Search

Your search keyword '"Linden, H."' showing total 939 results
Start Over Author "Linden, H."
939 results on '"Linden, H."'

1. Facile Amide Bond Formation with TCFH-NMI in an Organic Laboratory Course

Author

Oliver W. M. Baldwin, Linden H. Conrad-Marut, Gregory L. Beutner, and David A. Vosburg

Abstract

A new undergraduate organic laboratory experiment has been developed for amide bond formation between biorenewable 2-furoic acid and either of two substituted piperazines to prepare medicinally relevant amide products using a procedure with industrial significance. The reactions proceeded smoothly under ambient conditions using the combination of N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate (TCFH) and N-methylimidazole (NMI) in a minimal volume of acetonitrile with a direct crystallization upon addition of water. Students successfully collected their product by filtration and then characterized it by NMR ([superscript 1]H, [superscript 13]C, COSY, DEPT-135, HSQC), IR, MS, and melting point. Students also explored the reaction mechanism and compared green chemistry aspects of their procedure with literature routes. A virtual version of the experiment was adapted for remote instruction. [This paper was presented at the Spring 2022 American Chemical Society National Meeting and the 2022 National Organic Symposium.]

Published
2022
Full Text
View/download PDF

5. Generalized Elliptic Integrals and the Legendre M-function

Author

Heikkala, V., Lindén, H., Vamanamurthy, M. K., and Vuorinen, M.

Subjects
Mathematics - Classical Analysis and ODEs, Mathematics - Complex Variables, 33B15
Abstract

We study monotonicity and convexity properties of functions arising in the theory of elliptic integrals, and in particular in the case of a Schwarz-Christoffel conformal mapping from a half-plane to a trapezoid. We obtain sharp monotonicity and convexity results for combinations of these functions, as well as functional inequalities and a linearization property., Comment: 28 pages

Published
2007
Full Text
View/download PDF

7. An implementation of the Deutsch-Jozsa algorithm on a three-qubit NMR quantum computer

Author

Freeman, N Linden H Barjat R

Subjects
Quantum Physics
Abstract

A new approach to the implementation of a quantum computer by high-resolution nuclear magnetic resonance (NMR) is described. The key feature is that two or more line-selective radio-frequency pulses are applied simultaneously. A three-qubit quantum computer has been investigated using the 400 MHz NMR spectrum of the three coupled protons in 2,3-dibromopropanoic acid. It has been employed to implement the Deutsch-Jozsa algorithm for distinguishing between constant and balanced functions. The extension to systems containing more coupled spins is straightforward and does not require a more protracted experiment., Comment: 13 pages, 1 figure

Published
1998

10. Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier

Author

Khalil, Ramzi, Boels, Margien G. S., Bezuijen, A., Boers, J. E., de Bruin, P. C., van Dijk, M. A. A. M., Drillenburg, P., Hamel, A. F., Hazelbag, H. M., Jonges, G. N., Kibbelaar, R. E., Lam, K. H., van der Linden, H., van Marsdijk, J., Meijer, C., Nagtegaal, I. D., Oudejans, J. J., Roelofs, J. J. T. H., Rozendaal, L., Sastrowijoto, S. H., Smits, M. M., Stavast, J., van den Berg, Bernard M., Bruijn, Jan A., Rabelink, Ton J., Hogendoorn, Pancras C. W., Baelde, Hans J., Neurology, Pathology, Internal medicine, ACS - Diabetes & metabolism, and ACS - Pulmonary hypertension & thrombosis

Subjects
Hereditary multiple exostosis, General Medicine, Multiple osteochondromas, N-Acetylglucosaminyltransferases, Glycocalyx, Bone neoplasm, urologic and male genital diseases, Glomerular filtration barrier, Proteinuria, Mutation, Genetics, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], Humans, Albuminuria, Heparitin Sulfate, Endothelium, Molecular Biology
Abstract

