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The qualitative relationship between hydrogen concentration and notch tensile strength has been investigated for 5Ni-16Cr-Mo steel with different strength. The notch tensile strength was determined by means of slow strain rate test (SSRT) on circumferentially notched round bar specimens with the notch root radius of 0.15 mm after hydrogen charging. Meanwhile, the hydrogen diffusion behaviors of various strength steel were studied by thermal desorption spectroscopy (TDS) analysis. The SSRT results show that the T460 steel has higher susceptibility of hydrogen embrittlement in contrast with T520 steel. The activation energies and microstructure indicate that the dislocations and interfaces of martensitic laths are hydrogen traps in 5Ni-16Cr-Mo steel. By SSRT, the elastic limit of charged specimen loaded in air is higher than the flow stress without hydrogen charging before unloading, while the difference is defined as hydrogen-induced stress. The value of hydrogen-induced stress σ* increases linearly with hydrogen concentration: σ*=−0.622+2.015C0. The finite element analysis results of stress distributions near the notch tip have shown that the maximum principal stress increases with the notch root radius decreasing.

Objectives: To investigate the cardioprotective effect of dexmedetomidine(DEX) on elderly patients with cervical cancer in the Trendelenburg position (TP). Methods: Eighty patients with cervical cancer presenting with laparoscopic radical hysterectomy (or with laparoscopic pelvic lymphadenectomy) were randomly assigned to the control group (Group C) or the DEX group (Group D), with a total of 40 patients per group. Patients in Group D were given dexmedetomidine, whereas normal saline was administered as placebo in Group C. The data collected for this study included general information (age, body mass index [BMI], anesthesia time, operation time, extubation time and hospital stay), hemodynamic parameters (Heart rate [HR] and mean arterial pressure [MAP]), concentrations of markers of myocardial injury (cardiac troponin I [cTnI] , creatine kinase MB [CK-MB]) and inflammatory factors (Tumor necrosis factor α [TNF-α] , interleukin 6 [IL-6], and C-reactive protein [CRP]) before entering the operating room (T0), 6 h after the surgery(T9) and 24 h after the surgery (T10). Results: Compared to T0, cTnI, CK-MB, TNF-α, IL-6 and CRP were significantly higher at T9 and T10, while cTnI, CK-MB, IL-6 and CRP were significantly lower in group D than those of group C at T9 and T10. Whilst there was no significant difference in TNF-α between the two groups at T9 (P = 0.821), TNF-α concentrations were significantly lower in group D compared to group C at T10 (P = 0.022). Extubation time (P = 0.009) and hospital stay (P = 0.014) were significantly lower in group D, than in group C. There was no significant difference in the adverse reactions between the two groups (P = 0.263). Conclusions: In elderly patients with cervical cancer, TP may cause perioperative myocardial damage. DEX could mitigate the damaging effects and show good hemodynamic stability, which is conducive to rapid postoperative resuscitation, and anti-inflammatory mechanism may play an important role.

To observe the effect of moxibustion on interleukin-6(IL-6)/signal transduction and transcriptional activator 3(STAT3) signaling pathway in the frontal cortex of fatigue rats, so as to reveal its mechanisms underlying alleviation of fatigue.Twenty-one male SD rats were randomly divided into normal control, model, and moxibustion groups (After modeling, the levels of IL-6 content and p-STAT3 protein expression and ratio of p-STAT3/STAT3 were significantly increased in the model group relevant to the normal control group (Moxibustion intervention can relieve fatigue in fatigue rats, which is associated with its function in inhibiting IL-6/STAT3 signaling pathway to reduce inflammatory injury.

To observe the effect of moxibustion at "Zusanli"(ST36) on peripheral and central IL-6, IL-10 and IL-10/IL-6 changes in fatigue rats, so as to explore its mechanisms underlying relief of fatigue.Twenty-one male SD rats were randomly divided into normal control, model and moxibustion groups with 7 rats in each group. The fatigue model was induced by exhausted weight-loaded swimming, once daily for 21 days. Moxibustion was applied to bilateral ST36 once every other day, for successive 11 times. The overall state and the body weight were observed. The levels of IL-6 and IL-10 in the serum, gastrocnemius and frontal cortex tissues were detected by enzyme-linked immunosorbent assay (ELISA).Compared with the normal group, the body weight was significantly reduced on the 7Moxibustion can inhibit weight-loaded swimming induced decrease of body weight in fatigue rats, which may be associated with its effects in balancing the levels of peripheral and central pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10.

