13 results on '"Lindstedt, Ew"'
Search Results
2. Orbital Inflammation due to Intraocular Malignant Melanoma
- Author
-
Lindstedt, EW, Hafezi, F, Veckeneer, MA, Mooy, CM, Paridaens, Dion, Pathology, and Ophthalmology
- Published
- 2008
3. Anti-TNF-alpha therapy for sight threatening uveitis
- Author
-
Lindstedt, EW, Baarsma, GS, Kuijpers, Robert, van Hagen, P.M., Ophthalmology, and Immunology
- Published
- 2005
4. Molecular genetic analysis of the von Hippel-Lindau and human peroxisome proliferator-activated receptor ? tumor-suppressor genes in adenocarcinomas of the gastroesophageal junction
- Author
-
Wijnhoven, Bas, Lindstedt, EW, Abbou, M, IJzendoorn, Y (Ynske), de Krijger, Ronald, Tilanus, Hugo, Dinjens, Winand, Surgery, Pathology, and Pediatric Surgery
- Published
- 2001
5. Comparison of surgical outcomes of Carlevale sutureless scleral fixation and Artisan Aphakia intraocular lens.
- Author
-
Van Severen V, Maaijwee KJM, Pennekamp CWA, Feenstra HMA, van Dijk EHC, Lindstedt EW, and Bamonte G
- Subjects
- Humans, Retrospective Studies, Female, Male, Aged, Middle Aged, Follow-Up Studies, Prosthesis Design, Postoperative Complications, Aphakia, Postcataract surgery, Aphakia, Postcataract physiopathology, Lenses, Intraocular, Treatment Outcome, Adult, Aged, 80 and over, Suture Techniques, Sclera surgery, Visual Acuity physiology, Refraction, Ocular physiology, Sutureless Surgical Procedures methods, Lens Implantation, Intraocular methods
- Abstract
Purpose: To compare intra- and postoperative results of sutureless scleral fixated Carlevale intraocular lens (IOL) with iris fixated Artisan IOL., Methods: Monocentre, retrospective analysis of refractive outcomes and intra- and postoperative complications of patients who received a Carlevale or Artisan IOL between January 2019 and March 2022., Results: 178 eyes of 169 patients were included (101 Carlevale and 77 Artisan IOLs). The standard follow-up time was 1 month. Two statistically significant differences were found: in the deviation of the postoperative spherical equivalent of the refraction from the preoperative chosen IOL target (p = 0.019; mean deviation was -0.46 in the Carlevale and 0.08 in the Artisan group), and the number of eyes with complications between the Carlevale and Artisan groups (p = 0.003; 33 in the Carlevale and 42 in the Artisan group)., Conclusion: The current study is the largest so far comparing both refractive outcomes and complications after implantation of Carlevale and Artisan IOL. The Carlevale IOL does not carry a greater complication risk on the short-term follow-up. This provides additional evidence that the Carlevale IOL has to be added to the armamentarium of the ophthalmic surgeon., (© 2023 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.)
- Published
- 2024
- Full Text
- View/download PDF
6. A prospective multicentre randomized placebo-controlled superiority trial in patients with suspected bacterial endophthalmitis after cataract surgery on the adjuvant use of intravitreal dexamethasone to intravitreal antibiotics.
- Author
-
Manning S, Ugahary LC, Lindstedt EW, Wubbels RJ, van Dissel JT, Jansen JTG, Gan I, van Goor AT, Bennebroek CA, van der Werf DJ, Ossewaarde-van Norel A, Mayland Nielsen CC, Tilanus M, van den Biesen PR, Schellekens PA, La Heij E, Faridpooya K, van Overdam K, Veckeneer M, and van Meurs JC
- Subjects
- Aged, Anti-Bacterial Agents administration & dosage, Endophthalmitis etiology, Female, Follow-Up Studies, Glucocorticoids administration & dosage, Humans, Intravitreal Injections, Male, Prospective Studies, Surgical Wound Infection etiology, Treatment Outcome, Visual Acuity, Cataract Extraction adverse effects, Dexamethasone administration & dosage, Endophthalmitis drug therapy, Eye Infections, Bacterial etiology, Gentamicins administration & dosage, Surgical Wound Infection drug therapy, Vancomycin administration & dosage
- Abstract
Purpose: We aimed to determine whether intravitreal dexamethasone as an adjuvant to intravitreal antibiotics is beneficial in the treatment of suspected bacterial endophthalmitis after cataract surgery., Methods: Randomized, placebo-controlled superiority trial in three tertiary referral centres in the Netherlands. Patients with suspected bacterial endophthalmitis within 6 weeks after cataract surgery were eligible. A diagnostic vitreous biopsy was taken for culture, and patients received intravitreal injections of 400 μg dexamethasone (without preservatives) or placebo, in addition to 0.2 mg vancomycin and 0.05 mg gentamicin. The vancomycin and dexamethasone or placebo injections were repeated once at day 3 or 4. Primary outcome measure was best-corrected visual acuity (BCVA) at 1 year., Results: Between 1 November 2004 and 1 March 2014 (excluding two interruptions totalling 20 months), 324 eligible patients presented. A total of 167 patients (81 dexamethasone, 86 placebo) were available for the intention-to-treat analysis. Biopsies of 114 patients (68%) were culture-positive. Final BCVA did not differ between the dexamethasone and the placebo group (logMAR 0.31 ± 0.58 versus 0.27 ± 0.50; p = 0.90), nor did the number of patients with final vision of no light perception (LP, 7 versus 13). Pain, corneal oedema, the absence of a red fundus reflex on presentation, LP on presentation and culture of virulent pathogens from biopsy were statistically significantly associated with an unfavourable visual outcome., Conclusion: Intravitreal dexamethasone without preservatives as an adjuvant to intravitreal antibiotics does not improve visual acuity (VA) in patients treated for suspected bacterial endophthalmitis after cataract surgery., (© 2017 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.)
