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15 results on '"Linghu, Lang"'

8. Dendrobine-type alkaloids from Dendrobium nobile.

Author

Zhang, Mao-Sheng, Linghu, Lang, Wang, Gang, He, Yu-Qi, Sun, Cheng-Xin, and Xiao, Shi-Ji

Subjects
ALKALOIDS, DENDROBIUM, SILICA gel, COLUMN chromatography, CELL lines
Abstract

Six dendrobine-type alkaloids were isolated from the tubes of Dendrobium nobile by silica gel, Sephadex LH-20 gel column chromatography, and preparative HPLC. Compound 1 is a new alkaloid containing a pair of amide tautomers, whereas compound 2 is a new dendrobine-type alkaloid. By using spectroscopic techniques including 1 D and 2 D NMR, the structures of compounds 1‒6 were identified as N-methoxylcarbonyldendrobine (1), dendronboic acid (2), dendrobine (3), 6-hydroxyldendrobine (4), dendrobine N-oxide (5), and denrine (6). The cytotoxic effects of the isolated compounds on two human tumour cell lines (HCT-116 and SW1990) were evaluated using MTT assay. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Homogenate-Ultrasound-Assisted Ionic Liquid Extraction of Total Flavonoids from Selaginella involven: Process Optimization, Composition Identification, and Antioxidant Activity

Author

Lei, Jie, primary, Zhu, Lei, additional, Zheng, Yu, additional, Yu, Ming, additional, Li, Gang, additional, Zhang, Feng, additional, Linghu, Lang, additional, Yu, Jiaqi, additional, Luo, Yong, additional, Luo, Xirong, additional, Gang, Wang, additional, and Qin, Cheng, additional

Published
2021
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14. A natural phenylpropionate derivative from Mirabilis himalaica inhibits cell proliferation and induces apoptosis in HepG2 cells

Author

LingHu Lang, Haixia Fan, Shanlin Li, Min Chen, Xiaozhong Lan, Haoxing Zhang, Shunqin Zhu, Hongjuan Cui, Panpan Yang, and Zhihua Liao

Subjects
Carcinoma, Hepatocellular, Clinical Biochemistry, Pharmaceutical Science, Apoptosis, Inhibitory postsynaptic potential, Biochemistry, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Humans, Molecular Biology, Cell Proliferation, Biological Products, Phenylpropionates, Cell growth, Organic Chemistry, Liver Neoplasms, Hep G2 Cells, Cell cycle, medicine.disease, Molecular biology, Cell biology, chemistry, Hepatocellular carcinoma, Cancer cell, Molecular Medicine, Mirabilis, Derivative (chemistry)
Abstract

Bioactivity-guided study led to the isolation of a natural phenylpropionate derivative, (E)-3-(4-hydroxy-2-methoxyphenyl)-propenoic acid 4-hydroxy-3-methoxyphenyl ester from the roots of Mirabilis himalaica. Cellular analysis showed that compound 1 specifically inhibited the cancer cell growth through the S phase arrest. Mechanistically, compound 1 was able to induce the apoptosis in HepG2 cells through mitochondrial apoptosis pathway in which Bcl-2 and p53 were required. Interestingly, the cellular phenotype of compound 1 were shown specifically in cancer cells originated from hepatocellular carcinoma (HepG2) while compromised influence by compound 1 were detected within the normal human liver cells (L-02). Consistently, the in vivo inhibitory effects of compound 1 on tumor growth were validated by the in xenograft administrated with HepG2 cells. Our results provided a novel compound which might serve as a promising candidate and shed light on the therapy of the hepatocellular carcinoma.

Published
2014

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