27 results on '"Linda J, Harrison"'
Search Results
2. Taking a Detailed Look at Early Childhood Educators' Worktime
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Linda J. Harrison, Sandie Wong, Judith E. Brown, Megan Gibson, Tamara Cumming, Michael Bittman, and Frances Press
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Despite the acknowledged complexity and time pressures of early childhood educators' work, very few studies have examined the nature of this work, minute-by-minute, over the working day. This paper reports on data gathered through 10,155 time-use diary (TUD) records provided by 321 educators participating in the Exemplary Early Childhood Educators at Work Australian Research Council Linkage Project. Participants were recruited from preschool/kindergarten and long day care centres that had achieved a rating of Exceeding the Australian National Quality Standard on all seven Quality Areas. Analyses of this extensive dataset illustrate the rhythm and diversity of educators' work across a typical day and identify the similarities and differences in worktime distributions for educators working in preschool vs. long day care settings, and for educators with different qualifications and positional responsibilities. The findings suggest differential allocations of worktime that raise important considerations for achieving high quality early childhood education and care services.
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- 2024
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3. Measuring Early Childhood Educators' Time at Work Using an Electronic Random Time-Sampling Approach
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Sandie Wong, Linda J. Harrison, Megan L. Gibson, Frances Press, Michael Bittman, Kim Crisp, and Sharon Ryan
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Despite the acknowledged complexity of early childhood educators' work, little is documented about how early childhood educators actually spend their time at work. A typical way of studying time at work is through the use of time-use diaries. Recent developments have shown the benefits of using randomized sampling electronic time-use diaries. This paper reports on the development and useability testing of a random time sampling (RTS) time-use smart-phone application to capture the work of educators, the first time such a method has been used in early childhood settings. Descriptive analyses were conducted of time use data collected from 20 Australian early childhood educators. Seventeen went on to participate in follow-up focus groups / interviews, which were thematically analysed. The paper demonstrates the capacity of RTS apps to gather accurate and useful data about educators' work, and points to the acceptability of this method to educators, and its manageability within early childhood settings. Limitations of the method, including, participant buy-in, design and technical requirements, and cost, are also highlighted.
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- 2024
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4. Investigating Multi-Tasking and Task Rotation as Aspects of the Complexity of Early Childhood Educators' Work
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Tamara Cumming, S. Richardson, Megan Gibson, Kim Crisp, Linda J. Harrison, Frances Press, and Sandie Wong
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Researchers of early childhood educators' practice have noted the usefulness of applying various conceptual and methodological resources to create accounts of complexity. This article contributes to an under-researched area, providing evidence of multi-tasking and task rotation as aspects of the complexity of early childhood educators' practice. The data regarding these aspects were generated in 46 focus groups conducted with 111 directors, teachers and assistants working in Australian early childhood education and care services. Findings of the thematic analysis of focus group data suggest that for participants, multi-tasking and task rotation were considered an integral and regular aspect of practice. Participants also described a range of ways services had to make these sometimes-challenging aspects of practice work for themselves, children and families. This article concludes with suggestions for making multi-tasking and task rotation more manageable through shared understandings and the creation of enabling conditions within early childhood work environments.
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- 2024
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5. Unpacking and Unpicking the Challenge of 600 Hours of Preschool Attendance
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Linda J. Harrison, Tracy Redman, Judith E. Brown, Leanne Lavina, Belinda Davis, Sheila Degotardi, Loraine Fordham, Fay Hadley, Catherine Jones, Manjula Waniganayake, and Sandie Wong
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The Australian Government's (2022) Preschool Reform Funding Agreement and initiatives by state governments aim to lift enrolment and maximise the benefits of early childhood education (ECE) in the year before school. The Agreement is particularly relevant for children and families from vulnerable and disadvantaged backgrounds, many of whom do not utilise the annual attendance target of 600 hours available to every child. Children's enrolment and daily attendance records are key to understanding participation in ECE, but few studies or government reports have examined this information in detail. Drawing on administrative records provided by 19 long day care and preschool centres/schools in areas of socio-economic disadvantage, we analysed weekly attendance for 971 preschool-aged children over four 10-week terms. Results for the 'percentage of enrolled days' attended (M = 88%) and 'total hours' attended (M = 576 h) approached the target but differed for children enrolled in preschool versus long day care.
