1. Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants
- Author
-
Richard C. Hartley and Linsey Robertson
- Subjects
chemistry.chemical_classification ,Reactive oxygen species ,Zincke reaction ,Pyridinium Compounds ,Spin trapping ,010405 organic chemistry ,Radical ,Organic Chemistry ,010402 general chemistry ,medicine.disease_cause ,01 natural sciences ,Combinatorial chemistry ,Biochemistry ,Article ,0104 chemical sciences ,Nitrone ,chemistry.chemical_compound ,chemistry ,Drug Discovery ,medicine ,Organic chemistry ,QD ,Pyridinium ,Oxidative stress - Abstract
The generation of excess reactive oxygen species (ROS) in mitochondria is responsible for much of the oxidative stress associated with ageing (aging), and mitochondrial dysfunction is part of the pathology of neurodegeneration and type 2 diabetes. Lipophilic pyridinium ions are known to accumulate in mitochondria and this paper describes a general route for the preparation of nitrone-containing N-arylpyridinium salts having a range of lipophilicities, as potential therapeutic antioxidants. The compatibility of nitrones with the Zincke reaction is the key to their synthesis. Their trapping of carbon-centred radicals and the EPR spectra of the resulting nitroxides are reported., Graphical abstract
- Published
- 2009
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