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6 results on '"Linda S. Newton"'

1. Three-Component, Stereoselective Palladium-Catalyzed Synthesis of Functionalized Bicyclopentanoids

Author

Linda S. Newton, Shawn Cabral, and Aaron J. Walker, Bernard Hulin, and Jon Bordner

Subjects
chemistry.chemical_classification, Aryl, Organic Chemistry, Iodide, chemistry.chemical_element, General Medicine, Biochemistry, Medicinal chemistry, Adduct, Catalysis, chemistry.chemical_compound, Malonate, chemistry, Organic chemistry, Physical and Theoretical Chemistry, Trifluoromethanesulfonate, Octane, Palladium
Abstract

1,5-Cyclooctadiene can be stereoselectively transformed into a substituted bicyclo[3.3.0]octane ring system under palladium catalysis with concomitant formation of three carbon-carbon bonds. Reaction with an aryl iodide or triflate and malonate gives an exo-endo product, while the reaction with a malonate in the presence of oxygen affords a bis-endo adduct.

Published
2004
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5. Folate antagonists.17. Synthesis and biological properties of a 2,4-diamino-6-thioquinazoline analog of aminopterin

Author

Edward F. Elslager, Leslie M. Werbel, and Linda S. Newton

Subjects
biology, Chemistry, Organic Chemistry, Thio, Pharmacology, biology.organism_classification, Aminopterin, Biochemistry, Biological property, parasitic diseases, Dihydrofolate reductase, medicine, biology.protein, High doses, heterocyclic compounds, Plasmodium berghei, Mode of action, Trypanosoma cruzi, medicine.drug
Abstract

A multistep route for the synthesis of N-[4-[(2,4-diamino-6-quinazolinyl)thio]benzoyl]-L-glutamic acid (2) from 4-mercaptobenzoic acid and 5-chloro-2-nitrobenzonitrile is described. Although this aminopterin analog lacked significant antimalarial activity, it was a potent inhibitor of dihydrofolate reductase from Trypanosoma cruzi. The pteroic ester analog 11, however, was active against Plasmodium berghei infections in mice at high doses.

Published
1980
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6. 2-Mercaptoacetamidine and derivatives as antiradiation agents

Author

Jerry M. Barton, Roger D. Westland, Mary M. Merz, Marie M. Grenan, Terry T. Conway, Prabhakar B. Devdhar, Susan M. Alexander, Linda S. Newton, Ludwig Bauer, and Krishan K. Khullar

Subjects
Dose-Response Relationship, Drug, Chemistry, Radiochemistry, Amidines, Administration, Oral, Radiation-Protective Agents, Sulfides, Radiation Dosage, Combinatorial chemistry, Lethal Dose 50, Mice, Structure-Activity Relationship, Acetamides, Drug Discovery, Animals, Molecular Medicine, 2-mercaptoacetamidine, Injections, Intraperitoneal
Published
1972
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