9 results on '"Lindahl KH"'
Search Results
2. Elastosis perforans serpiginosa related to vascular Ehlers-Danlos syndrome.
- Author
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Uldall Pallesen KA, Lindahl KH, and Bygum A
- Subjects
- Adult, Female, Humans, Skin Diseases complications, Skin Diseases pathology, Ehlers-Danlos Syndrome complications, Skin Diseases diagnosis
- Abstract
Elastosis perforans serpiginosa (EPS) is a rare skin disease with elimination of connective tissue fibers from dermis to epidermis. The typical presentation shows hyperkeratotic red or skin-colored papules arranged in a circinate pattern. We present a 26-year-old woman with EPS known to have vascular Ehlers-Danlos syndrome.
- Published
- 2019
3. Evaluation of the proliferation marker Ki-67 in gliomas: Interobserver variability and digital quantification.
- Author
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Nielsen LAG, Bangsø JA, Lindahl KH, Dahlrot RH, Hjelmborg JVB, Hansen S, and Kristensen BW
- Subjects
- Biomarkers, Tumor analysis, Biomarkers, Tumor standards, Cell Proliferation, Humans, Image Processing, Computer-Assisted, Neoplasm Grading standards, Observer Variation, Pathology, Clinical methods, Pathology, Clinical standards, Brain Neoplasms pathology, Glioma pathology, Ki-67 Antigen analysis, Mitotic Index standards, Neoplasm Grading methods
- Abstract
Background: The Ki-67 Labelling Index (LI) is used as an ancillary tool in glioma diagnostics. Interobserver variability has been reported and no precise guidelines are available. Nor is it known whether novel digital approaches would be an advantage. Our aim was to evaluate the inter- and intraobserver variability of the Ki-67 LI between two pathologists and between pathologists and digital quantification both in whole tumour slides and in hot spots using narrow but diagnostically relevant intervals., Methods: In samples of 235 low and high grade gliomas, two pathologists (A and B) estimated the Ki-67 LI (5-10% intervals) for whole tumour slides and for hot spots. In 20 of the cases intraobserver variability was evaluated. For digital quantification (C) slides were scanned with subsequent systematic random sampling of viable tumour areas. A software classifier trained to identify positive and negative nuclei calculated the Ki-67 LI. The interobserver agreements were evaluated using kappa (κ) statistics., Results: The observed proportions of agreement and κ values for Ki-67 LI for whole tumour slides were: A/B: 46% (κ = 0.32); A/C: 37% (κ = 0.26); B/C: 37% (κ = 0.26). For hot spots equivalent values were: A/B: 14% (κ = 0.04); A/C: 18% (κ = 0.09); B/C: 31% (κ = 0.21)., Conclusions: Interobserver variability was pronounced between pathologists and for pathologists versus digital quantification when attempting to estimate a precise value of the Ki-67 LI. Ki-67 LI should therefore be used with caution and should not be over interpreted in the grading of gliomas. Digital quantification of Ki-67 LI in gliomas was feasible, but intra- and interlaboratory robustness need to be determined.
- Published
- 2018
- Full Text
- View/download PDF
4. [Sweet syndrome manifestations].
- Author
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Zeraiq L, Lindahl KH, and Bygum A
- Subjects
- Diagnosis, Differential, Humans, Sweet Syndrome classification, Sweet Syndrome diagnosis, Sweet Syndrome drug therapy, Sweet Syndrome pathology
- Abstract
Sweet syndrome (SS) exists as classical, malignancy-associated, drug-induced and as the new variants: giant cellulitis-like SS and neutrophilic dermatosis of the hands. SS exhibits different morphologies. Skin manifestations are usually accompanied by fever and neutrocytosis. All variants respond to systemic corticosteroids, but SS can recur. SS may be the first sign of malignancy or recurrence of previous cancer. It is important to be aware of the disease, which may mimic other reactive and febrile diseases, to enable patients to obtain the correct diagnostic set-up and treatment.