- Published
- 2018
- Full Text
- View/download PDF
7. A prospective multicenter randomized placebo-controlled trial of dexamethasone as an adjuvant in the treatment of postoperative bacterial endophthalmitis: interim safety analysis of the study drug and analysis of overall treatment results.
- Author
-
Lindstedt EW, Bennebroek CA, van der Werf DJ, Veckeneer M, Norel AO, Nielsen CC, Wubbels RJ, van Dissel JT, and van Meurs JC
- Subjects
- Aged, Aged, 80 and over, Bacteria isolation & purification, Dexamethasone adverse effects, Double-Blind Method, Endophthalmitis microbiology, Eye Enucleation, Eye Evisceration, Eye Infections, Bacterial microbiology, Female, Glucocorticoids adverse effects, Humans, Intravitreal Injections, Male, Middle Aged, Prospective Studies, Visual Acuity physiology, Vitreous Body microbiology, Dexamethasone therapeutic use, Endophthalmitis drug therapy, Eye Infections, Bacterial drug therapy, Glucocorticoids therapeutic use, Phacoemulsification, Postoperative Complications
- Abstract
Purpose: In an ongoing prospective multicenter randomised placebo-controlled trial we study the adjuvant use of intravitreal dexamethasone in the treatment of patients with suspected bacterial endophthalmitis after phacoemulsification. In accordance with the study protocol, a mid-inclusion interim analysis of the safety of the study drug was performed., Patients and Methods: Patients with suspected endophthalmitis after phacoemulsification were asked to participate in this study. A diagnostic vitreous biopsy was taken and the patients received intravitreal injections of 400 micrograms dexamethasone or a placebo, plus 0.2 mg vancomycin and 0.05 mg gentamicin. Injections were repeated after 3 or 4 days. The safety analysis included: the number of eyes with an evisceration; no light perception; or a visual acuity of less than 5/200. Treatment outcome was evaluated in terms of: the percentage of patients with a visual acuity of 20/40 or more and 20/100 or more., Results: The interim analysis included 81 patients with at least 1 year follow-up. Sixty-three patients (65 %) were culture-positive. Safety analysis: 7 eyes were eviscerated (3 dexamethasone, 4 placebo); 4 eyes had no light perception (2 dexamethasone, 2 placebo); and 4 eyes had less than 5/200 vision (3 dexamethasone, 1 placebo). Treatment outcome: 70 % of patients had a visual acuity of at least 20/40., Conclusion: The safety analysis does not warrant premature discontinuation of the study. So far, the overall outcome of our treatment regimen, consisting of merely a diagnostic biopsy instead of a vitrectomy and an optimized antibiotic dosing, compares favourably to published literature.
