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Anthocyanins, vital metabolites in plants, are formed by anthocyanidins combined with various monosaccharides, including glucose, rhamnose, and arabinose. Rhamnose contributes greatly to the glycosylation of anthocyanidins. There are two kinds of rhamnose synthase (RS): rhamnose biosynthesis (RHM), and nucleotide-RS/epimerase-reductase (UER1). Nevertheless, no RS isoform was reported to be involved in anthocyanin synthesis. Here, three homologous PhRHM genes, namely PhRHM1, PhRHM2, and PhRHM3, and one PhUER1 gene from petunia were cloned and characterized. Green fluorescent protein fusion protein assays revealed that PhRHMs and PhUER1 are localized in the cytoplasm. We obtained PhRHM1 or/and PhRHM2 or PhUER1 silenced petunia plants and did not attempt to obtain PhRHM3 silenced plants since PhRHM3 mRNA was not detected in petunia organs examined. PhRHM1 and PhRHM2 (PhRHM1-2) silencing induced abnormal plant growth and decreased the contents of l-rhamnose, photosynthetic pigments and total anthocyanins, while PhUER1 silencing did not cause any visible phenotypic changes. Flavonoid metabolome analysis further revealed that PhRHM1-2 silencing reduced the contents of anthocyanins with rhamnose residue. These results revealed that PhRHMs contribute to the biosynthesis of rhamnose and that PhRHMs participate in the anthocyanin rhamnosylation in petunia, while PhUER1 does not.

Cytosolic acetyl-CoA is an intermediate of the synthesis of most secondary metabolites and the source of acetyl for protein acetylation. The formation of cytosolic acetyl-CoA from citrate is catalysed by ATP-citrate lyase (ACL). However, the function of ACL in global metabolite synthesis and global protein acetylation is not well known. Here, four genes, PaACLA1, PaACLA2, PaACLB1, and PaACLB2, which encode the ACLA and ACLB subunits of ACL in Petunia axillaris, were identified as the same sequences in Petunia hybrida ‘Ultra’. Silencing of PaACLA1-A2 and PaACLB1-B2 led to abnormal leaf and flower development, reduced total anthocyanin content, and accelerated flower senescence in petunia ‘Ultra’. Metabolome and acetylome analysis revealed that PaACLB1-B2 silencing increased the content of many downstream metabolites of acetyl-CoA metabolism and the levels of acetylation of many proteins in petunia corollas. Mechanistically, the metabolic stress induced by reduction of acetyl-CoA in PaACL-silenced petunia corollas caused global and specific changes in the transcriptome, the proteome, and the acetylome, with the effect of maintaining metabolic homeostasis. In addition, the global proteome and acetylome were negatively correlated under acetyl-CoA deficiency. Together, our results suggest that ACL acts as an important metabolic regulator that maintains metabolic homeostasis by promoting changes in the transcriptome, proteome. and acetylome., PaACL silencing reduced anthocyanin contents, accelerated flower senescence, and changed the proteome and acetylome to maintain metabolic homeostasis in petunia

It is well known that the existence of interstitial Fe is a great obstacle to enhancing the superconducting properties of the Fe(Se, Te) system. In this work, a silver and oxygen codoping effect toward enhancement of the superconductivity and flux pinning in Fe(Se, Te) bulks is reported. The oxygen ions from SeO

The effects of carbon fiber additions on the electrical and thermoelectric performance in p-type CoSb3-based skutterudite are reported. A threefold enhancement in electrical conductivity is found. Two different explanations for the increased electrical conductivity are considered: Either carbon atoms enter the CoSb3 lattice as a dopant that makes it more and more conductive, or the increase in conductivity is due to electrical percolation of the carbon fibers in the composite. X-ray diffraction data show that the lattice parameter of the CoSb3 is not affected by the presence of the carbon fiber; however, adding carbon is associated with precipitation of 20 wt. % elemental Sb. DFT calculations show that the enthalpy of formation of a solid solution of carbon (interstitial or as a substitution for Sb) is slightly positive. This would be offset by an increased entropy contribution at higher temperatures, so the free energy change overall is likely to be favorable. All of the results support an explanation based on an improved electrical conductivity of a very dilute solid solution of C in CoSb3. The average thermoelectric parameters of the composite material, including heat conductivity, average composite Seebeck coefficient, Hall effect, carrier mobility, and carrier concentration, were influenced by the carbon addition. Unfortunately, the effects largely cancel each other so that the overall zT of the composite was not improved.

