1,181 results on '"Linseisen, J"'
Search Results
2. Associations between anthropometric parameters and immune-phenotypical characteristics of circulating Tregs and serum cytokines
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Schmitz, Timo, Freuer, D., Meisinger, C., and Linseisen, J.
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- 2023
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3. Sex-specific associations between systolic, diastolic and pulse pressure and hemostatic parameters in the population-based KORA-Fit study: a cross-sectional study
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Vogel von Falckenstein, J., Freuer, D., Peters, A., Heier, M., Linseisen, J., and Meisinger, C.
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- 2023
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4. Associations between serum cholesterol and immunophenotypical characteristics of circulatory B cells and Tregs
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Schmitz, T., Freuer, D., Linseisen, J., and Meisinger, C.
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- 2023
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5. Prognostic value of stress hyperglycemia ratio on short- and long-term mortality after acute myocardial infarction
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Schmitz, T., Freuer, D., Harmel, E., Heier, M., Peters, A., Linseisen, J., and Meisinger, C.
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- 2022
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6. Inflammatory plasma proteins predict short-term mortality in patients with an acute myocardial infarction
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Schmitz, T., Harmel, E., Heier, M., Peters, A., Linseisen, J., and Meisinger, C.
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- 2022
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7. Anterior-wall and non-anterior-wall STEMIs do not differ in long-term mortality: results from the augsburg myocardial infarction registry
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Bauke, F., primary, Schmitz, T., additional, Harmel, E., additional, Raake, P., additional, Heier, M., additional, Linseisen, J., additional, Peters, A., additional, and Meisinger, C., additional
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- 2024
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8. Depressivität und Ängstlichkeit zwei Jahre nach einer akuten Lungenembolie: Prävalenz und Prädiktoren
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Fischer, S, additional, Meisinger, C, additional, Linseisen, J, additional, Berghaus, T, additional, and Kirchberger, I, additional
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- 2023
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9. COVID-19 risk perceptions, worries and preventive behaviors in patients with previous myocardial infarction: results from the myocardial infarction registry Augsburg.
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Harmel, E., Schmitz, T., Meisinger, C., Linseisen, J., von Scheidt, W., Thilo, C., and Kirchberger, I.
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MYOCARDIAL infarction complications ,RESEARCH ,MEDICAL quality control ,COVID-19 ,SCIENTIFIC observation ,HEALTH services accessibility ,ATTITUDE (Psychology) ,CROSS-sectional method ,FISHER exact test ,RISK perception ,HEALTH literacy ,PREVENTIVE health services ,RISK assessment ,COMPARATIVE studies ,T-test (Statistics) ,PATIENTS' attitudes ,HEALTH attitudes ,HEALTH behavior ,DESCRIPTIVE statistics ,QUESTIONNAIRES ,CHI-squared test ,STATISTICAL correlation ,PSYCHOLOGICAL adaptation ,PATIENT compliance ,DATA analysis software ,SOCIODEMOGRAPHIC factors ,LONGITUDINAL method - Abstract
Despite the known association of chronic cardiovascular diseases and more severe courses of COVID-19, little is known about individual risk perception of patients with a history of acute myocardial infarction (AMI) and resulting preventive behaviours. In May 2020, a postal survey was conducted, including 150 patients with previous AMI from the myocardial infarction registry Augsburg. The study objective was to assess COVID-19 knowledge, individual risk perception, worries, infection likelihood and preventive behaviours in this patient cohort. From the 100 respondents, 69.7% perceived themselves to be at high risk of developing a severe course of COVID-19. There was a significant positive correlation between dangerousness assessment and knowledge on COVID-19. Despite a majority (70%) of patients rating their susceptibility for an infection as moderate to very high, the individual likelihood of being infected was rated at only 3%. Almost 70% of patients with previous MI classified themselves at high risk for a severe course of COVID-19 infection. As seen in other risk groups as well, the availability of valuable information sources as well as the support in individual risk reduction strategies and psychological coping mechanisms are mandatory, especially since higher knowledge correlates with dangerousness assessment and might lead to better compliance with preventive behaviours. [ABSTRACT FROM AUTHOR]
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- 2023
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10. Are sleep duration, midpoint of sleep and sleep quality associated with dietary intake among Bavarian adults?
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Kleiser, C., Wawro, N., Stelmach-Mardas, M., Boeing, H., Gedrich, K., Himmerich, H., and Linseisen, J.
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Food habits -- Health aspects ,Sleep -- Health aspects ,Food/cooking/nutrition ,Health - Abstract
Background/Objectives: Only few epidemiologic studies examined sleep characteristics in relation to dietary behaviour. Our aim was to analyse associations of sleep duration, midpoint of sleep and sleep quality with dietary intake among the Bavarian population. Subjects/Methods: Within the cross-sectional Bavarian Food Consumption Survey II, 1050 subjects aged 13-81 years were recruited. Dietary intake was assessed with three 24-h dietary recalls by telephone (EPIC-Soft). In our study, 814 participants aged 18 years or older, who completed at least two 24-h dietary recalls and who had complete and plausible information on sleep characteristics were analysed. Dietary intake was described by the consumption of main food groups, energy-proving nutrients and energy intake. Sleep was measured by the Pittsburgh Sleep Quality Index Questionnaire, from which categories of self-reported usual sleep duration in half-h-steps per night, midpoint of sleep and overall sleep quality were derived. Results: Sleep duration was associated with intake of non-alcoholic beverages (P Conclusions: Our findings demonstrate only specific associations between sleep characteristics and dietary intake, and mainly sleep duration was associated with beverage intake., Author(s): C Kleiser [sup.1] [sup.2] , N Wawro [sup.1] [sup.2] , M Stelmach-Mardas [sup.3] , H Boeing [sup.3] , K Gedrich [sup.4] , H Himmerich [sup.5] , J Linseisen [sup.1] [...]
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- 2017
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11. Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS
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Hellbach, F., Sinke, L., Costeira, R., Baumeister, S.E., Beekman, M., Louca, P., Leeming, E.R., Mompeo, O., Berry, S., Wilson, R., Wawro, N., Freuer, D., Hauner, H., Peters, A., Winkelmann, J., Koenig, W., Meisinger, C., Waldenberger, M., Heijmans, B.T., Slagboom, P.E., Bell, J.T., and Linseisen, J.
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Nutrition and Dietetics ,Medicine (miscellaneous) ,Humans ,Diet ,Ewas ,Food Group ,High-fat Foods ,ddc:610 ,Food group ,High-fat foods ,EWAS - Abstract
Purpose Examining epigenetic patterns is a crucial step in identifying molecular changes of disease pathophysiology, with DNA methylation as the most accessible epigenetic measure. Diet is suggested to affect metabolism and health via epigenetic modifications. Thus, our aim was to explore the association between food consumption and DNA methylation. Methods Epigenome-wide association studies were conducted in three cohorts: KORA FF4, TwinsUK, and Leiden Longevity Study, and 37 dietary exposures were evaluated. Food group definition was harmonized across the three cohorts. DNA methylation was measured using Infinium MethylationEPIC BeadChip in KORA and Infinium HumanMethylation450 BeadChip in the Leiden study and the TwinsUK study. Overall, data from 2293 middle-aged men and women were included. A fixed-effects meta-analysis pooled study-specific estimates. The significance threshold was set at 0.05 for false-discovery rate-adjusted p values per food group. Results We identified significant associations between the methylation level of CpG sites and the consumption of onions and garlic (2), nuts and seeds (18), milk (1), cream (11), plant oils (4), butter (13), and alcoholic beverages (27). The signals targeted genes of metabolic health relevance, for example, GLI1, RPTOR, and DIO1, among others. Conclusion This EWAS is unique with its focus on food groups that are part of a Western diet. Significant findings were mostly related to food groups with a high-fat content.
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- 2022
12. Assessment of the association of exposure to polycyclic aromatic hydrocarbons, oxidative stress, and inflammation: A cross-sectional study in Augsburg, Germany
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Wu, Xiao, primary, Cao, Xin, additional, Lintelmann, Jutta, additional, Peters, Annette, additional, Koenig, Wolfgang, additional, Zimmermann, Ralf, additional, Schneider, Alexandra, additional, Wolf, Kathrin, additional, Peters, A., additional, Schwettmann, L., additional, Leidl, R., additional, Heier, M., additional, Linkohr, B., additional, Grallert, H., additional, Gieger, C., additional, and Linseisen, J., additional
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- 2022
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13. Seasonality of food groups and total energy intake: a systematic review and meta-analysis
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Stelmach-Mardas, M., Kleiser, C., Uzhova, I., Penalvo, J.L., La Torre, G., Palys, W., Lojko, D., Nimptsch, K., Suwalska, A., Linseisen, J., Saulle, R., Colamesta, V., and Boeing, H.
