphan, additional, Bertrand, Yves, additional, Fattizzo, Bruno, additional, Yakoub-Agha, Ibrahim, additional, Aljurf, Mahmoud, additional, Corti, Paola, additional, Massaccesi, Erika, additional, Lioure, Bruno, additional, Calabuig, Marisa, additional, Klammer, Matthias, additional, Unal, Emel, additional, Wu, Depei, additional, Chevallier, Patrice, additional, Forcade, Edouard, additional, Snowden, John A., additional, Ozdogu, Hakan, additional, Risitano, Antonio, additional, and De Latour, Régis Peffault, additional

Published
2023
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24. Phase 1 Study of the Combination of Escalated Total Marrow Irradiation Using Helical Tomotherapy and Fixed High-Dose Melphalan (140 mg/m²) Followed by Autologous Stem Cell Transplantation at First Relapse in Multiple Myeloma

Author

Cailleteau, Axel, primary, Maingon, Philippe, additional, Choquet, Sylvain, additional, Bourdais, Rémi, additional, Antoni, Delphine, additional, Lioure, Bruno, additional, Hulin, Cyrille, additional, Batard, Stéphanie, additional, Llagostera, Camille, additional, Guimas, Valentine, additional, Touzeau, Cyrille, additional, Moreau, Philippe, additional, Mahé, Marc-André, additional, and Supiot, Stéphane, additional

Published
2023
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25. Comparison of autologous and allogeneic hematopoietic cell transplantation strategies in patients with primary plasma cell leukemia, with dynamic prediction modeling

Author

Lawless, Sarah, Iacobelli, Simona, Knelange, Nina Simone, Chevallier, Patrice, Blaise, Didier, Milpied, Noel, Foà, Roberto, Cornelissen, Jan J., Lioure, Bruno, Benjamin, Ruben, Poiré, Xavier, Minnema, Monique C., Collin, Matthew, Lenhoff, Stig, Snowden, John A., Santarone, Stella, Wilson, Keith M.O., Trigo, Fernanda, Dreger, Peter, Böhmer, Lara H., Putter, Hein, Garderet, Laurent, Kröger, Nicolaus, Yaukoub-Agha, Ibrahim, Schönland, Stefan, Morris, Curly, Lawless, Sarah, Iacobelli, Simona, Knelange, Nina Simone, Chevallier, Patrice, Blaise, Didier, Milpied, Noel, Foà, Roberto, Cornelissen, Jan J., Lioure, Bruno, Benjamin, Ruben, Poiré, Xavier, Minnema, Monique C., Collin, Matthew, Lenhoff, Stig, Snowden, John A., Santarone, Stella, Wilson, Keith M.O., Trigo, Fernanda, Dreger, Peter, Böhmer, Lara H., Putter, Hein, Garderet, Laurent, Kröger, Nicolaus, Yaukoub-Agha, Ibrahim, Schönland, Stefan, and Morris, Curly

Abstract

Primary plasma cell leukemia (pPCL) is a rare and challenging malignancy. There are limited data regarding optimum transplant approaches. We therefore undertook a retrospective analysis from 1998-2014 of 751 patients with pPCL undergoing one of four transplant strategies; single autologous transplant (single auto), single allogeneic transplant (allo-first) or a combined tandem approach with an allogeneic transplant following an autologous transplant (auto-allo) or a tandem autologous transplant (auto-auto). To avoid time bias, multiple analytic approaches were employed including Cox models with time-dependent covariates and dynamic prediction by landmarking. Initial comparisons were made between patients undergoing allo-first (n=70) versus auto-first (n=681), regardless of a subsequent second transplant. The allo-first group had a lower relapse rate (45.9%, 95% confidence interval [95% CI]: 33.2-58.6 vs. 68.4%, 64.4-72.4) but higher non-relapse mortality (27%, 95% CI: 15.9-38.1 vs. 7.3%, 5.2-9.4) at 36 months. Patients who underwent allo-first had a remarkably higher risk in the first 100 days for both overall survival and progression-free survival. Patients undergoing auto-allo (n=122) had no increased risk in the short term and a significant benefit in progression-free survival after 100 days compared to those undergoing single auto (hazard ratio [HR]=0.69, 95% CI: 0.52- 0.92; P=0.012). Auto-auto (n=117) was an effective option for patients achieving complete remission prior to their first transplant, whereas in patients who did not achieve complete remission prior to transplantation our modeling predicted that auto-allo was superior. This is the largest retrospective study reporting on transplantation in pPCL to date. We confirm a significant mortality risk within the first 100 days for allo-first and suggest that tandem transplant strategies are superior. Disease status at time of transplant influences outcome. This knowledge may help to guide clinical decisi

Published
2023

26. Comparison of autologous and allogeneic hematopoietic cell transplantation strategies in patients with primary plasma cell leukemia, with dynamic prediction modeling