In this study, the effect of heterozygous germline mutations in the heparan sulfate (HS) glycosaminoglycan chain co-polymerases EXT1 and EXT2 on glomerular barrier function and the endothelial glycocalyx in humans is investigated. Heparan sulfate (HS) glycosaminoglycans are deemed essential to the glomerular filtration barrier, including the glomerular endothelial glycocalyx. Animal studies have shown that loss of HS results in a thinner glycocalyx. Also, decreased glomerular HS expression is observed in various proteinuric renal diseases in humans. A case report of a patient with an EXT1 mutation indicated that this could result in a specific renal phenotype. This patient suffered from multiple osteochondromas, an autosomal dominant disease caused by mono-allelic germline mutations in the EXT1 or EXT2 gene. These studies imply that HS is indeed essential to the glomerular filtration barrier. However, loss of HS did not lead to proteinuria in various animal models. We demonstrate that multiple osteochondroma patients do not have more microalbuminuria or altered glycocalyx properties compared to age-matched controls (n = 19). A search for all Dutch patients registered with both osteochondroma and kidney biopsy (n = 39) showed that an EXT1 or EXT2 mutation does not necessarily lead to specific glomerular morphological phenotypic changes. In conclusion, this study shows that a heterozygous mutation in the HS backbone elongating enzymes EXT1 and EXT2 in humans does not result in (micro)albuminuria, a specific renal phenotype or changes to the endothelial glycocalyx, adding to the growing knowledge on the role of EXT1 and EXT2 genes in pathophysiology.

Published
2022
Full Text
View/download PDF

16. In-situ X-ray diffraction annealing study of electroplated and sputtered Cu-In-Ga precursors for application to sequential Cu(In,Ga)Se-2 processes

Author

Aninat, R., Hovestad, A., Zelst, F.H.M. van, Bruele, F. J. van den, Schermer, J.J., Emmelkamp, J., Vlieg, E., Linden, H., Theelen, M., Aninat, R., Hovestad, A., Zelst, F.H.M. van, Bruele, F. J. van den, Schermer, J.J., Emmelkamp, J., Vlieg, E., Linden, H., and Theelen, M.

Abstract

Contains fulltext : 282600.pdf (Publisher’s version ) (Closed access)

Published
2022

18. Sex differences in perceived expectations of the outcome of total hip and knee arthroplasties and their fulfillment: an observational cohort study.

Author

Latijnhouwers, Daisy A. J. M., Vlieland, Thea P. M. Vliet, Marijnissen, Willem Jan, Damen, Pieter-Jan, Nelissen, Rob G. H. H., Gademan, Maaike G. J., The Longitudinal Leiden Orthopaedics Outcomes of Osteoarthritis Study (LOAS) Group, van der Linden, H. M. J., Kaptein, B. L., Verdegaal, S. H. M., Kaptijn, H. H., Vehmeijer, S. B. W., and Onstenk, R.

Subjects
TOTAL knee replacement, TOTAL hip replacement, EXPECTATION (Psychology), COHORT analysis
Abstract