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Food consumption -- Health aspects ,Bioenergetics -- Observations ,Energy metabolism -- Observations ,Food/cooking/nutrition ,Health - Abstract
BACKGROUND/OBJECTIVES: The aim of this systematic review and meta-analysis was to assess the effect of season on food intake from selected food groups and on energy intake in adults. SUBJECTS/METHODS: The search process was based on selecting publications listed in the following: Medline, Scopus, Web of Science, Embase and Agris. Food frequency questionnaires, 24-h dietary recalls and food records as methods for assessment of dietary intake were used to assess changes in the consumption of 11 food groups and of energy intake across seasons. A meta-analysis was performed. RESULTS: Twenty-six studies were included. Articles were divided into those reporting data on four seasons (winter, spring, summer and autumn) or on two seasons (pre-and post-harvest). Four of the studies could be utilized for meta-analysis describing changes in food consumption across four season scheme: from winter to spring fruits decreased, whereas vegetables, eggs and alcoholic beverages increased; from spring to summer vegetable consumption further increased and cereals decreased; from summer to autumn fruits and cereals increased and vegetables, meat, eggs and alcoholic beverages decreased; from autumn to winter cereals decreased. A significant association was also found between energy intake and season, for 13 studies reporting energy intake across four seasons (favors winter) and for eight studies across pre- and post-harvest seasons (favors post-harvest). CONCLUSIONS: The winter or the post-harvest season is associated with increased energy intake. The intake of fruits, vegetables, eggs, meat, cereals and alcoholic beverages is following a seasonal consumption pattern and at least for these foods season is determinant of intake. European Journal of Clinical Nutrition (2016) 70, 700-708; doi:10.1038/ejcn.2015.224; published online 13 January 2016, INTRODUCTION A seasonal food can be defined as 'food that is outdoor grown or produced during the natural growing/production period for the country or region where it is produced. It [...]
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- 2016
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14. Association of serum vitamin D with change in weight and total body fat in a German cohort of older adults
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Vogt, S., Zierer, A., Laxy, M., Koenig, W., Linkohr, B., Linseisen, J., Peters, A., and Thorand, B.
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Body weight -- Measurement ,Adipose tissue -- Measurement ,Vitamin D -- Analysis -- Physiological aspects ,Food/cooking/nutrition ,Health - Abstract
We examined the association of baseline serum 25-hydroxyvitamin D (25(OH)D) with change in weight and total body fat in a cohort of community-dwelling older adults from Southern Germany. A total of 735 participants of the population-based KORA-Age Study (2009-2012), aged 65-90 years, were followed for 2.9 [+ or -]0.1 years. Body fat was assessed with bioelectrical impedance analysis. Linear and multinomial logistic models, adjusted for baseline covariables, were used to examine the association of 25(OH)D with percentage weight and body fat change during follow-up. 25(OH)D levels were not associated with overall weight change or body fat loss. Higher 25(OH)D levels were associated with a lower likelihood of having gained > 3% of body fat in women but not in men. As we cannot exclude residual confounding by outdoor physical activity and diet, our results are not sufficient to support a causal role of 25(OH)D in the etiology of obesity in Caucasian older adults. doi:10.1038/ejcn.2015.89; published online 22 July 2015, INTRODUCTION In older adults, obesity is associated with severe health consequences. (1) As weight loss, however, is only restrictively recommended to this age group, as it may have adverse effects [...]
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- 2016
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15. COVID-19 risk perceptions, worries and preventive behaviors in patients with previous myocardial infarction: results from the myocardial infarction registry Augsburg
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Harmel, E., primary, Schmitz, T., additional, Meisinger, C., additional, Linseisen, J., additional, von Scheidt, W., additional, Thilo, C., additional, and Kirchberger, I., additional
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- 2022
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16. Additional file 1 of Inflammatory plasma proteins predict short-term mortality in patients with an acute myocardial infarction
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Schmitz, T., Harmel, E., Heier, M., Peters, A., Linseisen, J., and Meisinger, C.
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Additional file 1: Table S1. Results of the logistic regression models including the biomarkers full names. Table S2. Predictive ability of the individual components of the GRACE score. For each component, a ROC analyses for 28-day mortality was calculated and its results are displayed in the table below. Figure S1. Multivariable adjusted logistic regression models including the additional covariate ‘prehospital time’. P-values were FDR-adjusted. Names of the markers are presented for all markers with FDR-adjusted p-values below 0.05. Figure S2. Multivariable adjusted logistic regression models including only observations of patients who received PCI treatment. P-values were FDR-adjusted. Names of the markers are presented for all markers with FDR-adjusted p-values below 0.05. Figure S3. ROC curves for the biomarker score (on the left) and the combined total score (on the right) in comparison to the GRACE score (blue curve). Only cases of patients who received PCI treatment were included. The displayed p-values were obtained from comparing the AUC values via bootstrapping.
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- 2022
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17. Das Design der Machbarkeitsstudien für eine bundesweite Kohortenstudie in Deutschland: Die Pretests der Nationalen Kohorte (NAKO)
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Ahrens, W., Greiser, H., Linseisen, J., Kluttig, A., Schipf, S., Schmidt, B., and Günther, K.
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- 2014
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18. Feasibility and quality development of biomaterials in the pretest studies of the German National Cohort
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Kühn, A., Nieters, A., Köttgen, A., Goek, O.N., Michels, K., Nöthlings, U., Jacobs, G., Meisinger, C., Pessler, F., Akmatov, M.F., Kühnisch, J., Moebus, S., Glocker, E., Naus, S., Keimling, M., Leitzmann, M., Linseisen, J., Sarioglu, H., von Toerne, C., Hauck, S.M., Wallaschofski, H., Wichmann, H.E., and Illig, Thomas
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- 2014
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19. Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Büchner, F. L., Bueno-de-Mesquita, H. B., Linseisen, J., Boshuizen, H. C., Kiemeney, L. A. L. M., Ros, M. M., Overvad, K., Hansen, L., Tjonneland, A., Raaschou-Nielsen, O., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Touillaud, M., Kaaks, R., Rohrmann, S., Boeing, H., Nöthlings, U., Trichopoulou, A., Zylis, D., Dilis, V., Palli, D., Sieri, S., Vineis, P., Tumino, R., Panico, S., Peeters, P. H. M., van Gils, C. H., Lund, E., Gram, I. T., Braaten, T., Martinez, C., Agudo, A., Arriola, L., Ardanaz, E., Navarro, C., Rodríguez, L., Manjer, J., Wirfält, E., Hallmans, G., Rasmuson, T., Key, T. J., Roddam, A. W., Bingham, S., Khaw, K.-T., Slimani, N., Bofetta, P., Byrnes, G., Norat, T., Michaud, D., and Riboli, E.
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- 2010
20. Meat Intake and Bladder Cancer in a Prospective Study: A Role for Heterocyclic Aromatic Amines?
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Lumbreras, B., Garte, S., Overvad, K., Tjonneland, A., Clavel-Chapelon, F., Linseisen, J. P., Boeing, H., Trichopoulou, A., Palli, D., Peluso, M., Krogh, V., Tumino, R., Panico, S., Bueno-De-Mesquita, H. B., Peeters, P. H., Lund, E., Martinez, C., Dorronsoro, M., Barricarte, A., Chirlaque, M.-D., Quiros, J. R., Berglund, G., Hallmans, G., Day, N. E., Key, T. J., Saracci, R., Kaaks, R., Malaveille, C., Ferrari, P., Boffetta, P., Norat, T., Riboli, E., Gonzalez, C. A., and Vineis, P.
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- 2008
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21. Modified Mediterranean diet and survival after myocardial infarction: the EPIC-Elderly study
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Trichopoulou, A., Bamia, C., Norat, T., Overvad, K., Schmidt, E. B., Tjønneland, A., Halkjær, J., Clavel-Chapelon, F., Vercambre, M. -N., Boutron-Ruault, M. -C., Linseisen, J., Rohrmann, S., Boeing, H., Weikert, C., Benetou, V., Psaltopoulou, T., Orfanos, P., Boffetta, P., Masala, G., Pala, V., Panico, S., Tumino, R., Sacerdote, C., Bueno-de-Mesquita, H. B., Ocke, M. C., Peeters, P. H., Van der Schouw, Y. T., González, C., Sanchez, M. J., Chirlaque, M. D., Moreno, C., Larrañaga, N., Van Guelpen, B., Jansson, J. -H., Bingham, S., Khaw, K. -T., Spencer, E. A., Key, T., Riboli, E., and Trichopoulos, D.