We study the structural and bulk superconducting properties of self-flux grown PdBi2Te3 single crystal. Phase purity of as grown crystal is confirmed by Rietveld refinement of gently crushed powder XRD of the same. PdBi2Te3 crystallizes in rhombohedral structure with R-3 m space group along with small impurity of Bi. Scanning electron microscopy (SEM) images showed layered structure and the elemental analysis by energy dispersive X-ray analysis (EDAX) done on same confirmed the stoichiometry to be near to PdBi2Te3. Characteristic vibrational modes, viz., A11g, Eg2, and A21g, are clearly observed in Raman spectrum and are slightly shifted from that as in case of Bi2Te3. Bulk superconductivity is confirmed by FC and ZFC magnetization measurements (M-T) exhibiting diamagnetic transition with Tconset at around 6 K. M-H plots at different temperatures of 2 K, 2.5 K, 3 K, 3.5 K, 4 K, 4.5 K, 5 K, and 6 K showed clear opening of the loop right up to 6 K. Both M-T and M-H clearly establish the appearance of bulk type II superconductivity below 6 K in studied PdBi2Te3. The lower critical field Hc1 and upper critical field Hc2 are at 180 Oe at 4800 Oe, respectively, at 2 K for as grown PdBi2Te3 crystal. Other critical parameters of superconductivity such as coherence length, penetration depth and kappa parameter are also calculated.

We report crystal growth and below 2.5K superconductivity of Nb0.25Bi2Se3. These crystals are grown by self-flux method. The X-ray diffraction (XRD) pattern of a grown crystal flake shows (00l) plane (c-orientation) growth. The Rietveld refinement of crushed crystal powder XRD (PXRD) pattern confirms the phase purity of the studied sample having R-3m space group of rhombohedral crystalline structure. The Raman spectrum of the studied Nb0.25Bi2Se3 crystal distinctly shows three well-defined vibrational modes in terms of A11g, Eg2, and A21g at around 72, 129, and 173 cm−1, which are slightly shifted in comparison with pure Bi2Se3. Magnetization studies in terms of field cooled (FC) and zero field cooled (ZFC) magnetic susceptibility measurements show the diamagnetic transition (Tconset) of the compound at around 2.5K and near saturation of the same below around 2.1K. The isothermal magnetization (MH) being taken at 2K revealed the lower critical field (Hc1) of around 50 Oe and the upper critical field (Hc2) of 900 Oe. It is clear that the studied Nb0.25Bi2Se3 is a bulk superconductor. The superconducting critical parameters thus calculated, viz the coherence length, upper and lower critical fields, and superconducting transition temperature for a grown Nb0.25Bi2Se3 single crystal are reported here.

We report the first study on the significant effect of in-situ hydrostatic pressure on the magnetic relaxation in Fe 1− x Co x Se 0.5 Te 0.5 single crystals. We find that vortex creep rates are significantly suppressed by pressure, and a crossover from elastic to plastic creep is observed. The pressure also induces vortex creep to move from the large bundle to the small bundle region. Our study indicates that in-situ hydrostatic pressure is very effective for not only significantly increasing the pinning energy and the critical current density, but also reducing the size of flux bundles to suppress the decrease in current density from vortex motion.

The time-dependent Ginzburg–Landau equations have been solved numerically by a finite element method for a hybrid system consisting of a finite-size superconducting film with a magnetic strip on top. It is demonstrated that the coexistence of vortices and antivortices could occur in the mesoscopic superconducting film due to the important influence of the magnetic strip, which could help us to understand the experimental results.

Fluorine-doped Fe(Se, Te) has been successfully synthesized using the melting method. A dual-oscillation effect was found in the F-doped sample, which combined both microstructural oscillation and chemical compositional oscillation. The microstructural oscillation could be attributed to alternate growth of tetragonal β-Fe(Se, Te) and hexagonal δ-Fe(Se, Te), which formed a pearlite-like structure and led to the enhancement of δ l flux pinning due to the alternating distributed nonsuperconducting δ-Fe(Se, Te) phase. The chemical compositional oscillations in β-Fe(Se, Te) phase were because of the inhomogeneously distributed Se and Te, which changes the pinning mechanism from surface pinning in the undoped sample to Δκ pinning in the 5% F-doped one. As a result, the critical current, upper critical field, and thermally activated flux-flow activation energy of FeSe0.45Te0.5F0.05 were enhanced by 7, 2, and 3 times, respectively. Our work revealed the physical insights into F-doping resulting in high-performance Fe(Se, Te) superconductors and inspired a new approach to optimize superconductivities in iron-based superconductors through phase and element manipulations.