The influence of sex on preoperative expectations and their fulfillment following total hip and knee arthroplasty (THA/TKA) remains unexplored. We investigated differences between men and women in perceived preoperative expectations on the outcome of THA/TKA and their fulfillment 1 year postoperatively. We performed a cohort study. Expectations were collected preoperatively and 1 year postoperatively using the Hospital for Special Surgery Hip/Knee Replacement Expectations Surveys (HSS-HRES/KRES; not applicable = 0, applicable: back to normal = 1, much = 2/moderate = 3/slight improvement = 4). Fulfillment of expectations was calculated by subtracting preoperative from postoperative scores (score < 0:unfulfilled; score ≥ 0:fulfilled). We included patients with "applicable" expectations. Chi-square and ordinal regression were used to compare expectations and fulfillment regarding sex. 2333 THA (62% women) and 2398 TKA (65% women) patients were included. 77% of THA and 76% of TKA patients completed the HSS-HRES/HSS-KRES both preoperatively and 1 year postoperatively. Men more often perceived items as "applicable", with differences in 9/20 (HSS-HRES) and 9/19 (HSS-KRES) preoperative items and, respectively, 12/20 (HSS-HRES) and 10/19 (HSS-KRES) postoperative items. The largest differences (> 10%) were found in sexual activity and working ability. 16/20 (HSS-HRES) and 14/19 (HSS-KRES) items showed an increased probability of having higher preoperative expectations of ≥ 10%, in favor of men. In all items, 60% of the respondents indicated that their expectation was fulfilled. Differences were observed in 16/20 (HSS-HRES) and 6/19 (HSS-KRES) items in favor of men. Sex differences were present in expectations and fulfillment, with higher applicability of items, preoperative expectations and fulfillment in men, especially on items related to functional activities. Trial registration: Trial-ID NTR3348. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

20. 206TiP Randomized, multicenter, international phase III ARTEST study to evaluate enobosarm versus active control for the treatment of AR+ ER+ HER2- metastatic breast cancer in patients who previously received an estrogen-blocking agent and a CDK 4/6 inhibitor

Author

Brufsky, A., primary, Linden, H., additional, Rugo, H.S., additional, Vogel, C., additional, O'Shaughnessy, J., additional, Getzenberg, R.H., additional, Barnette, K.G., additional, Rodriguez, D., additional, Steiner, M.S., additional, and Mayer, E., additional

Published
2022
Full Text
View/download PDF

25. Diagnosis of early stage knee osteoarthritis based on early clinical course: data from the CHECK cohort

Author

Wang, Qiuke, Runhaar, Jos, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W. J., Bierma-Zeinstra, Sita M. A., Aerts-Lankhorst, N. E., Agricola, R., Bastick, A. N., van Bentveld, R. D. W., van den Berg, P. J., Bijsterbosch, J., de Boer, A., Boers, M., Bohnen, A. M., Boonen, A. E. R. C. H., Bos, P. K., Boymans, T. A. E. J., Breedveldt-Boer, H. P., Brouwer, R. W., Colaris, J. W., Damen, J., Elshout, G., Emans, P. J., Enthoven, W. T. M., Frölke, E. J. M., Glijsteen, R., van der Heide, H. J. C., Huisman, A. M., van Ingen, R. D., Jacobs, M. L., Janssen, R. P. A., Kevenaar, P. M., van Koningsbrugge, M. A., Krastman, P., Kuchuk, N. O., Landsmeer, M. L. A., Lems, W. F., van der Linden, H. M. J., van Linschoten, R., Mahler, E. A. M., van Meer, B. L., Meuffels, D. E., der Laan, W. H. Noort-van, van Ochten, J. M., van Oldenrijk, J., Pols, G. H. J., Piscaer, T. M., Vis, M., de Vries, A., Orthopaedic Biomechanics, Epidemiology and Data Science, AII - Inflammatory diseases, APH - Methodology, Rheumatology, AMS - Musculoskeletal Health, AMS - Tissue Function & Regeneration, Cardiology, ACS - Atherosclerosis & ischemic syndromes, ACS - Pulmonary hypertension & thrombosis, APH - Aging & Later Life, General Practice, and Orthopedics and Sports Medicine

Subjects
medicine.medical_specialty, Diseases of the musculoskeletal system, Osteoarthritis, Early clinical course, Cohort Studies, Internal medicine, medicine, Humans, Stage (cooking), Generalized estimating equation, CHECK cohort, Receiver operating characteristic, business.industry, Osteoarthritis, Knee, medicine.disease, Knee/diagnostic imaging, Rheumatology, Confidence interval, Osteoarthritis, Knee/diagnostic imaging, Early Diagnosis, RC925-935, ROC Curve, Cohort, Orthopedic surgery, Disease Progression, Knee osteoarthritis, business, Research Article
Abstract