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- 2007
22. Relationship of Alcohol Intake and Sex Steroid Concentrations in Blood in Pre- and Post-Menopausal Women: The European Prospective Investigation into Cancer and Nutrition
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Rinaldi, S., Peeters, P. H. M., Bezemer, I. D., Dossus, L., Biessy, C., Sacerdote, C., Berrino, F., Panico, S., Palli, D., Tumino, R., Khaw, K. T., Bingham, S., Allen, N. E., Key, T., Jensen, M. K., Overvad, K., Olsen, A., Tjonneland, A., Amiano, P., Ardanaz, E., Agudo, A., Martinez-García, C., Quirós, J. Ramón, Tormo, M. J., Nagel, G., Linseisen, J., Boeing, H., Schulz, M., Grobbee, D. E., Bueno-De-Mesquita, H. B., Koliva, M., Kyriazi, G., Thrichopoulou, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Ferrari, P., Slimani, N., Saracci, R., Riboli, E., and Kaaks, R.
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- 2006
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23. Development and evaluation of a short 24-h food list as part of a blended dietary assessment strategy in large-scale cohort studies
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Freese, J., Feller, S., Harttig, U., Kleiser, C., Linseisen, J., Fischer, B., Leitzmann, M.F., Six-Merker, J., Michels, K.B., Nimptsch, K., Steinbrecher, A., Pischon, T., Heuer, T., Hoffmann, I., Jacobs, G., Boeing, H., and Nothlings, U.
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Nutrition -- Product/Service Evaluations ,Food consumption -- Health aspects ,Food/cooking/nutrition ,Health - Abstract
BACKGROUND/OBJECTIVES: The validity of dietary assessment in large-scale cohort studies has been questioned. Combining data sources for the estimation of usual intake in a blended approach may enhance the validity of dietary measurement. Our objective was to develop a web-based 24-h food list for Germany to identify foods consumed during the previous 24 h and to evaluate the performance of the new questionnaire in a feasibility study. SUBJECTS/METHODS: Available data from the German National Nutrition Survey II were used to develop a finite list of food items. A total of 508 individuals were invited to fill in the 24-h food list via the Internet up to three times during a 3-6-month time period. In addition, participants were asked to evaluate the questionnaire using a brief online evaluation form. RESULTS: In total, 246 food items were identified for the 24-h food list, reflecting > 75% variation in intake of 27 nutrients and four major food groups. Among the individuals invited, 64% participated in the feasibility study. Of these, 100%, 85% and 68% of participants completed the 24-h food list one, two or three times, respectively. The average time needed to complete the questionnaire was 9 min, and its acceptability by participants was rated as high. CONCLUSIONS: The 24-h food list represents a promising new dietary assessment tool that can be used as part of a blended approach combining multiple data sources for valid estimation of usual dietary intake in large-scale cohort studies. European Journal of Clinical Nutrition (2014) 68, 324-329; doi:10.1038/ejcn.2013.274; published online 8 January 2014 Keywords: nutritional epidemiology; dietary assessment; statistical modelling Keywords: nutritional epidemiology; dietary assessment; statistical modelling, INTRODUCTION The valid estimation of long-term dietary intake in large-scale cohort studies represents a methodological challenge. Food frequency questionnaires (FFQs) have long been the instrument of choice. However, FFQs measure [...]
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- 2014
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24. Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study
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Abbas, S, Linseisen, J, Rohrmann, S, Beulens, J W J, Buijsse, B, Amiano, P, Ardanaz, E, Balkau, B, Boeing, H, Clavel-Chapelon, F, Fagherazzi, G, Franks, P W, Gavrila, D, Grioni, S, Kaaks, R, Key, T J, Khaw, K T, Kühn, T, Mattiello, A, Molina-Montes, E, Nilsson, P M, Overvad, K, Quirós, J R, Rolandsson, O, Sacerdote, C, Saieva, C, Slimani, N, Sluijs, I, Spijkerman, A M W, Tjonneland, A, Tumino, R, van der A, D L, Zamora-Ros, R, Sharp, S J, Langenberg, C, Forouhi, N G, Riboli, E, and Wareham, N J
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- 2014
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25. Red blood cell fatty acids and risk of colorectal cancer in the European Prospective investigation into cancer and nutrition (EPIC)
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Linseisen, J., Grundmann, N., Zoller, D., Kuhn, T., Chajes, V., Fedirko, V., Weiderpass, E., Dahm, C.C., Overvad, K., Tjønneland, A., Boutron-Ruault, M.-C., Rothwell, J.A., Severi, G., Kaaks, R., Schulze, M.B., Aleksandrova, K., Sieri, S., Panico, S., Tumino, R., Masala, G., de Marco, L., Bueno-De-Mesquita, B., Vermeulen, R., Gram, I.T., Skeie, G., Chirlaque, M.-D., Ardanaz, E., Agudo, A., Sánchez, M.-J., Amiano, P., Wennberg, M., Bodén, S., Perez-Cornago, A., Aglago, E.K., Gunter, M.J., Jenab, M., Heath, A.K., Nieters, A., IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2
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Oncology ,Epidemiology - Abstract
Background: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer risk. However, data from large-scale epidemiologic studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce. Methods: We investigate the association between red blood cell (RBC) membrane FAs and risk of colorectal cancer in a case–control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1,069 incident colorectal cancer cases were identified and matched to 1,069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The FA composition of RBC phospholipids (in mol%) was analyzed by gas chromatography, and their association with risk of colorectal cancer was estimated by multivariable adjusted conditional logistic regression models. Results: After correction for multiple testing, subjects with higher concentrations of RBC stearic acid were at higher risk for colorectal cancer (OR ¼ 1.23; 95% CI ¼ 1.07–1.42, per 1 mol%). Conversely, colorectal cancer incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62–0.92, per 1 mol%). The findings for the n-6 PUFA arachidonic acid were inconsistent. Conclusions: The positive association between prediagnostic RBC stearic acid and colorectal cancer reflects putative differences in FA intake and metabolism between cancer cases and matched controls, which deserve further investigation. The inverse relationship between EPA and colorectal cancer is in line with the repeatedly reported protective effect of fish consumption on colorectal cancer risk. Impact: These findings add to the evidence on colorectal cancer prevention.
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- 2021
26. TNF-α, soluble TNF receptor and interleukin-6 plasma levels in the general population
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Himmerich, H., Fulda, S., Linseisen, J., Seiler, H., Wolfram, G., Himmerich, S., Kurt Gedrich, and Pollmächer, T.
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- 2021
27. Host traits, lifestyle and environment are associated with human skin bacteria
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Moitinho‐Silva, L., primary, Boraczynski, N., additional, Emmert, H., additional, Baurecht, H., additional, Szymczak, S., additional, Schulz, H., additional, Haller, D., additional, Linseisen, J., additional, Gieger, C., additional, Peters, A., additional, Tittmann, L., additional, Lieb, W., additional, Bang, C., additional, Franke, A., additional, Rodriguez, E., additional, and Weidinger, S., additional
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- 2021
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28. The association of education with long-term weight change in the EPIC-PANACEA cohort
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Rohrmann, S, Steinbrecher, A, Linseisen, J, Hermann, S, May, A, Luan, J, Ekelund, U, Overvad, K, Tjønneland, A, Halkjær, J, Fagherazzi, G, Boutron-Ruault, M-C, Clavel-Chapelon, F, Agnoli, C, Tumino, R, Masala, G, Mattiello, A, Ricceri, F, Travier, N, Amiano, P, Ardanaz, E, Chirlaque, M-D, Sanchez, M-J, Rodríguez, L, Nilsson, L M, Johansson, I, Hedblad, B, Rosvall, M, Lund, E, Braaten, T, Naska, A, Orfanos, P, Trichopoulou, A, van den Berg, S, Bueno-de-Mesquita, H B, Bergmann, M M, Steffen, A, Kaaks, R, Teucher, B, Wareham, N J, Khaw, K-T, Crowe, F L, Illner, A-K, Slimani, N, Gallo, V, Mouw, T, Norat, T, and Peeters, P H M
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- 2012
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29. Die Nationale Kohorte
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Wichmann, H.-E., Kaaks, R., Hoffmann, W., Jöckel, K.-H., Greiser, K.H., and Linseisen, J.