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- 2024
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6. Structures and Systems Influencing Quality Improvement in Australian Early Childhood Education and Care Centres
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Linda J. Harrison, Manjula Waniganayake, Jude Brown, Rebecca Andrews, Hui Li, Fay Hadley, Susan Irvine, Lennie Barblett, Belinda Davis, and Maria Hatzigianni
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This study assessed the impact of structural characteristics on quality rating and improvement systems (QRIS) outcomes in an Australian national study. Data from the Australian Children's Education and Care Quality Authority (ACECQA) repository of National Quality Standard (NQS) ratings were used to identify long day care services that had improved from Working Towards NQS to Meeting or Exceeding NQS or had no change over two assessments. QRIS outcomes were examined for state/territory jurisdiction, urban-rural location, community socio-economic status, type and size of provider organisation, centre size and stability of centre owner/provider using multinomial logistic regression analyses. Controlling for jurisdiction, results showed that improvement to Meeting NQS was more likely for not-for-profit versus for-profit providers and for large multi-site provider organisations versus small, stand-alone providers. Improvement to Exceeding NQS was also associated with not-for-profit and larger provider organisations, as well as larger versus smaller centres, and centres that had stable ownership.
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- 2024
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7. Engaging stakeholders to inform policy developments in early childhood education and outside school hours care
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Fay Hadley, Linda J. Harrison, Leanne Lavina, Lennie Barblett, Susan Irvine, Francis Bobongie-Harris, and Jennifer Cartmel
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education and care ,stakeholder engagement ,policy ,early childhood ,participation ,multi-method ,Education (General) ,L7-991 - Abstract
The application of engagement strategies to ensure democracy of decisions is increasingly valued and adopted by governments to ensure trust in the process and ownership of the outcome. This paper describes the approach and methods used to engage early childhood education and care (ECEC) and outside school hours care (OSHC) stakeholders in the contemporizing and updating of Australia’s national Approved Learning Frameworks (ALFs): Belonging, Being and Becoming: The Early Years Learning Framework for Australia (EYLF) and My Time Our Place: Framework for School Age Care (MTOP). Theoretical underpinnings of a robust stakeholder engagement strategy ensured a range of methods were developed to communicate with and encourage participation by the diversity of stakeholders who are invested in ECEC and OSHC in Australia – broadly defined as approved providers, teachers, educators, families, children and young people, regulatory authorities and other professionals who provide support and advice. A mixed-method, sequential 3-Stage design was developed to gather the insights, responses, and perspectives of stakeholders who provided, worked in, used, attended, or supported ECEC and/or OSHC settings. Stakeholder feedback included survey ratings and written comments, focus group and panel discussions, educator documentation and video-diaries, and the writings, talking, and drawings of children and young people. Evaluation methods focus on the number, diversity, and depth of stakeholder responses. In conclusion, we reflect on the usefulness, benefits, limitations, and effectiveness of our approach to participatory engagement to inform government policy development and decision making.
