27 results on '"Linda L, Black"'
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2. Women, You’ve Come a Long Way, Baby; or Have You?: Male Clinicians-in-Training’s Perceptions of Women
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Jody Huntington and Linda L. Black
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Gender Studies ,genetic structures ,Perception ,media_common.quotation_subject ,education ,Gender bias ,Psychology ,Applied Psychology ,Clinical psychology ,media_common - Abstract
The focus of this study was to better understand male clinicians-in-training’s perceptions of female clients, peers, and faculty and how those perceptions may impact their interactions. In this study, 10 male clinicians-in-training’s perceptions related to gender with respect to female clients, peers, and faculty were explored by engaging in semi-structured interviews, responding to journal prompts, and providing artifacts. The findings supported a need for a focus on gender, as well as increased sensitivity to gender and gender issues, and the importance of clinician self-awareness.
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- 2014
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3. Altruism–Self-Interest Archetypes: A Paradigmatic Narrative of Counseling Professionals
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Stephen V. Flynn and Linda L. Black
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Therapeutic relationship ,Professional boundaries ,media_common.quotation_subject ,Self-interest ,Narrative ,Psychology ,Social psychology ,Focus group ,Altruism ,Pleasure ,media_common ,Narrative inquiry - Abstract
The quality of the therapeutic relationship and the personal characteristics of professional counselors are key determinants of positive counseling outcomes and decision making, and they are believed to be influenced by conscious and unconscious processes. Beliefs about the unconscious nature of altruism and self-interest among 25 mental health professionals were examined through a paradigmatic narrative analysis. Data from 19 semistructured individual interviews, one focus group, 19 artifacts and participant member checks were subjected to a secondary qualitative analysis. The results of the analysis generated three salient archetypes representative of the altruism-self-interest dynamic: exocentric altruist, endocentric altruist, and psychological egoist.Keywords: professional counselors, altruism, self-interest, archetype, qualitative, paradigmatic narrative analysisThe constructs altruism and self-interest have long been described in dichotomous terms and as the sole motivators of human behavior (Holmes, Miller, & Lemer, 2002; Simpson, Irwin, & Lawrence, 2006). In 1851, Comte defined the term altruism as "self-sacrifice for the benefit of others" (1875/2001, p. 565). More than a century later, Sober (1993) defined self-interest as "the sole fixation on gaining pleasure and avoiding pain." Because these two constructs typically have been associated with individuals' actions and viewed through a polarized lens, there is a dearth of research examining the unified and unconscious nature of both altruism and self-interest (Bishop, 2000). The heretofore dichotomous and superficial understanding of these constructs has enabled individuals to maintain an inaccurate view of altruistic and self-interest oriented behaviors (Flynn & Black, 2011; Holmes, Miller, & Lemer, 2002), resulting in a value-based perspective that perpetuates underinformed over-generalizations of the phenomenon (e.g., people who give to others are "good" and those who take for themselves are "bad").Professional literature presents mixed messages regarding altruism and self-interest. To date, the concept of self-interest has seldom been explicitly examined within the counseling profession. Current literature largely describes professional counselors' self-interest in terms of personal wellness, self-advocacy, positive beliefs, self-care and the development of self-regulatory systems (Hendricks, 2008; Hermon & Hazier, 1999; Myers & Sweeney, 2008; Myers, Sweeney, & White, 2002; Osborn, 2004). A smaller body of literature encourages professional counselors to maintain effective professional boundaries and to seek compensation commensurate with their level of training (Bernard, 2006; Myers et al., 2002). The literature on wellness, boundaries and monetary compensation sometimes conflicts with professional counseling's altruistic foundation and has garnered less attention than professional literature that focuses almost exclusively on meeting the needs of clients. Although recent efforts have been made to address counselor impairment and burnout (e.g., Ohrt & Cunningham, 2012; Parker & Henfield, 2012), very little attention has centered on understanding counselor self-interest. For example, professional counselors are called to advocate for the underserved, to provide a percentage of their services pro bono, and to secure referrals for clients unable to pay the professional counselor's rate (American Counseling Association, 2005; Osborn, West, Bubenzer, Duba, & Olson, 2003). Professional counseling is a service-oriented profession, yet the almost exclusive focus on altruistic acts (e.g., giving of oneself) without a concomitant discussion of professional counselor self-interest potentially creates a culture of professional self-sacrifice and martyrdom that places counselors at risk for burnout and clients at risk for negative outcomes.Although the negative consequences of an exclusive focus on altruism in professional counseling are evident, there has been limited scholarly dialogue on the unconscious nature of altruism and self-interest. …