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- 2012
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30. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)
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Crusius, J.B.A., Canzian, F., Capellá, G., Peña, A.S., Pera, G., Sala, N., Agudo, A., Rico, F., Del Giudice, G., Palli, D., Plebani, M., Boeing, H., Bueno-de-Mesquita, H.B., Carneiro, F., Pala, V., Save, V.E., Vineis, P., Tumino, R., Panico, S., Berglund, G., Manjer, J., Stenling, R., Hallmans, G., Martínez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quirós, J.R., Allen, N., Key, T.J., Binghan, S., Caldas, C., Linseisen, J., Kaaks, R., Overvad, K., Tjønneland, A., Büchner, F.C., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Trichopoulou, A., Lund, E., Jenab, M., Rinaldi, S., Ferrari, P., Riboli, E., and González, C.A.
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- 2008
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31. Diet and hip fractures among elderly Europeans in the EPIC cohort
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Benetou, V, Orfanos, P, Zylis, D, Sieri, S, Contiero, P, Tumino, R, Giurdanella, M C, Peeters, P H M, Linseisen, J, Nieters, A, Boeing, H, Weikert, C, Pettersson, U, Johansson, I, Bueno-de-Mesquita, H B, Dorronsoro, M, Boffetta, P, and Trichopoulou, A
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- 2011
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32. Depression, comorbidities and the TNF-α system
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Himmerich, H., Fulda, S., Linseisen, J., Seiler, H., Wolfram, G., Himmerich, S., Gedrich, K., Kloiber, S., Lucae, S., Ising, M., Uhr, M., Holsboer, F., and Pollmächer, T.
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- 2008
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33. Dietary β-carotene, vitamin C and E intake and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Nagel, G., Linseisen, J., van Gils, C. H., Peeters, P. H., Boutron-Ruault, M. C., Clavel-Chapelon, F., Romieu, I., Tjønneland, A., Olsen, A., Roswall, N., Witt, P. M., Overvad, K., Rohrmann, S., Kaaks, R., Drogan, D., Boeing, H., Trichopoulou, A., Stratigakou, V., Zylis, D., Engeset, D., Lund, E., Skeie, G., Berrino, F., Grioni, S., Mattiello, A., Masala, G., Tumino, R., Zanetti, R., Ros, M. M., Bueno-de-Mesquita, H. B., Ardanaz, E., Sánchez, M. J., Huerta, J. M., Amiano, P., Rodríguez, L., Manjer, J., Wirfält, E., Lenner, P., Hallmans, G., Spencer, E. A., Key, T. J., Bingham, S., Khaw, K. T., Rinaldi, S., Slimani, N., Boffetta, P., Gallo, V., Norat, T., and Riboli, E.
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- 2010
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34. A bivariate measurement error model for nitrogen and potassium intakes to evaluate the performance of regression calibration in the European Prospective Investigation into Cancer and Nutrition study
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Ferrari, P., Roddam, A., Fahey, M.T., Jenab, M., Bamia, C., Ocke, M., Amiano, P., Hjartaker, A., Biessy, C., Rinaldi, S., Huybrechts, I., Tjonneland, A., Dethlefsen, C., Niravong, M., Clavel-Chapelon, F., Linseisen, J., Boeing, H., Oikonomou, E., Orfanos, P., Palli, D., Santucci de Magistris, M., Bueno-de-Mesquita, H.B., Peeters, P.H.M., Parr, C.L., Braaten, T., Dorronsoro, M., Berenguer, T., Gullberg, B., Johansson, I., Welch, A.A., Riboli, E., Bingham, S., and Slimani, N.
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Oncology, Experimental -- Health aspects -- Measurement -- Methods ,Nutrition -- Product/Service Evaluations ,Potassium in the body -- Health aspects -- Measurement -- Methods ,Cancer -- Research ,Nitrogen in the body -- Health aspects -- Measurement -- Methods ,Food/cooking/nutrition ,Health - Abstract
Objectives: Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, the performance of 24-h dietary recall (24-HDR) measurements as reference measurements in a linear regression calibration model is evaluated critically at the individual (within-centre) and aggregate (between-centre) levels by using unbiased estimates of urinary measurements of nitrogen and potassium intakes. Methods: Between 1995 and 1999, 1072 study subjects (59% women) from 12 EPIC centres volunteered to collect 24-h urine samples. Log-transformed questionnaire, 24-HDR and urinary measurements of nitrogen and potassium intakes were analysed in a multivariate measurement error model to estimate the validity of coefficients and error correlations in self-reported dietary measurements. In parallel, correlations between means of 24-HDR and urinary measurements were computed. Linear regression calibration models were used to estimate the regression dilution (attenuation) factors. Results: After adjustment for sex, centre, age, body mass index and height, the validity coefficients for 24-HDRs were 0.285 (95% confidence interval: 0.194, 0.367) and 0.371 (0.291, 0.446) for nitrogen and potassium intakes, respectively. The attenuation factors estimated in a linear regression calibration model were 0.368 (0.228, 0.508) for nitrogen and 0.500 (0.361, 0.639) for potassium intakes; only the former was different from the estimate obtained using urinary measurements in the measurement error model. The aggregate-level correlation coefficients between means of urinary and 24-HDR measurements were 0.838 (0.637, 0.932) and 0.756 (0.481, 0.895) for nitrogen and potassium intakes, respectively. Conclusions: This study suggests that 24-HDRs can be used as reference measurements at the individual and aggregate levels for potassium intake, whereas, for nitrogen intake, good performance is observed for between-centre calibration, but some limitations are apparent at the individual level. Keywords: measurement errors; urinary measurements; EPIC; 24-h dietary recall; EPIC-SOFT doi: 10.1038/ejcn.2009.80, Introduction The accuracy of dietary assessment instruments used in nutritional epidemiology studies, that is, questionnaires such as food frequency questionnaires or dietary histories, has been repeatedly questioned (Freedman et al., [...]
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- 2009
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35. Dietary intake of the water-soluble vitamins B1, B2, B6, B12 and C in 10 countries in the European Prospective Investigation into Cancer and Nutrition
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Olsen, A., Halkjaer, J., van Gils, C.H., Buijsse, B., Verhagen, H., Jenab, M., Boutron-Ruault, M.C., Ericson, U., Ocke, M.C., Peeters, P.H.M., Touvier, M., Niravong, M., Waaseth, M., Skeie, G., Khaw, K.T., Travis, R., Ferrari, P., Sanchez, M.J., Agudo, A., Overvad, K., Linseisen, J., Weikert, C., Sacerdote, C., Evangelista, A., Zylis, D., Tsiotas, K., Manjer, J., van Guelpen, B., Riboli, E., Slimani, N., and Bingham, S.
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Oncology, Experimental -- Health aspects ,Vitamin C -- Health aspects -- Research ,Vitamin B -- Health aspects -- Research ,Cancer -- Research ,Vitamin B in human nutrition -- Research -- Health aspects ,Vitamin B complex -- Health aspects -- Research ,Recommended daily allowances -- Research -- Health aspects ,Food/cooking/nutrition ,Health - Abstract
Objectives: To describe the intake of vitamins thiamine (B1), riboflavin (B2), B6 (pyridoxine), B12 (cobalamine) and C (ascorbic acid) and their food sources among 27 centres in 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: Between 1995 and 2000, 36 034 persons aged between 35 and 74 years were administered a standardized 24-h dietary recall using a computerized interview software programme (EPIC-SOFT). Intakes of the four B vitamins and vitamin C were estimated using the standardized EPIC Nutrient Database (ENDB). Mean intakes were adjusted for age and weighted by season and day of recall. Results: Intake of B vitamins did not vary considerably between centres, except in the UK health-conscious cohort, in which substantially higher intakes of thiamine and lower intakes of vitamin B12 were reported compared with other centres. Overall, meat was the most important contributor to the B vitamins in all centres except in the UK health-conscious group. Vitamin C showed a clear geographical gradient, with higher intakes in the southern centres as compared with the northern ones; this was more pronounced in men than in women. Vegetables and fruits were major contributors to vitamin C in all centres, but juices and potatoes were also important sources in the northern centres. Conclusions: This study showed no major differences across centres in the mean intakes of B vitamins (thiamine, riboflavin, B6, B12), whereas a tendency towards a north-south gradient was observed for vitamin C. doi: 10.1038/ejcn.2009.78 Keywords: water-soluble vitamins; 24-h dietary recall; standardization; ENDB; EPIC; Europe, Introduction The B vitamins, together with vitamin C, constitute the water-soluble group of vitamins. Classic syndromes caused by a deficiency of water-soluble vitamins, such as scurvy (vitamin C) and beriberi [...]
