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369 results on '"Lindner, Daniel J"'

1. Role of Kindlin 2 in prostate cancer

Author

Bialkowska, Katarzyna, El Khalki, Lamyae, Rana, Priyanka S., Wang, Wei, Lindner, Daniel J., Parker, Yvonne, Languino, Lucia R., Altieri, Dario C., Pluskota, Elzbieta, Sossey-Alaoui, Khalid, and Plow, Edward F.

Published
2024
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4. Rare germline alterations of myeloperoxidase predispose to myeloid neoplasms

Author

Kongkiatkamon, Sunisa, Terkawi, Laila, Guan, Yihong, Adema, Vera, Hasipek, Metis, Dombrovski, Tatiana, Co, Milo, Walter, Wencke, Awada, Hassan, Parker, Yvonne, Hutter, Stephan, Pagliuca, Simona, Gurnari, Carmelo, Rogers, Heesun J., Meggendorfer, Manja, Lindner, Daniel J., Haferlach, Torsten, Visconte, Valeria, LaFramboise, Thomas, Jha, Babal K., and Maciejewski, Jaroslaw P.

Published
2022
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8. Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy

Author

Biswas, Sudipta, primary, Kang, Kai, additional, Ng, Kwok Peng, additional, Radivoyevitch, Tomas, additional, Schalper, Kurt, additional, Zhang, Hua, additional, Lindner, Daniel J., additional, Thomas, Anish, additional, MacPherson, David, additional, Gastman, Brian, additional, Schrump, David S., additional, Wong, Kwok-Kin, additional, Velcheti, Vamsidhar, additional, and Saunthararajah, Yogen, additional

Published
2023
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10. A novel PSMA-targeting tracer with highly negatively charged linker demonstrates decreased salivary gland uptake in mice compared to [68Ga]Ga-PSMA-11.

Author

Huang, Steve S., DiFilippo, Frank P., Lindner, Daniel J., and Heston, Warren D.

Subjects
SALIVARY glands, INTRAVENOUS injections, RADIATION exposure
Abstract

Background: The current generation of radiolabeled PSMA-targeting therapeutic agents is limited by prominent salivary gland binding, which results in dose-limiting xerostomia from radiation exposure. JB-1498 is a urea-based small molecule with a highly negatively charged linker targeting prostate specific membrane antigen (PSMA). Prior work on a similar tracer with the same negatively charged linker demonstrated low normal organ/soft tissue background uptake compared to [68Ga]Ga-PSMA-11. The purpose of this study was to investigate if [68Ga]Ga-JB-1498 had reduced salivary gland uptake in mice compared to [68Ga]Ga-PSMA-11. Results: JB-1498 demonstrated high affinity for PSMA binding and tumor uptake in a murine tumor model. In an initial biodistribution study with low molar activity, [68Ga]Ga-JB-1498 demonstrated salivary gland uptake of 0.13 ± 0.01%ID/g. In a second biodistribution study in non-tumor-bearing mice with high molar activity, [68Ga]Ga-JB1498 demonstrated salivary gland uptake of 0.39 ± 0.24% ID/g and kidney activity of 10.12 ± 1.73% ID/g at one hour post IV injection. This salivary gland uptake is significantly less than the published uptake of [68Ga]Ga-PSMA-11. Micro-PET visually confirmed the findings of the biodistribution studies. Dynamic micro-PET imaging demonstrated gradually decreasing [68Ga]Ga-JB1498 activity in salivary glands and kidneys, compared to gradually increasing [68Ga]Ga-PSMA-11 activity in these two organs during the first hour. Conclusion: Biodistribution and micro-PET imaging of [68Ga]Ga-JB-1498 demonstrate significantly decreased salivary gland uptake and different pharmacokinetic behavior in kidneys and salivary glands in mice compared to [68Ga]Ga-PSMA-11. Our findings suggest that constructing a PSMA-targeting molecule with a highly negatively charged linker is a promising strategy to reduce salivary gland uptake of GCP-II/PSMA ligands in theranostic applications. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Data from Synergistic Simvastatin and Metformin Combination Chemotherapy for Osseous Metastatic Castration-Resistant Prostate Cancer