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- 2013
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4. Adipose-derived stem cell therapy for severe muscle tears in working German shepherds: Two case reports
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Linda L Black, S. Gary Brown, and Robert Harman
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Critical time ,education.field_of_study ,medicine.medical_specialty ,biology ,business.industry ,Athletes ,Population ,Adipose tissue ,Skeletal muscle ,biology.organism_classification ,Cell therapy ,medicine.anatomical_structure ,Physical medicine and rehabilitation ,Physical therapy ,Medicine ,Tears ,business ,education - Abstract
Injuries to muscle in the elite athlete are common and may be responsible for prolonged periods of loss of competitive activity. The implications for the athlete, his/her coach and team may be catastrophic if the injury occurs at a critical time in the athlete's diary. Imaging now plays a crucial role in diagnosis, prognostication and management of athletes with muscle injuries. This article discusses the methods available to clinicians and radiologists that are used to assess skeletal muscle injury. The spectrum of muscle injuries sustained in the elite athlete population is both discussed and illustrated.
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- 2012
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5. An Emergent Theory of Altruism and Self-Interest
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Stephen V. Flynn and Linda L. Black
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media_common.quotation_subject ,Self-interest ,Occupational stress ,Interpersonal communication ,Psychology ,Focus group ,Social psychology ,Altruism ,Mental health ,Applied Psychology ,Grounded theory ,media_common ,Ethical code - Abstract
The person of the counselor is at the center of counseling identity. Ethically, counselors are not to allow their needs or self-interests to impede the client’s growth (Corey, Corey, & Callanan, 2007). If counselors allowed their self-interests to emerge unchecked, it could create situations in which the counselors’ needs took precedence over their client’s, thus creating a potentially harmful situation for the client. Client protection and welfare are critical to successful therapeutic outcomes; however, the manner in which the ethical standards for counselors are proffered may lead some counselors to conclude that they are required or expected to deny, diminish, or acknowledge any professional or personal gains (American Counseling Association [ACA], 2005). The counseling profession, through its ethical standards, may be sending a contradictory message (i.e., counselor wellness is important, yet clients’ needs are superior to counselors’ needs). These ethical codes and values may inadvertently communicate that the work of counselors is primarily steeped in self-sacrifice, which may lead to counselor burnout. Ignoring appropriate self-interest holds a variety of negative consequences for counselors, particularly those who work in community mental health settings (Bernard, 2006; Hill, 2004; Lambie, 2007; Myers, 2003; Myers, Sweeney, & White, 2002). Examples of these consequences include overriding unselfish concern, ignoring one’s stress level, frustration, job dissatisfaction, stress-related health problems, lowered work productivity, inability to cope with occupational stress, interpersonal conflict
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- 2011
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6. The Initial Development of the Multicultural Supervision Scale
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Linda L. Black and Varunee Faii Sangganjanavanich
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050106 general psychology & cognitive sciences ,050103 clinical psychology ,Medical education ,Scale (ratio) ,Multiculturalism ,media_common.quotation_subject ,05 social sciences ,0501 psychology and cognitive sciences ,Psychology ,Three factor model ,media_common ,Counselor educators - Abstract
The Multicultural Supervision Scale (MSS) was administered to 304 counselor educators and clinical supervisors across the United States. A three factor model comprising 39 items seemed to define th...
