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23 results on '"Linnemann, Christoph"'

1. The Behavioural Dysfunction Questionnaire discriminates behavioural variant frontotemporal dementia from Alzheimer’s disease dementia and major depressive disorder

Author

Semenkova, Anna, Piguet, Olivier, Johnen, Andreas, Schroeter, Matthias L., Godulla, Jannis, Linnemann, Christoph, Mühlhauser, Markus, Sauer, Thomas, Baumgartner, Markus, Anderl-Straub, Sarah, Otto, Markus, Felbecker, Ansgar, Kressig, Reto W., Berres, Manfred, and Sollberger, Marc

Published
2023
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2. Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice

Author

Schumacher, Fabian, Edwards, Michael J., Mühle, Christiane, Carpinteiro, Alexander, Wilson, Greg C., Wilker, Barbara, Soddemann, Matthias, Keitsch, Simone, Scherbaum, Norbert, Müller, Bernhard W., Lang, Undine E., Linnemann, Christoph, Kleuser, Burkhard, Müller, Christian P., Kornhuber, Johannes, and Gulbins, Erich

Published
2022
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3. NfL reliability across laboratories, stage- dependent diagnostic performance and matrix comparability in genetic FTD: a large GENFI study.

Author

Linnemann, Christoph, Wilke, Carlo, Mengel, David, Zetterberg, Henrik, Heller, Carolin, Kuhle, Jens, Bouzigues, Arabella, Russell, Lucy L., Foster, Phoebe H., Ferry-Bolder, Eve, Van Swieten, John Cornelis, Jiskoot, Lize C., Seelaar, Harro, Moreno, Fermin, Borroni, Barbara, Sánchez-Valle, Raquel, Galimberti, Daniela, Laforce, Robert Jr, Graff, Caroline, and Masellis, Mario

Subjects
MEDICAL sciences, GLIAL fibrillary acidic protein, ALZHEIMER'S disease, RESEARCH universities & colleges, FRONTOTEMPORAL dementia, FRONTOTEMPORAL lobar degeneration
Published
2024
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4. Aging effects on the encoding/retrieval flip in associative memory: fMRI evidence from incidental contingency learning

Author

Schneider, Else, primary, Rajkovic, Marko, additional, Krug, Rudolf, additional, Caviezel, Marco P., additional, Reichert, Carolin F., additional, Bieri, Oliver, additional, Schmidt, André, additional, Borgwardt, Stefan, additional, Leyhe, Thomas, additional, Linnemann, Christoph, additional, Brühl, Annette B., additional, Lang, Undine E., additional, and Melcher, Tobias, additional

Published
2024
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5. NfL reliability across laboratories, stage-dependent diagnostic performance and matrix comparability in genetic FTD:a large GENFI study

Author

Linnemann, Christoph, Wilke, Carlo, Mengel, David, Zetterberg, Henrik, Heller, Carolin, Kuhle, Jens, Bouzigues, Arabella, Russell, Lucy L., Foster, Phoebe H., Ferry-Bolder, Eve, Van Swieten, John Cornelis, Jiskoot, Lize C., Seelaar, Harro, Moreno, Fermin, Borroni, Barbara, Sánchez-Valle, Raquel, Galimberti, Daniela, Laforce, Robert Jr, Graff, Caroline, Masellis, Mario, Tartaglia, Maria Carmela, Rowe, James Benedict, Finger, Elizabeth, Vandenberghe, Rik, Mendonca, Alexandre de, Butler, Chris R., Gerhard, Alexander, Ducharme, Simon, Ber, Isabelle L.E., Tiraboschi, Pietro, Santana, Isabel, Pasquier, Florence, Levin, Johannes, Otto, Markus, Sorbi, Sandro, Rohrer, Jonathan Daniel, Synofzik, Matthis, Linnemann, Christoph, Wilke, Carlo, Mengel, David, Zetterberg, Henrik, Heller, Carolin, Kuhle, Jens, Bouzigues, Arabella, Russell, Lucy L., Foster, Phoebe H., Ferry-Bolder, Eve, Van Swieten, John Cornelis, Jiskoot, Lize C., Seelaar, Harro, Moreno, Fermin, Borroni, Barbara, Sánchez-Valle, Raquel, Galimberti, Daniela, Laforce, Robert Jr, Graff, Caroline, Masellis, Mario, Tartaglia, Maria Carmela, Rowe, James Benedict, Finger, Elizabeth, Vandenberghe, Rik, Mendonca, Alexandre de, Butler, Chris R., Gerhard, Alexander, Ducharme, Simon, Ber, Isabelle L.E., Tiraboschi, Pietro, Santana, Isabel, Pasquier, Florence, Levin, Johannes, Otto, Markus, Sorbi, Sandro, Rohrer, Jonathan Daniel, and Synofzik, Matthis

