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11 results on '"Linares, Jenniffer"'

2. Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy

Author

Linares, Jenniffer, Sallent-Aragay, Anna, Badia-Ramentol, Jordi, Recort-Bascuas, Alba, Méndez, Ana, Manero-Rupérez, Noemí, Re, Daniele Lo, Rivas, Elisa I., Guiu, Marc, Zwick, Melissa, Iglesias, Mar, Martinez-Ciarpaglini, Carolina, Tarazona, Noelia, Varese, Monica, Hernando-Momblona, Xavier, Cañellas-Socias, Adrià, Orrillo, Mayra, Garrido, Marta, Saoudi, Nadia, Elez, Elena, Navarro, Pilar, Tabernero, Josep, Gomis, Roger R., Batlle, Eduard, Pisonero, Jorge, Cervantes, Andres, Montagut, Clara, and Calon, Alexandre

Published
2023
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4. Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+ breast tumors

Author

Rivas, Elisa I., Linares, Jenniffer, Zwick, Melissa, Gómez-Llonin, Andrea, Guiu, Marc, Labernadie, Anna, Badia-Ramentol, Jordi, Lladó, Anna, Bardia, Lídia, Pérez-Núñez, Iván, Martínez-Ciarpaglini, Carolina, Tarazona, Noelia, Sallent-Aragay, Anna, Garrido, Marta, Celià-Terrassa, Toni, Burgués, Octavio, Gomis, Roger R., Albanell, Joan, and Calon, Alexandre

Published
2022
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5. Unveiling acquired resistance to anti-EGFR therapies in colorectal cancer: a long and winding road.

Author

Ríos-Hoyo, Alejandro, Monzonís, Xavier, Vidal, Joana, Linares, Jenniffer, and Montagut, Clara

Subjects
COLORECTAL cancer, CIRCULATING tumor DNA, CANCER treatment, PANITUMUMAB, METASTASIS
Abstract

Emergence of acquired resistance limits the efficacy of the anti-EGFR therapies cetuximab and panitumumab in metastatic colorectal cancer. In the last decade, preclinical and clinical cohort studies have uncovered genomic alterations that confer a selective advantage to tumor cells under EGFR blockade, mainly downstream re-activation of RAS-MEK signaling and mutations in the extracellular domain of EGFR (EGFR-ECD). Liquid biopsies (genotyping of ctDNA) have been established as an excellent tool to easily monitor the dynamics of genomic alterations resistance in the blood of patients and to select patients for rechallenge with anti-EGFR therapies. Accordingly, several clinical trials have shown clinical benefit of rechallenge with anti-EGFR therapy in genomically-selected patients using ctDNA. However, alternative mechanisms underpinning resistance beyond genomics -mainly related to the tumor microenvironment-have been unveiled, specifically relevant in patients receiving chemotherapy-based multi-drug treatment in first line. This review explores the complexity of the multifaceted mechanisms that mediate secondary resistance to anti-EGFR therapies and potential therapeutic strategies to circumvent acquired resistance. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy

Author

Fundación Científica Asociación Española Contra el Cáncer, Instituto de Salud Carlos III, European Commission, Ministerio de Economía y Competitividad (España), Fundación la Caixa, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Linares, Jenniffer, Sallent-Aragay, Anna, Badia-Ramentol, Jordi, Recort-Bascuas, Alba, Méndez, Ana, Manero-Rupérez, Noemí, Re, Daniele Lo, Rivas, Elisa I., Guiu, Marc, Zwick, Melissa, Iglesias, Mar, Martinez-Ciarpaglini, Carolina, Tarazona, Noelia, Varese, Monica, Hernando-Momblona, Xavier, Cañellas-Socias, Adrià, Orriols, Mayra, Garrido, Marta, Saoudi, Nadia, Elez, Elena, Navarro Medrano, Pilar, Tabernero, Josep, Gomis, Roger R., Batlle, Eduard, Pisonero, Jorge, Cervantes, Andrés, Montagut, Clara, Calon, Alexandre, Fundación Científica Asociación Española Contra el Cáncer, Instituto de Salud Carlos III, European Commission, Ministerio de Economía y Competitividad (España), Fundación la Caixa, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Linares, Jenniffer, Sallent-Aragay, Anna, Badia-Ramentol, Jordi, Recort-Bascuas, Alba, Méndez, Ana, Manero-Rupérez, Noemí, Re, Daniele Lo, Rivas, Elisa I., Guiu, Marc, Zwick, Melissa, Iglesias, Mar, Martinez-Ciarpaglini, Carolina, Tarazona, Noelia, Varese, Monica, Hernando-Momblona, Xavier, Cañellas-Socias, Adrià, Orriols, Mayra, Garrido, Marta, Saoudi, Nadia, Elez, Elena, Navarro Medrano, Pilar, Tabernero, Josep, Gomis, Roger R., Batlle, Eduard, Pisonero, Jorge, Cervantes, Andrés, Montagut, Clara, and Calon, Alexandre

Abstract

A substantial proportion of cancer patients do not benefit from platinum-based chemotherapy (CT) due to the emergence of drug resistance. Here, we apply elemental imaging to the mapping of CT biodistribution after therapy in residual colorectal cancer and achieve a comprehensive analysis of the genetic program induced by oxaliplatin-based CT in the tumor microenvironment. We show that oxaliplatin is largely retained by cancer-associated fibroblasts (CAFs) long time after the treatment ceased. We determine that CT accumulation in CAFs intensifies TGF-beta activity, leading to the production of multiple factors enhancing cancer aggressiveness. We establish periostin as a stromal marker of chemotherapeutic activity intrinsically upregulated in consensus molecular subtype 4 (CMS4) tumors and highly expressed before and/or after treatment in patients unresponsive to therapy. Collectively, our study underscores the ability of CT-retaining CAFs to support cancer progression and resistance to treatment.

Published
2023

7. Peptide–Platinum(IV) Conjugation Minimizes the Negative Impact of Current Anticancer Chemotherapy on Nonmalignant Cells

Author

Linares, Jenniffer, primary, Varese, Monica, additional, Sallent-Aragay, Anna, additional, Méndez, Ana, additional, Palomo-Ponce, Sergio, additional, Iglesias, Mar, additional, Batlle, Eduard, additional, Pisonero, Jorge, additional, Montagut, Clara, additional, Giralt, Ernest, additional, Lo Re, Daniele, additional, and Calon, Alexandre, additional

Published
2023
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