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- 2011
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7. Counselor Education and Supervision: Our Voice, Vitality, and Vision
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Heather M. Helm and Linda L. Black
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Clinical Psychology ,Applied psychology ,Developmental and Educational Psychology ,Counselor education ,Vitality ,Psychology ,Education - Published
- 2009
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8. Clinical Supervision for International Counselors-in-Training: Implications for Supervisors
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Varunee Faii Sangganjanavanich and Linda L. Black
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050103 clinical psychology ,050106 general psychology & cognitive sciences ,Medical education ,05 social sciences ,Face (sociological concept) ,Clinical supervision ,0501 psychology and cognitive sciences ,Psychology ,Training (civil) - Abstract
International students face many challenges as counselors-in-training. This study sought to identify, through a phenomenological examination, the supervisory needs, experiences, attitudes, and perc...
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- 2009
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9. I Knew You When: A Case Study of Managing Preexisting Nonamorous Relationships in Counseling
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Linda L. Black and Kevin J. Heaton
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Therapeutic relationship ,Social Psychology ,Association (object-oriented programming) ,Applied psychology ,Psychology ,Social psychology ,Social Sciences (miscellaneous) ,Code (semiotics) ,Ethical code - Abstract
Multiple and dual relationships between client and counselor have been the topic of much discussion in our field. In 2005, the American Counseling Association revised and updated the code of ethics that further delineated the guidelines around these types of relationships. The impact of the code is addressed via a case study to demonstrate the issues surrounding multiple relationships in a personal, nonromantic relationship that had been established, prior to the therapeutic relationship. Implications of the previous relationship and the ethical decision-making process are addressed as well as recommendations for practitioners.
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- 2009
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10. The Development and Validation of the Social Privilege Measure
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Elisabeth C. Suarez, David A. Stone, Susan R. Hutchinson, and Linda L. Black
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Oppression ,media_common.quotation_subject ,05 social sciences ,050401 social sciences methods ,Social constructionism ,Racism ,Education ,Disadvantaged ,050106 general psychology & cognitive sciences ,0504 sociology ,Power structure ,Developmental and Educational Psychology ,0501 psychology and cognitive sciences ,Engineering ethics ,Psychology (miscellaneous) ,Psychology ,Social psychology ,Applied Psychology ,Privilege (social inequality) ,Social status ,media_common ,Social influence - Abstract
Privilege and oppression have an impact on society in numerous ways. Although studied in many disciplines, few empirical measures of these social constructs exist for educators or researchers. The ...
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- 2007
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11. The 2000 Cohort of New Assistant Professors of Counselor Education: Year 3
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Linda L. Black, Sandy Magnuson, and Maria K. E. Lahman
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Clinical Psychology ,Scholarship ,Promotion (rank) ,Nursing ,media_common.quotation_subject ,Cohort ,Developmental and Educational Psychology ,Counselor education ,Psychology ,Education ,Counselor educators ,media_common ,Pleasure - Abstract
This article is the 3rd in a series that has been focused on the experiences of assistant professors of counselor education who were at the conclusion of their 3rd year in the profession. Thirty-six participants provided information about their experiences, sources of pleasure and displeasure, professional contributions, areas of change, and expectations for tenure and promotion. Prominent themes that emerged from the data included mentoring, balance and family focus, and scholarship. Recommendations are presented for counselor educators-in-training, candidates, new counselor educators (CEs), and veteran CEs.
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- 2006
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12. Expanding the Definition of Privilege: The Concept of Social Privilege
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David A. Stone and Linda L. Black
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Cultural Studies ,Oppression ,Age differences ,Civil rights ,Anthropology ,media_common.quotation_subject ,Sexual orientation ,Social well being ,Sociology ,Economic well being ,Humanities ,Applied Psychology ,media_common - Abstract
Examinations of privilege have historically focused on gender and race. By placing privilege within the context of oppression, the authors offer an expanded view of the domains of privilege that include sexual orientation, socioeconomic status, age, differing degrees of ableness, and religious affiliation. Los examenes del privilegio se han enfocado historicamente en el genero y la raza. Colocando el privilegio dentro del contexto de la opresion, los autores ofrecen una vista ensanchada de los dominios del privilegio que incluye la orientacion sexual, la posicion socioeconomica, la edad, difiriendo los grados de habilidad, y de la afiliacion religiosa.
