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526 results on '"Lindsberg, Perttu J."'

10. Retinal vessel diameters and microvascular abnormalities in patients with carotid stenosis before and 6 months after carotid endarterectomy: A prospective study

Author

Ala‐Kauhaluoma, Marianne, primary, Ijäs, Petra, additional, Koskinen, Suvi M., additional, Nuotio, Krista, additional, Vikatmaa, Pirkka, additional, Silvennoinen, Heli, additional, Relander, Kristiina, additional, Lindsberg, Perttu J., additional, Soinne, Lauri, additional, and Summanen, Paula A., additional

Published
2023
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18. Flicker‐induced retinal vascular dilation in ipsi‐ and contralateral eyes of patients with carotid stenosis before and after carotid endarterectomy: a prospective study

Author

Ala‐Kauhaluoma, Marianne, primary, Vikatmaa, Pirkka, additional, Koskinen, Suvi M., additional, Ijäs, Petra, additional, Nuotio, Krista, additional, Silvennoinen, Heli, additional, Relander, Kristiina, additional, Lindsberg, Perttu J., additional, Soinne, Lauri, additional, and Summanen, Paula A., additional

Published
2022
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21. Warfarin Treatment Is Associated to Increased Internal Carotid Artery Calcification

Author

Nuotio, Krista, Koskinen, Suvi M., Mäkitie, Laura, Tuimala, Jarno, Ijäs, Petra, Heikkilä, Hanna M., Saksi, Jani, Vikatmaa, Pirkka, Sorto, Pia, Kasari, Sonja, Paakkari, Ilari, Silvennoinen, Heli, Valanne, Leena, Mäyränpää, Mikko I., Soinne, Lauri, Kovanen, Petri T., Lindsberg, Perttu J., HUS Neurocenter, Research Programs Unit, Perttu Lindsberg / Principal Investigator, Clinicum, Neurologian yksikkö, HUS Medical Imaging Center, Department of Diagnostics and Therapeutics, Department of Neurosciences, Department of Pathology, University of Helsinki, HUS Abdominal Center, Verisuonikirurgian yksikkö, Medicum, Department of Pharmacology, Faculty of Medicine, Helsinki University Hospital Area, and HUSLAB

Subjects
RISK, carotid artery, 3112 Neurosciences, VITAMIN-K ANTAGONIST, GUIDELINES, 3124 Neurology and psychiatry, MECHANISMS, warfarin, histology, calcification, PATHOLOGY, ATHEROSCLEROSIS, VASCULAR CALCIFICATION, MICROCALCIFICATIONS, MANAGEMENT, cardiovascular diseases, CORONARY, computed tomography angiography
Abstract

Background: Long-term treatment with the vitamin K antagonist warfarin is widely used for the prevention of venous thrombosis and thromboembolism. However, vitamin K antagonists may promote arterial calcification, a phenomenon that has been previously studied in coronary and peripheral arteries, but not in extracranial carotid arteries. In this observational cohort study, we investigated whether warfarin treatment is associated with calcification of atherosclerotic carotid arteries. Methods: Overall, 500 consecutive patients underwent carotid endarterectomy, 82 of whom had received long-term warfarin therapy. The extent of calcification was assessed with preoperative computed tomography angiography, and both macroscopic morphological grading and microscopic histological examination of each excised carotid plaque were performed after carotid endarterectomy. Results: Compared with non-users, warfarin users had significantly more computed tomography angiography-detectable vascular calcification in the common carotid arteries (odds ratio 2.64, 95% confidence interval 1.51-4.63, P < 0.001) and even more calcification in the internal carotid arteries near the bifurcation (odds ratio 18.27, 95% confidence interval 2.53-2323, P < 0.001). Histological analysis revealed that the intramural calcified area in plaques from warfarin users was significantly larger than in plaques from non-users (95% confidence interval 3.36-13.56, P = 0.0018). Conclusions: Long-lasting warfarin anticoagulation associated with increased calcification of carotid atherosclerotic plaques, particularly in locations known to be the predilection sites of stroke-causing plaques. The clinical significance of this novel finding warrants further investigations.

