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7 results on '"Linling Cai"'

1. Characterization of the white deposit on the surface of cement mortars by correlative light-electron microscopy (CLEM)

Author

Xianping Liu, Peiming Wang, Hanqing Gao, Herve Fryda, and Linling Cai

Subjects
CLEM, Cement mortar, White deposit, Surface whitening, Hydrates, Cement industries, TP875-888
Abstract

This study focuses on the characterization of white deposit occurring after wet/dry cycles on the surface of cement mortars presenting large amount of AFt phase. Correlative light-electron microscopy (CLEM) was confirmed to be a powerful method in characterizing and identifying microscopic visible white deposit that causes macroscopic visible surface whitening in those cement mortars. It was discovered that the white deposit formed after wet/dry cycles was caused by solids precipitated on the surface of cement mortars during hydration and/or on drying, and those solids were composed of CaCO3, AFt, AFm or their solid solutions. Due to the resolution limit of the human eye, there is a threshold size 100 μm for the microscopic visible white deposit or its cluster to become macroscopic visible surface whitening. Partial covering of red pigments by the newly formed solids on the surface of the cement mortars further confirmed the relationship between the size and quantity of microscopic visible white deposit and macroscopic visible surface whitening.

Published
2022
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3. Development and Validation of a Nomogram to Predict the Overall Survival of Patients with Stage I Non-Small Cell Lung Cancer After Surgery

Author

haixi yan, linling cai, hui lin, and chunlong wu

Abstract

Background: This study aimed to establish an effective prognostic nomogram for stage I non-small cell lung cancer (NSCLC) patients receiving surgery.Methods: Stage I NSCLC patients at Taizhou Hospital of Zhejiang Province from October 2010 to June 2014 were included. Clinical, pathological and laboratory variables ascertained before surgery were selected through least absolute shrinkage and selection operator and Cox regression analysis, and a nomogram model was established. The nomogram model was validated using stage I NSCLC patients from the same institution between July 2014 and December 2015. Results: Training cohort included 274 patients. From 46 potential predictors, the independent risk factors for Overall survival (OS) of patients with stage I NSCLC were age, CA125, and tumor diameter. The C index of the nomogram model was 0.759(95% confidence interval (CI)，0.666–0.852). The area under the ROC curve of the nomogram was 0.776. The patients in the low-risk subgroup had significantly better survival than those in the high-risk subgroup (logrank, p < 0.001). The AUC in the validation cohort was 0.809, and the C index was 0.707(95% CI, 0.572-0.842).Conclusion: We developed a nomogram model that includes clinical, pathological and laboratory variables to predict the OS of stage I NSCLC patients.

Published
2021
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4. Preoperative lymphocyte-to-monocyte ratio versus platelet-to-lymphocyte ratio as a prognostic predictor for non-small cell lung cancer patients

Author

Linling Cai, Jun Li, Shuaishuai Chen, and Haixi Yan

Subjects
0301 basic medicine, medicine.medical_specialty, prognosis overall survival - disease-free survival, Lymphocyte, Gastroenterology, lcsh:Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Platelet, lcsh:QD415-436, lymphocyte/monocyte, Lung cancer, non-small cell lung cancer, Original Paper, business.industry, Proportional hazards model, Monocyte, medicine.disease, platelet count/lymphocyte, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cohort, T-stage, Non small cell, business
Abstract

We investigated the prognostic value of the preoperative lymphocyte-to-mononuclear ratio (LMR) and platelet-to-lymphocyte ratio (PLR) in a large cohort of patients with non-small cell lung cancer (NSCLC).Clinical-pathological data from 507 NSCLC patients at Taizhou Hospital of Zhejiang Province between 2010 and 2016 were retrospectively evaluated. X-tile software was used to assess the optimal cutoff levels for LMR and PLR. Univariate and multivariate Cox regression models were used to assess the prognostic factors.The median follow-up duration after surgical resection was 34.5 months. Patients were stratified into 2 groups by LMR (2.6 and2.6) and PLR (179.6 and179.6). Our results revealed that lower LMR (HR = 3.163 (1.821-5.493), P = 0.000), age (HR = 2.252 (1.412-3.592), P = 0.001), T stage (HR = 3.749 (2.275-6.179), P = 0.000), N stage (HR = 3.106 (1.967-4.902), P = 0.000), and cut edge (HR = 3.830 (1.077-13.618), P = 0.038) were considered to be independent indicators for overall survival (OS) of NSCLC patients. For disease-free survival (DFS), age, sex, T stage, N stage, LMR and cut edge were verified to be independent prognostic factors in patients with NSCLC.In the study cohort, reduced LMR was a robust independent predictor for both OS and DFS in patients with NSCLC who underwent surgical resection.Ispitali smo prognostičku vrednost preoperativnog odnosa limfocita i mononuklearnih jedinjenja (LMR) i odnosa trombocita i limfocita (PLR) u velikoj grupi pacijenata sa nemikrocelularnim karcinomom pluća (NSCLC).Izvršena je retrospektivna evaluacija 507 NSCLC pacijenata u Taizhou bolnici u provinciji Zhejiang između 2010. i 2016. godine. Korišćen je X-tile softver za procenu optimalnih graničnih nivoa za LMR i PLR. Za procenu prognostičkih faktora korišćeni su univarijatni i multivarijatni Cox regresioni modeli.Srednje vreme praćenja nakon hirurške resekcije bilo je 34,5 meseci. Pacijenti su stratifikovani u 2 grupe u zavisnosti od LMR (2,6 i2,6) i PLR (179,6 i179,6). Naši rezultati su pokazali da su niži LMR (HR = 3,163 (1,821-5,493), P = 0,000), starost (HR = 2,252 (1,412-3,592), P = 0,001), T stadijum (HR = 3,749 (2,275-6.179), P = 0,000), N faza (HR = 3,106 (1,967-4,902), P = 0,000), i granične vrednost (HR = 3,830 (1,077-13,618), P = 0,038) smatrani nezavisnim pokazateljima ukupne stope preživljavanja (OS) pacijenata sa NSCLC. Za preživljavanje bez bolesti (DFS), starost, pol, T stadijum, N faza, LMR i cut-off vrednost su potvrđeni kao nezavisni prognostički faktori kod pacijenata sa NSCLC.U kohorti studije redukovani LMR je bio robustan nezavisni prediktor i za OS i za DFS kod pacijenata sa NSCLC koji su bili podvrgnuti hirurškoj resekciji.