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- 2009
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36. Variation in intakes of calcium, phosphorus, magnesium, iron and potassium in 10 countries in the European Prospective Investigation into Cancer and Nutrition study
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Welch, A.A., Fransen, H., Jenab, M., Boutron-Ruault, M.C., Tumino, R., Agnoli, C., Ericson, U., Johansson, I., Ferrari, P., Engeset, D., Lund, E., Lentjes, M., Key, T., Touvier, M., Niravong, M., Larranaga, N., Rodriguez, L., Ocke, M.C., Peeters, P.H.M., Tjonneland, A., Bjerregaard, L., Vasilopoulou, E., Dilis, V., Linseisen, J., Nothlings, U., Riboli, E., Slimani, N., and Bingham, S.
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Iron in the body -- Health aspects -- Research ,Chronic diseases -- Risk factors -- Research ,Potassium in the body -- Health aspects -- Research ,Calcium, Dietary -- Health aspects -- Research ,Cancer -- Risk factors ,Phosphorus in the body -- Health aspects -- Research ,Magnesium in the body -- Health aspects -- Research ,Diet -- Health aspects -- Research ,Food/cooking/nutrition ,Health - Abstract
Background/objectives: Adequate mineral intake is important for the maintenance of bone health, cellular function and general metabolism, and possibly in the aetiology of cancer and other chronic diseases. This study aimed at investigating variation in intakes of selected minerals across 10 European countries participating in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: Nutrient intakes for 36 034 subjects, aged between 35 and 74 years, in 27 centres were obtained using standardized 24-h dietary recall software (EPIC-SOFT). Mean intakes of calcium, phosphorus, magnesium, iron and potassium were calculated by centre and weighted by season and day of the week and were also stratified by age group. The contribution of food groups to total nutrient intake was calculated. Results: There was clear geographical variability in intakes, with differences ranging from 35% for magnesium to 90% for iron in men and 36% for potassium to 75% for calcium in women, and a twofold difference in sources of haem iron (meat and fish). There was a geographical gradient in iron intake, with higher intakes in Southern than in Northern Europe and also around a twofold north-south gradient in the contribution of fruits and vegetables to potassium intake. Compared with reference intakes, the majority of age groups and centres had intakes above the recommended levels. Dairy foods and products contributed the most to calcium and phosphorus intake in almost all centres. Cereals and cereal products contributed the most to magnesium and iron intakes, except in Greece and Germany. Conclusions: Intakes of minerals vary substantially throughout Europe, with some geographical variability in their food sources. doi: 10.1038/ejcn.2009.77 Keywords: calcium; phosphorus; magnesium; iron; potassium; EPIC, Introduction Minerals are essential nutrients, and adequate intakes are important not only for the maintenance of bone health but also for cellular function and general metabolism. Aspects of mineral metabolism [...]
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- 2009
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37. Alcohol consumption patterns, diet and body weight in 10 European countries
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Sieri, S., Krogh, V., Saieva, C., Grobbee, D.E., Bergmann, M., Rohrmann, S., Tjonneland, A., Ferrari, P., Chloptsios, Y., Dilis, V., Jenab, M., Linseisen, J., Wallstrom, P., Johansson, I., Chirlaque, M.D., Sanchez, M.J., Niravong, M., Clavel-Chapelon, F., Welch, A.A., Allen, N.E., Bueno-de-Mesquita, H.B., van der Schouw, Y.T., Sacerdote, C., Panico, S., Parr, C.L., Braaten, T., Olsen, A., Jensen, M.K., Bingham, S., Riboli, E., and Slimani, N.
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Drinking of alcoholic beverages -- Health aspects -- Demographic aspects -- Analysis ,Body weight -- Analysis -- Health aspects ,Diet -- Health aspects -- Analysis ,Food/cooking/nutrition ,Health - Abstract
Background/objectives: Europe has the highest level of alcohol consumption in the world. As drinking patterns are important determinants of the beneficial and harmful effects of alcohol consumption, we investigated alcohol consumption in relation to nutrient intake, place of consumption, education and body weight in a sample of adults from 10 European countries. Methods: A 24-h dietary recall interview was conducted on 13 025 men and 23 009 women, aged 35-74 years, from 27 centres participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Means and standard errors of alcohol consumption, adjusted for age, were calculated, stratified by gender and centre. Results: In many centres, higher level drinkers (males consuming >24 g of ethanol/day, equivalent to 42 standard drinks and females consuming >12 g of ethanol/day equivalent to >1 standard drink) obtained more energy from fat and protein and less from sugar than did abstainers. The proportion of energy from starch tended to be higher for male and lower for female higher level drinkers than for abstainers. Female higher level drinkers had a lower body mass index than did abstainers, whereas male higher level drinkers generally weighed more. Male higher level drinkers were less educated than abstainers in Mediterranean countries, but were more educated elsewhere. Female higher level drinkers were usually more educated than were abstainers. Outside the home, consumption (both genders) tended to be at friends' homes, particularly among men in Northern and Central Europe, and in bars in Spain. Conclusions: This study reveals clear geographical differences in drinking habits across Europe, and shows that the characteristics of different alcohol consumption categories also vary. doi: 10.1038/ejcn.2009.76 Keywords: Alcohol; EPIC; 24-h dietary recall; EPIC-Soft; ENDB, Introduction Europe has the highest level of alcohol consumption in the world (Rehm et al., 2003a). Studies on drinking patterns across Europe, in terms of place of consumption, types of [...]
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- 2009
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38. Dietary fat intake in the European Prospective Investigation into Cancer and Nutrition: results from the 24-h dietary recalls
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Linseisen, J., Welch, A.A., Ocke, M., Amiano, P., Agnoli, C., Ferrari, P., Sonestedt, E., Chajes, V., Bueno-de-Mesquita, H.B., Kaaks, R., Weikert, C., Dorronsoro, M., Rodriguez, L., Ermini, I., Mattiello, A., van der Schouw, Y.T., Manjer, J., Nilsson, S., Jenab, M., Lund, E., Brustad, M., Halkjaer, J., Jakobsen, M.U., Khaw, K.T., Crowe, F., Georgila, C., Misirli, G., Niravong, M., Touvier, M., Bingham, S., Riboli, E., and Slimani, N.
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Cholesterol -- Health aspects ,Dietary fat -- Health aspects ,Cancer -- Risk factors ,Diet -- Health aspects ,Food/cooking/nutrition ,Health - Abstract
Objectives: This paper describes the dietary intake of total fat, saturated (SFA), monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA) and cholesterol of participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) in 27 centres across 10 countries. Methods: Between 1995 and 2000, a stratified random sample of 36 034 participants (age range 35-74 years) completed a standardized 24-h dietary recall, assessed by means of the computer software EPIC-SOFT. Lipid intake data were calculated using a standardized nutrient database. Results: On average, the contribution of fat to total energy intake was ≥ 34% of energy intake (%en) in women and ≥ 36%en in men for most EPIC centres, except for the British, Dutch and most Italian cohorts. Total fat (440%en) and MUFA intakes (21%en, mainly from olive oil) were highest in Greece. Except for the Greek, Spanish and Italian centres, the average MUFA intake ranged between 10 and 13%en, with a high proportion derived from animal sources. SFA intake in women and men was lowest in the Greek, Spanish, Italian and UK cohorts with an average of ≤ 13%en (down to 9%en), and highest in the Swedish centres (16%en). The mean PUFA intake was in the range of 4-8%en, being highest in the UK health-conscious cohort. The average cholesterol intake across EPIC varied from 140 to 384 mg/d in women and 215-583 mg/d in men. Conclusions: The presented data show differences and similarities in lipid intake across the European EPIC cohorts and also show differences in food sources of dietary lipids. doi: 10.1038/ejcn.2009.75 Keywords: EPIC; 24-h diet recalls; dietary intake; lipids; EPIC-Soft; ENDB, Introduction Diet has a major impact on modulating the risk and severity of a number of chronic diseases including obesity and obesity-related metabolic disorders, cardiovascular diseases and cancer. Among macronutrients, [...]
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- 2009
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39. Intake of total, animal and plant proteins, and their food sources in 10 countries in the European Prospective Investigation into Cancer and Nutrition
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Halkjaer, J., Olsen, A., Bjerregaard, L.J., Deharveng, G., Tjonneland, A., Welch, A.A., Crowe, F.L., Wirfalt, E., Hellstrom, V., Niravong, M., Touvier, M., Linseisen, J., Steffen, A., Ocke, M.C., Peeters, P.H.M., Chirlaque, M.D., Larranaga, N., Ferrari, P., Contiero, P., Frasca, G., Engeset, D., Lund, E., Misirli, G., Kosti, M., Riboli, E., Slimani, N., and Bingham, S.