Published
2021

26. Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): a prospective registry study

Author

Schonewille, Wouter J, Wijman, Christine AC, Michel, Patrik, Rueckert, Christina M, Weimar, Christian, Mattle, Heinrich P, Engelter, Stefan T, Tanne, David, Muir, Keith W, Molina, Carlos A, Thijs, Vincent, Audebert, Heinrich, Pfefferkorn, Thomas, Szabo, Kristina, Lindsberg, Perttu J, de Freitas, Gabriel, Kappelle, L Jaap, and Algra, Ale

Published
2009
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27. Comatose With Basilar Artery Occlusion : Still Odds of Favorable Outcome With Recanalization Therapy

Author

Ritvonen, Juhani, Sairanen, Tiina, Silvennoinen, Heli, Virtanen, Pekka, Salonen, Oili, Lindsberg, Perttu J., Strbian, Daniel, Department of Neurosciences, University of Helsinki, HUS Neurocenter, Clinicum, Perttu Lindsberg / Principal Investigator, Research Programs Unit, Neurologian yksikkö, Helsinki University Hospital Area, and HUS Medical Imaging Center

Subjects
ISCHEMIC-STROKE, recanalization therapy, SCORE, outcome, 3112 Neurosciences, INTRAARTERIAL, basilar artery, coma, INTRAVENOUS THROMBOLYSIS, PREDICTORS, stroke, 3124 Neurology and psychiatry
Abstract

Background: Around 30-60% of patients with basilar artery occlusion (BAO) present with coma, which is often considered as a hallmark of poor prognosis. Aim: To examine factors that will help predict outcomes in patients with BAO comatose on admission. Methods: A total of 312 patients with angiography-proven BAO were analyzed. Comas were assessed as Glasgow Coma Scale (GCS) of Results: In total, 103/259 (39.8%) of BAO patients were comatose on admission. Factors associated with acute coma were higher age, coronary artery disease, convulsions, extent of early ischemia by posterior circulation Acute Stroke Prognosis Early CT Score (pc-ASPECTS) < 8, absence of patent posterior collateral vasculature, and occlusion over multiple segments of BA. A total of 21/103 (20.4%) of comatose patients had a favorable outcome (mRS 0-3), and 12/103 (11.7%) had a good outcome (mRS 0-2). Factors associated with a favorable outcome in comatose BAO patients were younger age (p = 0.010), less extensive baseline ischemia (p = 0.027), recanalization (p = 0.013), and avoiding symptomatic intracranial hemorrhage (sICH) (p = 0.038). Factors associated with the poorest outcome or death (mRS 5-6) were older age (p = 0.001), diabetes (p = 0.022), atrial fibrillation (p = 0.016), lower median GCS [4 (IQR 3.6) vs. 6 (5-8); p = 0.006], pc-ASPECTS < 8 (p = 0.003), unsuccessful recanalization (p = 0.006), and sICH (p = 0.010). Futile recanalization (mRS 4-6) was significantly more common in comatose patients (49.4 vs. 18.5%, p < 0.001). Conclusions: One in five BAO patients with acute coma had a favorable outcome. Older patients with cardiovascular comorbidities and already existing ischemic lesions before reperfusion therapies tended to have a poor prognosis, especially if no recanalization is achieved and sICH occurred.

Published
2021

29. Ultra-Early Differential Diagnosis of Acute Cerebral Ischemia and Hemorrhagic Stroke by Measuring the Prehospital Release Rate of GFAP

Author

Mattila, Olli S, primary, Ashton, Nicholas J, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Harve-Rytsälä, Heini, additional, Pihlasviita, Saana, additional, Ritvonen, Juhani, additional, Sibolt, Gerli, additional, Nukarinen, Tiina, additional, Curtze, Sami, additional, Strbian, Daniel, additional, Pystynen, Mikko, additional, Tatlisumak, Turgut, additional, Kuisma, Markku, additional, and Lindsberg, Perttu J, additional

Published
2021
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30. Warfarin Treatment Is Associated to Increased Internal Carotid Artery Calcification