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- 2024
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8. The quest for continuous quality improvement in Australian long day care services: getting the most out of the Assessment and Rating process
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Susan Lee Irvine, Lennie Barblett, Manjula Waniganayake, Fay Hadley, Rebecca Andrews, Maria Hatzigianni, Hui Li, Leanne Lavina, Linda J. Harrison, and Belinda Davis
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quality improvement ,early childhood education and care ,assessment and rating ,meaningful engagement ,long day care ,Education (General) ,L7-991 - Abstract
The National Quality Framework (NQF) was intended to drive continuous improvement in education and care services in Australia. Ten years into implementation, the effectiveness of the NQF is demonstrated by steady improvements in quality as measured against the National Quality Standard (NQS). The process of assessing and rating services is a key element in the NQF, drawing together regulatory compliance and quality assurance. This paper draws on findings from a national Quality Improvement Research Project investigating the characteristics, processes, challenges and enablers of quality improvement in long day care services, concentrating on Quality Area 1 Educational program and practice and Quality Area 7 Governance and leadership. This was a mixed-method study focusing on long day care services that had improved their rating from Working toward NQS to Meeting NQS or to Exceeding NQS. The study comprised three phases, and in this paper, we draw on Phase 3 to understand the contribution of the NQS Assessment and Rating (A&R) process to continuous quality improvement from the standpoint of providers and professionals delivering these services. Phase 3 involved qualitative case studies of 15 long day care services to investigate factors that enabled and challenged quality improvement. Data was collected during two-day site visits, using professional conversations and field notes to elicit the views and experiences of service providers, leaders and educators. In this paper, we look at how the A&R process is experienced by those involved in service provision, with a focus on the factors that enabled and challenged quality improvement. Recognizing the interchangeability of enablers and challenges, three broad themes emerged: (i) curriculum knowledge, pedagogical skills and agency; (ii) collaborative leadership and teamwork; and (iii) meaningful engagement in the A&R process. The study found that meaningful engagement in the A&R process informed priorities for ongoing learning and acted as a catalyst for continuous quality improvement. Apprised by stakeholder views and experiences of A&R, we offer a model to foster stakeholder participation in quality assurance matters through affordances of meaningful engagement.
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- 2024
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9. The role of digital technologies in supporting quality improvement in Australian early childhood education and care settings
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Maria Hatzigianni, Tanya Stephenson, Linda J. Harrison, Manjula Waniganayake, Philip Li, Lennie Barblett, Fay Hadley, Rebecca Andrews, Belinda Davis, and Susan Irvine
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Digital technology ,Early childhood education ,Quality improvement ,Quality standards ,Bronfenbrenner ,Education (General) ,L7-991 ,Special aspects of education ,LC8-6691 - Abstract
Abstract This national study explored the role of digital technologies in early childhood education and care settings and whether they could contribute to quality improvement as reported by educators and assessors of quality in Australia. In this paper, data from Stage 2 of the Quality Improvement Research Project were used, which comprised 60 Quality Improvement Plans from educators linked with 60 Assessment and Rating reports from the assessors who visited early childhood centres as part of the administration of the National Quality Standards by each of Australia’s State and Territory jurisdictions. Bronfenbrenner’s ecological systems theory ( Bronfenbrenner, U. (1995). Developmental ecology through space and time: A future perspective. In P. Moen, G. H. Elder, Jr., & K. Lüscher (Eds.), Examining lives in context: Perspectives on the ecology of human development (pp. 619–647). American Psychological Association. https://doi.org/10.1037/10176-018 ; Bronfenbrenner & Ceci, Bronfenbrenner and Ceci, Psychological Review 101:568–586, 1994) was adopted to facilitate a systemic and dynamic view on the use of digital technologies in these 60 ECEC settings. References (e.g. comments/ suggestions/ examples) made by the educators about the implementation of digital technologies were counted and thematically analysed. Results revealed the strong role new technologies (e.g. documentation and management platforms, tablets, apps, etc.) play in the majority of ECEC settings and especially in relation to three of the seven Quality Areas: Educational programme and practice (Quality Area 1); Collaborative partnerships with families and communities (Quality Area 6) and Governance and leadership (Quality Area 7). Future directions for research are suggested and implications for embracing a more holistic, integrated and broad view on the use of digital technologies are discussed.