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- 2005
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13. Women of Spirit: Leaders in the Counseling Profession
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Sandy Magnuson and Linda L. Black
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Power (social and political) ,media_common.quotation_subject ,Great Man theory ,Counselor education ,Institution ,Professional association ,Gender role ,Shared leadership ,Psychology ,Leadership ,Social psychology ,Applied Psychology ,media_common - Abstract
The counseling literature documents the profession's inception and growth in a variety of ways. Current examples include Counseling Today's "ACA Turns 50" feature series and "Passing the Tradition: ACES Presidents 1940-97" (Sheeley, 1997). Professional counselors often identify the late 1940s and early 1950s as the time of the profession's beginning. The Association for Counselor Education and Supervision (ACES) was founded in 1952, and the American Counseling Association (ACA) was founded in 1951. Thus, these organizations emerged prior to the women's movement of the 1960s and 1970s, yet there remains no formal documentation of the roles that women, and in particular female leaders, have played in these professional organizations. Leadership has historically been defined by the nature of the position held within a hierarchical system. An examination of one dimension of leadership, presidential terms, revealed that women had limited formal or recognized involvement during the early years of the counseling profession. In fact, the first 34 presidents of ACES were men. Although Mary Corre was the fourth president of ACA (Simmons, 2002), she was one of only five female presidents who served prior to 1980. Although women were not prominent in presidential roles, they most likely offered leadership through informal means. In this study, we considered a broader description of leadership that extended beyond the constraints of position. We used the framework of positional and nonpositional leaders described by Astin and Leland (1991) in their study of leadership within the women's movement. Positional leaders (i.e., leaders of people) were described as individuals who "head an organization or institution" (p. 8), and nonpositional leaders were identified as university professors and other researchers (i.e., leaders of ideas) who "create knowledge central to social change" (p. 9). This article features an initial effort to document and draw on the experiences of 10 women who have been leaders in the counseling profession. Our goal in conducting this inquiry was to explore their professional lives and interactions in order to identify the common threads from which the rich tapestry of leadership was woven. Relevant Literature What makes an individual a leader? Is it style, position, behaviors, or some combination thereof? Scholars have routinely sought answers to this question through an examination of the differences in roles, styles, or traits of male and female leaders (Eagly & Johnson, 1990). Many of these studies emanated from the "great man" theory of leadership (Kellerman, 1986). Proponents of this theory posited that leadership was a masculine phenomenon because great leaders (e.g., politicians, kings, philosophers, heroes) were male. Thus, because great leaders were male, leadership, by definition, must be characterized by male traits (e.g., decisiveness, authority, power). Not surprisingly, these lines of inquiry led to a period of gender stereotyping regarding the expected behaviors and styles of leaders. Men were viewed as natural leaders, whereas women experienced a double bind. In order to lead, an individual must exhibit competitiveness, dominance, and decisiveness; these characteristics are typically at odds with the cultural expectations of women (e.g., cooperation, submissiveness, and hesitancy). Women who attempted to adopt the "expected" leader behaviors were evaluated as "bitchy," "manly," or "difficult" (Eagly, Makhijani, & Klonsky, 1992) because they belied the expected gender role expectations. The characteristics customarily ascribed to women were in direct conflict with the characteristics associated with leadership. Since the mid-1980s, researchers have reported a range of findings. Large-scale studies indicated that effective female leaders were thought to be empathetic, supportive, nurturing, focused on relationship building, and willing to share (Eagly, Karau, & Makhijani, 1995; Wagensteen, 1997; Wajcman, 1998). …
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- 2005
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14. Supervising School Counselors and Interns: Resources for Site Supervisors
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Ken Norem, Sandy Magnuson, and Linda L. Black
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050103 clinical psychology ,050106 general psychology & cognitive sciences ,Medical education ,ComputingMilieux_THECOMPUTINGPROFESSION ,Nursing ,business.industry ,Internship ,05 social sciences ,ComputingMilieux_COMPUTERSANDEDUCATION ,Medicine ,0501 psychology and cognitive sciences ,business - Abstract
This article features a review of selected resources related to supervision of school counselors and school counselors-in-training during their internship. These resources are grouped by profession...