- Published
- 2014
- Full Text
- View/download PDF
8. Persistent subretinal fluid after surgery for rhegmatogenous retinal detachment: hypothesis and review.
- Author
-
Veckeneer M, Derycke L, Lindstedt EW, van Meurs J, Cornelissen M, Bracke M, and Van Aken E
- Subjects
- Aged, Aged, 80 and over, Drainage, Female, Humans, Immunohistochemistry, Male, Microscopy, Electron, Transmission, Middle Aged, Retinal Detachment physiopathology, Rhodopsin metabolism, Rod Cell Outer Segment metabolism, Scleral Buckling, Tomography, Optical Coherence, Visual Acuity physiology, Vitrectomy, Postoperative Complications, Retinal Detachment surgery, Rod Cell Outer Segment ultrastructure, Subretinal Fluid cytology
- Abstract
Background: Persistent subretinal fluid after rhegmatogenous retinal detachment (RRD) surgery is responsible for delayed recovery, and may affect the final visual outcome. Cause, consequences, and treatment remain elusive., Design: Literature review and case series., Methods: We reviewed the pathophysiological principles and therapeutic options from the literature, and we report the results from a subretinal fluid cytology study. Nine eyes from nine patients with macula-involving RRD underwent surgical repair. The cellular content of subretinal fluid (SRF) was studied by electron microscopy and anti-rhodopsin immunostaining. All eyes were assessed postoperatively with optical coherence tomography for the detection of persistent submacular fluid (PSF) (Ethics Committee Ghent University Hospital, registration number B6702006169)., Results: Certain patient characteristics as well as surgical methods were implicated. PSF appears to occur more frequently in patients with longstanding detachments treated with buckling surgery. Several therapeutic options have been suggested but safety and efficacy remain unclear. We found PSF in three eyes on postoperative OCT scans, which corresponded to the three cell-rich subretinal samples., Conclusions: PSF after successful RRD repair seems to be related to fluid composition. We hypothesize, in the absence of an effective treatment, that a modified surgical drainage, including a washout of the subretinal space, could evacuate the subretinal fluid more completely, and may prevent this complication.
- Published
- 2012
- Full Text
- View/download PDF
9. [Orbital inflammation due to intraocular malignant melanoma].
- Author
-
Lindstedt EW, Hafezi F, Veckeneer MA, Mooy CM, and Paridaens D
- Subjects
- Aged, 80 and over, Diagnosis, Differential, Endophthalmitis prevention & control, Eye Neoplasms therapy, Female, Humans, Melanoma therapy, Endophthalmitis diagnosis, Endophthalmitis etiology, Eye Neoplasms complications, Eye Neoplasms diagnosis, Melanoma complications, Melanoma diagnosis
- Published
- 2008
- Full Text
- View/download PDF
10. An epidemic of sticky silicone oil at the Rotterdam Eye Hospital. Patient review and chemical analyses.
- Author
-
Veckeneer MA, de Voogd S, Lindstedt EW, Menz DH, and van Meurs JC
- Subjects
- Drainage methods, Drug Interactions, Female, Fluorocarbons chemistry, Gas Chromatography-Mass Spectrometry, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged, Retinal Detachment surgery, Retrospective Studies, Silicone Oils chemistry, Vitrectomy, Adhesiveness, Fluorocarbons metabolism, Intraoperative Complications, Retina metabolism, Silicone Oils metabolism
- Abstract
Purpose: To report and study the phenomenon of abnormal silicone oil adherent to the retina at the time of removal in a number of patients., Materials and Methods: Chart review was performed to identify possible patient or procedural factors that could predispose to sticky silicone oil formation. Gas chromatography-mass spectroscopy and nuclear magnetic resonance spectroscopy analyses were performed on sticky silicone oil samples, on perfluorocarbon liquid and on silicone oil samples straight from the vial., Results: Sticky silicone oil remnants were seen on the retina in 28 out of 234 silicone oil removal procedures between January 2001 and November 2002. Forceful removal was complicated in two patients by a choroidal hemorrhage and in one patient by a retinal tear. The use of perfluoro-octane (PFO; C(8)F(18)) rather than perfluorodecalin (C(10)F(18)) was related to the phenomenon (P < 0.001). Gas chromatography-mass spectroscopy analysis revealed a significant presence of PFO in samples of sticky silicone oil, and traces of partially fluorinated carbon liquid were found in the sticky oil as well as in the PFO samples., Conclusions: The use of PFO may have been a predisposing factor for the occurrence of sticky silicone oil. While the presence of silicone oil remnants on the retina did not cause lasting side effect, forceful attempts at removal can lead to complications.
- Published
- 2008
- Full Text
- View/download PDF
11. Sclerochoroidal calcification: idiopathic or associated with systemic disease?
- Author
-
Lindstedt EW, van den Born LI, Veckeneer M, and Baarsma GS
- Abstract
Background: Idiopathic sclerochoroidal calcification is a rare disorder that may be confused with a malignant tumor. In most patients, its etiology is unknown. Some patients have associated systemic disorders or syndromes., Methods: We report the case history of a patient with hypercalcemia and extensive sclerochoroidal calcifications; furthermore, we evaluate a series of seven patients with sclerochoroidal calcification, investigating calcium-phosphorus metabolism and screening for primary renal tubular hypokalemic metabolic alkalosis syndromes., Results: One patient was diagnosed with bilateral sclerochoroidal calcification; she had primary hyperparathyroidism due to a parathyroid adenoma. None of the other seven patients met the criteria of primary renal tubular hypokalemic metabolic alkalosis syndromes or had significant problems of calcium-phosphorus metabolism. Nevertheless, two of them had a history of kidney stones, whereas two others had a history of arthritis., Conclusion: For all patients with sclerochoroidal calcification, it is important to exclude primary renal tubular hypokalemic metabolic alkalosis syndromes such as Bartter and Gitelman syndromes, because these patients have a higher risk of cardiovascular morbidity especially during anesthesia.