Background Early diagnosis of knee osteoarthritis (OA) is important in managing this disease, but such an early diagnostic tool is still lacking in clinical practice. The purpose of this study was to develop diagnostic models for early stage knee OA based on the first 2-year clinical course after the patient’s initial presentation in primary care and to identify whether these course factors had additive discriminative value over baseline factors. Methods We extracted eligible patients’ clinical and radiographic data from the CHECK cohort and formed the first 2-year course factors according to the factors’ changes over the 2 years. Clinical expert consensus-based diagnosis, which was made via evaluating patients’ 5- to 10-year follow-up data, was used as the outcome factor. Four models were developed: model 1, included clinical course factors only; model 2, included clinical and radiographic course factors; model 3, clinical baseline factors + clinical course factors; and model 4, clinical and radiographic baseline factors + clinical and radiographic course factors. All the models were built by a generalized estimating equation with a backward selection method. Area under the receiver operating characteristic curve (AUC) and its 95% confidence interval (CI) were calculated for assessing model discrimination. Delong’s method compared AUCs. Results Seven hundred sixty-one patients with 1185 symptomatic knees were included in this study. Thirty-seven percent knees were diagnosed as OA at follow-up. Model 1 contained 6 clinical course factors; model 2: 6 clinical and 3 radiographic course factors; model 3: 6 baseline clinical factors combined with 5 clinical course factors; and model 4: 4 clinical and 1 radiographic baseline factors combined with 5 clinical and 3 radiographic course factors. Model discriminations are as follows: model 1, AUC 0.70 (95% CI 0.67–0.74); model 2, 0.74 (95% CI 0.71–0.77); model 3, 0.77 (95% CI 0.74–0.80); and model 4, 0.80 (95% CI 0.77–0.82). AUCs of model 3 and model 4 were slightly but significantly higher than corresponding baseline-factor models (model 3 0.77 vs 0.75, p = 0.031; model 4 0.80 vs 0.76, p = 0.003). Conclusions Four diagnostic models were developed with “fair” to “good” discriminations. First 2-year course factors had additive discriminative value over baseline factors.

Published
2021
Full Text
View/download PDF

26. Synthesis and structure determination of racemic (Δ/Λ)-tris-(ethyl-enedi-amine)-cobalt(III) trichloride hemi(hexa-aqua-sodium chloride)

Author

Eric W. Reinheimer, Linden H. Conrad-Marut, and Adam R. Johnson

Subjects
crystal structure, Hydrogen bond, Chemistry, Ligand, Sodium, ethyl­ene di­amine, chemistry.chemical_element, General Chemistry, Crystal structure, Condensed Matter Physics, HEXA, enanti­omer, Chloride, Research Communications, Crystallography, medicine, General Materials Science, racemate, Enantiomer, Cobalt, medicine.drug
Abstract

In the racemic title compound, the [Co(en)3]3+ and [Na(H2O)6]+cations exist in distorted octa­hedral coordination environments and charge neutrality in the salt is furnished by Cl− anions. Structural cohesion is maintained by an array of C—H⋯O, N—H⋯Cl and O—H⋯Cl hydrogen bonds., The synthesis and crystal structure of the title racemic compound, [Co(C2H8N2)3]Cl3.{[Na(H2O)6]Cl}0.5, are reported. The trivalent cobalt atom, which resides on a crystallographic threefold axis, is chelated by a single ethyl­ene di­amine (en) ligand and yields the tris-chelate [Co(en)3]3+ cation with distorted octa­hedral geometry after the application of crystal symmetry. The sodium cation (site symmetry ), has a single water mol­ecule bound to it in the asymmetric unit and yields a distorted, octa­hedrally coordinated hydrated [Na(H2O)6]+ cation after the application of symmetry. One of the chloride ions lies on a general position and the other has site symmetry. An extensive array of C—H⋯O, N—H⋯Cl and O—H⋯Cl hydrogen bonds exists between the ethyl­ene di­amine ligands, the water mol­ecules of hydration, and the anions present, thereby furnishing solid-state stability.