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Oncology, Experimental -- Health aspects -- Measurement ,Proteins in human nutrition -- Health aspects -- Measurement -- Research ,Plant proteins -- Consumption data -- Health aspects -- Research -- Measurement ,Cancer -- Research ,Food/cooking/nutrition ,Health - Abstract
Objective: To describe dietary protein intakes and their food sources among 27 redefined centres in 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Between 1995 and 2000, 36 034 persons, aged between 35 and 74 years, were administered a standardized 24-h dietary recall (24-HDR) using a computerized interview software programme (EPIC-SOFT). Intakes (g/day) of total, animal and plant proteins were estimated using the standardized EPIC Nutrient Database (ENDB). Mean intakes were adjusted for age, and weighted by season and day of recall. Results: Mean total and animal protein intakes were highest in the Spanish centres among men, and in the Spanish and French centres among women; the lowest mean intakes were observed in the UK health-conscious group, in Greek men and women, and in women in Potsdam. Intake of plant protein was highest among the UK health-conscious group, followed by some of the Italian centres and Murcia, whereas Sweden and Potsdam had the lowest intake. Cereals contributed to the highest proportion of plant protein in all centres. The combined intake of legumes, vegetables and fruit contributed to a greater proportion of plant protein in the southern than in the northern centres. Total meat intake (with some heterogeneity across subtypes of meat) was, with few exceptions, the most important contributor to animal protein in all centres, followed by dairy and fish products. Conclusions: This study shows that intake of protein, especially of animal origin, differs across the 10 European countries, and also shows some differences in food sources of protein across Europe. doi: 10.1038/ejcn.2009.73 Keywords: total proteins; animal proteins; plant proteins; EPIC; 24-h dietary recall; ENDB, Introduction Dietary protein is an important macronutrient, contributing to around 15-20% of the total dietary energy intake in Western countries (CDC, 2004; Elmadfa and Weichselbaum, 2005). Protein, which contributes essential [...]
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- 2009
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40. Energy intake and sources of energy intake in the European Prospective Investigation into Cancer and Nutrition
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Ocke, M.C., Larranaga, N., Grioni, S., van den Berg, S.W., Ferrari, P., Salvini, S., Benetou, V., Linseisen, J., Wirfalt, E., Rinaldi, S., Jenab, M., Halkjaer, J., Jakobsen, M.U., Niravong, M., Clavel-Chapelon, F., Kaaks, R., Bergmann, M., Moutsiou, E., Trichopoulou, A., Lauria, C., Sacerdote, C., Bueno-de-Mesquita, H.B., Peeters, P.H.M., Hjartaker, A., Parr, C.L., Tormo, M.J., Sanchez, M.J., Manjer, J., Hellstrom, V., Mulligan, A., Spencer, E.A., Riboli, E., Bingham, S., and Slimani, N.
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Oncology, Experimental -- Methods -- Health aspects ,Cancer -- Research ,Diet -- Health aspects -- Demographic aspects -- Research -- Methods ,Food/cooking/nutrition ,Health - Abstract
Objectives: To describe energy intake and its macronutrient and food sources among 27 regions in 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: Between 1995 and 2000, 36034 subjects aged 35-74 years were administered a standardized 24-h dietary recall. Intakes of macronutrients (g/day) and energy (kcal/day) were estimated using standardized national nutrient databases. Mean intakes were weighted by season and day of the week and were adjusted for age, height and weight, after stratification by gender. Extreme low- and high-energy reporters were identified using Goldberg's cutoff points (ratio of energy intake and estimated basal metabolic rate 2.72), and their effects on macronutrient and energy intakes were studied. Results: Low-energy reporting was more prevalent in women than in men. The exclusion of extreme-energy reporters substantially lowered the EPIC-wide range in mean energy intake from 2196-2877 to 2309-2866 kcal among men. For women, these ranges were 1659-2070 and 1873-2108 kcal. There was no north-south gradient in energy intake or in the prevalence of low-energy reporting. In most centres, cereals and cereal products were the largest contributors to energy intake. The food groups meat, dairy products and fats and oils were also important energy sources. In many centres, the highest mean energy intakes were observed on Saturdays. Conclusions: These data highlight and quantify the variations and similarities in energy intake and sources of energy intake among 10 European countries. The prevalence of low-energy reporting indicates that the study of energy intake is hampered by the problem of underreporting. Keywords: energy intake; underreporting; dietary fat; 24-h dietary recall; Europe; EPIC-soft doi: 10.1038/ejcn.2009.72, Introduction Nowadays, in Europe, an enormously rich variety of foods is available on the market, and this very abundance, especially of energy-dense foods and drinks, is considered to be one [...]
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- 2009
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41. General and abdominal adiposity and risk of death in Europe
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Pischon, T., Boeing, H, Hoffmann, K., Bergmann, M., Schulze, M.B., Overvad, K., van der Schouw, Y.T., Spencer E., Moons, K.G.M., Tjonneland, A., Halkjaer, J., Jensen, M.K., Stegger, J., Clavel-Chapelon, F., Boutron-Ruault, M.C., Chajes, V., Linseisen, J., Kaaks, R., Trichopoulou, A., Trichopoulou, D., Bamia, C., Sieri, S., Palli, D., Tumino, R., Vineis, P., Panico, S., Peeters, P.H.M., May, A.M., Bueno-de-Mesquita, H.B, van Duijnhoven, F.J.B., Hallmans, G., Weinehall, L., Manjer, J., Hedblad, B., Lund, E., Agudo, A., Arriola, L., Barricarte, A., Navarro, C., Martinez, C., Quiros, J.R., Key, T., Bingham, S., Khaw, K.T., Chir, B., Boffetta, P., Jenab, M., Ferrari, P., and Riboli, E.
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Body mass index -- Research ,Obesity -- Risk factors ,Europe -- Health aspects - Abstract
The study aims to investigate whether general and abdominal adiposity is a contributory factor in increasing the risk of death in Europe. The results indicate that both general and abdominal adiposity are associated with a higher risk of death.
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- 2008
42. Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women
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Norat, T, Dossus, L, Rinaldi, S, Overvad, K, Grønbæk, H, Tjønneland, A, Olsen, A, Clavel-Chapelon, F, Boutron-Ruault, M C, Boeing, H, Lahmann, P H, Linseisen, J, Nagel, G, Trichopoulou, A, Trichopoulos, D, Kalapothaki, V, Sieri, S, Palli, D, Panico, S, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, H B, Peeters, P H M, van Gils, C H, Agudo, A, Amiano, P, Ardanoz, E, Martinez, C, Quirós, R, Tormo, M J, Bingham, S, Key, T J, Allen, N E, Ferrari, P, Slimani, N, Riboli, E, and Kaaks, R
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- 2007
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43. Häufigkeit von Asthma bronchiale und Alter bei der Erstdiagnose - erste Ergebnisse der NAKO Gesundheitsstudie [Occurrence of bronchial asthma and age at initial asthma diagnosis-first results of the German National Cohort]
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Langer, S., Horn, J., Kluttig, A., Mikolajczyk, R., Karrasch, S., Schulz, H., Wichmann, H.E., Linseisen, J., Jaeschke, L., Pischon, T., Fricke, J., Keil, T., Ahrens, W., Günther, K., Kuß, O., Schikowski, T., Schmidt, B., Jöckel, K.H., Michels, K.B., Franzke, C.W., Becher, H., Jagodzinski, A., Castell, S., Kemmling, Y., Lieb, W., Waniek, S., Wirkner, K., Löffler, M., Kaaks, R., Greiser, K.H., Berger, K., Legath, N., Meinke-Franze, C., Schipf, S., Leitzmann, M., Baurecht, H., Weigl, K., Amitay, E., and Gottschick, C.
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Cardiovascular and Metabolic Diseases - Abstract
BACKGROUND: Asthma is one of the most common chronic diseases in both children and adults. Asthma first occurring in adulthood (adult-onset asthma, AOA) is associated with poorer prognosis compared to childhood-onset asthma (COA), which urgently calls for more research in this area. The aim of this work was to analyze the data on asthma collected in the German National Cohort and compare it with the German Health Interview and Examination Survey for Adults (DEGS), in particular regarding AOA. MATERIAL AND METHODS: Our analysis was based on the dataset of the main questionnaire at mid-term of the German National Cohort baseline examination, comprising 101,723 participants. Variables considered in the analyses were self-reported diagnosis of asthma, age at first diagnosis, asthma treatment in the past 12 months, age, and sex. RESULTS: In the midterm dataset, 8.7% of women and 7.0% of men in the German National Cohort reported that they had ever been diagnosed with asthma. Approximately one third of participants with asthma received their initial diagnosis before their 18th birthday. COA affected 2.2% of women and 2.8% of men, whereas AOA affected 6.5% of women and 4.2% of men. During the previous 12 months, 33% of COA cases and 60% of AOA cases were medically treated. CONCLUSION: The proportion of persons affected by asthma in the German National Cohort, as well as observed patterns regarding age and gender, corresponds to other data sources such as DEGS. However, in our analysis, the proportion of individuals with AOA was higher than described in the literature. The increase in cumulative asthma diagnoses with age is markedly steeper in younger participants, indicating a rising trend over time.