- Published
- 2018
5. Atypical Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6 in Denmark: A Diagnostic Mimicker.
- Author
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Horsten HH, Kemp M, Fischer TK, Lindahl KH, and Bygum A
- Subjects
- Adult, Aged, Child, Child, Preschool, Denmark epidemiology, Diagnosis, Differential, Enterovirus A, Human pathogenicity, Female, Hand, Foot and Mouth Disease epidemiology, Hand, Foot and Mouth Disease transmission, Hospitals, University, Host-Pathogen Interactions, Humans, Infant, Male, Middle Aged, Phenotype, Predictive Value of Tests, Skin pathology, Young Adult, Enterovirus A, Human isolation & purification, Hand, Foot and Mouth Disease diagnosis, Hand, Foot and Mouth Disease virology, Skin virology
- Abstract
Since 2008, outbreaks of atypical hand, foot, and mouth disease (HFMD) in children and adults have been reported worldwide. The majority of these outbreaks are caused by a new lineage of Coxsackie virus A6 (CV-A6) presenting a more severe clinical phenotype than the classical childhood HFMD caused by CV-A16. Between June 2014 and January 2016, 23 cases of atypical HFMD disease presented at a Dermatology Department at a regional University Hospital in Denmark. Patients were referred by general practitioners and dermatologists with a variety of clinical diagnoses, including eczema herpeticum, vasculitis, syphilis, dermatophytid, erythema multiforme and Stevens-Johnson syndrome. Three adults and 3 children required hospitalization due to extensive skin involvement and fever. All reported patients had laboratory-confirmed enterovirus infection. This study demonstrated an upsurge in atypical HFMD caused by CV-A6 in the Region of Southern Denmark and that atypical HFMD can be difficult to diagnose clinically as it may mimic other severe skin diseases.
- Published
- 2018
- Full Text
- View/download PDF
6. Two patients with localised hyperhidrosis of the hand based on functional and structural abnormalities of sweat glands.
- Author
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Kristiansen BH, Lindahl KH, Pallesen KAU, and Bygum A
- Subjects
- Adolescent, Adult, Female, Humans, Hyperhidrosis diagnosis, Hyperhidrosis psychology, Patient Satisfaction, Sweat Glands pathology, Treatment Outcome, Activities of Daily Living psychology, Botulinum Toxins, Type A therapeutic use, Hand pathology, Hyperhidrosis drug therapy, Neuromuscular Agents therapeutic use, Sweat Glands abnormalities
- Abstract
A 14-year-old girl and a 30-year-old woman presented with localised hyperhidrosis on the dorsal hand and wrist, respectively, provoked by different stimuli such as physical activity and minor trauma to the skin. The skin was seemingly normal in both patients where an iodine-starch test revealed a well-demarcated area of hyperhidrosis. Following histopathological examination, the diagnosis was unilateral localised hyperhidrosis in both cases; one with normal histology and one with a nevus sudoriferous. Both patients were successfully treated with botulinum toxin type A. The 30-year-old woman additionally used low-dose propantheline bromide periodically and experienced long-term remission on this therapy. Hyperhidrosis may embarrass and interfere with patients' school and careers, and it is therefore important to tailor an effective individual treatment., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
- Published
- 2018
- Full Text
- View/download PDF
7. Henoch-Schönlein Purpura: A Literature Review.
- Author
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Hetland LE, Susrud KS, Lindahl KH, and Bygum A
- Subjects
- Adrenal Cortex Hormones adverse effects, Humans, IgA Vasculitis diagnosis, IgA Vasculitis immunology, Immunosuppressive Agents adverse effects, Risk Factors, Time Factors, Treatment Outcome, Adrenal Cortex Hormones therapeutic use, IgA Vasculitis drug therapy, Immunosuppressive Agents therapeutic use
- Abstract
Henoch-Schönlein purpura is the most common childhood vasculitis, but may also affect adults. This article reviews the literature since 2011 on advances in diagnosis, clinical disease manifestations, pathophysiology and treatment of Henoch-Schönlein purpura. The clinical manifestations are thought to arise from IgA depositions in blood vessel walls in the affected organs, mostly skin, gastrointestinal tract, joints and kidneys. Corticosteroids may be effective in rapid resolution of renal manifestations and treating joint and abdominal pain, but they are not proven effective for treating organ manifestations and complications, such as glomerulonephritis, bowel infarction or intussusception. Mycophenolate mofetil or cyclosporine A may be better treatment choices in case of renal involvement. Other immunosuppressive and immunomodulating drugs, such as rituximab and dapsone, are promising, but larger studies are needed to confirm these findings. Cancer screening should be considered in older males diagnosed with Henoch-Schönlein purpura.
