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3 results on '"Linda van Delden"'

1. Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment

Author

Eline H. van Roekel, Martijn J. L. Bours, Linda van Delden, Stéphanie O. Breukink, Michèl Aquarius, Eric T. P. Keulen, Audrey Gicquiau, Vivian Viallon, Sabina Rinaldi, Paolo Vineis, Ilja C. W. Arts, Marc J. Gunter, Michael F. Leitzmann, Augustin Scalbert, and Matty P. Weijenberg

Subjects
Medicine, Science
Abstract

Abstract We investigated longitudinal associations of moderate-to-vigorous physical activity (MVPA) and light-intensity physical activity (LPA) with plasma concentrations of 138 metabolites after colorectal cancer (CRC) treatment. Self-reported physical activity data and blood samples were obtained at 6 weeks, and 6, 12 and 24 months post-treatment in stage I-III CRC survivors (n = 252). Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQp180 kit). Linear mixed models were used to evaluate confounder-adjusted longitudinal associations. Inter-individual (between-participant differences) and intra-individual associations (within-participant changes over time) were assessed as percentage difference in metabolite concentration per 5 h/week of MVPA or LPA. At 6 weeks post-treatment, participants reported a median of 6.5 h/week of MVPA (interquartile range:2.3,13.5) and 7.5 h/week of LPA (2.0,15.8). Inter-individual associations were observed with more MVPA being related (FDR-adjusted q-value

Published
2021
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2. Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment

Author

Marc J. Gunter, Ilja C. W. Arts, Stephanie O. Breukink, Eline H. van Roekel, Michel Aquarius, Vivian Viallon, Linda van Delden, Augustin Scalbert, Michael F. Leitzmann, Sabina Rinaldi, Eric T.P. Keulen, Matty P. Weijenberg, Paolo Vineis, Audrey Gicquiau, Martijn J.L. Bours, Epidemiologie, RS: GROW - R1 - Prevention, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, Surgery, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Maastricht Centre for Systems Biology, RS: FHML MaCSBio, RS: FPN MaCSBio, RS: FSE MaCSBio, and RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome

Subjects
Male, 0301 basic medicine, Arginine, Epidemiology, Colorectal cancer, Metabolite, SERUM, chemistry.chemical_compound, 0302 clinical medicine, Cancer Survivors, Tandem Mass Spectrometry, QUALITY-OF-LIFE, Interquartile range, REPRODUCIBILITY, Citrulline, Longitudinal Studies, Multidisciplinary, Middle Aged, Sphingomyelins, 030220 oncology & carcinogenesis, TARGETED METABOLOMICS, Plasma concentration, Metabolome, Medicine, Female, HEALTH, Colorectal Neoplasms, After treatment, medicine.medical_specialty, Science, BIOMARKERS, QUESTIONNAIRE, Physical activity, Article, CLASSIFICATION, Gastrointestinal cancer, 03 medical and health sciences, Cancer epidemiology, Carnitine, Internal medicine, medicine, Humans, Metabolomics, Histidine, Exercise, SIGNATURES, Aged, business.industry, MORTALITY, Lysophosphatidylcholines, medicine.disease, 030104 developmental biology, Endocrinology, Risk factors, chemistry, Quality of Life, Self Report, business
Abstract

We investigated longitudinal associations of moderate-to-vigorous physical activity (MVPA) and light-intensity physical activity (LPA) with plasma concentrations of 138 metabolites after colorectal cancer (CRC) treatment. Self-reported physical activity data and blood samples were obtained at 6 weeks, and 6, 12 and 24 months post-treatment in stage I-III CRC survivors (n = 252). Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQp180 kit). Linear mixed models were used to evaluate confounder-adjusted longitudinal associations. Inter-individual (between-participant differences) and intra-individual associations (within-participant changes over time) were assessed as percentage difference in metabolite concentration per 5 h/week of MVPA or LPA. At 6 weeks post-treatment, participants reported a median of 6.5 h/week of MVPA (interquartile range:2.3,13.5) and 7.5 h/week of LPA (2.0,15.8). Inter-individual associations were observed with more MVPA being related (FDR-adjusted q-value

Published
2021

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