Author

MS Hematologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, Lawless, Sarah, Iacobelli, Simona, Knelange, Nina Simone, Chevallier, Patrice, Blaise, Didier, Milpied, Noel, Foà, Roberto, Cornelissen, Jan J, Lioure, Bruno, Benjamin, Ruben, Poiré, Xavier, Minnema, Monique C, Collin, Matthew, Lenhoff, Stig, Snowden, John A, Santarone, Stella, Wilson, Keith M O, Trigo, Fernanda, Dreger, Peter, Böhmer, Lara H, Putter, Hein, Garderet, Laurent, Kröger, Nicolaus, Yaukoub-Agha, Ibrahim, Schönland, Stefan, Morris, Curly, MS Hematologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, Lawless, Sarah, Iacobelli, Simona, Knelange, Nina Simone, Chevallier, Patrice, Blaise, Didier, Milpied, Noel, Foà, Roberto, Cornelissen, Jan J, Lioure, Bruno, Benjamin, Ruben, Poiré, Xavier, Minnema, Monique C, Collin, Matthew, Lenhoff, Stig, Snowden, John A, Santarone, Stella, Wilson, Keith M O, Trigo, Fernanda, Dreger, Peter, Böhmer, Lara H, Putter, Hein, Garderet, Laurent, Kröger, Nicolaus, Yaukoub-Agha, Ibrahim, Schönland, Stefan, and Morris, Curly

Published
2023

27. Matching for the nonconventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD

Author

Carapito, Raphael, Jung, Nicolas, Kwemou, Marius, Untrau, Meiggie, Michel, Sandra, Pichot, Angélique, Giacometti, Gaëlle, Macquin, Cécile, Ilias, Wassila, Morlon, Aurore, Kotova, Irina, Apostolova, Petya, Schmitt-Graeff, Annette, Cesbron, Anne, Gagne, Katia, Oudshoorn, Machteld, van der Holt, Bronno, Labalette, Myriam, Spierings, Eric, Picard, Christophe, Loiseau, Pascale, Tamouza, Ryad, Toubert, Antoine, Parissiadis, Anne, Dubois, Valérie, Lafarge, Xavier, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Vago, Luca, Ciceri, Fabio, Paillard, Catherine, Querol, Sergi, Sierra, Jorge, Fleischhauer, Katharina, Nagler, Arnon, Labopin, Myriam, Inoko, Hidetoshi, von dem Borne, Peter A., Kuball, Jürgen, Ota, Masao, Katsuyama, Yoshihiko, Michallet, Mauricette, Lioure, Bruno, Peffault de Latour, Régis, Blaise, Didier, Cornelissen, Jan J., Yakoub-Agha, Ibrahim, Claas, Frans, Moreau, Philippe, Milpied, Noël, Charron, Dominique, Mohty, Mohamad, Zeiser, Robert, Socié, Gérard, and Bahram, Seiamak

Published
2016
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28. Dasatinib and low-intensity chemotherapy in elderly patients with Philadelphia chromosome–positive ALL

Author

Rousselot, Philippe, Coudé, Marie Magdelaine, Gokbuget, Nicola, Gambacorti Passerini, Carlo, Hayette, Sandrine, Cayuela, Jean-Michel, Huguet, Françoise, Leguay, Thibaut, Chevallier, Patrice, Salanoubat, Celia, Bonmati, Caroline, Alexis, Magda, Hunault, Mathilde, Glaisner, Sylvie, Agape, Philippe, Berthou, Christian, Jourdan, Eric, Fernandes, José, Sutton, Laurent, Banos, Anne, Reman, Oumedaly, Lioure, Bruno, Thomas, Xavier, Ifrah, Norbert, Lafage-Pochitaloff, Marina, Bornand, Anne, Morisset, Laure, Robin, Valérie, Pfeifer, Heike, Delannoy, Andre, Ribera, Josep, Bassan, Renato, Delord, Marc, Hoelzer, Dieter, Dombret, Herve, and Ottmann, Oliver G.

Published
2016
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29. Management of Myelodysplastic Syndrome Relapsing after Allogeneic Hematopoietic Stem Cell Transplantation: A Study by the French Society of Bone Marrow Transplantation and Cell Therapies

Author

Guièze, Romain, Damaj, Gandhi, Pereira, Bruno, Robin, Marie, Chevallier, Patrice, Michallet, Mauricette, Vigouroux, Stéphane, Beguin, Yves, Blaise, Didier, El Cheikh, Jean, Roos-Weil, Damien, Thiebaut, Anne, Rohrlich, Pierre-Simon, Huynh, Anne, Cornillon, Jérôme, Contentin, Nathalie, Suarez, Felipe, Lioure, Bruno, Mohty, Mohamad, Maillard, Natacha, Clement, Laurence, François, Sylvie, Guillerm, Gaëlle, and Yakoub-Agha, Ibrahim