N6-methyladenosine (m

In this article, we report the occurrence of superconductivity in Sn0.4Sb0.6 single crystal at below 4K. Rietveld refined Powder XRD data confirms the phase purity of as grown crystal, crystallizing in rhombohedral R-3m space group with an elongated (2xc) unit cell in c-direction. Scanning Electron Microscope (SEM) image and EDAX measurement confirm the laminar growth and near to desired stoichiometry ratio. Raman Spectroscopy data shows the vibrational modes of Sn-Sb and Sb-Sb modes at 110 and 135cm-1. ZFC (Zero-Field-Cooled) magnetization measurements done at 10Oe showed sharp superconducting transitions at 4K along with a minor step at 3.5K. On the other hand, Paramagnetic Meissner Effect (PME) is observed in FC measurements. Magnetization vs applied field (M-H) plots at 2, 2.2, 2.5, 2.7, 3, 3.2, 3.5, and 3.7K shows typical Type-II nature of observed superconductivity with lower and upper critical fields (Hc1 and Hc2) at 69.42Oe and 630Oe respectively at 2K. Type-II superconductivity is also confirmed by calculated Ginzburg-Landau Kappa parameter value of 3.55. Characteristics length viz. coherence length and penetration depth are also calculated. Weak granular coupling is observed from R-T plot, in which resistance is not dropping to zero down to 2K., 21 Pages Text + Figs

Zone-melted Bi2Te2.7Se0.3 (ZM BTS) alloys are typical n-type commercial thermoelectric (TE) materials and are utilized for refrigeration and power generation near room temperature. They usually suffer from poor mechanical performance, as well as having a low figure of merit (ZT). In this work, we report an effective composite strategy to improve both the TE and mechanical performance of n-type BTS materials by incorporating carbon microfibers. The introduction of carbon microfibers in BTS effectively reduces the lattice thermal conductivity due to phonon scattering at multi-scale boundaries and due to the large interfacial thermal resistance arising from phonon mismatch between the constituent phases. Simultaneously, it also gives rise to an enhancement of the electrical conductivity, which originates from the increased carrier density without significant limitation on its weighted mobility. Consequently, a high peak ZT of 1.1 at 400 K and an average ZTave value of 0.95 are achieved in the temperature range 300 ~ 550 K, yielding a calculated efficiency of η = 9%. Moreover, the BTS/carbon microfiber composites show superior compressive strength compared to a commercial ZM BTS sample. This improved strength is highly desirable for real-world TE applications. Our results demonstrate a novel way to produce high-performance TE materials, in which interfaces with large thermal resistance are used to achieve low thermal conductivity without significantly degrading the electrical properties of the materials.

The investigations into the interfaces in iron selenide (FeSe) thin films on various substrates have manifested the great potential of showing high-temperature-superconductivity in this unique system. In present work, we obtain FeSe thin films with a series of thicknesses on calcium fluoride (CaF2) (100) substrates and glean the detailed information from the FeSe/CaF2 interface by using scanning transmission electron microscopy (STEM). Intriguingly, we have found the universal existence of a calcium selenide (CaSe) interlayer with a thickness of approximate 3 nm between FeSe and CaF2 in all the samples, which is irrelevant to the thickness of FeSe layers. A slight Se deficiency occurs in the FeSe layer due to the formation of CaSe interlayer. This Se deficiency is generally negligible except for the case of the ultrathin FeSe film (8 nm in thickness), in which the stoichiometric deviation from FeSe is big enough to suppress the superconductivity. Meanwhile, in the overly thick FeSe layer (160 nm in thickn...

Substrate engineering is very significant in the synthesis of the high-temperature superconductor (HTS) coated conductor. Here we design and synthesize several distinct and stable Cerium oxide (CeO 2 ) surface reconstructions which are used to grow epitaxial films of the HTS YBa 2 Cu 3 O 7-δ (YBCO). To identify the influence of annealing and post-annealing surroundings on the nature of nucleation centers, including Ar/5%H 2 , humid Ar/5%H 2 and O 2 in high temperature annealing process, we study the well-controlled structure, surface morphology, crystal constants and surface redox processes of the ceria buffers by using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and field-emission scanning electronic microscopy (FE-SEM), respectively. The ceria film post-annealed under humid Ar/5%H 2 gas shows the best buffer layer properties. Furthermore, the film absorbs more oxygen ions, which appears to contribute to oxygenation of superconductor film. The film is well-suited for ceria model studies as well as a perfect substitute for CeO 2 bulk material.