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- 2004
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15. Helping Students Help Themselves: Strategies for Successful Mentoring Relationships
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Sondra Medina, Elisabeth C. Suarez, and Linda L. Black
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ComputingMilieux_THECOMPUTINGPROFESSION ,Higher education ,business.industry ,media_common.quotation_subject ,Counselor education ,Education ,ComputingMilieux_GENERAL ,Clinical Psychology ,Interpersonal relationship ,Promotion (rank) ,Pedagogy ,ComputingMilieux_COMPUTERSANDEDUCATION ,Developmental and Educational Psychology ,Apprenticeship ,Set (psychology) ,Psychology ,business ,media_common ,Counselor educators - Abstract
Mentoring has long been heralded as a method of training and socializing the next generation of professional counselors and counselor educators. Yet, there appears to be a disparity between the promotion and the practice of mentoring in counselor education. The authors attempted to reconcile this disparity by suggesting a set of strategies that mentors and apprentices may use as they establish and maintain successful mentoring relationships. Implications for counselors and counselor educators are discussed.
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- 2004
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16. Rape Myth Acceptance: Implications for Counselor Education Programs
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Kristin D Kushmider, Jennifer E Beebe, and Linda L Black
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Sexual violence ,Applied psychology ,Counselor education ,Clinical supervision ,Mythology ,Complicity ,Rape myth ,Psychology ,Social psychology ,Curriculum ,Naturalistic inquiry - Abstract
A sexually violent act or rape is committed every 1.9 minutes in the United States (USDJ, 2009, p.1). Blaming the rape victim for their perceived complicity is one component of the construct known as rape myth, a term identified by Burt (1980). This study explored and examined the perceptions, and understanding of sexual violence, rape, and rape myths by master’s level counselors-in-training (n=5). Phenomenology and naturalistic inquiry guided the qualitative design and implementation. Suggestions for implementing rape education and training into counseling curriculums and clinical supervision are provided.
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- 2015
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17. Defining Moments: The Golden Anniversary of Counselor Education and Supervision
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Heather M. Helm and Linda L. Black
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Clinical Psychology ,Medical education ,Developmental and Educational Psychology ,Counselor education ,Psychology ,Education - Published
- 2010
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18. Teaching Research Methods for Counselors
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Varunee Faii Sangganjanavanich and Linda L. Black
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Medical education ,Pedagogy ,Psychology ,Teaching research - Published
- 2011
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19. Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs
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Linda L, Black, James, Gaynor, Cheryl, Adams, Sarit, Dhupa, Andrew E, Sams, Robert, Taylor, Susan, Harman, Daniel A, Gingerich, and Robert, Harman
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Male ,Time Factors ,Lameness, Animal ,Mesenchymal Stem Cell Transplantation ,Transplantation, Autologous ,Injections, Intra-Articular ,Dogs ,Treatment Outcome ,Chronic Disease ,Elbow Joint ,Osteoarthritis ,Animals ,Female ,Dog Diseases ,Range of Motion, Articular - Abstract
Autologous adipose-derived mesenchymal stem cell (AD-MSC) therapy involves harvesting fat from the patient, isolating the stem and regenerative cells, and administering the cells back to the patient. Autologous AD-MSC therapy in veterinary regenerative medicine has been commercially available since 2003. Previously reported results from a blinded, controlled trial in dogs with chronic osteoarthritis of the coxofemoral (hip) joint demonstrated efficacy of a single intraarticular injection of autologous AD-MSC therapy. The primary objective of the current study was to evaluate the effectiveness of this therapy in dogs with chronic osteoarthritis of the humeroradial (elbow) joints and to determine the duration of effect. Fourteen dogs were recruited. Veterinarians assessed each dog for lameness, pain on manipulation, range of motion, and functional disability using a numeric rating scale at baseline and specified intervals up to 180 days after treatment. Statistically significant improvement in outcome measures was demonstrated.