Published
2016
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30. Reduced 8-Gray Compared to Standard 12-Gray Total Body Irradiation for Allogeneic Transplantation in First Remission Acute Lymphoblastic Leukemia: A Study of the Acute Leukemia Working Party of the EBMT

Author

Spyridonidis, Alexandros, primary, Labopin, Myriam, additional, Savani, Bipin, additional, Giebel, Sebastian, additional, Bug, Gesine, additional, Schönland, Stefan, additional, Kröger, Nicolaus, additional, Stelljes, Matthias, additional, Schroeder, Thomas, additional, McDonald, Andrew, additional, Blau, Igor-Wolfgang, additional, Bornhäuser, Martin, additional, Rovira, Montse, additional, Bethge, Wolfgang, additional, Neubauer, Andreas, additional, Ganser, Arnold, additional, Bourhis, Jean Henri, additional, Edinger, Matthias, additional, Lioure, Bruno, additional, Wulf, Gerald, additional, Schäfer-Eckart, Kerstin, additional, Arat, Mutlu, additional, Peric, Zinaida, additional, Schmid, Christoph, additional, Bazarbachi, Ali, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2023
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31. Higher busulfan dose intensity appears to improve leukemia-free and overall survival in AML allografted in CR2: An analysis from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation

Author

Kharfan-Dabaja, Mohamed A., Labopin, Myriam, Bazarbachi, Ali, Socie, Gerard, Kroeger, Nicolaus, Blaise, Didier, Veelken, Hendrik, Bermudez, Arancha, Or, Reuven, Lioure, Bruno, Beelen, Dietrich, Fegueux, Nathalie, Hamladji, Rose Marie, Nagler, Arnon, and Mohty, Mohamad

Published
2015
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32. Hematopoietic Stem Cell Transplantation in Multiple Myeloma: A Retrospective Study of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)

Author

Beaussant, Yvan, Daguindau, Etienne, Pugin, Aurore, Mohty, Mohamad, Avet-Loiseau, Hervé, Roos-Weil, Damien, Michallet, Mauricette, Chevalier, Patrice, Raus, Nicole, El-Cheikh, Jean, Tabrizi, Reza, Huyn, Anne, Buzyn, Agnès, Socié, Gérard, Vincent, Laure, Guilhot, François, Yakoub-Agha, Ibrahim, Lenain, Pascal, François, Sylvie, Beckerich, Florence, Lioure, Bruno, Bulabois, Claude-Eric, and Deconinck, Eric

Published
2015
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33. Effect of Graft Source on Unrelated Donor Hemopoietic Stem Cell Transplantation in Adults with Acute Myeloid Leukemia after Reduced-Intensity or Nonmyeloablative Conditioning: A Study from the Société Francaise de Greffe de Moelle et de Thérapie Cellulaire

Author

Malard, Florent, Milpied, Noel, Blaise, Didier, Chevallier, Patrice, Michallet, Mauricette, Lioure, Bruno, Clément, Laurence, Hicheri, Yosr, Cordonnier, Catherine, Huynh, Anne, Yakoub-Agha, Ibrahim, Peffault de Latour, Regis, and Mohty, Mohamad

Published
2015
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34. Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation

Author

Ruggeri, Annalisa, de Wreede, Liesbeth C., Müller, Carlheinz R., Crivello, Pietro, Bonneville, Edouard F., Petersdorf, Effie W., Socié, Gerard, Dubois, Valérie, Niittyvuopio, Riitta, Peräsaari, Juha, Yakoub-Agha, Ibrahim, Cornelissen, Jan J., Wieten, Lotte, Gedde-Dahl, Tobias, Forcade, Edouard, Crawley, Charles R., Marsh, Steven G.E., Gandemer, Virginie, Tholouli, Eleni, Bulabois, Claude-Eric, Huynh, Anne, Choi, Goda, Deconinck, Eric, Itäla-Remes, Maija, Lenhoff, Stig, Bengtsson, Mats, Johansson, Jan-Erik, van Gorkom, Gwendolyn, Hoogenboom, Jorinde D., Vago, Luca, Rocha, Vanderson, Bonini, Chiara, Chabannon, Christian, Fleischhauer, Katharina, Clausen, Johannes, Holter, Wolfgang, Kalhs, Peter, Beguin, Yves, Bron, Dominique, Deeren, Dries, Lung, Wu Ka, Kerre, Tessa, Poiré, Xavier, Selleslag, Dominik, Schroyens, Wilfried, Jindra, Pavel, Mayer, Jiri, Vydra, Jan, Zák, Pavel, Nielsen, Bendt, Sengeloev, Henrik, Kaare, Ain, Partanen, Anu, Bay, Jacques-Olivier, Bertrand, Yves, Blaise, Didier, Bourhis, Jean Henri, Chevallier, Patrice, Cluzeau, Thomas, Damaj, Gandhi, Fegueux, Nathalie, Guyotat, Denis, Hunault-Berger, Mathilde, Labussière-Wallet, Hélène, Leleu, Xavier, Lioure, Bruno, Maury, Sebastien, Michel, Gérard, Mohty, Mohamad, Rubio, Marie Thérèse, Tilly, Herve, Turlure, Pascal, Bethge, Wolfgang, Casper, Jochen, Einsele, Hermann, Ganser, Arnold, Kröger, Nicolaus, Martin, Sonja, Platzbecker, Uwe, Reinhardt, Christian, Schäfer-Eckart, Kerstin, Thurner, Lorenz, Valerius, Thomas, Wulf, Gerald G., Karakasis, Dimitrios, Spyridonidis, Alexandros, Hauser, Peter, Reményi, Péter, Reykdal, Sigrun, Mousavi, Ashrafsadat, Angelucci, Emanuele, Arcese, William, Benedetti, Fabio, Bernasconi, Paolo, Biondi, Andrea, Bonifazi, Francesca, Carella, Angelo Michele, Carluccio, Paola, Casini, Marco, Cavanna, Luigi, Ciceri, Fabio, Cimino, Giuseppe, Corradini, Paolo, Fanin, Renato, Galieni, Piero, Grillo, Giovanni, Iori, Anna Paola, La Nasa, Giorgio, Locatelli, Franco, Marotta, Giuseppe, Martino, Massimo, Mazza, Patrizio, Mordini, Nicola, Musso, Maurizio, Olivieri, Attilio, Pavone, Vincenzo, Pane, Fabrizio, Petrini, Mario, Pioltelli, Pietro, Rambaldi, Alessandro, Ruggeri, Marco, Saccardi, Riccardo, Santarone, Stella, Scimè, Rosanna, Sica, Simona, Tarella, Corrado, Velardi, Andrea, Visani, Giuseppe, Zecca, Marco, Tanase, Alina, Kulagin, Aleksandr, Savchenko, Valery, López, Carmen Albo, Amor, Adrián Alegre, López, Jose Luis Bello, Caballero, Dolores, Duarte, Rafael, Cascon, Maria Jesús Pascual, Porras, Rocio Parody, Pérez-Simón, Jose Antonio, Rovira, Montserrat, Sanz, Jaime, Carrete, Juan Pio Torres, Cammenga, Jörg, Isaksson, Cecilia, Mielke, Stephan, Chalandon, Yves, Passweg, Jakob, Schanz, Urs, Meijer, Ellen, Kuball, Jürgen, Veelken, Joan Hendrik, Apperley, Jane, Bloor, Adrian, Byrne, Jenny, Carpenter, Ben, Clark, Andrew, Collin, Matthew, Craddock, Charles, Gibson, Brenda E., Khan, Anjum, Martin, Murray, Medd, Patrick, Nicholson, Emma, Orchard, Kim, Patel, Amit, Peniket, Andy, Potter, Victoria, Snowden, John, Wilson, Keith M.O., RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Transplant. Immunology/Tissue Typing lab, Interne Geneeskunde, MUMC+: MA Hematologie (9), Hematology, IRCCS San Raffaele Scientific Institute [Milan, Italie], EFS, CHU Lille, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], Oslo University Hospital [Oslo], CHU Bordeaux [Bordeaux], CHU Pontchaillou [Rennes], Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), University of Groningen [Groningen], Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), and Essen University Hospital

Subjects
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, [SDV]Life Sciences [q-bio], HSCT, Medizin, Hematology, Hematologi
Abstract

International audience; Not available.

Published
2023
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35. Low Non Relapse Mortality and Good Hematological Response after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma Patients with Renal Insufficiency at Transplant: A Prospective Société Francaise De Greffe De Moelle-Thérapie Cellulaire Observational Study

Author

Garderet, Laurent, primary, Ouldjeriouat, Hafida, additional, Bekadja, Mohamed-Amine, additional, Daguenet, Elisabeth, additional, Vincent, Laure, additional, Roos Weil, Damien, additional, Vignon, Marguerite, additional, Mohty, Mohamad, additional, Abraham, Julie, additional, Escoffre-Barbe, Martine, additional, Lioure, Bruno, additional, Nacer, redhouane Ahmed, additional, Caillot, Denis, additional, Mariette, Clara, additional, Karlin, Lionel, additional, Morel, Pierre, additional, Gilis, Lila, additional, Leray, Emanuelle, additional, Blouet, Anaise, additional, Raus, Nicole, additional, Robin, Marie, additional, Boffa, jean Jacques, additional, Ronco, Pierre, additional, Rubio, Marie Thérèse, additional, Lambert, Jerome, additional, and Cornillon, Jérôme, additional

Published
2022
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36. Current Use of Androgens in Bone Marrow Failure Disorders: A Report from the Severe Aplastic Anemia Working Party (SAAWP) of the European Society of Blood and Marrow Transplantation (EBMT)