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- 2023
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10. Mapping the leap: differences in quality improvement in relation to assessment rating outcomes
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Belinda Davis, Rosemary Dunn, Linda J. Harrison, Manjula Waniganayake, Fay Hadley, Rebecca Andrews, Hui Li, Susan Irvine, Lennie Barblett, and Maria Hatzigianni
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quality ,improvement ,Australia ,regulation ,early childhood education ,Education (General) ,L7-991 - Abstract
IntroductionAustralia’s National Quality Standard (NQS) outlines the criteria to assess the quality of early childhood services. A four-point rating scale: (i) Exceeding NQS; (ii) Meeting NQS; (iii) Working Toward NQS; and (iv) Significant Improvement Required is applied to services following a regular assessment and rating process. Settings rated as Working Toward are reassessed within 12 months. Most settings achieved a one-step improvement in this Time 2 reassessment, moving to a Meeting rating but some settings made a two-step improvement, moving to an Exceeding rating. The QIP is a key document used by authorities to assess the quality of a service.MethodsA grounded theory, data driven approach was taken to deepen understanding of quality rating improvements in long day care services in Australia of quality rating improvements by early childhood education and care [ECEC] services in Australia. This study, part of the second phase of a three phase study involved a document analysis of the Time 2 Quality Improvement Plans (QIPs) of a representative sample of Long Day Care (LDC) services (n = 60) from all Australian states and territories to determine what factors may have contributed to these different levels of improvement, with a focus on Quality Area 1 (QA1) (Educational programs and practices) and Quality Area 7 (QA7) (Governance and leadership). The study utilized the semantic analysis tool Leximancer 4.5. Leximancer 4.5 statistically analyses the semantic relationships between concepts in documents by measuring word proximity and correlation. The software creates visual maps of concepts and their connections to each other in texts. Concepts located near one another on the map are more likely to be contextually related. This tool is particularly useful when there are multiple, complex documents to analyze, reducing the potential biases that can arise from documents that use language with which these researchers are very familiar with.ResultsThe analysis found clear differences between the Time 2 QIPs of services who had made a two-step rating improvement and those who made a one-step improvement. Two-step (Exceeding NQS) category improvers for QA1 placed attention in their QIPs on improvement to the program and overall practice, with an orientation to the role of the educational leader. Two-step (Exceeding NQS) category improvers for QA7 seemed to be more oriented to a systemic view of the processes encompassed by QA7; how the management of the service and information supports the work of educators, with stronger links made between leadership roles (the manager and nominated supervisor) and the work of educators.DiscussionThe QIPs demonstrated how the intentional and systemic processes in these quality areas related to practice, management, and leadership.
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- 2023
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11. Macro-structural predictors of Australian family day care quality
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Vincent Char, Linda J. Harrison, and Hui Li
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family day care ,national quality framework ,systemic features ,early childcare ,QRIS ,Public aspects of medicine ,RA1-1270 - Abstract
IntroductionThis study explores the predictive power of macro-structural characteristics on quality rating and improvement system (QRIS) outcomes of Family Day Care (FDC) services in Australia.MethodsThe dataset consisted of 441 FDC National Quality Standard (NQS) ratings from all Australian states and territories, with overall ratings of Exceeding NQS, Meeting NQS, Working Towards NQS, or Significant Improvement Required.ResultsMultinomial logistic regressions confirmed that management type, community socioeconomic status (SES), level of urbanization, and government jurisdiction explained 6.9 to 19.3% of the variation in QRIS outcomes. Results indicated that lower FDC NQS ratings were more likely for (1) private for-profit vs. not-for-profit; (2) low-SES vs. high-SES area; and (3) regional or remote area vs. metropolitan. State/territory jurisdiction also influenced NQS ratings.DiscussionThese findings imply the need for policy attention to inequalities in FDC quality associated with systemic and organizational differences. Greater effort is needed to promote equality and equity in FDC services.