- Published
- 2007
- Full Text
- View/download PDF
12. Anti-TNF-alpha therapy for sight threatening uveitis.
- Author
-
Lindstedt EW, Baarsma GS, Kuijpers RW, and van Hagen PM
- Subjects
- Adult, Aged, Behcet Syndrome drug therapy, Behcet Syndrome physiopathology, Female, Follow-Up Studies, Humans, Infliximab, Male, Middle Aged, Treatment Outcome, Uveitis physiopathology, Uveitis, Posterior drug therapy, Uveitis, Posterior physiopathology, Visual Acuity drug effects, Antibodies, Monoclonal therapeutic use, Tumor Necrosis Factor-alpha antagonists & inhibitors, Uveitis drug therapy
- Abstract
Aim: To describe the effect of additional treatment with anti-TNF-alpha therapy in a case series of 13 patients with serious sight threatening uveitis., Methods: 13 patients with serious sight threatening uveitis were included, of whom six had Behçet's disease, five had idiopathic posterior uveitis, one had sarcoidosis, and one birdshot retinochoroiditis. Onset and course of ocular inflammation, inflammatory signs, and visual acuity were assessed. Patients were treated with 200 mg (approximately 3 mg/kg) infliximab infusion. Repeat infusions were given based on clinical response., Results: Infliximab treatment resulted in an effective suppression of ocular inflammation in all patients. In patients with non-Behcet's disease uveitis visual acuity in six out of eight improved or was stable. In patients with Behcet's disease visual acuity in five out of six improved or was stable., Conclusion: Anti-TNF-alpha treatment may be of value in the treatment of uveitis, and in patients with Behçet's disease, leading to suppression of ocular inflammation, vasculitis, and improvement of vision in the majority. Based on these results a controlled masked study is warranted.
- Published
- 2005
- Full Text
- View/download PDF
13. Molecular genetic analysis of the von Hippel-Lindau and human peroxisome proliferator-activated receptor gamma tumor-suppressor genes in adenocarcinomas of the gastroesophageal junction.
- Author
-
Wijnhoven BP, Lindstedt EW, Abbou M, Ijzendoorn Y, de Krijger RR, Tilanus HW, and Dinjens WN
- Subjects
- Adenocarcinoma pathology, Esophageal Neoplasms pathology, Humans, Immunohistochemistry, Loss of Heterozygosity, Polymorphism, Single-Stranded Conformational, Stomach Neoplasms pathology, Tumor Cells, Cultured, Von Hippel-Lindau Tumor Suppressor Protein, Adenocarcinoma genetics, Esophageal Neoplasms genetics, Genes, Tumor Suppressor, Ligases genetics, Receptors, Cytoplasmic and Nuclear genetics, Stomach Neoplasms genetics, Transcription Factors genetics, Tumor Suppressor Proteins, Ubiquitin-Protein Ligases
- Abstract
We investigated whether 2 candidate tumor-suppressor genes, VHL at 3p25-26 and PPAR gamma at 3p24.2-25, are involved in GEJ adenocarcinogenesis. In 43 GEJ tumor samples from 40 patients, the entire coding sequence of the VHL gene and the 5' and part of the 3' UTR as well as exons 3 and 5 of the PPAR gamma gene were screened by PCR-SSCP analysis. LOH at 3p25-26 was analyzed with 2 polymorphic microsatellite markers and with the VHL exon 1 and intron 2 polymorphisms. The relationship between LOH and clinicopathologic parameters was assessed. Expression of VHL was investigated by immunohistochemistry with a VHL-specific antibody. PCR-SSCP analysis of VHL revealed 2 different aberrant patterns in 19 patients. Upon DNA sequencing, 1 pattern appeared to be a previously described exon 1 polymorphism. The other single aberrant pattern was an intron 2 polymorphism, not yet described. PCR-SSCP analysis of PPAR gamma showed no aberrant migration patterns. LOH analysis revealed 3p25-26 loss in 24/36 (67%) informative cases, but this was not significantly correlated with clinicopathologic parameters. By immunohistochemistry, all tumors showed expression of VHL protein. Despite the very frequent LOH of 3p in GEJ adenocarcinomas, mutations in VHL and PPAR gamma were not detected. Mutations outside the screened sequences, a gene dosage effect or involvement of another tumor-suppressor gene on 3p as the target of LOH should be considered., (Copyright 2001 Wiley-Liss, Inc.)
- Published
- 2001
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.