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- 2008
20. Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial
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Linda L, Black, James, Gaynor, Dean, Gahring, Cheryl, Adams, Dennis, Aron, Susan, Harman, Daniel A, Gingerich, and Robert, Harman
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Male ,Lameness, Animal ,Mesenchymal Stem Cell Transplantation ,Severity of Illness Index ,Transplantation, Autologous ,United States ,Injections, Intra-Articular ,Dogs ,Treatment Outcome ,Adipose Tissue ,Double-Blind Method ,Animals ,Female ,Hip Dysplasia, Canine ,Pain Measurement - Abstract
Autologous stem cell therapy in the field of regenerative veterinary medicine involves harvesting tissue, such as fat, from the patient, isolating the stem and regenerative cells, and administering the cells back to the patient. Autologous adipose-derived stem cell therapy has been commercially available since 2003, and the current study evaluated such therapy in dogs with chronic osteoarthritis of the hip. Dogs treated with adipose-derived stem cell therapy had significantly improved scores for lameness and the compiled scores for lameness, pain, and range of motion compared with control dogs. This is the first randomized, blinded, placebo-controlled clinical trial reporting on the effectiveness of stem cell therapy in dogs.
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- 2008
21. Cycloaddition reactions of nitrile sulfides with acetylenic esters. Synthesis of isothiazolecarboxylates
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Robert K. Howe, Terry A. Gruner, Linda G. Carter, Linda L. Black, and John E. Franz
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Organic Chemistry - Published
- 1978
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22. The effect of uterine-derived mesenchymal stromal cells for the treatment of canine atopic dermatitis: A pilot study.
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Black L, Zacharias S, Hughes M, Bautista R, Taechangam N, and Sand T
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Canine atopic dermatitis (cAD) is a common allergic skin condition among dogs that may respond to treatment with mesenchymal stromal cells (MSCs). The aim of this pilot study was to evaluate the safety and efficacy of allogeneic uterine tissue-derived MSCs (UMSCs) for the reduction and control of clinical signs associated with cAD. At two sites, seven client-owned dogs with cAD received two doses of approximately 3.6 x 10
7 UMSCs given intravenously over 30 min, on Day 0 and Day 14, with monthly clinical follow-up until Day 90 and optional owner phone interview on Day 180. Primary outcomes were pruritus and skin lesions. Pruritus was measured by the owner-assessed Pruritus Visual Analog Scale (PVAS), with treatment success defined as a 2-point reduction in PVAS score at any timepoint after treatment. Skin lesions were evaluated by two veterinarians according to the Canine Atopic Dermatitis Extent and Severity Index (CADESI-4). The secondary outcome was safety, which was evaluated via physical exam and hematology, including complete blood count (CBC), serum chemistry, and urinalysis (UA). Treatment was generally well tolerated and associated with a significant reduction in PVAS on Day 30 that was maintained through Day 180. On Day 60, five dogs (71%) achieved treatment success (at least 2-point reduction in PVAS), and three dogs (43%) had a PVAS improvement of 4-5 points. Mean CADESI-4 score was significantly improved on Day 14, Day 30, Day 60, and Day 90, with the lowest mean score observed on Day 60. Three dogs exhibited mild and transient adverse events. These findings suggest that IV-administered allogeneic UMSCs reduce and control clinical signs of cAD, with a durable benefit lasting 3-6 months., Competing Interests: Authors LB, SZ, MH, RB, NT, and TS were employed by Gallant, which is developing UMSCs as an investigational product for clinical studies and commercial use., (Copyright © 2022 Black, Zacharias, Hughes, Bautista, Taechangam and Sand.)- Published
- 2022
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23. Financial costs for teaching in rural and urban Australian general practices: is there a difference?