The inducible nitric oxide synthase/nitric oxide (iNOS/NO) signaling pathway and inflammatory cytokines play important roles in the pathogenesis of exercise-induced fatigue. Studies have found that Mongolian warm acupuncture (WA) could alleviate exercise-induced fatigue. However, the exact mechanisms underlying its effects remain unclear. In the present study, we investigated the effects of Mongolian WA on iNOS/NO signaling pathway and proinflammatory cytokines in a chronic exhaustive swimming-induced fatigue rat model. Animals were randomly divided into Control group, Ctrl + WA group, Model group, and Model + WA group. The body weight, exhaustive swimming time test, and Morris water maze test were performed before and after the chronic exhaustive swimming. The serum levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), and iNOS were detected by enzyme linked immunosorbent assay (ELISA). The mRNA expressions of IL-1β, IL-6, TNF-α, IFN-γ, and iNOS in the hippocampus were measured by real-time polymerase chain reaction (RT-PCR). Moreover, the protein expression of iNOS in the hippocampus was measured by western blot, and the NO productions in the serum and hippocampus were detected by Griess reaction system. Chronic exhaustive exercise significantly reduced the body weight and exhaustive swimming time, and induced impairment in learning and memory, and which were reversed by WA treatment. Chronic exhaustive exercise also increased the expressions of iNOS and proinflammatory cytokines, while WA treatment significantly decreased the level of iNOS and proinflammatory cytokines. However, chronic exhaustive exercise did not affect the NO production. These findings demonstrated that WA could alleviate the chronic exhaustive swimming-induced fatigue and improve the learning and memory ability, and the actions might be related to the reduction of inflammatory response and iNOS expression.

Accumulating data indicates that brain inflammation plays an important role in the pathophysiology of chronic exercise-induced fatigue. Moxibustion in traditional Chinese medicine has been found to alleviate exercise-induced fatigue. However, it remains unclear whether the effect of moxibustion is related to its anti-inflammatory properties. In this study, rats were exposed to 3-week exhaustive swimming to induce chronic exercise-induced fatigue. The body weight, exhaustive swimming time, tail suspension test and open-field test were observed. Real-time polymerase chain reaction (RT-PCR) was used to determine the mRNA expression of proinflammatory cytokines (interleukin-1β [IL-1β], interleukin-6 [IL-6], and tumor necrosis factor-α[TNF-α]), and enzyme-linked immunosorbent assay (ELISA) was used to detect IL-1β, IL-6, and TNF-α concentrations. Chronic exhaustive exercise significantly reduced the body weight and exhaustive swimming time, and increased tail suspension immobility time, which were reversed by moxibustion treatment. Compared with control rats, the mRNA and protein expression of IL-1β, IL-6, and TNF-α in the hippocampus was significantly increased in exhaustive swimming trained rats. Moxibustion significantly decreased the level of IL-6 in the hippocampus, but not affected IL-1β and TNF-α level significantly. Our results suggested that a potential inflammatory damage in the brain may be involved during chronic exhaustive exercise-induced fatigue. Moxibustion could attenuate the inflammatory impairment in exercise-induced fatigue, which might be mediated by inhibition of the proinflammatory cytokine IL-6 levels in the brain region.

To investigate the effect of moxibustion of "Zusanli "(ST36) on levels of inflammatory cytokines in the hippocampus and hypothalamus regions of rats with fatigue, so as to reveal its anti-fatigue mechanism.Twenty-four male Sprague-Dawley rats were randomly divided into normal control, fatigue model, and moxibustion groups, with 8 rats in each group. The fatigue model was established by chronic weight-loaded exhaustive swimming. During modeling, the rats in the moxibustion group were given moxibustion (3 moxa cones, about 8 min in duration) at bilateral ST36, once every other day for 11 times in total. The duration of exhausted swimming was observed, and ELISA was used to measure the contents of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interferon gamma (IFN-γ) in the hippocampus and hypothalamus tissues.The duration of exhausted swimming was obviously prolonged on day 14 and 21 after moxibustion intervention relevant to the model group (Moxibustion can significantly down-regulate hippocampal IL-6 content in fatigue rats, which maybe contribute to its effect in alleviating fatigue. Further studies need being conducted to identify this conclusion.

In this paper, we give some solutions L2×2 for L2×23≡A2×2(modN) when A2×2 is zero, identity, [ ef00 ] and [ ef0h ] matrices. As a result, the use of a secret key L4×4=[ L2×2I−L2×2I+L2×2−L2×2 ] should be avoided in order to enhance the security of Cipher Tetragraphic Trifunction transformations, C4×J(t)≡L4×4P4×j(modN) where t∈ { 1,2,3 }, C4×j(t) is ciphertext and P4×j is plaintext.