Abstract

Background:Blood neurofilament light chain (NfL) is increasingly considered as a key trial biomarker in genetic frontotemporal dementia (gFTD). We aimed to facilitate the use of NfL in gFTD multicentre trials by testing its (1) reliability across labs; (2) reliability to stratify gFTD disease stages; (3) comparability between blood matrices and (4) stability across recruiting sites. Methods:Comparative analysis of blood NfL levels in a large gFTD cohort (GENFI) for (1)–(4), with n=344 samples (n=148 presymptomatic, n=11 converter, n=46 symptomatic subjects, with mutations in C9orf72, GRN or MAPT; and n=139 within-family controls), each measured in three different international labs by Simoa HD-1 analyzer. Results:NfL revealed an excellent consistency (intraclass correlation coefficient (ICC) 0.964) and high reliability across the three labs (maximal bias (pg/mL) in Bland-Altman analysis: 1.12±1.20). High concordance of NfL across laboratories was moreover reflected by high areas under the curve for discriminating conversion stage against the (non-converting) presymptomatic stage across all three labs. Serum and plasma NfL were largely comparable (ICC 0.967). The robustness of NfL across 13 recruiting sites was demonstrated by a linear mixed effect model. Conclusions:Our results underline the suitability of blood NfL in gFTD multicentre trials, including cross-lab reliable stratification of the highly trial-relevant conversion stage, matrix comparability and cross-site robustness.

Published
2024

10. Genotype-specific patterns of atrophy progression are more sensitive than clinical decline in SCA1, SCA3 and SCA6

Author

Reetz, Kathrin, Costa, Ana S., Mirzazade, Shahram, Lehmann, Anna, Juzek, Agnes, Rakowicz, Maria, Boguslawska, Romana, Schöls, Ludger, Linnemann, Christoph, Mariotti, Caterina, Grisoli, Marina, Dürr, Alexandra, van de Warrenburg, Bart P., Timmann, Dagmar, Pandolfo, Massimo, Bauer, Peter, Jacobi, Heike, Hauser, Till-Karsten, Klockgether, Thomas, and Schulz, Jörg B.

Published
2013
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11. Depression comorbidity in spinocerebellar ataxia†‡§

Author

Schmitz-Hübsch, Tanja, Coudert, Mathieu, Tezenas du Montcel, Sophie, Giunti, Paola, Labrum, Robyn, Dürr, Alexandra, Ribai, Pascale, Charles, Perrine, Linnemann, Christoph, Schöls, Ludger, Rakowicz, Maryla, Rola, Rafal, Zdzienicka, Elszbieta, Fancellu, Roberto, Mariotti, Caterina, Baliko, Lazlo, Melegh, Bela, Filla, Alessandro, Salvatore, Elena, van de Warrenburg, Bart P.C., Szymanski, Sandra, Infante, Jon, Timmann, Dagmar, Boesch, Sylvia, Depondt, Chantal, Kang, Jun-Suk, Schulz, Jörg B., Klopstock, Thomas, Lossnitzer, Nicole, Löwe, Bernd, Frick, Caroline, Rottländer, Daniela, Schlaepfer, Thomas E., and Klockgether, Thomas

Published
2011
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18. Peripheral Neuropathy in Spinocerebellar Ataxia Type 1, 2, 3, and 6

Author

Linnemann, Christoph, primary, Tezenas du Montcel, Sophie, additional, Rakowicz, Maryla, additional, Schmitz-Hübsch, Tanja, additional, Szymanski, Sandra, additional, Berciano, Jose, additional, van de Warrenburg, Bart P., additional, Pedersen, Karine, additional, Depondt, Chantal, additional, Rola, Rafal, additional, Klockgether, Thomas, additional, García, Antonio, additional, Mutlu, Gurkan, additional, and Schöls, Ludger, additional