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Laurence CO, Coombs M, Bell J, and Black L
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- Australia, Cost-Benefit Analysis, Costs and Cost Analysis, General Practice economics, Humans, General Practice education, Rural Health Services economics, Urban Health Services economics
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Objective: To determine if the financial costs of teaching GP registrars differs between rural and urban practices., Design: Cost-benefit analysis of teaching activities in private GP for GP vocational training. Data were obtained from a survey of general practitioners in South Australia and Western Australia., Setting and Participants: General practitioners and practices teaching in association with the Adelaide to Outback General Practice Training Program or the Western Australian General Practice Training., Main Outcome Measures: Net financial effect per week per practice., Results: At all the training levels, rural practices experienced a financial loss for teaching GP registrars, while urban practices made a small financial gain. The differences in net benefit between rural and urban teaching practices was significant at the GPT2/PRRT2 (-$515 per week 95% CI -$1578, -$266) and GPT3/PRRT3 training levels (-$396 per week, 95% CI (-$2568, -$175). The variables contributing greatest to the difference were the higher infrastructure costs for a rural practice and higher income to the practice from the GP registrars in urban practices., Conclusion: There were significant differences in the financial costs and benefits for a teaching rural practice compared with an urban teaching practice. With infrastructure costs which include accommodation, being a key contributor to the difference found, it might be time to review the level of incentives paid to practices in this area. If not addressed, this cost difference might be a disincentive for rural practices to participate in teaching., (© 2014 National Rural Health Alliance Inc.)
- Published
- 2014
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24. Exploration of the preconceptions of living in a rural community by general practitioner registrar partners.
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Panozzo S, Laurence C, Black L, and Poole L
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- Australia, Focus Groups, Humans, Attitude of Health Personnel, Physicians, Family psychology, Rural Population
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- 2009
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25. Evaluation of a novel precision template-guided biopsy system for detecting prostate cancer.
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Megwalu II, Ferguson GG, Wei JT, Mouraviev V, Polascik TJ, Taneja S, Black L, Andriole GL, and Kibel AS
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- Aged, Aged, 80 and over, Biopsy instrumentation, Humans, Male, Middle Aged, Prostate-Specific Antigen blood, Rectum, Retrospective Studies, Biopsy standards, Prostate pathology, Prostatic Neoplasms pathology, Ultrasonography, Interventional methods
- Abstract
Objective: To explore the ability of a novel transrectal ultrasonography (TRUS) device (TargetScan, Envisioneering Medical Technologies, St. Louis MO) that creates a three-dimensional map of the prostate and calculates an optimal biopsy scheme, to accurately sample the prostate and define the true extent of disease, as standard TRUS-guided prostate biopsy relies on the operator to distribute the biopsy sites, often resulting in under- and oversampling regions of the gland., Patients and Methods: In a multicentre retrospective chart review evaluating patients who had a TargetScan prostate biopsy between January 2006 and June 2007, we determined the overall cancer detection rate in all patients and in subgroups based on prostate specific antigen level, digital rectal examination, and indication for biopsy. We assessed the pathological significance of cancer detected, defined as a Gleason score of > or = 7, positive margins, extracapsular disease or > 20% tumour volume in the prostatectomy specimen. We also evaluated the concordance in Gleason score between the biopsy and prostatectomy specimen., Results: Cancer was detected in 50 (35.7%) of the 140 patients biopsied, including 39 (47.6%) with no previous biopsies. Of 23 prostatectomy specimens, 20 (87%) had pathologically significant disease. The biopsy predicted the prostatectomy Gleason score in 12 patients (52%), overestimated in two (9%), underestimated in eight (35%), and biopsy Gleason score could not be assigned in one (4%)., Conclusions: Template-guided biopsy potentially produces a higher cancer detection rate and more accurate assessment of grade. Prostatectomy specimens did not have a high rate of pathologically insignificant disease.
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- 2008
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26. Characterization and differentiation of equine umbilical cord-derived matrix cells.