Published
2020

5. PREOPERATIVE PREALBUMIN-TO-FIBRINOGEN RATIO TO PREDICT SURVIVAL OUTCOMES IN HEPATOCELLULAR CARCINOMA PATIENTS AFTER HEPATIC RESECTION.

Author

Haixi Yan, Shuaishuai Chen, Yang Qiong, and Linling Cai

Subjects
SURVIVAL rate, HEPATOCELLULAR carcinoma, PROGRESSION-free survival, REGRESSION analysis, OVERALL survival, SURVIVAL analysis (Biometry)
Abstract

Copyright of Journal of Medical Biochemistry is the property of Society of Medical Biochemists of Serbia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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6. [Hederagenin inhibits proliferation and promotes apoptosis of cervical cancer CaSki cells by blocking STAT3 pathway]

Author

Liwen, Fang, Mingming, Liu, and Linling, Cai

Subjects
STAT3 Transcription Factor, Cell Line, Tumor, Humans, Uterine Cervical Neoplasms, Antineoplastic Agents, Apoptosis, Female, Oleanolic Acid, Cell Proliferation
Abstract

Objective To investigate the effect of hederagenin on the activity and apoptosis of cervical cancer cells and its mechanism. Methods Cervical cancer CaSki cells were cultured and treated with 0, 10, 20, 40, 80 μg/mL hederagenin. Cell viability was determined by MTT assay. The 50% inhibitory concentration (IC

Published
2019

7. PREOPERATIVE LYMPHOCYTE-TO-MONOCYTE RATIO VERSUS PLATELET-TO-LYMPHOCYTE RATIO AS A PROGNOSTIC PREDICTOR FOR NON-SMALL CELL LUNG CANCER PATIENTS.

Author

Haixi Yan, Linling Cai, Shuaishuai Chen, and Jun Li

Subjects
*NON-small-cell lung carcinoma, *OVERALL survival, *CANCER patients, *PROGNOSIS, *PROGRESSION-free survival
Abstract

Background: We investigated the prognostic value of the preoperative lymphocyte-to-mononuclear ratio (LMR) and platelet-to-lymphocyte ratio (PLR) in a large cohort of patients with non-small cell lung cancer (NSCLC). Methods: Cli nical-pathological data from 507 NSCLC patients at Taizhou Hospital of Zhejiang Province between 2010 and 2016 were retrospectively evaluated. X-tile software was used to assess the optimal cutoff levels for LMR and PLR. Univariate and multivariate Cox regression models were used to assess the prognostic factors. Results: The median follow-up duration after surgical resection was 34.5 months. Patients were stratified into 2 groups by LMR (2.6 and > 2.6) and PLR (179.6 and > 179.6). Our results revealed that lower LMR (HR = 3.163 (1.821-5.493), P = 0.000), age (HR = 2.252 (1.412-3.592), P = 0.001), T stage (HR = 3.749 (2.275-6.179), P = 0.000), N stage (HR = 3.106 (1.967-4.902), P = 0.000), and cut edge (HR = 3.830 (1.077-13.618), P = 0.038) were considered to be independent indicators for overall survival (OS) of NSCLC patients. For disease-free survival (DFS), age, sex, T stage, N stage, LMR and cut edge were verified to be independent prognostic factors in patients with NSCLC. Conclusions: In the study cohort, reduced LMR was a robust independent predictor for both OS and DFS in patients with NSCLC who underwent surgical resection. [ABSTRACT FROM AUTHOR]

Published
2020
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