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5. Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration

Author

Smith, Eric E, Biessels, Geert Jan, De Guio, François, de Leeuw, Frank Erik, Duchesne, Simon, Düring, Marco, Frayne, Richard, Ikram, M Arfan, Jouvent, Eric, MacIntosh, Bradley J, Thrippleton, Michael J, Vernooij, Meike W, Adams, Hieab, Backes, Walter H, Ballerini, Lucia, Black, Sandra E, Chen, Christopher, Corriveau, Rod, DeCarli, Charles, Greenberg, Steven M, Gurol, M Edip, Ingrisch, Michael, Job, Dominic, Lam, Bonnie YK, Launer, Lenore J, Linn, Jennifer, McCreary, Cheryl R, Mok, Vincent CT, Pantoni, Leonardo, Pike, G Bruce, Ramirez, Joel, Reijmer, Yael D, Romero, Jose Rafael, Ropele, Stefan, Rost, Natalia S, Sachdev, Perminder S, Scott, Christopher JM, Seshadri, Sudha, Sharma, Mukul, Sourbron, Steven, Steketee, Rebecca ME, Swartz, Richard H, van Oostenbrugge, Robert, van Osch, Matthias, van Rooden, Sanneke, Viswanathan, Anand, Werring, David, Dichgans, Martin, and Wardlaw, Joanna M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurodegenerative, Biomedical Imaging, Brain Disorders, Neurosciences, Neurological, Cerebrovascular disease, Stroke, Dementia, Magnetic resonance imaging, Radiology, Genetics, Biological psychology
Abstract

IntroductionMany consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease.MethodsSurveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis.ResultsA framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository.ConclusionsThe HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.

Published
2019

7. The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI–neuropathology diagnostic accuracy study

Author

Charidimou, Andreas, Boulouis, Gregoire, Frosch, Matthew P, Baron, Jean-Claude, Pasi, Marco, Albucher, Jean Francois, Banerjee, Gargi, Barbato, Carmen, Bonneville, Fabrice, Brandner, Sebastian, Calviere, Lionel, Caparros, François, Casolla, Barbara, Cordonnier, Charlotte, Delisle, Marie-Bernadette, Deramecourt, Vincent, Dichgans, Martin, Gokcal, Elif, Herms, Jochen, Hernandez-Guillamon, Mar, Jäger, Hans Rolf, Jaunmuktane, Zane, Linn, Jennifer, Martinez-Ramirez, Sergi, Martínez-Sáez, Elena, Mawrin, Christian, Montaner, Joan, Moulin, Solene, Olivot, Jean-Marc, Piazza, Fabrizio, Puy, Laurent, Raposo, Nicolas, Rodrigues, Mark A, Roeber, Sigrun, Romero, Jose Rafael, Samarasekera, Neshika, Schneider, Julie A, Schreiber, Stefanie, Schreiber, Frank, Schwall, Corentin, Smith, Colin, Szalardy, Levente, Varlet, Pascale, Viguier, Alain, Wardlaw, Joanna M, Warren, Andrew, Wollenweber, Frank A, Zedde, Marialuisa, van Buchem, Mark A, Gurol, M Edip, Viswanathan, Anand, Al-Shahi Salman, Rustam, Smith, Eric E, Werring, David J, and Greenberg, Steven M

Published
2022
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10. Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer’s disease (DEBBIE-AD): a prospective observational multicohort study protocol

Author

Padrela, Beatriz, primary, Mahroo, Amnah, additional, Tee, Mervin, additional, Sneve, Markus H, additional, Moyaert, Paulien, additional, Geier, Oliver, additional, Kuijer, Joost P A, additional, Beun, Soetkin, additional, Nordhøy, Wibeke, additional, Zhu, Yufei David, additional, Buck, Mareike A, additional, Hoinkiss, Daniel C, additional, Konstandin, Simon, additional, Huber, Jörn, additional, Wiersinga, Julia, additional, Rikken, Roos, additional, de Leeuw, Diederick, additional, Grydeland, Håkon, additional, Tippett, Lynette, additional, Cawston, Erin E, additional, Ozturk-Isik, Esin, additional, Linn, Jennifer, additional, Brandt, Moritz, additional, Tijms, Betty M, additional, van de Giessen, Elsmarieke M, additional, Muller, Majon, additional, Fjell, Anders, additional, Walhovd, Kristine, additional, Bjørnerud, Atle, additional, Pålhaugen, Lene, additional, Selnes, Per, additional, Clement, Patricia, additional, Achten, Eric, additional, Anazodo, Udunna, additional, Barkhof, Frederik, additional, Hilal, Saima, additional, Fladby, Tormod, additional, Eickel, Klaus, additional, Morgan, Catherine, additional, Thomas, David L, additional, Petr, Jan, additional, Günther, Matthias, additional, and Mutsaerts, Henk J M M, additional