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- 2020
44. Erforschung von Erkrankungen in der NAKO Gesundheitsstudie: die wichtigsten gesundheitlichen Endpunkte und ihre Erfassung [The investigation of health outcomes in the German National Cohort: the most relevant endpoints and their assessment]
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Ahrens, W., Greiser, K.H., Linseisen, J., Pischon, T., and Pigeot, I.
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Cardiovascular and Metabolic Diseases - Abstract
The focus of the German National Cohort, the largest population-based cohort study in Germany to date, is the investigation of the most important widespread diseases, such as cardiovascular diseases, diabetes, cancer, neurological and psychiatric disorders, and frequent respiratory and infectious diseases. This cohort will answer questions on the development of these diseases and on the impact of genetic, environmental and lifestyle-related risk factors. Another focus is on the identification of early, subclinical markers of emerging diseases. To answer these questions, a comprehensive assessment of these health outcomes as well as of all potential determinants and precursors is mandatory.This paper describes the various health outcomes that are assessed in the German National Cohort, as well as the examination modules that are applied for deep phenotyping of study participants. Repeated collection of biosamples as well as functional measurements and application of modern imaging techniques at various time points allow for assessing the dynamics of physiological changes related to the individuals' health status. The prognostic value of these changes for disease development will be explored and translated to novel approaches for prevention and personalised medicine. Incident diseases are being assessed through self-reports by study participants and through record linkage with data from health insurances and cancer registries. Additional information about clinical diagnoses is obtained from the treating physicians to ensure the highest possible validity.
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- 2020
45. Häufigkeiten muskuloskelettaler Symptome und Erkrankungen in der bevölkerungsbezogenen NAKO Gesundheitsstudie [Frequencies of musculoskeletal symptoms and disorders in the population-based German National Cohort (GNC)]
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Schmidt, C.O., Günther, K.P., Goronzy, J., Albrecht, K., Chenot, J.F., Callhoff, J., Richter, A., Kasch, R., Ahrens, W., Becher, H., Berger, K., Brenner, H., Fischer, B., Franzke, C.W., Hoffmann, W., Holleczek, B., Jaeschke, L., Jenning, C., Jöckel, K.H., Kaaks, R., Keil, T., Kluttig, A., Krause, G., Kuß, O., Leitzmann, M., Lieb, W., Linseisen, J., Löffler, M., Meinke-Franze, C., Meisinger, C., Michels, K.B., Mikolajczyk, R., Obi, N., Peters, A., Pischon, T., Schikowski, T., Schipf, S., Specker, C., Völzke, H., Wirkner, K., Zink, A., and Sander, O.
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Cardiovascular and Metabolic Diseases - Abstract
BACKGROUND: Musculoskeletal diseases and symptoms are very common in the general population. They lead to high healthcare costs and pose a significant burden to the national economy. OBJECTIVES: Based on data from the population-based German National Cohort (GNC), frequencies of musculoskeletal symptoms and diseases are reported, including back pain, osteoporosis, osteoarthritis, and arthritis. MATERIALS AND METHODS: Data were collected from March 2014 to March 2017 in adults aged 20-75 years during the first half of the baseline survey of the GNC. The sample comprised 101,779 interviewed subjects, including 9370 subjects who underwent clinical musculoskeletal examinations. The interview included questions about specific musculoskeletal disorders. A clinical examination of the hand provided information about palpable swollen joints and pressure-sensitive joints. Resting pain of the knees and hips was also assessed by a clinical examination. Frequencies were standardized to the German standard population of the year 2011. RESULTS: Having ever been diagnosed with recurrent back pain (22.5%) or osteoarthritis (20.6%) were the most common complaints reported in the interview; osteoporosis (2.9%) and rheumatoid arthritis (1.9%) were stated more seldom. According to the hand examination, 6.0% of all participants experienced pain in at least one finger joint. Resting pain was present in at least one knee among 8.2% and in at least one hip among 5.1% of the participants as assessed during the clinical examination. Women were more likely to report musculoskeletal disorders and symptoms than men. The proportion of adults affected by musculoskeletal diseases increased strongly with age. CONCLUSION: Musculoskeletal disorders and symptoms occur frequently. The burden of complaints and diagnoses is comparable to previous population-based surveys.
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- 2020
46. Design und Qualitätskontrolle der zahnmedizinischen Untersuchung in der NAKO Gesundheitsstudie [Design and quality control of the oral health status examination in the German National Cohort (GNC)]
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Holtfreter, B., Samietz, S., Hertrampf, K., Aarabi, G., Hagenfeld, D., Kim, T.S., Kocher, T., Koos, B., Schmitter, M., Ahrens, W., Alwers, E., Becher, H., Berger, K., Brenner, H., Damms-Machado, A., Ebert, N., Fischer, B., Franzke, C.W., Frölich, S., Greiser, H., Gies, A., Günther, K., Hassan, L., Hoffmann, W., Jaeschke, L., Keil, T., Kemmling, Y., Krause, G., Krist, L., Legath, N., Lieb, W., Leitzmann, M., Linseisen, J., Loeffler, M., Meinke-Franze, C., Michels, K.B., Mikolajczyk, R., Obi, N., Peters, A., Pischon, T., Schipf, S., Schmidt, B., Völzke, H., Waniek, S., Wigmann, C., Wirkner, K., Schmidt, C.O., Kühnisch, J., and Rupf, S.
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stomatognathic diseases ,Cardiovascular and Metabolic Diseases - Abstract
BACKGROUND: Caries and periodontitis are highly prevalent worldwide. Because detailed data on these oral diseases were collected within the framework of the German National Cohort (GNC), associations between oral and systemic diseases and conditions can be investigated. OBJECTIVES: The study protocol for the oral examination was designed to ensure a comprehensive collection of dental findings by trained non-dental staff within a limited examination time. At the mid-term of the GNC baseline examination, a first quality evaluation was performed to check the plausibility of results and to propose measures to improve the data quality. MATERIALS AND METHODS: A dental interview, saliva sampling and oral diagnostics were conducted. As part of the level‑1 examination, the number of teeth and prostheses were recorded. As part of the level‑2 examination, detailed periodontal, cariological and functional aspects were examined. All examinations were conducted by trained non-dental personnel. Parameters were checked for plausibility and variable distributions were descriptively analysed. RESULTS: Analyses included data of 57,967 interview participants, 56,913 level‑1 participants and 6295 level‑2 participants. Percentages of missing values for individual clinical parameters assessed in level 1 and level 2 ranged between 0.02 and 3.9%. Results showed a plausible distribution of the data; rarely, implausible values were observed, e.g. for measurements of horizontal and vertical overbite (overjet and overbite). Intra-class correlation coefficients indicated differences in individual parameters between regional clusters, study centres and across different examiners. CONCLUSIONS: he results confirm the feasibility of the study protocol by non-dental personnel and its successful integration into the GNC's overall assessment program. However, rigorous dental support of the study centres is required for quality management.
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- 2020
47. Selbstberichtete Krebserkrankungen in der NAKO Gesundheitsstudie: Erfassungsmethoden und erste Ergebnisse [Self-reported cancer in the German National Cohort (NAKO Gesundheitsstudie): assessment methods and first results]
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Nimptsch, K., Jaeschke, L., Chang-Claude, J., Kaaks, R., Katzke, V., Michels, K.B., Franzke, C.W., Obi, N., Becher, H., Kuß, O., Schikowski, T., Schulze, M.B., Gastell, S., Hoffmann, W., Schipf, S., Ahrens, W., Günther, K., Krist, L., Keil, T., Jöckel, K.H., Schmidt, B., Brenner, H., Holleczek, B., Fischer, B., Leitzmann, M., Lieb, W., Berger, K., Krause, G., Löffler, M., Schmidt-Pokrzywniak, A., Mikolajczyk, R., Linseisen, J., Greiser, K.H., and Pischon, T.