Author

Pagliuca, Simona, primary, Kulasekararaj, Austin, additional, Eikema, Dirk-Jan, additional, Piepenbroek, Brian, additional, Iftikhar, Raheel, additional, Satti, Tariq Mahmood, additional, Griffin, Morag, additional, Laurino, Marica, additional, Kupesiz, O. Alphan, additional, Bertrand, Yives, additional, Fattizzo, Bruno, additional, Yakoub-Agha, Ibrahim, additional, Aljurf, Mahmoud, additional, Corti, Paola, additional, Massaccesi, Erika, additional, Lioure, Bruno, additional, Calabuig, Marisa, additional, Klammer, Matthias, additional, Unal, Emel, additional, Wu, Depei, additional, Chevallier, Patrice, additional, Forcade, Edouard, additional, Snowden, John A., additional, Ozdogu, Hakan, additional, Risitano, Antonio, additional, and Peffault de Latour, Régis, additional

Published
2022
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37. Frequency and Impact of Pre-Transplant Somatic Co-Occurring Mutations on Clinical Outcomes of Acute Myeloid Leukemia Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation: On Behalf of the EBMT Acute Leukemia Working Party

Author

Bazarbachi, Ali, primary, Galimard, Jacques-Emmanuel, additional, Labopin, Myriam, additional, Abou Dalle, Iman, additional, Lioure, Bruno, additional, Maertens, Johan A., additional, Itälä-Remes, Maija, additional, Gallego Hernanz, Maria Pilar, additional, Bug, Gesine, additional, Ribera, Josep-Maria, additional, Gadisseur, Alain, additional, Schmid, Christoph, additional, Poiré, Xavier, additional, Jurado Chacón, Manuel, additional, Baron, Frederic, additional, Brissot, Eolia, additional, Nagler, Arnon, additional, Ciceri, Fabio, additional, and Mohty, Mohamad, additional

Published
2022
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38. Antithymocyte Globulin before Allogeneic Stem Cell Transplantation for Progressive Myelodysplastic Syndrome: A Study from the French Society of Bone Marrow Transplantation and Cellular Therapy

Author

Duléry, Rémy, Mohty, Mohamad, Duhamel, Alain, Robin, Marie, Beguin, Yves, Michallet, Mauricette, Vigouroux, Stéphane, Lioure, Bruno, Garnier, Alice, El Cheikh, Jean, Bulabois, Claude-Eric, Huynh, Anne, Bay, Jacques-Olivier, Daguindau, Etienne, Ceballos, Patrice, Clément, Laurence, Dauriac, Charles, Maillard, Natacha, Legrand, Faezeh, Cornillon, Jérôme, Guillerm, Gaëlle, François, Sylvie, Lapusan, Simona, Chevallier, Patrice, Damaj, Gandhi, and Yakoub-Agha, Ibrahim

Published
2014
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40. Comparison of autologous and allogeneic hematopoietic cell transplantation strategies in patients with primary plasma cell leukemia, with dynamic prediction modeling

Author

Lawless, Sarah, primary, Iacobelli, Simona, additional, Knelange, Nina Simone, additional, Chevallier, Patrice, additional, Blaise, Didier, additional, Milpied, Noel, additional, Foà, Roberto, additional, Cornelissen, Jan J., additional, Lioure, Bruno, additional, Benjamin, Ruben, additional, Poiré, Xavier, additional, Minnema, Monique C., additional, Collin, Matthew, additional, Lenhoff, Stig, additional, Snowden, John A., additional, Santarone, Stella, additional, Wilson, Keith M. O., additional, Trigo, Fernanda, additional, Dreger, Peter, additional, Böhmer, Lara H., additional, Putter, Hein, additional, Garderet, Laurent, additional, Kröger, Nicolaus, additional, Yaukoub-Agha, Ibrahim, additional, Schönland, Stefan, additional, and Morris, Curly, additional

Published
2022
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41. Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia

Author

Jourdan, Eric, Boissel, Nicolas, Chevret, Sylvie, Delabesse, Eric, Renneville, Aline, Cornillet, Pascale, Blanchet, Odile, Cayuela, Jean-Michel, Recher, Christian, Raffoux, Emmanuel, Delaunay, Jacques, Pigneux, Arnaud, Bulabois, Claude-Eric, Berthon, Céline, Pautas, Cécile, Vey, Norbert, Lioure, Bruno, Thomas, Xavier, Luquet, Isabelle, Terré, Christine, Guardiola, Philippe, Béné, Marie C., Preudhomme, Claude, Ifrah, Norbert, and Dombret, Hervé

Published
2013
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42. Total body irradiation + fludarabine compared to busulfan + fludarabine as 'reduced-toxicity conditioning' for patients with acute myeloid leukemia treated with allogeneic hematopoietic cell transplantation in first complete remission: a study by the Acute Leukemia Working Party of the EBMT