Published
2015
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19. Innovative diagnostic tools for early detection of Alzheimer's disease

Author

Laske, Christoph, primary, Sohrabi, Hamid R., additional, Frost, Shaun M., additional, López-de-Ipiña, Karmele, additional, Garrard, Peter, additional, Buscema, Massimo, additional, Dauwels, Justin, additional, Soekadar, Surjo R., additional, Mueller, Stephan, additional, Linnemann, Christoph, additional, Bridenbaugh, Stephanie A., additional, Kanagasingam, Yogesan, additional, Martins, Ralph N., additional, and O'Bryant, Sid E., additional

Published
2014
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21. Innovative diagnostic tools for early detection of Alzheimer's disease.

Author

Laske, Christoph, Sohrabi, Hamid R., Frost, Shaun M., López-de-Ipiña, Karmele, Garrard, Peter, Buscema, Massimo, Dauwels, Justin, Soekadar, Surjo R., Mueller, Stephan, Linnemann, Christoph, Bridenbaugh, Stephanie A., Kanagasingam, Yogesan, Martins, Ralph N., and O'Bryant, Sid E.

Abstract

Current state-of-the-art diagnostic measures of Alzheimer's disease (AD) are invasive (cerebrospinal fluid analysis), expensive (neuroimaging) and time-consuming (neuropsychological assessment) and thus have limited accessibility as frontline screening and diagnostic tools for AD. Thus, there is an increasing need for additional noninvasive and/or cost-effective tools, allowing identification of subjects in the preclinical or early clinical stages of AD who could be suitable for further cognitive evaluation and dementia diagnostics. Implementation of such tests may facilitate early and potentially more effective therapeutic and preventative strategies for AD. Before applying them in clinical practice, these tools should be examined in ongoing large clinical trials. This review will summarize and highlight the most promising screening tools including neuropsychometric, clinical, blood, and neurophysiological tests. [ABSTRACT FROM AUTHOR]

Published
2015
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22. [Suicide in the elderly – risk factors and prevention].

Author

Linnemann C and Leyhe T

Subjects
Aged, Aged, 80 and over, Depression diagnosis, Depression therapy, Female, Humans, Male, Risk Assessment methods, Depression psychology, Geriatric Assessment methods, Geriatric Psychiatry methods, Social Isolation psychology, Suicide psychology, Suicide Prevention
Abstract

Suicide rates are highest among the elderly in Switzerland. The estimated number of unreported cases is particularly high in this age group. The risk factors are multidimensional, including depression and social isolation. The detection and management of the controllable risk factors, foremost depression, is of particular importance for suicide prevention. Old age depression often shows an atypical presentation, is misinterpreted as a normal process of aging and is not adequately treated.

Published
2015
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23. Innovative diagnostic tools for early detection of Alzheimer's disease.

Author

Laske C, Sohrabi HR, Frost SM, López-de-Ipiña K, Garrard P, Buscema M, Dauwels J, Soekadar SR, Mueller S, Linnemann C, Bridenbaugh SA, Kanagasingam Y, Martins RN, and O'Bryant SE

Subjects
Alzheimer Disease blood, Alzheimer Disease complications, Depression etiology, Diagnostic Tests, Routine standards, Electrophysiology, Eye physiopathology, Gait physiology, Humans, Memory Disorders etiology, Alzheimer Disease diagnosis, Diagnostic Tests, Routine methods, Early Diagnosis
Abstract

Current state-of-the-art diagnostic measures of Alzheimer's disease (AD) are invasive (cerebrospinal fluid analysis), expensive (neuroimaging) and time-consuming (neuropsychological assessment) and thus have limited accessibility as frontline screening and diagnostic tools for AD. Thus, there is an increasing need for additional noninvasive and/or cost-effective tools, allowing identification of subjects in the preclinical or early clinical stages of AD who could be suitable for further cognitive evaluation and dementia diagnostics. Implementation of such tests may facilitate early and potentially more effective therapeutic and preventative strategies for AD. Before applying them in clinical practice, these tools should be examined in ongoing large clinical trials. This review will summarize and highlight the most promising screening tools including neuropsychometric, clinical, blood, and neurophysiological tests., (Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.)

Published
2015
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