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- 2023
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12. Sample size calculation for randomized trials via inverse probability of response weighting when outcome data are missing at random
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Linda J. Harrison and Rui Wang
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Statistics and Probability ,Epidemiology - Published
- 2023
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13. Measuring early childhood educators’ time at work using an electronic random time-sampling approach
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Sandie Wong, Linda J. Harrison, Megan L. Gibson, Frances Press, Michael Bittman, Kim Crisp, and Sharon Ryan
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Education - Published
- 2022
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14. Nasal and Plasma Severe Acute Respiratory Syndrome Coronavirus 2 RNA Levels Are Associated With Timing of Symptom Resolution in the ACTIV-2 Trial of Nonhospitalized Adults With Coronavirus Disease 2019
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Yijia Li, Linda J Harrison, Kara W Chew, Judy S Currier, David A Wohl, Eric S Daar, Teresa H Evering, Ryan Wu, Mark Giganti, Justin Ritz, Arzhang Cyrus Javan, Robert W Coombs, Carlee Moser, Michael D Hughes, Joseph J Eron, Davey M Smith, and Jonathan Z Li
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Microbiology (medical) ,Infectious Diseases - Abstract
Acute Coronavirus Disease 2019 symptoms limit daily activities, but little is known about its association with severe acute respiratory syndrome coronavirus 2 viral burden. In this exploratory analysis of placebo recipients in the ACTIV-2/A5401 platform trial, we showed that high anterior nasal RNA levels and detectable plasma RNA were associated with delayed symptom improvement.Clinical Trials Registration. https://clinicaltrials.gov/ct2/show/NCT04518410.
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- 2022
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15. Drawing Talking: Listening to Children With Speech Sound Disorders
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Jane McCormack, Sharynne McLeod, Linda J. Harrison, and Erin L. Holliday
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Linguistics and Language ,Speech-Language Pathology ,Australia ,Art Therapy ,Stuttering ,Speech Sound Disorder ,Language and Linguistics ,Speech and Hearing ,Phonetics ,Child, Preschool ,Auditory Perception ,Humans ,Speech ,Language Development Disorders - Abstract
Purpose: Listening to children using age-appropriate techniques supports evidence-based clinical decision-making. In this article, we test the Sound Effects Study Drawing Protocol, an arts-based technique, to support children with speech sound disorder (SSD) to express their views about talking. Method: Participants were 124 Australian children aged 4–5 years in the Sound Effects Study. Their parents and teachers were concerned about their talking, and they were assessed as having SSD on the Diagnostic Evaluation of Articulation and Phonology. Drawings and children's interpretations were elicited then analyzed using the (a) Who Am I? Draw-a-Person Scale and (b) Sound Effects Study Focal Points. Results: Drawings were developmentally typical for 4- to 5-year-olds. The six Sound Effects Study Focal Points were identified across the 124 drawings: body parts and facial expressions, talking and listening, relationships and connection, positivity, negativity, and no talking. Participants portrayed talking and listening as an action requiring mouths and ears represented by symbols (letters, speech bubbles) or as an activity with a variety of people. Children typically portrayed themselves as happy when talking; however, some portrayed negativity and some chose not to draw talking. Conclusions: In keeping with Articles 12 and 13 of the Convention on the Rights of the Child, this research demonstrated that 4- to 5-year-old children with SSD can express their views about talking via drawing. Professionals may use the Sound Effects Study Drawing Protocol as a child-friendly technique to support children to express views to guide holistic, evidence-based, child-centered speech-language pathology practice.