Published
2021

39. Liquid injection field desorption/ionization as a powerful tool to characterize volatile, labile, and reactive metal–organic complexes

Author

Linden, H. Bernhard, Boysen, Nils, and Devi, Anjana

Abstract

Electron ionization mass spectrometry (EI-MS) is often used to characterize volatile and thermally stable organometallic complexes relevant for chemical vapor deposition (CVD) processes. However, this method has limitations for thermally unstable and labile organometallic complexes. In this context, EI-MS is not the preferred method of choice for characterizing such compounds. With three different representative organometallic complexes based on the transition metals yttrium, iridium, and silver, relevant as precursors for CVD of different materials, the significance of liquid injection field desorption/ionization mass spectrometry (LIFDI-MS) as an important precursor characterization tool is exemplified. The precursors are not only reactive toward ambient air, but also thermally labile especially in the case of iridium and silver complexes. As a promising alternative, LIFDI-MS is used to overcome the limitations of EI-MS. For the first time, these complexes were successfully analyzed using LIFDI-MS. The comparison between EI-MS and LIFDI-MS highlights that LIFDI-MS is superior for the mass spectrometric analysis of sensitive and labile complexes. In terms of precursor characterization, LIFDI-MS can be fully exploited to gain valuable insights into the decomposition mechanisms and identifying the nuclearity of organometallic precursors used for CVD applications.

Published
2023
Full Text
View/download PDF

40. Synthesis, characterization, and liquid injection field desorption ionization mass spectrometry analysis of pincer ligated group 6 (Cr, Mo, W) carbonyl complexes

Author

Linden, H. Bernhard, Duletski, Olivia L., Arulsamy, Navamoney, and Mock, Michael T.

Abstract

We report the synthesis of molybdenum and tungsten bromo dicarbonyl complexes (POCOPtBu)MIIBr(CO)2(M  =  Mo or W; POCOPtBu=  κ3-C6H3-1,3-[OP(tBu)2]2) supported by an anionic PCP pincer ligand, and the chromium complex (PNPtBu)Cr0(CO)3(PNPtBu=  2,6-bis(di-tert-butyl-phosphinomethyl)pyridine) bearing a neutral PNP pincer scaffold. The three group six complexes described in this study have been characterized by Liquid Injection Field Desorption Ionization Mass Spectrometry (LIFDI-MS), NMR, and IR spectroscopy. Single crystal X-ray diffraction studies show the MoIIand WIIcomplexes adopt a six-coordinate distorted trigonal prismatic geometry, whereas the Cr0complex exhibits a distorted octahedral geometry.

Published
2023
Full Text
View/download PDF

41. Identification and characterization of selected silyl substituted silyl anions by liquid injection field desorption ionization mass spectrometry

Author

Linden, H. Bernhard, Lainer, Thomas, Fischer, Roland C, and Haas, Michael

Abstract

Silyl anions are crucial building blocks in silicon chemistry and are frequently used in organosilicon chemistry. These so-called silanides are negatively charged three-coordinate species, isoelectronic to carbanions. In this contribution, we synthesized already literature known and unknown anionic silicon species. Here we focused on silyl substituted silyl anions with different substituted silicon atoms like hydrogen, methyl, and methoxy groups. Furthermore, we investigated these species with liquid injection field desorption ionization mass spectrometry.