Author

Nuotio, Krista, primary, Koskinen, Suvi M., additional, Mäkitie, Laura, additional, Tuimala, Jarno, additional, Ijäs, Petra, additional, Heikkilä, Hanna M., additional, Saksi, Jani, additional, Vikatmaa, Pirkka, additional, Sorto, Pia, additional, Kasari, Sonja, additional, Paakkari, Ilari, additional, Silvennoinen, Heli, additional, Valanne, Leena, additional, Mäyränpää, Mikko I., additional, Soinne, Lauri, additional, Kovanen, Petri T., additional, and Lindsberg, Perttu J., additional

Published
2021
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31. The Low-Expression Variant of FABP4 Is Associated With Cardiovascular Disease in Type 1 Diabetes

Author

Dahlström, Emma H., primary, Saksi, Jani, additional, Forsblom, Carol, additional, Uglebjerg, Nicoline, additional, Mars, Nina, additional, Thorn, Lena M., additional, Harjutsalo, Valma, additional, Rossing, Peter, additional, Ahluwalia, Tarunveer S., additional, Lindsberg, Perttu J., additional, Sandholm, Niina, additional, and Groop, Per-Henrik, additional

Published
2021
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33. Kandin tietolaatikko : neurologia erikoisalana

Author

Lindsberg, Perttu J., Tienari, Pentti, HUS Neurokeskus, Neurotieteiden osasto, Clinicum, and Neurologian yksikkö

Subjects
3112 Neurotieteet, 3124 Neurologia ja psykiatria
Abstract

Teema : neuroimmunologia.

Published
2021

34. Nya vindar inom akutbehandling av hjärninfarkt i Finland

Author

Curtze, Sami, Lindsberg, Perttu J., Clinicum, HUS Neurocentrum, Neurologian yksikkö, and Avdelningen för neurovetenskaper

Subjects
3121 Allmänmedicin, inre medicin och annan klinisk medicin
Abstract

English summary.

Published
2021

35. The Low-Expression Variant of FABP4 Is Associated With Cardiovascular Disease in Type 1 Diabetes

Author

Dahlström, Emma H., Saksi, Jani, Forsblom, Carol, Uglebjerg, Nicoline, Mars, Nina, Thorn, Lena M., Harjutsalo, Valma, Rossing, Peter, Ahluwalia, Tarunveer S., Lindsberg, Perttu J., Sandholm, Niina, Groop, Per Henrik, Dahlström, Emma H., Saksi, Jani, Forsblom, Carol, Uglebjerg, Nicoline, Mars, Nina, Thorn, Lena M., Harjutsalo, Valma, Rossing, Peter, Ahluwalia, Tarunveer S., Lindsberg, Perttu J., Sandholm, Niina, and Groop, Per Henrik

Abstract

Fatty acid binding protein 4 (FABP4) is implicated in the pathogenesis of cardiometabolic disorders. Pharmacological inhibition or genetic deletion of FABP4 improves cardiometabolic health and protects against atherosclerosis in preclinical models. As cardiovascular disease (CVD) is common in type 1 diabetes, we examined the role of FABP4 in the development of complications in type 1 diabetes, focusing on a functional, low-expression variant (rs77878271) in the promoter of the FABP4 gene. For this, we assessed the risk of CVD, stroke, coronary artery disease (CAD), end-stage kidney disease, and mortality using Cox proportional hazards models for the FABP4 rs77878271 in 5,077 Finnish individuals with type 1 diabetes. The low-expression G allele of rs77878271 increased the risk of CVD, independent of confounders. Findings were tested for replication in 852 Danish and 3,678 Finnish individuals with type 1 diabetes. In the meta-analysis, each G allele increased the risk of stroke by 26% (P = 0.04), CAD by 26% (P = 0.006), and CVD by 17% (P = 0.003). In Mendelian randomization, a 1-SD unit decrease in FABP4 increased risk of CAD 2.4-fold. Hence, in contrast with the general population, among patients with type 1 diabetes the low-expression G allele of rs77878271 increased CVD risk, suggesting that genetically low FABP4 levels may be detrimental in the context of type 1 diabetes.

Published
2021

40. Reply

Author

Strbian, Daniel, Sairanen, Tiina, Kaste, Markku, and Lindsberg, Perttu J.

Published
2014
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43. Ocular signs of carotid stenosis in ipsi‐ and contralateral eyes before and after carotid endarterectomy: a prospective study.