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- 2022
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16. Children’s drawings of student-teacher relationship quality: examining change over the first year of school
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Elizabeth Murray, Linda J. Harrison, and Tania Trapolini
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Social Psychology ,Developmental and Educational Psychology ,Pediatrics - Published
- 2022
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17. The Leadership Role of Australian Early Childhood Education Organizations in Communicating Health Information during COVID-19
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Sandie Wong, Lauren Sadow, Manjula Waniganayake, Yvonne Zurynski, Janaki Amin, Rebecca Bull, Maria R. Dahm, Sheila Degotardi, Michael J. Donovan, Fay Hadley, and Linda J. Harrison
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- 2023
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18. Free play predicts self-regulation years later: Longitudinal evidence from a large Australian sample of toddlers and preschoolers
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Yeshe Colliver, Linda J. Harrison, Judith E. Brown, and Peter Humburg
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Sociology and Political Science ,Developmental and Educational Psychology ,Education - Published
- 2022
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19. 881. Nasal and Plasma SARS-CoV-2 RNA Levels Predict Timing of Symptom Resolution in the ACTIV-2 Trial of Non-hospitalized Adults with COVID-19
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Yijia Li, Linda J Harrison, Kara W Chew, Joseph J Eron, Eric S Daar, David A Wohl, Ryan Wu, Carlee Moser, Justin Ritz, Mark Giganti, Arzhang Cyrus Javan, Robert Coombs, Michael D Hughes, Judith S Currier, Davey M Smith, and Jonathan Z Li
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Infectious Diseases ,Oncology - Abstract
Background Symptoms during acute COVID-19 can limit daily activities and delay return to work and school. Little is known about the association between SARS-CoV-2 burden in either the upper airway or plasma and the duration of COVID-19 symptoms. Methods ACTIV-2/A5401 is a platform trial for COVID-19 treatments in non-hospitalized symptomatic adults enrolled within 10 days of symptom onset. We included participants randomized to placebo from August 2020 to July 2021. Participants self-reported severity of 13 symptoms daily from day 0 (baseline) to 28 as Absent 0, Mild 1, Moderate 2, Severe 3; total symptom score was calculated as the sum of all scores. Anterior nasal (AN) and plasma SARS-CoV-2 RNA levels at day 0 were measured with a quantitative qPCR assay. The relationship between day 0 RNA and time to symptom improvement or resolution (first of 2 consecutive days of all symptoms improved or resolved from day 0, respectively) was evaluated using proportional hazards regression adjusted for time from symptom onset. Time to resolution of distinct symptoms was also assessed. Results Among 570 participants randomized to placebo, median age was 48 years, 51% were female, and median time since symptom onset at baseline was 6 days; 7% had prior COVID-19 vaccination. At day 0, AN RNA was detectable in 80% with a median of 4.1 log10 copies/ml (n=533, quartiles: 1.7, 6.0) and plasma RNA was detectable in 19% (91/476). Detectable plasma RNA at day 0, but not AN RNA, was associated with more severe symptoms at day 0 (2.4-point higher mean total symptom score, P=0.001). Both high AN (≥6 vs < 2 log10 copies/ml, adjusted hazard ratio [aHR] 0.63, P=0.001) and detectable plasma RNA (aHR 0.74, P=0.03) at day 0 predicted delayed symptom improvement. High AN RNA at day 0 also predicted a delay in symptom resolution (aHR 0.59, P=0.001). Both high AN RNA and detectable plasma RNA levels predicted delays in the resolution of cough and shortness of breath. Detectable plasma RNA also predicted delayed body pain resolution. Conclusion COVID-19 outpatients with high AN or detectable plasma SARS-CoV-2 RNA at day 0 are more likely to have prolonged symptoms, particularly respiratory symptoms. Additional studies are needed to determine whether the decline in viral load with early treatment impacts symptom duration. Disclosures Kara W. Chew, M.D., M.S., Merck Sharp & Dohme: Grant/Research Support|Pardes Bioscences: Advisor/Consultant Joseph J. Eron, MD, GSK: Advisor/Consultant|Merck: Advisor/Consultant Eric S. Daar, M.D., Gilead: Advisor/Consultant|Gilead: Grant/Research Support|Merck: Advisor/Consultant|ViiV: Advisor/Consultant|ViiV: Grant/Research Support David A. Wohl, M.D., Gilead: Advisor/Consultant|Gilead: Grant/Research Support|Lilly: Grant/Research Support|ViiV: Advisor/Consultant|ViiV: Grant/Research Support Judith S. Currier, M.D., MSc, Merck: Advisor/Consultant Davey M. Smith, M.D., M.A.S., Arena Pharmaceuticals: Advisor/Consultant|Bayer Pharmaceuticals: Advisor/Consultant|Brio Clinical.: Advisor/Consultant|Fluxergy: Advisor/Consultant|Kiadis: Advisor/Consultant|Linear Therapies: Advisor/Consultant|Matrix BioMed: Advisor/Consultant|Model Medicines: Advisor/Consultant|Signant Health: Advisor/Consultant|VxBiosciences: Advisor/Consultant Jonathan Z. Li, MD, MMSc, Abbvie: Advisor/Consultant|Merck: Grant/Research Support.