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Hoynowski SM, Fry MM, Gardner BM, Leming MT, Tucker JR, Black L, Sand T, and Mitchell KE
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- Adipocytes chemistry, Adipocytes cytology, Adipocytes metabolism, Adipogenesis, Alkaline Phosphatase metabolism, Animals, Anthraquinones chemistry, Azo Compounds chemistry, Cell Cycle, Cell Proliferation, Cells, Cultured, Chondrocytes chemistry, Chondrocytes cytology, Chondrocytes metabolism, Chondrogenesis, Female, Flow Cytometry, Horses, Immunohistochemistry, Multipotent Stem Cells chemistry, Multipotent Stem Cells metabolism, Neurons chemistry, Neurons cytology, Neurons metabolism, Osteocytes chemistry, Osteocytes cytology, Osteocytes metabolism, Osteogenesis, Umbilical Cord metabolism, Cell Differentiation, Multipotent Stem Cells cytology, Umbilical Cord cytology
- Abstract
Stem cells are being evaluated in numerous human clinical trials and are commercially used in veterinary medicine to treat horses and dogs. Stem cell differentiation, homing to disease sites, growth and cytokine factor modulation, and low antigenicity contribute to their therapeutic success. Bone marrow and adipose tissue are the two most common sources of adult-derived stem cells in animals. We report on the existence of an alternative source of primitive, multipotent stem cells from the equine umbilical cord cellular matrix (Wharton's jelly). Equine umbilical cord matrix (EUCM) cells can be cultured, cryogenically preserved, and differentiated into osteo-, adipo-, chondrogenic, and neuronal cell lineages. These results identify a source of stem cells that can be non-invasively collected at birth and stored for future use in that horse or used as donor cells for treating unrelated horses.
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- 2007
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27. Efficacy of a canarypox-vectored recombinant vaccine expressing the hemagglutinin gene of equine influenza H3N8 virus in the protection of ponies from viral challenge.
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Minke JM, Toulemonde CE, Coupier H, Guigal PM, Dinic S, Sindle T, Jessett D, Black L, Bublot M, Pardo MC, and Audonnet JC
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- Animals, Antibodies, Viral blood, Gene Expression Regulation, Viral, Horse Diseases immunology, Horses, Influenza A Virus, H3N8 Subtype physiology, Male, Orthomyxoviridae Infections immunology, Orthomyxoviridae Infections prevention & control, Orthomyxoviridae Infections virology, Vaccines, Synthetic genetics, Vaccines, Synthetic immunology, Canarypox virus genetics, Hemagglutinin Glycoproteins, Influenza Virus genetics, Hemagglutinin Glycoproteins, Influenza Virus immunology, Horse Diseases prevention & control, Horse Diseases virology, Influenza A Virus, H3N8 Subtype immunology, Orthomyxoviridae Infections veterinary
- Abstract
Objective: To determine onset and duration of immunity provided by a 2- or 3-dose series of a new canarypox-vectored recombinant vaccine for equine influenza virus (rCP-EIV vaccine) expressing the hemagglutinin genes of influenza H3N8 virus strains A/eq/Kentucky/94 and A/eq/Newmarket/2/93 in ponies., Animals: Forty-nine 1- to 3-year-old male Welsh Mountain Ponies that were seronegative for equine influenza virus., Procedures: Vaccinated and control ponies were challenged with aerosolized influenza virus A/eq/Sussex/89 (H3N8), representative of the Eurasian lineage of circulating influenza viruses. In trial 1, control ponies and ponies that received rCP-EIV vaccine were challenged 2 weeks after completion of the 2-dose primary vaccination program. In trial 2, ponies were challenged 5 months after 2 doses of rCP-EIV vaccine or 1 year after the first boosting dose of rCP-EIV vaccine, administered 5 months after completion of the primary vaccination program. After challenge, ponies were observed daily for clinical signs of influenza and nasal swab specimens were taken to monitor virus excretion., Results: The challenge reliably produced severe clinical signs consistent with influenza infection in the control ponies, and virus was shed for up to 7 days. The vaccination protocol provided clinical and virologic protection to vaccinates at 2 weeks and 5 months after completion of the primary vaccination program and at 12 months after the first booster., Conclusion and Clinical Relevance: The rCP-EIV vaccine provided protection of ponies to viral challenge. Of particular importance was the protection at 5 months after the second dose, indicating that this vaccine closes an immunity gap between the second and third vaccination.
- Published
- 2007
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