Published
2024
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35. Anatomie

Author

Linn, Jennifer, Linn, Jennifer, Wiesmann, Martin, and Brückmann, Hartmut

Published
2011
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36. Flow diversion for compressive unruptured internal carotid artery aneurysms with neuroophthalmological symptoms: a systematic review and meta-analysis.

Author

Kaiser, Daniel P. O., Cuberi, Ani, Linn, Jennifer, and Gawlitza, Matthias

Subjects
CAROTID artery diseases, META-analysis, CONFIDENCE intervals, SYSTEMATIC reviews, THERAPEUTIC embolization, BLOOD circulation, DESCRIPTIVE statistics, ODDS ratio, INTRACRANIAL aneurysms
Abstract

Background Data on the safety and efficacy of flow diverters (FD) for the treatment of unruptured internal carotid artery (ICA) aneurysms with compressive neuroophthalmological symptoms (NOS) are scarce and comprise mainly small case series. Methods We performed a search of three databases and included series with ≥10 patients, with unruptured aneurysms of the ICA and NOS, treated with FD. Random-effects analysis of treatment results and safety was performed. Results A total of 22 studies reporting on 594 patients were included. Pooled proportions of NOS recovery, improvement, transient and permanent worsening were: 47.4% (95% CI 35.0% to 60.1%); 74.5% (95% CI 67.9% to 80.2%); 7.1% (95% CI 3.3% to 14.7%); and 4.9% (95% CI 3.2% to 7.4%), respectively. Rates of complete recovery and improvement in patients with isolated visual symptoms were 30.6% (95% CI 12.5% to 57.7%) and 56.6% (95% CI 42.3% to 69.9%). Isolated oculomotor symptoms recovered completely in 47.8% (95% CI 29.9% to 66.3%) and improved in 78% (95% CI 69.2% to 84.9%). Morbidity occurred in 5% (95% CI 2.8% to 9%) and mortality in 3.9% (95% CI 2% to 7.5%) of patients. An increased likelihood of symptom improvement was observed when treatment was performed early (<1 month) after symptom onset (OR=11.22, 95% CI 3.9% to 32.5%). Conclusion Flow diversion promotes recovery or improvement of compressive symptoms in a large proportion of patients but is associated with significant rates of morbidity and mortality. Transient and permanent NOS worsening is not uncommon. Early treatment is of utmost importance, as it increases the likelihood of symptom improvement more than 10-fold. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Flow Diversion for ICA Aneurysms with Compressive Neuro-Ophthalmologic Symptoms: Predictors of Morbidity, Mortality, and Incomplete Aneurysm Occlusion

Author

Kaiser, D.P.O., Boulouis, G., Soize, S., Maus, V., Fischer, S., Lobsien, D., Klisch, J., Styczen, H., Deuschl, C., Abdullayev, N., Kabbasch, C., Jamous, A., Behme, D., Janot, K., Bellanger, G., Cognard, C., Pierot, L., Gawlitza, M., Manceau, Pierre-François, Sahnoun, Maher, Gelmini, Christophe, Bibi, Richard, Herbreteau, Denis, Ifergan, Heloïse, Bankolle, Nourou Dine Adeniran, and Linn, Jennifer

Subjects
Interventional, Endovascular Procedures, Medizin, Intracranial Aneurysm, Middle Aged, Embolization, Therapeutic, Blood Vessel Prosthesis, Treatment Outcome, Humans, Radiology, Nuclear Medicine and imaging, Female, Stents, Neurology (clinical), Morbidity, Retrospective Studies
Abstract