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- 2022
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20. Nasal and Plasma SARS-CoV-2 RNA Levels are Associated with Timing of Symptom Resolution in the ACTIV-2 Trial of Non-hospitalized Adults with COVID-19
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Yijia, Li, Linda J, Harrison, Kara W, Chew, Judy S, Currier, David A, Wohl, Eric S, Daar, Teresa H, Evering, Ryan, Wu, Mark, Giganti, Justin, Ritz, Arzhang Cyrus, Javan, Robert, Coombs, Carlee, Moser, Michael D, Hughes, Joseph J, Eron, Davey M, Smith, and Jonathan Z, Li
- Abstract
Acute COVID-19 symptoms limit daily activities, but little is known about its association with SARS-CoV-2 viral burden. In this exploratory analysis of placebo recipients in the ACTIV-2/A5401 platform trial, we showed that high anterior nasal (AN) RNA levels and detectable plasma RNA were associated with delayed symptom improvement.
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- 2022
21. Readability and beyond - Health literacy and numeracy and COVID-19 communications in Early Childhood Education: Are we communicating effectively?
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Maria R. Dahm, Rebecca Bull, Lauren Sadow, Dung Tran, Yvonne Zurynski, Janaki Amin, Fay Hadley, Linda J. Harrison, Manjula Waniganayake, Sandie Wong, and Sheila Degotardi
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General Medicine - Published
- 2023
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22. Flourishing on the margins: a study of babies and belonging in an Australian Aboriginal community childcare centre
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Linda J. Harrison, Jennifer Sumsion, Ben Bradley, Karen Letsch, and Andi Salamon
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- 2020
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23. Security issues and Ada runtime support.
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Linda J. Harrison
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- 1989
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24. HIV type-1 drug resistance in antiretroviral treatment-naive adults infected with non-B subtype virus in the United Kingdom
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Daniella N, Chilton, Hannah, Castro, Sam, Lattimore, Linda J, Harrison, Esther, Fearnhill, Valerie, Delpech, Brian, Rice, Deenan, Pillay, David T, Dunn, and Hongyi, Zhang
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Adult ,Male ,Nevirapine ,Anti-HIV Agents ,HIV Infections ,Drug resistance ,Biology ,Virus ,03 medical and health sciences ,0302 clinical medicine ,Acquired immunodeficiency syndrome (AIDS) ,Drug Resistance, Viral ,Prevalence ,medicine ,Humans ,Pharmacology (medical) ,030212 general & internal medicine ,Sida ,Pharmacology ,0303 health sciences ,030306 microbiology ,Transmission (medicine) ,medicine.disease ,biology.organism_classification ,Virology ,United Kingdom ,3. Good health ,Infectious Diseases ,Mutation ,Immunology ,Lentivirus ,HIV-1 ,Reverse Transcriptase Inhibitors ,Female ,Viral disease ,medicine.drug - Abstract
Background There is an increasing prevalence of non-B subtype HIV type-1 (HIV-1) infections in Europe, refecting patterns of migration. We examined the characteristics of HIV-1 drug resistance in antiretroviral treatment (ART)-naive individuals migrating to the UK. Methods Resistance tests reported to the UK HIV Drug Resistance Database between 2001 and 2006 were included. Demographic data were obtained via linkage to national databases. Resistance was defined as ≥1 drug resistance mutation. Non-B HIV-1 subtype was used as a surrogate marker of infection acquired outside the UK. Logistic regression was used to examine the association between demographics and the prevalence of resistance. Results Overall, 196/4,291 (4.6%) samples with non-B subtype showed resistance compared with 745/6,435 (11.6%) samples for subtype B. Among non-B subtypes, the prevalence of resistance decreased over time (6.0% in 2001–2003 to 3.2% in 2006) and was independently associated with later calendar year of sampling ( P=0.001). Resistance was confined mainly to one ART