Published
2023
Full Text
View/download PDF

42. Group 6 germylidyne complexes in the gas phase by LIFDI and APCI mass spectrometry

Author

Linden, H. Bernhard, Maurer, Leonard R., and Engeser, Marianne

Abstract

Although showing fascinating chemical properties and reactivity in solution, heavier tetrelylidyne complexes with M≡E triple bonds have not been studied in the gas phase before due to their high sensitivity towards air and moisture. We selected four group 6 germylidyne complexes, [Cp(PMe3)2M≡GeArMes] (M = Mo (1-Mo), W (1-W), ArMes= 2,6-dimesitylphenyl) and [Tp’(CO)2M≡GeArMes] (M = Mo (2-Mo), W (2-W), Tp’ = κ3-N,N’,N’’-hydridotris(3,5-dimethylpyrazolyl) borate), for a mass-spectrometric study. Liquid Injection Field Desorption Ionization (LIFDI) proved to be a well-suited technique to ionize these sensitive compounds as the spectra show the molecular ions as radical cations and only minor traces of fragmentation or degradation products. In addition, Atmospheric Pressure Chemical Ionization (APCI) connected to a high-resolving tandem mass spectrometer allowed us to study the gas-phase fragmentation behaviour of these compounds. The fragmentation patterns not only comprise the expected losses of phosphane or carbonyl ligands, respectively, but also indicate C–H bond activation by the electron-deficient metal centre. An enhanced reactivity of the tungsten species is visible in a preferred methyl abstraction in the phosphane complex 1-Wcompared to 1-Mo. Although degradation in solution before ionization obviously can destroy the M≡Ge triple bond, the cleavage of the M≡Ge bond upon gas-phase activation is not observed for the Mo species and only as a minor pathway for the W compounds, highlighting the high bonding energy between metal and tetrel.

Published
2023
Full Text
View/download PDF

43. 100P Efficacy of enobosarm, a selective androgen receptor (AR) targeting agent, in patients with metastatic AR+/ER+ breast cancer resistant to estrogen receptor targeted agents and CDK 4/6 inhibitor in a phase II clinical study

Author

Palmieri, C., primary, Linden, H., additional, Birrell, S., additional, Lim, E., additional, Schwartzberg, L.S., additional, Rugo, H.S., additional, Cobb, P., additional, Jain, K., additional, Vogel, C., additional, O'Shaughnessy, J., additional, Johnston, S.R.D., additional, Getzenberg, R.H., additional, Barnette, K.G., additional, Steiner, M., additional, Brufsky, A.M., additional, and Overmoyer, B., additional

Published
2021
Full Text
View/download PDF

44. Recovery and the use of postoperative physical therapy after total hip or knee replacement.

Author

Groot, L., Latijnhouwers, D. A. J. M., Reijman, M., Verdegaal, S. H. M., Vliet Vlieland, T. P. M., Gademan, M. G. J., on behalf of the Longitudinal Leiden Orthopaedics Outcomes of Osteoarthritis Study (LOAS) Group, Nelissen, R. G. H. H., van der Linden, H. M. J., Kaptein, B. L., Damen, P. J., Kaptijn, H. H., Vehmeijer, S. B. W., Marijnissen, W. J. C. M., Onstenk, R., and Longitudinal Leiden Orthopaedics Outcomes of Osteoarthritis Study (LOAS) Group

Subjects
RESEARCH, TOTAL knee replacement, TOTAL hip replacement, CONVALESCENCE, PHYSICAL therapy, RESEARCH methodology, EVALUATION research, TREATMENT effectiveness, COMPARATIVE studies, IMPACT of Event Scale, REHABILITATION
Abstract