- Published
- 2017
- Full Text
- View/download PDF
8. Two cases of erythema induratum of Bazin--a rare cutaneous manifestation of tuberculosis.
- Author
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von Huth S, Øvrehus AL, Lindahl KH, and Johansen IS
- Subjects
- Aged, Erythema Induratum pathology, Female, Humans, Male, Middle Aged, Erythema Induratum diagnosis
- Abstract
Tuberculosis remains a global disease burden, counting more than 9 million new cases per year. Tuberculosis is caused by infection with Mycobacterium tuberculosis-complex. Though most commonly affecting the lungs, any organ can become a site of tuberculous infection. Cutaneous tuberculosis is rare, representing 1-2% of all cases of tuberculosis. There are numerous different cutaneous manifestations of tuberculosis. We describe two cases of erythema induratum of Bazin, a so-called tuberculid manifestation of cutaneous TB. Both cases are patients from endemic areas. In the cases presented, there were no signs of other organs affected, and cutaneous lesions disappeared during anti-tuberculous treatment., (Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
9. Can EGFR mutation status be reliably determined in pre-operative needle biopsies from adenocarcinomas of the lung?
- Author
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Lindahl KH, Sørensen FB, Jonstrup SP, Olsen KE, and Loeschke S
- Subjects
- Adenocarcinoma drug therapy, Adenocarcinoma surgery, Adenocarcinoma of Lung, Adult, Aged, Aged, 80 and over, Antineoplastic Agents therapeutic use, Base Sequence, Biopsy, Needle methods, Carcinoma, Non-Small-Cell Lung drug therapy, Carcinoma, Non-Small-Cell Lung surgery, DNA Mutational Analysis, ErbB Receptors antagonists & inhibitors, Erlotinib Hydrochloride, Female, Gefitinib, Humans, Lung Neoplasms drug therapy, Lung Neoplasms surgery, Male, Middle Aged, Mutation, Preoperative Care, Protein Kinase Inhibitors therapeutic use, Quinazolines therapeutic use, Retrospective Studies, Sequence Analysis, DNA, Adenocarcinoma genetics, Carcinoma, Non-Small-Cell Lung genetics, ErbB Receptors genetics, Lung Neoplasms genetics
- Abstract
The identification of EGFR mutations in non-small-cell lung cancer is important for selecting patients, who may benefit from treatment with EGFR tyrosine kinase inhibitors. The analysis is usually performed on cytological aspirates and/or histological needle biopsies, representing a small fraction of the tumour volume. The aim of the present investigation was to evaluate the diagnostic performance of this molecular test. We retrospectively included 201 patients with primary adenocarcinoma of the lung. EGFR mutation status (exon 19 deletions and exon 21 L858R point mutation) was evaluated on both pre-operative biopsies (131 histological and 70 cytological) and on the surgical specimens, using PCR. Samples with low tumour cell fraction were assigned to laser micro-dissection (LMD). We found nine (4.5%) patients with EGFR mutation in the lung tumour resections, but failed to identify mutation in one of the corresponding pre-operative, cytological specimens. Several (18.4%) analyses of the pre-operative biopsies were inconclusive, especially in case of biopsies undergoing LMD and regarding exon 21 analysis. Discrepancy of mutation status in one patient may reflect intra-tumoural heterogeneity or technical issues. Moreover, several inconclusive results in the diagnostic biopsies reveal that attention must be paid on the suitability of pre-operative biopsies for EGFR mutation analysis., (© 2014 APMIS. Published by John Wiley & Sons Ltd.)
- Published
- 2015
- Full Text
- View/download PDF
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