class (85%); non-nucleoside reverse transcriptase inhibitor resistance was more common in subtype C (47%) compared with non-B non-C subtypes (29%; P=0.02). M184V was more common in non-B subtypes (non-B 30% versus B 5%; PConclusions In ART-naive individuals living in the UK, but who are likely to have acquired HIV-1 abroad, we observed a downward trend in resistance over time, which is surprising in light of ART roll-out in resource-limited settings. Reassuringly, resistance was mainly confined to one drug class; however, patterns of resistance differed by subtype, with some evidence of possible undisclosed prior therapy in non-B subtypes.
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- 2010
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25. Lived Spaces of Infant-Toddler Education and Care : Exploring Diverse Perspectives on Theory, Research and Practice
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Linda J. Harrison, Jennifer Sumsion, Linda J. Harrison, and Jennifer Sumsion
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- Educational psychology, Early childhood education
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This book conceptualizes the ‘lived spaces'of infant and toddler early education and care settings by bringing together international authors researching within diverse theoretical frameworks. It highlights diverse ways of understanding the experiences of very young children by exposing the ways that the authors are grappling with the unknown. The work explores broadly the construct and meanings of ‘lived spaces'as relational spaces, interactional spaces, transitional spaces, curriculum spaces or pedagogical spaces operating within the social, physical and temporal environment of infant-toddler education settings. The book invites interchange between and among diverse theories and approaches and through this build new understanding of infants'and toddlers'experiences and interactions in early education and care settings. It also considers the implications of this work for policy and practice in infant and toddler education and care.
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- 2014
26. Maternal employment and infant-mother attachment security at 12 months postpartum
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Linda J. Harrison and Judy A. Ungerer
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Developmental and Educational Psychology ,Life-span and Life-course Studies ,Demography - Published
- 2002
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27. Proceedings from the Workshop on Issues of Integrity and Security in an ADA Runtime Environment Held in Orlando, Florida on 3-5 April 1990
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Linda J. Harrison, Sue LeGrand, Jon Shultis, John McHugh, and William R. Worger
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World Wide Web ,Ada ,Computer science ,Computer security ,computer.software_genre ,Working group ,computer ,computer.programming_language - Abstract
This document provides a summary of the results of the 1990 Workshop on issues of Integrity and Security in an Ada Runtime Environment, which was held April 3-5, 1990 in Orlando, Florida. This section provides a background on the workship and an introduction to each of the working groups. Appendix A is a compilation of the position papers that the conference attendees submitted. Appendix B contains the preliminary review of the current Catalog of Implementation Features and Options (CIFO) from a security perspective. The CIFO review, which was held as an evening meeting, was attended by a few of the workshop participants. Appendix C is a list of names and addresses of all the workship participants. The objectives of this Workshop were: (1) to identify and discuss the security and integrity issues related to the Ada runtime environment; and (2) to bring together and create some synergy among the security/integrity and Ada specialists in order to adequately address security and integrity issues related to the Ada runtime environment.
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- 1990
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