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Cardiovascular and Metabolic Diseases - Abstract
BACKGROUND: In the German National Cohort (NAKO Gesundheitsstudie), the largest prospective cohort study in Germany, data on self-reported cancer diagnoses are now available for the first half of participants. OBJECTIVES: Description of the methods to assess self-reported cancer diagnoses and type of cancer in the NAKO and presentation of first results. MATERIALS AND METHODS: In a computer-assisted, standardized personal interview, 101,787 participants (54,526 women, 47,261 men) were asked whether they had ever been diagnosed with cancer (malignant tumors including in situ) by a physician and how many cancer diagnoses they had. The type of cancer was classified with a list. Absolute and relative frequencies of self-reported cancer diagnoses and types of cancer were calculated and compared with cancer registry data. RESULTS: A physician-diagnosed cancer was reported by 9.4% of women and 7.0% of men. Of the participants who reported a cancer diagnosis, 88.3% reported to have had only one cancer diagnosis. In women, the most frequent malignancies were breast cancer, cervical cancer, and melanoma. In men, the most frequent malignancies were prostate cancer, melanoma, and colorectal cancer. Comparing the frequencies of cancer diagnoses reported by 45- to 74-year-old NAKO participants within the last five years to cancer registry-based 5‑year prevalences, most types of cancer were less frequent in the NAKO, with the exception of melanoma in men and women, cervical cancer and liver cancer in women, and bladder cancer and breast cancer in men. CONCLUSIONS: The NAKO is a rich data basis for future investigations of incident cancer.
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- 2020
48. Erfassung selbst berichteter kardiovaskulärer und metabolischer Erkrankungen in der NAKO Gesundheitsstudie: Methoden und erste Ergebnisse [Assessment of self-reported cardiovascular and metabolic diseases in the German National Cohort (GNC, NAKO Gesundheitsstudie): methods and initial results]
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Jaeschke, L., Steinbrecher, A., Greiser, K.H., Dörr, M., Buck, T., Linseisen, J., Meisinger, C., Ahrens, W., Becher, H., Berger, K., Braun, B., Brenner, H., Castell, S., Fischer, B., Franzke, C.W., Gastell, S., Günther, K., Hoffmann, W., Holleczek, B., Jagodzinski, A., Kaaks, R., Kluttig, A., Krause, G., Krist, L., Kuß, O., Lehnich, A.T., Leitzmann, M., Lieb, W., Löffler, M., Michels, K.B., Mikolajczyk, R., Peters, A., Schikowski, T., Schipf, S., Schmidt, B., Schulze, M., Völzke, H., Willich, S.N., and Pischon, T.
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Cardiovascular and Metabolic Diseases - Abstract
BACKGROUND: Data on self-reported cardiovascular and metabolic diseases are available for the first 100,000 participants of the population-based German National Cohort (GNC, NAKO Gesundheitsstudie). OBJECTIVES: To describe assessment methods and the frequency of self-reported cardiovascular and metabolic diseases in the German National Cohort. MATERIALS AND METHODS: Using a computer-based, standardized personal interview, 101,806 participants (20-75 years, 46% men) from 18 nationwide study centres were asked to use a predefined list to report medical conditions ever diagnosed by a physician, including cardiovascular or metabolic diseases. For the latter, we calculated sex-stratified relative frequencies and compared these with reference data. RESULTS: With regard to cardiovascular diseases, 3.5% of men and 0.8% of women reported to have ever been diagnosed with a myocardial infarction, 4.8% and 1.5% with angina pectoris, 3.5% and 2.5% with heart failure, 10.1% and 10.4% with cardiac arrhythmia, 2.7% and 1.8% with claudicatio intermittens, and 34.6% and 27.0% with arterial hypertension. The frequencies of self-reported diagnosed metabolic diseases were 8.1% and 5.8% for diabetes mellitus, 28.6% and 24.5% for hyperlipidaemia, 7.9% and 2.4% for gout, and 10.1% and 34.3% for thyroid diseases. Observed disease frequencies were lower than reference data for Germany. CONCLUSIONS: In the German National Cohort, self-reported cardiovascular and metabolic diseases diagnosed by a physician are assessed from all participants, therefore representing a data source for future cardio-metabolic research in this cohort.
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- 2020
49. Die Basiserhebung der NAKO Gesundheitsstudie: Teilnahme an den Untersuchungsmodulen, Qualitätssicherung und Nutzung von Sekundärdaten [The baseline assessment of the German National Cohort (NAKO Gesundheitsstudie): participation in the examination modules, quality assurance, and the use of secondary data]
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Schipf, S., Schöne, G., Schmidt, B., Günther, K., Stübs, G., Greiser, K.H., Bamberg, F., Meinke-Franze, C., Becher, H., Berger, K., Brenner, H., Castell, S., Damms-Machado, A., Fischer, B., Franzke, C.W., Fricke, J., Gastell, S., Günther, M., Hoffmann, W., Holleczek, B., Jaeschke, L., Jagodzinski, A., Jöckel, K.H., Kaaks, R., Kauczor, H.U., Kemmling, Y., Kluttig, A., Krist, L., Kurth, B., Kuß, O., Legath, N., Leitzmann, M., Lieb, W., Linseisen, J., Löffler, M., Michels, K.B., Mikolajczyk, R., Pigeot, I., Mueller, U., Peters, A., Rach, S., Schikowski, T., Schulze, M.B., Stallmann, C., Stang, A., Swart, E., Waniek, S., Wirkner, K., Völzke, H., Pischon, T., and Ahrens, W.
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Cardiovascular and Metabolic Diseases - Abstract
BACKGROUND: The German National Cohort (NAKO) is an interdisciplinary health study aimed at elucidating causes for common chronic diseases and detecting their preclinical stages. This article provides an overview of design, methods, participation in the examinations, and their quality assurance based on the midterm baseline dataset (MBD) of the recruitment. METHODS: More than 200,000 women and men aged 20-69 years derived from random samples of the German general population were recruited in 18 study centers (2014-2019). The data collection comprised physical examinations, standardized interviews and questionnaires, and the collection of biomedical samples for all participants (level 1). At least 20% of all participants received additional in-depth examinations (level 2), and 30,000 received whole-body magnet resonance imaging (MRI). Additional information will be collected through secondary data sources such as medical registries, health insurances, and pension funds. This overview is based on the MBD, which included 101,839 participants, of whom 11,371 received an MRI. RESULTS: The mean response proportion was 18%. The participation in the examinations was high with most of the modules performed by over 95%. Among MRI participants, 96% completed all 12 MRI sequences. More than 90% of the participants agreed to the use of complementary secondary and registry data. DISCUSSION: Individuals selected for the NAKO were willing to participate in all examinations despite the time-consuming program. The NAKO provides a central resource for population-based epidemiologic research and will contribute to developing innovative strategies for prevention, screening and prediction of chronic diseases.
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- 2020
50. Soziodemografische und erwerbsbezogene Merkmale in der NAKO Gesundheitsstudie [Socio-demographic and employment-related factors in the German National Cohort (GNC; NAKO Gesundheitsstudie)]
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Dragano, N., Reuter, M., Greiser, K.H., Becher, H., Zeeb, H., Mikolajczyk, R., Kluttig, A., Leitzmann, M., Fischer, B., Jöckel, K.H., Emmel, C., Krause, G., Castell, S., Damms-Machado, A., Obi, N., Schikowski, T., Kuss, O., Hoffmann, W., Schipf, S., Pischon, T., Jaeschke, L., Krist, L., Keil, T., Lieb, W., Holleczek, B., Brenner, H., Wirkner, K., Loeffler, M., Michels, K.B., Franzke, C.W., Peters, A., Linseisen, J., Berger, K., Legath, N., Ahrens, W., Lampert, T., and Schmidt, B.
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Cardiovascular and Metabolic Diseases - Abstract
BACKGROUND: In epidemiologic studies, standardised measurement of socio-demographic and employment-related factors is becoming increasingly important, as variables such as gender, age, education or employment status are factors influencing health and disease risks. AIMS: The article gives an overview of the scientific background and assessment of socio-demographic factors in the German National Cohort Study. In addition, the distribution of individual characteristics in the cohort as well as relationships with health-related measures are presented by way of example. MATERIAL AND METHODS: The analysis is based on the data of the first half of the baseline survey (n = 101,724). On this basis, we present the distribution of key socio-demographic characteristics and analyse relationships with exemplary selected health indicators (body mass index, self-reported health) to assess the validity of socio-demographic data measurements. RESULTS: On average, study participants were 52.0 years old (SD = 12.4). Of the participants, 53.6% were women, 54.3% had high education, 60.1% were married and 72% were employed while 3.4% were unemployed. Well-established correlations between socio-demographic factors and health could be reproduced with the German National Cohort data. For example, low education, old age and unemployment were associated with an increased prevalence of obesity and poor self-reported health. DISCUSSION: The German National Cohort provides a comprehensive measurement of socio-demographic characteristics. Combined with a wide range of health data and the longitudinal measurements available in the future, this opens up new opportunities for health science and social epidemiological research in Germany.
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- 2020
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