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8 results on '"Ling Zhenzhen"'

2. Acupuncture regulates the Th17/Treg balance and improves cognitive deficits in a rat model of vascular dementia

Author

Liu Qiuping, Pan Pan, Ling Zhenzhen, Zhang Zhen, Zhang Xuezhu, and Li Shuting

Subjects
Vascular dementia, Acupuncture, Inflammation, Th17/treg, Balance, Cognitive deficits, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Objective: The present study was developed to explore the impact of acupuncture on the Th17/Treg balance in the brain and the periphery and associated changes in cognitive deficits in a rat model of vascular dementia (VD). Methods: Male Wistar rats (8 weeks old) were randomly assigned to sham-operated (Gs, n = 10), and operation (n = 30) groups. A VD model was established for all rats in the operation group via the permanent bilateral occlusion of the common carotid artery. Behavioral screening of these rats was conducted via a hidden platform trial at 2 months post-operation. These operation group rats were then further subdivided into impaired (Gi) and acupuncture (Ga) groups (n = 10/group). Acupuncture was performed over a 21-day period for rats in the Ga group. A Morris water maze (MWM) test was used to assess cognitive function for rats in all groups. Flow cytometry and fluorescent staining were used to detect Th17 and Treg cells in samples from these animals based on IL-17/FoxP3 or CD4+FoxP3+/CD4+RORγt+ staining profiles. Results: Relative to the Gs group, escape latency values for rats in the Gi group were significantly increased. Following treatment, rats in the Ga group exhibited significant reductions in escape latency values as compared to rats in the Gi group (P 0.05), whereas the frequency of Th17 cells in the peripheral blood and spleen of Ga group rats trended downward relative to the Gi group (P > 0.05). Significantly fewer CD4+RORγt+ and RORγt+ cells were detected in the Ga group relative to the Gi group, whereas CD4+FoxP3+ and FoxP3+ cell counts were increased (P

Published
2023
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3. Gp130–HIF1α axis–induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling

Author

Kang, Sujin, primary, Onishi, Shinya, additional, Ling, Zhenzhen, additional, Inoue, Hitomi, additional, Zhang, Yingying, additional, Chang, Hao, additional, Zhao, Hui, additional, Wang, Tong, additional, Okuzaki, Daisuke, additional, Matsuura, Hiroshi, additional, Takamatsu, Hyota, additional, Oda, Jun, additional, and Kishimoto, Tadamitsu, additional

Published
2024
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6. Acupuncture Can Regulate the Peripheral Immune Cell Spectrum and Inflammatory Environment of the Vascular Dementia Rat, and Improve the Cognitive Dysfunction of the Rats

Author

Pan, Pan, primary, Ma, Zhinan, additional, Zhang, Zhen, additional, Ling, Zhenzhen, additional, Wang, Yao, additional, Liu, Qiuping, additional, Lin, Xiaolin, additional, Xu, Pan, additional, Yang, Dan, additional, Zhi, Hui, additional, Wang, Runmin, additional, and Zhang, Xuezhu, additional

Published
2021
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7. Effect of electro-scalp acupuncture on acute ischemic stroke: a randomized, single blind, trial

Author

Chang Shichen, Liu Xiaoxi, Jia Yujie, Ling Zhenzhen, Wang Yao, Li Jing, Zhang Xuezhu, and Nie Kun

Subjects
Activities of daily living, business.industry, General Medicine, Acupuncture treatment, medicine.disease, 030205 complementary & alternative medicine, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Anesthesia, Scalp, medicine, Acupuncture, cardiovascular diseases, Clinical efficacy, Single blind, business, Acute ischemic stroke, Stroke, 030217 neurology & neurosurgery
Abstract

To determine the clinical efficacy and safety of electro-scalp acupuncture in the treatment of patients with acute ischemic stroke.Totally 74 patients with acute ischemic stroke were enrolled and divided into either body acupuncture (Control) or electro-scalp acupuncture (ESA) groups according to randomized controlled principle. The patients in the control group were given body acupuncture treatment once daily for 28 d, whereas except for the body acupuncture, electro-scalp acupuncture was additional treatment given to the ESA group. Neurological deficits, everyday motor function and muscle strength were evaluated at baseline and the 28th d by NIH Stroke Scale (NIHSS), Fugl-Meyer Assessment (FMA) and Modified Barthel Index Score (MBI), respectively.There were not obvious between-group differences in the baseline efficacy parameters (NIHSS, FMA and MBI) (all P0.05), whereas significant between-group differences were found in post-treatment NIHSS, FMA-UE and MBI scores (all P0.05). After acupuncture treatment, systematic within-group improvements were found in the two groups for any of the efficacy parameters assessed (all P0.01), and the ESA group showed higher significant improvements in NIHSS, FMA-UE and MBI scores (all P0.05).Electro-scalp acupuncture was efficacious in the treatment of acute ischemic stroke, which resulted in meaningful improvements in neurologic function, motor function and activities of daily living of patients.

Published
2020

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