Author

Babcook, Melissa A., primary, Shukla, Sanjeev, primary, Fu, Pingfu, primary, Vazquez, Edwin J., primary, Puchowicz, Michelle A., primary, Molter, Joseph P., primary, Oak, Christine Z., primary, MacLennan, Gregory T., primary, Flask, Chris A., primary, Lindner, Daniel J., primary, Parker, Yvonne, primary, Daneshgari, Firouz, primary, and Gupta, Sanjay, primary

Published
2023
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14. Supplementary Figures 1 through 26, Supplementary Tables 1 through 5, and Supplementary Materials and Methods from Synergistic Simvastatin and Metformin Combination Chemotherapy for Osseous Metastatic Castration-Resistant Prostate Cancer

Author

Babcook, Melissa A., primary, Shukla, Sanjeev, primary, Fu, Pingfu, primary, Vazquez, Edwin J., primary, Puchowicz, Michelle A., primary, Molter, Joseph P., primary, Oak, Christine Z., primary, MacLennan, Gregory T., primary, Flask, Chris A., primary, Lindner, Daniel J., primary, Parker, Yvonne, primary, Daneshgari, Firouz, primary, and Gupta, Sanjay, primary

Published
2023
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18. Data from Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma

Author

Vatolin, Sergei, primary, Phillips, James G., primary, Jha, Babal K., primary, Govindgari, Shravya, primary, Hu, Jennifer, primary, Grabowski, Dale, primary, Parker, Yvonne, primary, Lindner, Daniel J., primary, Zhong, Fei, primary, Distelhorst, Clark W., primary, Smith, Mitchell R., primary, Cotta, Claudiu, primary, Xu, Yan, primary, Chilakala, Sujatha, primary, Kuang, Rebecca R., primary, Tall, Samantha, primary, and Reu, Frederic J., primary

Published
2023
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19. Supplementary Data 1 from KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Author

Qiu, Hong, primary, Makarov, Vladimir, primary, Bolzenius, Jennifer K., primary, Halstead, Angela, primary, Parker, Yvonne, primary, Wang, Allen, primary, Iyer, Gopakumar V., primary, Wise, Hannah, primary, Kim, Daniel, primary, Thayaparan, Varna, primary, Lindner, Daniel J., primary, Haber, Georges-Pascal, primary, Ting, Angela H., primary, Ren, Bing, primary, Chan, Timothy A., primary, Arora, Vivek, primary, Solit, David B., primary, and Lee, Byron H., primary

Published
2023
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20. Supplementary Figure Legends from Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma

Author

Vatolin, Sergei, primary, Phillips, James G., primary, Jha, Babal K., primary, Govindgari, Shravya, primary, Hu, Jennifer, primary, Grabowski, Dale, primary, Parker, Yvonne, primary, Lindner, Daniel J., primary, Zhong, Fei, primary, Distelhorst, Clark W., primary, Smith, Mitchell R., primary, Cotta, Claudiu, primary, Xu, Yan, primary, Chilakala, Sujatha, primary, Kuang, Rebecca R., primary, Tall, Samantha, primary, and Reu, Frederic J., primary

Published
2023
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21. Supplementary Table S1 from Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma

Author

Vatolin, Sergei, primary, Phillips, James G., primary, Jha, Babal K., primary, Govindgari, Shravya, primary, Hu, Jennifer, primary, Grabowski, Dale, primary, Parker, Yvonne, primary, Lindner, Daniel J., primary, Zhong, Fei, primary, Distelhorst, Clark W., primary, Smith, Mitchell R., primary, Cotta, Claudiu, primary, Xu, Yan, primary, Chilakala, Sujatha, primary, Kuang, Rebecca R., primary, Tall, Samantha, primary, and Reu, Frederic J., primary

Published
2023
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22. Supplementary Figure 1 from KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Author

Qiu, Hong, primary, Makarov, Vladimir, primary, Bolzenius, Jennifer K., primary, Halstead, Angela, primary, Parker, Yvonne, primary, Wang, Allen, primary, Iyer, Gopakumar V., primary, Wise, Hannah, primary, Kim, Daniel, primary, Thayaparan, Varna, primary, Lindner, Daniel J., primary, Haber, Georges-Pascal, primary, Ting, Angela H., primary, Ren, Bing, primary, Chan, Timothy A., primary, Arora, Vivek, primary, Solit, David B., primary, and Lee, Byron H., primary