BACKGROUND AND PURPOSE: Flow diversion is an effective treatment for aneurysms of the ICA with compression-related neuro-ophthalmologic symptoms, especially when treatment is initiated early after symptom onset and aneurysm occlusion is complete. However, non-negligible complication rates have been reported. Our aim was to identify risk factors for morbidity/mortality and incomplete aneurysm occlusion. MATERIALS AND METHODS: We performed a secondary analysis of a previous publication, which included all patients treated with flow diversion for an unruptured aneurysm of the ICA with compression-related symptoms. RESULTS: Fifty-four patients with 54 aneurysms (48 women, 88.9%; mean age, 59.2 [SD, 15.9] years; range, 21–86 years) treated with flow diversion were included. We observed morbidity and mortality rates of 7.4% and 3.7%. Increasing age (OR per decade, 3.2; 95% CI, 1.23–8.49; P = .02) and dual-antiplatelet therapy with ticagrelor (OR, 13.9; 95% CI, 1.16–165.97; P = .04) were significantly associated with morbidity/mortality. After a median follow-up of 13.3 [SD, 10.5] months, the rates of complete aneurysm occlusion, neck remnant, and aneurysm remnant were 74%, 14%, and 12%. Incomplete occlusion at follow-up was less frequently observed in aneurysms treated with additional coil embolization (OR, 0.1; 95% CI, 0.01–0.86; P = .04). CONCLUSIONS: Although a promising treatment for compressive ICA aneurysms, flow diversion carries a relevant risk for complications and incomplete aneurysm occlusion. Our results may help identify patients in which flow diversion may not be the ideal treatment method. Additional coil embolization increased the likelihood of complete aneurysm occlusion at follow-up.

Published
2022

42. Prädiktion des IDH-Mutationsstatus in Gliomen mittels 2-Hydroxyglutarat Magnetresonanzspektorskopie

Author

Juratli, Tareq, Daubner, Dirk, Peitzsch, Mirko, Eisenhofer, Graeme, Schackert, Gabriele, Krex, Dietmar, Linn, Jennifer, and Werner, Annett

Subjects
ddc: 610, Medicine and health, neoplasms
Abstract

Objective: Non-invasive and accurate diagnostic techniques to detect isocitrate dehydrogenase (IDH) mutant glioma have great potential in routine clinical practice. To date, only a few centers worldwide were able to establish 2HG detection by magnetic resonance spectroscopy (MRS) in glioma. Here, we [for full text, please go to the a.m. URL]

Published
2022
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47. Regional Associations of Cortical Superficial Siderosis and ��-Amyloid-Positron-Emission-Tomography Positivity in Patients With Cerebral Amyloid Angiopathy

Author

Finze, Anika, Wahl, Hannes, Janowitz, Daniel, Buerger, Katharina, Linn, Jennifer, Rominger, Axel, St��cklein, Sophia, Bartenstein, Peter, Wollenweber, Frank Arne, Catak, Cihan, and Brendel, Matthias

Subjects
surgical procedures, operative, mental disorders, otorhinolaryngologic diseases, 610 Medicine & health
Abstract

Objective This is a cross-sectional study to evaluate whether ��-amyloid-(A��)-PET positivity and cortical superficial siderosis (cSS) in patients with cerebral amyloid angiopathy (CAA) are regionally colocalized. Methods Ten patients with probable or possible CAA (73.3 �� 10.9 years, 40% women) underwent MRI examination with a gradient-echo-T2*-weighted-imaging sequence to detect cSS and 18F-florbetaben PET examination to detect fibrillar A��. In all cortical regions of the Hammers Atlas, cSS positivity (MRI: ITK-SNAP segmentation) and A��-PET positivity (PET: ��� mean value + 2 standard deviations of 14 healthy controls) were defined. Regional agreement of cSS- and A��-PET positivity was evaluated. A��-PET quantification was compared between cSS-positive and corresponding contralateral cSS-negative atlas regions. Furthermore, the A��-PET quantification of cSS-positive regions was evaluated in voxels close to cSS and in direct cSS voxels. Results cSS- and A��-PET positivity did not indicate similarity of their regional patterns, despite a minor association between the frequency of A��-positive patients and the frequency of cSS-positive patients within individual regions (r s = 0.277, p = 0.032). However, this association was driven by temporal regions lacking cSS- and A��-PET positivity. When analyzing all composite brain regions, A��-PET values in regions close to cSS were significantly higher than in regions directly affected with cSS (p < 0.0001). However, A��-PET values in regions close to cSS were not different when compared to corresponding contralateral cSS-negative regions (p = 0.603). Conclusion In this cross-sectional study, cSS and A��-PET positivity did not show regional association in patients with CAA and deserve further exploitation in longitudinal designs. In clinical routine, a specific cross-sectional evaluation of A��-PET in cSS-positive regions is probably not useful for visual reading of A��-PETs in patients with CAA.

Published
2022
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