Background: Total hip or knee arthroplasties (THA/TKA) show favorable long-term effects, yet the recovery process may take weeks to months. Physical therapy (PT) following discharge from hospital is an effective intervention to enhance this recovery process. To investigate the relation between recovery and postoperative PT usage, including the presence of comorbidities, 6 months after THA/TKA.Methods: Multicenter, observational study in primary THA/TKA patients who completed preoperative and 6 months postoperative assessments. The assessments included questions on PT use (yes/no and duration; long term use defined as ≥ 12 weeks), comorbidities (musculoskeletal, non-musculoskeletal, sensory comorbidities and frequency of comorbidities). Recovery was assessed with the HOOS/KOOS on all 5 subdomains. Logistic regression with long term PT as outcome was performed adjusted for confounding including an interaction term (comorbidity*HOOS/KOOS-subdomain).Results: In total, 1289 THA and 1333 TKA patients were included, of whom 95% received postoperative PT, 56% and 67% received postoperative PT ≥ 12 weeks respectively. In both THA and TKA group, less improvement on all HOOS/KOOS domain scores was associated with ≥ 12 weeks of postoperative PT (range Odds Ratios 0.97-0.99). In the THA group the impact of recovery was smaller in patient with comorbidities as non- musculoskeletal comorbidities modified all associations between recovery and postoperative PT duration (Odds Ratios range 1.01-1.05). Musculoskeletal comorbidities modified the associations between Function-in-Daily-Living-and Sport-and-recreation recovery and postoperative PT. Sensory comorbidities only had an effect on Sport-and-recreation recovery and postoperative PT. Also the frequency of comorbidities modified the relation between Function-in-Daily-Living, pain and symptoms recovery and postoperative PT. In the TKA group comorbidity did not modify the associations.Conclusion: Worse recovery was associated with longer duration of postoperative PT suggesting that PT provision is in line with patients' needs. The impact of physical recovery on the use of long-term postoperative PT was smaller in THA patients with comorbidities.Trial Registration: Registered in the Dutch Trial Registry on March 13, 2012. TRIAL ID NTR3348; registration number: P12.047. https://www.trialregister.nl/trial/3197 . [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

50. Acute pain after total hip and knee arthroplasty does not affect chronic pain during the first postoperative year: observational cohort study of 389 patients.

Author

Latijnhouwers, D. A. J. M., Martini, C. H., Nelissen, R. G. H. H., Verdegaal, S. H. M., Vliet Vlieland, T. P. M., Gademan, M. G. J., the Longitudinal Leiden Orthopaedics Outcomes of Osteoarthritis Study (LOAS) Group, van der Linden, H. M. J., Kaptein, B. L., Damen, P. J., Kaptijn, H. H., Vehmeijer, S. B. W., Marijnissen, W. C. M., and Onstenk, R.

Subjects
TOTAL hip replacement, TOTAL knee replacement, CHRONIC pain, POSTOPERATIVE pain, COHORT analysis
Abstract

Chronic pain is frequently reported after total hip and knee arthroplasties (THA/TKA) in osteoarthritis (OA) patients. We investigated if severity of acute postoperative pain following THA/TKA in OA patients was associated with pain during the first postoperative year. From an observational study, OA patients scheduled for primary THA/TKA (June 2012–December 2017) were included from two hospitals in the Netherlands. Acute postoperative pain scores were collected within 72 h postoperatively and categorized as no/mild (NRS ≤ 4) or moderate/severe (NRS > 4). Pain was assessed preoperatively, 3, 6 and 12 months postoperatively using the HOOS/KOOS subscale pain. With Multilevel Mixed-effects-analyses, we estimated associations between acute and chronic pain until one year postoperative, adjusted for confounders and including an interaction term (Time*Acute pain). 193 THA and 196 TKA patients were included, 29% of THA and 51% of TKA patients reported moderate/severe pain acutely after surgery. In the THA group, the difference in pain at 3 months between the no/mild and moderate/severe groups, was approximately six points, in favor of the no/mild group (95% CI [−12.4 to 0.9]) this difference became smaller over time. In the TKA group we found similar differences, with approximately four points (95% CI [−9.6 to 1.3]) difference between the no/mild and moderate/severe group at 6 months, this difference attenuated at 12 months. No association between severity of acute postoperative pain and pain during the first postoperative year was found. These findings suggest that measures to limit acute postoperative pain will likely not impact development of chronic pain. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results