Author

Giebel, Sebastian, Labopin, Myriam, Sobczyk-Kruszelnicka, Malgorzata, Stelljes, Matthias, Byrne, Jenny, Fegueux, Nathalie, Beelen, Dietrich, Rovira, Montserrat, Spyridonidis, Alexandros, Blaise, Didier, Bornhäuser, Martin, Karadogan, Ihsan, Savani, Bipin, Nagler, Arnon, Mohty, Mohamad, Martin, Sonja, Chevallier, Patrice, Neubauer, Andreas, Damaj, Gandhi, Koc, Yener, Ganser, Arnold, Collin, Matthew, Yakoub-Agha, Ibrahim, Ozdogu, Hakan, Araujo, Mercedes Colorado, Itäla-Remes, Maija, Orchard, Kim, Isaksson, Cecilia, Bethge, Wolfgang, Martin, Hans, Aljurf, Mahmoud, Faber, Edgar, Caballero, Dolores, Zák, Pavel, Leleu, Xavier, Bay, Jacques-Olivier, Rohrlich, Pierre-Simon, Kröger, Nicolaus, Huynh, Anne, Schäfer-Eckart, Kerstin, Milpied, Noel, Lenhoff, Stig, Ho, Aloysius, López, Jose Luis Bello, Mordini, Nicola, Lioure, Bruno, Halaburda, Kazimierz, Olivieri, Attilio, Gedde-Dahl, Tobias, Protheroe, Rachel, Tischer, Johanna, Klammer, Matthias, Clausen, Johannes, Potter, Victoria, Ladetto, Marco, Tilly, Herve, Deconinck, Eric, Brecht, Arne, Müller, Lutz Peter, Heinicke, Thomas, Carrete, Juan Pio Torres, Bazarbachi, Ali, Reményi, Péter, Rubio, Marie Thérèse, Fanin, Renato, Pérez-Simón, Jose Antonio, Niels, Murawski, Diez-Martin, J., Arat, Mutlu, Hermine, Olivier, Socié, Gerard, Cornelissen, Jan, Santarone, Stella, Guyotat, Denis, Bulabois, Claude Eric, Bernasconi, Paolo, Johansson, Jan-Erik, Vrhovac, Radovan, Greinix, Hildegard, Lorenzo, José Luis López, Apte, Shashikant, Craddock, Charles, Kobbe, Guido, Zahrani, Mohsen Al, Dreger, Peter, Lange, Andrzej, Tbakhi, Abdelghani, Meijer, Ellen, Llamas, Carlos Vallejo, Santasusana, Josep Maria Ribera, Corradini, Paolo, Benedetti, Fabio, Rambaldi, Alessandro, Gandemer, Virginie, Malfuson, Jean-Valère, Kaare, Ain, Risitano, Antonio, Petrini, Mario, Selleri, Carmine, Wu, Depei, Hematology, CCA - Cancer Treatment and quality of life, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
medicine.medical_specialty, Transplantation Conditioning, MESH: Busulfan, Medizin, MESH: Graft vs Host Disease, Graft vs Host Disease, [SDV.CAN]Life Sciences [q-bio]/Cancer, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Busulfan, MESH: Hematopoietic Stem Cell Transplantation, MESH: Transplantation Conditioning, Retrospective Studies, Transplantation, Acute leukemia, MESH: Humans, MESH: Middle Aged, business.industry, Hazard ratio, Hematopoietic Stem Cell Transplantation, Myeloid leukemia, MESH: Retrospective Studies, Retrospective cohort study, Hematology, Middle Aged, Total body irradiation, Fludarabine, Leukemia, Myeloid, Acute, Regimen, 030220 oncology & carcinogenesis, MESH: Vidarabine, [SDV.IMM]Life Sciences [q-bio]/Immunology, MESH: Leukemia, Myeloid, Acute, business, MESH: Whole-Body Irradiation, Vidarabine, Whole-Body Irradiation, 030215 immunology, medicine.drug
Abstract

International audience; The optimal conditioning for patients with acute myeloid leukemia in first complete remission treated with allogeneic hematopoietic cell transplantation (allo-HCT) has not been defined so far. In this retrospective study, we compared two "reduced-toxicity" regimens: intravenous busulfan at a total dose of 9.6 mg/kg (3 days) + fludarabine (Bu3/Flu) and total body irradiation at a dose of 8 Gy + fludarabine (TBI8Gy/Flu). In the entire study cohort (n = 518), the probabilities of overall survival (OS), leukemia-free survival (LFS), relapse and non-relapse mortality (NRM) at 2 years for Bu3/Flu and TBI8Gy/Flu were 62% vs. 72.5% (p = 0.051), 59.5% vs. 65% (p = 0.15), 30% vs. 20% (p = 0.01), and 10% vs. 14% (p = 0.18), respectively. In multivariate model for patients

Published
2021
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43. Autologous hematopoietic cell transplantation for relapsed multiple myeloma performed with cells procured after previous transplantation–study on behalf of CMWP of the EBMT