Objective: To observe the effects of warm acupuncture on “Dinghui Acupoint” and “Heart Acupoint” in Traditional Mongolian Medicine on behavior and hypothalamic inflammatory cytokines IL-1β, IL-6 and IFN-r in Rats with Chronic Fatigue Syndrome. Methods: SD rats were randomly divided into normal group, model group, warm acupuncture group and moxibustion positive control group. The latter three groups of rats were used to establish a model of rats with chronic fatigue syndrome (CFS) using a combination of physical fatigue and mental fatigue. When establishing the model of warm acupuncture group, “Dinghui Acupoint” and “Heart Acupoint” intervention was carried out; when establishing the model of moxibustion positive control group, “Zusanli Acupoint” intervention was carried out on both sides. Behavioral observations (body weight, exhaustive swimming time, tail suspension experiment, water maze) were performed before and after modeling. The hypothalamic inflammatory cytokines IL-1β, IL-6 and IFN-r were detected by ELISA method after warm acupuncture and moxibustion intervention. Results: After 21 days of modeling, the body weight of the rats in each group was significantly lower than that in the normal group, and there was a significant difference (P0.05); Compared with the normal group, IL-1β, IL-6 and IFN-r increased significantly in the model group and there was a significant difference (P0.05); Compared with the moxibustion group, the levels of IL-1β, IL-6 and IFN-r were not significantly different (P>0.05). Conclusion: Warm acupuncture on “Dinghui Acupoint” and “Heart Acupoint” in Traditional Mongolian Medicine has the ability to improve the body’s defense and self-healing ability, improve chronic fatigue syndrome (CFS), and thus play a preventive role. The results of this research indicate that the warm acupuncture group and the moxibustion group have the same effect.

By using advanced IPv6 technology, This paper presents a design of family wireless medical sensor networks(WMSN) and a implementation of ECG and temperature monitoring sensor node. The 6LoWPAN medical sensor nodes can add into the WMSN rapidly and the biomedical data are routed into the Internet through the gateway, therefore, it can get the information of health record on the web expediently and simply. In addition, this paper proposes a scheme of telemedicine for convenient and secure medical service.

By using liquid metal cooling method, the Ni-based superalloy DZ125 was directionally solidified under planar interface growth condition of drawing rate of 1.5 μm/s. The microstructures at different solidified fractions were examined by OM and SEM. The results showed that the solid/liquid interface is planar and the microstructure evolution undergoes three stages: the γ phase was formed as solidified fraction (fs) was below 0.26, and the fine HfC phase sparsely distributed in γ matrix; the coupled γ/MC growth appeared as fs ranged from 0.26 to 0.86, and the morphology of M Cw as fibrous or plate-like shapes; the γ/γ � eutectic was obtained as fs was more than and equaled 0.86 0.86, in which the octahedral M C was precipitated simultaneously. EPMA was used to determine the solute distribution along the longitudinal direction of the sample. The contents of Al, Ti, Ta and Mo increased with fs increasing, while the contents of W, Cr and Co decreased. The analysis showed that the microstructure transformation is attributed to macro-scale non-uniform solute distribution which resulted from solute redistribution during directional solidification.

The mechanisms underlying myocardial protection by sevoflurane post-conditioning are unclear. In the present study, we tested two hypotheses: (i) that sevoflurane post-conditioning produces cardioprotection via a phosphatidylinositol-3-kinase (PI3-K)-dependent pathway; and (ii) combining sevoflurane and ischaemic post-conditioning offers an additional benefit against reperfusion injury. Rat isolated perfused hearts were exposed to 25 min ischaemia followed by 90 min reperfusion. Sevoflurane post-conditioning was induced by administration of sevoflurane (3.0 vol%) for 15 min from the onset of reperfusion. In some groups, 15 micromol/L LY294002, a selective PI3-K inhibitor, was coadministrated with sevoflurane. Other groups of hearts were exposed to ischaemic post-conditioning or combined sevoflurane plus ischaemic post-conditioning in the presence and absence of LY294002. After 15 min reperfusion, phosphorylation of Akt and glycogen synthase kinase 3beta (GSK3beta) was determined by Western blot analysis. Infarct size was determined by 2,3,5-triphenyltetrazolium chloride staining and subsarcolemmal mitochondrial lesions were assessed by electron microscopy after 90 min reperfusion. Sevoflurane post-conditioning significantly decreased infarct size compared with control hearts (31 +/- 2 vs 42 +/- 3%, respectively; P < 0.05), diminished mitochondrial lesions and increased phosphorylation of Akt and GSK3beta, as did ischaemic post-conditioning. However, combined sevoflurane plus ischaemic post-conditioning did not further improve the cardioprotective effects compared with either intervention alone. Sevoflurane-mediated cardioprotection was abolished or inhibited by 15 micromol/L LY294002. In conclusion, sevoflurane acts during early reperfusion after ischaemia to salvage the myocardium by activating PI3-K. The combination of sevoflurane plus ischaemic post-conditioning does not offer any additional benefit over either intervention alone.