Published
2023
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23. Supplementary Data 2 from KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Author

Qiu, Hong, primary, Makarov, Vladimir, primary, Bolzenius, Jennifer K., primary, Halstead, Angela, primary, Parker, Yvonne, primary, Wang, Allen, primary, Iyer, Gopakumar V., primary, Wise, Hannah, primary, Kim, Daniel, primary, Thayaparan, Varna, primary, Lindner, Daniel J., primary, Haber, Georges-Pascal, primary, Ting, Angela H., primary, Ren, Bing, primary, Chan, Timothy A., primary, Arora, Vivek, primary, Solit, David B., primary, and Lee, Byron H., primary

Published
2023
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24. Supplementary Material and Method Details from Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma

Author

Vatolin, Sergei, primary, Phillips, James G., primary, Jha, Babal K., primary, Govindgari, Shravya, primary, Hu, Jennifer, primary, Grabowski, Dale, primary, Parker, Yvonne, primary, Lindner, Daniel J., primary, Zhong, Fei, primary, Distelhorst, Clark W., primary, Smith, Mitchell R., primary, Cotta, Claudiu, primary, Xu, Yan, primary, Chilakala, Sujatha, primary, Kuang, Rebecca R., primary, Tall, Samantha, primary, and Reu, Frederic J., primary

Published
2023
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25. Supplementary Figure 2 from KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Author

Qiu, Hong, primary, Makarov, Vladimir, primary, Bolzenius, Jennifer K., primary, Halstead, Angela, primary, Parker, Yvonne, primary, Wang, Allen, primary, Iyer, Gopakumar V., primary, Wise, Hannah, primary, Kim, Daniel, primary, Thayaparan, Varna, primary, Lindner, Daniel J., primary, Haber, Georges-Pascal, primary, Ting, Angela H., primary, Ren, Bing, primary, Chan, Timothy A., primary, Arora, Vivek, primary, Solit, David B., primary, and Lee, Byron H., primary

Published
2023
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26. Supplementary Figure 4 from KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Author

Qiu, Hong, primary, Makarov, Vladimir, primary, Bolzenius, Jennifer K., primary, Halstead, Angela, primary, Parker, Yvonne, primary, Wang, Allen, primary, Iyer, Gopakumar V., primary, Wise, Hannah, primary, Kim, Daniel, primary, Thayaparan, Varna, primary, Lindner, Daniel J., primary, Haber, Georges-Pascal, primary, Ting, Angela H., primary, Ren, Bing, primary, Chan, Timothy A., primary, Arora, Vivek, primary, Solit, David B., primary, and Lee, Byron H., primary

Published
2023
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27. Supplementary Figure 5 from KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Author

Qiu, Hong, primary, Makarov, Vladimir, primary, Bolzenius, Jennifer K., primary, Halstead, Angela, primary, Parker, Yvonne, primary, Wang, Allen, primary, Iyer, Gopakumar V., primary, Wise, Hannah, primary, Kim, Daniel, primary, Thayaparan, Varna, primary, Lindner, Daniel J., primary, Haber, Georges-Pascal, primary, Ting, Angela H., primary, Ren, Bing, primary, Chan, Timothy A., primary, Arora, Vivek, primary, Solit, David B., primary, and Lee, Byron H., primary

Published
2023
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29. Supplementary Figure 7 from KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Author

Qiu, Hong, primary, Makarov, Vladimir, primary, Bolzenius, Jennifer K., primary, Halstead, Angela, primary, Parker, Yvonne, primary, Wang, Allen, primary, Iyer, Gopakumar V., primary, Wise, Hannah, primary, Kim, Daniel, primary, Thayaparan, Varna, primary, Lindner, Daniel J., primary, Haber, Georges-Pascal, primary, Ting, Angela H., primary, Ren, Bing, primary, Chan, Timothy A., primary, Arora, Vivek, primary, Solit, David B., primary, and Lee, Byron H., primary

Published
2023
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30. Supplementary Figures S2-4 from Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma

Author

Vatolin, Sergei, primary, Phillips, James G., primary, Jha, Babal K., primary, Govindgari, Shravya, primary, Hu, Jennifer, primary, Grabowski, Dale, primary, Parker, Yvonne, primary, Lindner, Daniel J., primary, Zhong, Fei, primary, Distelhorst, Clark W., primary, Smith, Mitchell R., primary, Cotta, Claudiu, primary, Xu, Yan, primary, Chilakala, Sujatha, primary, Kuang, Rebecca R., primary, Tall, Samantha, primary, and Reu, Frederic J., primary

Published
2023
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31. Supplementary Figure S1 from Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma

Author

Vatolin, Sergei, primary, Phillips, James G., primary, Jha, Babal K., primary, Govindgari, Shravya, primary, Hu, Jennifer, primary, Grabowski, Dale, primary, Parker, Yvonne, primary, Lindner, Daniel J., primary, Zhong, Fei, primary, Distelhorst, Clark W., primary, Smith, Mitchell R., primary, Cotta, Claudiu, primary, Xu, Yan, primary, Chilakala, Sujatha, primary, Kuang, Rebecca R., primary, Tall, Samantha, primary, and Reu, Frederic J., primary

Published
2023
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32. Supplementary Figure Legends from KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Author

Qiu, Hong, primary, Makarov, Vladimir, primary, Bolzenius, Jennifer K., primary, Halstead, Angela, primary, Parker, Yvonne, primary, Wang, Allen, primary, Iyer, Gopakumar V., primary, Wise, Hannah, primary, Kim, Daniel, primary, Thayaparan, Varna, primary, Lindner, Daniel J., primary, Haber, Georges-Pascal, primary, Ting, Angela H., primary, Ren, Bing, primary, Chan, Timothy A., primary, Arora, Vivek, primary, Solit, David B., primary, and Lee, Byron H., primary

Published
2023
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33. Supplementary Figure 3 from KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Author

Qiu, Hong, primary, Makarov, Vladimir, primary, Bolzenius, Jennifer K., primary, Halstead, Angela, primary, Parker, Yvonne, primary, Wang, Allen, primary, Iyer, Gopakumar V., primary, Wise, Hannah, primary, Kim, Daniel, primary, Thayaparan, Varna, primary, Lindner, Daniel J., primary, Haber, Georges-Pascal, primary, Ting, Angela H., primary, Ren, Bing, primary, Chan, Timothy A., primary, Arora, Vivek, primary, Solit, David B., primary, and Lee, Byron H., primary

Published
2023
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34. Supplementary Table S1 from KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Author

Qiu, Hong, primary, Makarov, Vladimir, primary, Bolzenius, Jennifer K., primary, Halstead, Angela, primary, Parker, Yvonne, primary, Wang, Allen, primary, Iyer, Gopakumar V., primary, Wise, Hannah, primary, Kim, Daniel, primary, Thayaparan, Varna, primary, Lindner, Daniel J., primary, Haber, Georges-Pascal, primary, Ting, Angela H., primary, Ren, Bing, primary, Chan, Timothy A., primary, Arora, Vivek, primary, Solit, David B., primary, and Lee, Byron H., primary

Published
2023
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35. Supplementary Figure 6 from KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Author

Qiu, Hong, primary, Makarov, Vladimir, primary, Bolzenius, Jennifer K., primary, Halstead, Angela, primary, Parker, Yvonne, primary, Wang, Allen, primary, Iyer, Gopakumar V., primary, Wise, Hannah, primary, Kim, Daniel, primary, Thayaparan, Varna, primary, Lindner, Daniel J., primary, Haber, Georges-Pascal, primary, Ting, Angela H., primary, Ren, Bing, primary, Chan, Timothy A., primary, Arora, Vivek, primary, Solit, David B., primary, and Lee, Byron H., primary

Published
2023
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36. Supplementary Figure 8 from KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Author

Qiu, Hong, primary, Makarov, Vladimir, primary, Bolzenius, Jennifer K., primary, Halstead, Angela, primary, Parker, Yvonne, primary, Wang, Allen, primary, Iyer, Gopakumar V., primary, Wise, Hannah, primary, Kim, Daniel, primary, Thayaparan, Varna, primary, Lindner, Daniel J., primary, Haber, Georges-Pascal, primary, Ting, Angela H., primary, Ren, Bing, primary, Chan, Timothy A., primary, Arora, Vivek, primary, Solit, David B., primary, and Lee, Byron H., primary