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service d'hématologie, Drozd-Sokołowska, Joanna, Gras, Luuk, Zinger, Nienke, Snowden, John A., Arat, Mutlu, Basak, Grzegorz, Pouli, Anastasia, Crawley, Charles, Wilson, Keith M. O., Tilly, Herve, Byrne, Jennifer, Bulabois, Claude Eric, Passweg, Jakob, Ozkurt, Zubeyde Nur, Schroyens, Wilfried, Lioure, Bruno, Colorado Araujo, Mercedes, Poiré, Xavier, Van Gorkom, Gwendolyn, Gurman, Gunhan, de Wreede, Liesbeth C., Hayden, Patrick J., Beksac, Meral, Schönland, Stefan O., Yakoub-Agha, Ibrahim, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service d'hématologie, Drozd-Sokołowska, Joanna, Gras, Luuk, Zinger, Nienke, Snowden, John A., Arat, Mutlu, Basak, Grzegorz, Pouli, Anastasia, Crawley, Charles, Wilson, Keith M. O., Tilly, Herve, Byrne, Jennifer, Bulabois, Claude Eric, Passweg, Jakob, Ozkurt, Zubeyde Nur, Schroyens, Wilfried, Lioure, Bruno, Colorado Araujo, Mercedes, Poiré, Xavier, Van Gorkom, Gwendolyn, Gurman, Gunhan, de Wreede, Liesbeth C., Hayden, Patrick J., Beksac, Meral, Schönland, Stefan O., and Yakoub-Agha, Ibrahim

Abstract

Autologous hematopoietic cell transplantation (auto-HCT) may be performed in multiple myeloma (MM) patients relapsing after a previous auto-HCT. For those without an adequate dose of stored stem cells, remobilization is necessary. This retrospective study included patients who, following disease relapse after the first auto-HCT(s), underwent stem cell remobilization and auto-HCT performed using these cells. There were 305 patients, 68% male, median age at salvage auto-HCT was 59 years. The median time to relapse after the first-line penultimate auto-HCT(s) was 30.6 months, the median follow-up after salvage auto-HCT 31 months. The 2- and 4-year non-relapse mortality (NRM) after the salvage auto-HCT was 5 and 9%, the relapse incidence 56 and 76%, respectively. Overall survival (OS) after 2 and 4 years was 76 and 52%, progression-free survival (PFS) 39 and 15%. In multivariable analysis an increasing interval between the penultimate auto-HCT and relapse was associated with better OS and PFS, later calendar year of salvage auto-HCT with better OS. In conclusion, salvage auto-HCT performed with cells remobilized after a previous auto-HCT was associated with acceptable NRM. The leading cause of failure was disease progression of MM, which correlated with a shorter interval from the penultimate auto-HCT to the first relapse.

Published
2022

44. Allogeneic hematopoietic cell transplantation in patients with therapy-related myeloid neoplasm after breast cancer:a study of the Chronic Malignancies Working Party of the EBMT

Author

Nabergoj, Mitja, Mauff, Katya, Beelen, Dietrich, Ganser, Arnold, Kröger, Nicolaus, Stölzel, Friedrich, Finke, Jürgen, Passweg, Jakob, Cornelissen, Jan, Schub, Natalie, Veelken, Joan Hendrik, Beguin, Yves, Wilson, Keith, Zuckerman, Tsila, Hunault-Berger, Mathilde, Lioure, Bruno, Porras, Rocio Parody, Turlure, Pascal, Kerre, Tessa, Koster, Linda, Hayden, Patrick J., Onida, Francesco, Scheid, Christof, Chalandon, Yves, Robin, Marie, Yakoub-Agha, Ibrahim, Nabergoj, Mitja, Mauff, Katya, Beelen, Dietrich, Ganser, Arnold, Kröger, Nicolaus, Stölzel, Friedrich, Finke, Jürgen, Passweg, Jakob, Cornelissen, Jan, Schub, Natalie, Veelken, Joan Hendrik, Beguin, Yves, Wilson, Keith, Zuckerman, Tsila, Hunault-Berger, Mathilde, Lioure, Bruno, Porras, Rocio Parody, Turlure, Pascal, Kerre, Tessa, Koster, Linda, Hayden, Patrick J., Onida, Francesco, Scheid, Christof, Chalandon, Yves, Robin, Marie, and Yakoub-Agha, Ibrahim

Abstract

We performed a registry study on therapy-related myeloid neoplasm (t-MN), both therapy-related myelodysplastic syndrome (t-MDS) and acute myeloid leukemia (t-AML) following treatment for breast cancer who underwent a first allogeneic hematopoietic cell transplant (allo-HCT). Of 252 identified female patients (median age 57 years), 77% were transplanted for t-AML and 23% for t-MDS, with a median time from breast cancer diagnosis to the diagnosis of tMN and subsequent allo-HCT of 3.7 and 4.6 years, respectively. At transplant, 191 patients were in remission for breast cancer, while 4 were not (57 missing). T-MN was in a complete remission at the time of transplant in 67% of patients. 2-year overall survival, relapse free-survival, relapse incidence and non-relapse mortality were 50%, 45%, 33%, and 22%, respectively. Multivariable analysis revealed that if the t-MN was not in CR pre-transplant, this was associated with lower OS, RFS, and a higher relapse incidence. Seventeen cases of breast cancer recurrence were recorded after a median of 2.4 years post-transplant, and relapse of primary breast cancer accounted for 7% of deaths. This study indicates that allo-HCT for t-MN following treatment for breast cancer shows encouraging transplant outcomes. The incidence of breast cancer relapse post-transplant remains a cause for concern.