Author

Ala‐Kauhaluoma, Marianne, Nuotio, Krista, Ijäs, Petra, Koskinen, Suvi Maaria, Vikatmaa, Pirkka, Silvennoinen, Heli, Relander, Kristiina, Lindsberg, Perttu J., Soinne, Lauri, and Summanen, Paula A.

Subjects
CAROTID artery stenosis, CAROTID endarterectomy, TRANSIENT ischemic attack, MACULAR edema, INTRAOCULAR pressure, VISION disorders
Abstract

Purpose: We describe hypoperfusion‐related and embolic ocular signs of carotid stenosis (CS) before and six months after carotid endarterectomy (CEA) in a CS population. Methods: We enrolled prospectively 70 CEA patients (81% male, mean age 69) and 41 non‐medicated control subjects (76%, 68), from March 2015 to December 2018, assessing intraocular pressure (IOP), best‐corrected visual acuity (BCVA) in logMAR units and performing a bio‐microscopy examination. Results: Main index symptoms included amaurosis fugax (Afx) (29, 41%) and hemispheric TIA (17, 24%), and 17 (24%) were asymptomatic. Of the 70, 17 patients (24%, 95% CI 16‐36) showed ocular signs of CS. Of four embolic (Hollenhorst plaques) findings, one small macular plaque disappeared postoperatively. Four had hypoperfusion, that is ocular ischaemic syndrome (OIS), requiring panretinal photocoagulation: one for multiple mid‐peripheral haemorrhages, two for iris neovascularization and one for neovascular glaucoma (NVG); only the NVG proved irreversible. Nine (de novo in three) showed mild OIS, that is only few mid‐peripheral haemorrhages, ranging pre‐ /postoperatively in ipsilateral eyes from one to eleven (median two)/ one to two (median one), and in contralateral eyes from three to nine (median five)/ one to six (median three). Pre‐ and postoperative median BCVA was 0 or better, and mean IOP was normal, except in the NVG patient. Temporary visual impairment from 0 to 0.3 occurred in one eye soon after CEA due to ocular hyperperfusion causing macular oedema. Conclusions: Ocular signs of CS are common in CEA patients, ranging from few mid‐peripheral haemorrhages to irreversible NVG. Clinicians should be aware of these signs in detecting CS. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Asla Pitkänen : 'Olennaista on ymmärtää aivojen eri solutyypeissä etenevä molekulaarinen poikkeavuus ja löytää vaikutuskohdat, joihin voidaan kehittää interventio.'

Author

Lindsberg, Perttu J., Neurotieteiden osasto, Clinicum, and HUS Neurokeskus

Subjects
+drug therapy, +pathology, +cytology, Epilepsy, Biomedical Research, Neurology, Career Choice, Models, Animal, Brain Injuries, Traumatic, Brain, 3112 Neurotieteet
Abstract

Haastateltavana neurobiologian professori Asla Pitkänen. Kuukauden kollega.

Published
2020

47. Aivoinfarktin liuotushoito ja trombektomia käytännössä

Author

Strbian, Daniel, Isokangas, Juha-Matti, Lindsberg, Perttu J., Neurologian yksikkö, HUS Neurokeskus, Neurotieteiden osasto, and Helsingin yliopisto

Subjects
Brain Infarction, +drug therapy, Time Factors, Perfusion Imaging, 3126 Kirurgia, anestesiologia, tehohoito, radiologia, +methods, Magnetic Resonance Imaging, Cerebral Angiography, +diagnostic imaging, +therapy, Critical Pathways, Thrombolytic Therapy, Tomography, X-Ray Computed, +surgery, 3112 Neurotieteet, Thrombectomy, 3124 Neurologia ja psykiatria
Abstract

Teema : aivoinfarkti. English summary

Published
2020

48. Aivoinfarktin edistyneet hoitomahdollisuudet

Author

Lindsberg, Perttu J., HUS Neurokeskus, Neurotieteiden osasto, Neurologian yksikkö, Clinicum, and Helsingin yliopisto

Subjects
Brain Infarction, +therapy, Cerebral Infarction, 3112 Neurotieteet, 3124 Neurologia ja psykiatria
Abstract

Teema : aivoinfarkti

Published
2020

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