Published
2023
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39. KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Author

Qiu, Hong, primary, Makarov, Vladimir, additional, Bolzenius, Jennifer K., additional, Halstead, Angela, additional, Parker, Yvonne, additional, Wang, Allen, additional, Iyer, Gopakumar V., additional, Wise, Hannah, additional, Kim, Daniel, additional, Thayaparan, Varna, additional, Lindner, Daniel J., additional, Haber, Georges-Pascal, additional, Ting, Angela H., additional, Ren, Bing, additional, Chan, Timothy A., additional, Arora, Vivek, additional, Solit, David B., additional, and Lee, Byron H., additional

Published
2023
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40. Heightened Endoplasmic-Reticulum Stress Is a Targetable Vulnerability of Malignant Plasma Cells in Multiple Myeloma

Author

Dima, Danai, primary, Hasipek, Metis, additional, Singh, Divya Jyoti, additional, Jiang, Dongxu, additional, Tiwari, Anand D., additional, Grabowski, Dale, additional, Parker, Yvonne, additional, Lindner, Daniel J., additional, Zhao, Jianjun, additional, Shain, Kenneth H., additional, Khouri, Jack, additional, Maciejewski, Jaroslaw P., additional, and Jha, Babal K., additional

Published
2022
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44. Unrestricted Ketogenic Diet Feeding Enhances Epithelial Ovarian Cancer Growth In Vivo.

Author

AlHilli, Mariam M., Rhoades, Emily E., Chau, Danielle, Tewari, Surabhi, Reich, Adrian, Myers, Alex, Lindner, Daniel J., Lathia, Justin D., Zhang, Renliang, Willard, Belinda, Cresci, Gail, Berger, Nathan A., and Reizes, Ofer

Abstract

The ketogenic diet (KD) is hypothesized to impact tumor progression by altering tumor metabolism. In this study, we assessed the impact of an unrestricted KD on epithelial ovarian cancer (EOC) tumor growth, gene expression, and metabolite concentration in a mouse model. ID8 EOC cells, which were syngeneic with C57Bl/6J mouse strain and transfected with luciferase (ID8-luc), were injectedand monitored for tumor development. Female mice were fed either a strict KD, a high fat/low carbohydrate (HF/LC) diet, or a low fat/high carbohydrate (LF/HC) diet (n = 10 mice per group) ad libitum. EOC tumor growth was monitored weekly, and tumor burden was determined based on luciferase fluorescence (photons/second). At the endpoint (42 days), tumors were collected and processed for RNA sequencing. Plasma and tumor metabolites were evaluated using LC-MS. The KD-fed mice exhibited a statistically significant increase in tumor progression in comparison to the HF/LC- and LF/HC-fed groups (9.1 vs. 2.0 vs. 3.1-fold, respectively, p < 0.001). The EOC tumors of the KD-fed mice exhibited significant enrichment of the peroxisome proliferator-activated receptor (PPAR) signaling and fatty acid metabolism pathways based on the RNA sequencing analysis when compared to the LF/HC- and HF/LC-fed mice. Thus, unrestricted KD diet enhanced tumor progression in our mouse EOC model. KD was associated with the upregulation of fatty acid metabolism and regulation pathways, as well as enrichment of fatty acid and glutamine metabolites. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Therapeutic Targeting of Protein Disulfide Isomerase PDIA1 in Multiple Myeloma

Author

Hasipek, Metis, primary, Grabowski, Dale, additional, Guan, Yihong, additional, Alugubelli, Raghunandan Reddy, additional, Tiwari, Anand D., additional, Gu, Xiaorong, additional, DeAvila, Gabriel A., additional, Silva, Ariosto S., additional, Meads, Mark B., additional, Parker, Yvonne, additional, Lindner, Daniel J., additional, Saunthararajah, Yogen, additional, Shain, Kenneth H., additional, Maciejewski, Jaroslaw P., additional, Reu, Frederic J., additional, Phillips, James G., additional, and Jha, Babal K., additional

Published
2021
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