Published
2022

45. A cytogenetic study of 397 consecutive acute myeloid leukemia cases identified three with a t(7;21) associated with 5q abnormalities and exhibiting similar clinical and biological features, suggesting a new, rare acute myeloid leukemia entity

Author

Jeandidier, Eric, Gervais, Carine, Radford-Weiss, Isabelle, Zink, Estelle, Gangneux, Catherine, Eischen, Alice, Galoisy, Anne Cécile, Helias, Catherine, Dano, Laurent, Cammarata, Ornella, Jung, Georges, Harzallah, Inès, Guérin, Eric, Martzolff, Lionel, Drénou, Bernard, Lioure, Bruno, Tancrédi, Céline, Rimelen, Valérie, and Mauvieux, Laurent

Published
2012
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46. Early matched sibling hematopoietic cell transplantation for adult AML in first remission using an age-adapted strategy: long-term results of a prospective GOELAMS study

Author

Lioure, Bruno, Béné, Marie C., Pigneux, Arnaud, Huynh, Anne, Chevallier, Patrice, Fegueux, Nathalie, Blaise, Didier, Witz, Brigitte, Delain, Martine, Cornillon, Jérôme, Luquet, Isabelle, Blanchet, Odile, Cornillet-Lefebvre, Pascale, Carré, Martin, Hunault, Mathilde, Larosa, Fabrice, Lamy, Thierry, Randriamalala, Edouard, Ojeda-Uribe, Mario, Berthou, Christian, Fornecker, Luc, Harousseau, Jean-Luc, Bouscary, Didier, Ifrah, Norbert, and Cahn, Jean-Yves

Published
2012
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47. 20-Year Steady Increase in Survival of Adult Patients with Relapsed Philadelphia-Positive Acute Lymphoblastic Leukemia Post Allogeneic Hematopoietic Cell Transplantation

Author

Bazarbachi, Ali, primary, Labopin, Myriam, additional, Aljurf, Mahmoud, additional, Niittyvuopio, Riitta, additional, Balsat, Marie, additional, Blaise, Didier, additional, Yakoub-Agha, Ibrahim, additional, Grassi, Anna, additional, Reinhardt, Hans Christian, additional, Lenhoff, Stig, additional, Jindra, Pavel, additional, Passweg, Jakob, additional, Abou Dalle, Iman, additional, Stadler, Michael, additional, Lioure, Bruno, additional, Ceballos, Patrice, additional, Brissot, Eolia, additional, Giebel, Sebastian, additional, Nagler, Arnon, additional, Schmid, Christoph, additional, and Mohty, Mohamad, additional

Published
2022
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49. Dismal prognostic value of monosomal karyotype in elderly patients with acute myeloid leukemia: a GOELAMS study of 186 patients with unfavorable cytogenetic abnormalities

Author

Perrot, Aurore, Luquet, Isabelle, Pigneux, Arnaud, Mugneret, Francine, Delaunay, Jacques, Harousseau, Jean-Luc, Barin, Carole, Cahn, Jean-Yves, Guardiola, Philippe, Himberlin, Chantal, Recher, Christian, Vey, Norbert, Lioure, Bruno, Ojeda-Uribe, Mario, Fegueux, Nathalie, Berthou, Christian, Randriamalala, Edouard, Béné, Marie C., Ifrah, Norbert, and Witz, Francis

Published
2011
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50. Autologous Hematopoietic Cell Transplantation For Relapsed Multiple Myeloma Performed With Stem Cells Re-Mobilised Following A Prior AUTO-HCT - A Retrospective Study on Behalf of EBMT CMWP

Author

Byrne, Jennifer, Snowden, John A., Crawley, Charles, Colorado Araujo, Mercedes, de Wreede, Liesbeth, Passweg, Jakob, Van Gorkom, Gwendolyn, GÜRMAN, GÜNHAN, Zinger, Nienke, Gras, Luuk, Yakoub-Agha, Ibrahim, Schoenland, Stefan, Tilly, Herve, BEKSAÇ, MERAL, Hayden, Patrick, Bulabois, Claude Eric, Arat, Mutlu, Basak, Grzegorz, Pouli, Anastasia, Poire, Xavier, Wilson, Keith M. O., Lioure, Bruno, Schroyens, Wilfried, ÖZKURT, ZÜBEYDE NUR, and Drozd-Sokolowska, Joanna

Published
2021

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