Thermoelectric (TE) materials have attracted extensive interest because of their ability to achieve direct heat-to-electricity conversion. They provide an appealing renewable energy source in a variety of applications by harvesting waste heat. The record-breaking figure of merit reported for single crystal SnSe has stimulated related research on its polycrystalline counterpart. Boosting the TE conversion efficiency requires increases in the power factor and decreases in thermal conductivity. It is still a big challenge, however, to optimize these parameters independently because of their complex interrelationships. Herein, we propose an innovative approach to decouple electrical and thermal transport by incorporating carbon fiber (CF) into polycrystalline SnSe. We show that the incorporation of highly conductive CF can successfully enhance the electrical conductivity, while greatly reducing the thermal conductivity of polycrystalline SnSe. As a result, a high TE figure-of-merit (zT) of 1.3 at 823 K is obtained in p-type SnSe/CF composite polycrystalline materials. Furthermore, SnSe samples incorporated with CFs exhibit superior mechanical properties, which are favorable for device fabrication applications. Our results indicate that the dispersion of CF can be a good way to greatly improve both TE and mechanical performance.

In recent years, atomically thin superconductors, including atomically thin elemental superconductors, single layer FeSe films, and few-layer cuprate superconductors, have been studied extensively. This hot research field is mainly driven by the discovery of significant superconductivity enhancement and high-temperature interface superconductivity in single-layer FeSe films epitaxially grown on SrTiO3 substrates in 2012. This study has attracted tremendous research interest and generated more studies focusing on further enhancing superconductivity and finding the origin of the superconductivity. A few years later, research on atomically thin superconductors has extended to cuprate superconductors, unveiling many intriguing properties that have neither been proposed or observed previously. These new discoveries challenge the current theory regarding the superconducting mechanism of unconventional superconductors and indicate new directions on how to achieve high-transition-temperature superconductors. Herein, this exciting recent progress is briefly discussed, with a focus on the recent progress in identifying new atomically thin superconductors.

Acute myeloid leukemia (AML) is a heterogenous disease and the survival of AML patients is largely attributed to the improvement of supportive treatment. Wilms' tumor 1-associated protein (WTAP) is a nuclear protein functions in many physiological and pathological processes. Although its expression and function in many malignant diseases have been reported, its prognostic and epigenetic roles in AML are largely unknown.Peripheral blood or bone marrow samples were collected from AML patients. The WTAP expression was detected by western blot. WTAP expression level and patients clinical features were analyzed using statistical methods. WTAP knockdown AML cells were constructed. The experiments on proliferation, tumorigenic ability, cell cycle, and apoptosis were performed. Transcriptome sequencing was performed and analyzed. MWTAP was overexpressed in AML patients and was an independent poor-risk factor in AML (p = 0.0140). Moreover, we found that WTAP regulated proliferation, tumorigenesis, cell cycle, and differentiation of AML cells. Furthermore, WTAP made AML cells resistant to daunorubicin. In further investigations, mHigh WTAP expression predicts poor prognosis in AML and WTAP plays an epigenetic role in AML.

Since the discovery of iron-based superconductors, a new chapter has been opened in the history of the development of high temperature superconductivity. In the past decade, there have been remarkable achievements in the theory, experiments, and applications of iron-based superconductors, and our understanding of the mechanism of superconductivity has been deeply enriched. Here, we review the research progress on high-pressure studies on the superconductivity, flux pinning, and vortex dynamics of iron-based superconductor families. The topics include pressure-induced superconductivity, raising the superconducting transition temperature, pressure-induced elimination and re-emergence of superconductivity, the effects of phase separation on superconductivity, increasing the critical current density, significantly suppressing vortex creep, and reducing the size of the flux bundles.

Anthocyanins are important flavonoid pigments in plants. Malonyl CoA is an important intermediate in anthocyanin synthesis, and citrate, formed by citrate synthase (CS) catalysing oxaloacetate, is the precursor for the formation of malonyl-CoA. CS is composed of two isoforms, mitochondrial citrate synthase (mCS), a key enzyme of the tricarboxylic acid (TCA) cycle, and citrate synthase (CSY) localizated in microbodies in plants. However, no CS isoform involvement in anthocyanin synthesis has been reported. In this study, we identified the entire CS family in petunia (Petunia hybrida): PhmCS, PhCSY1 and PhCSY2. We obtained petunia plants silenced for the three genes. PhmCS silencing resulted in abnormal development of leaves and flowers. The contents of citrate and anthocyanins were significantly reduced in flowers in PhmCS-silenced plants. However, silencing of PhCSY1 and/or PhCSY2 did not cause a visible phenotype change in petunia. These results showed that PhmCS is involved in anthocyanin synthesis and the development of leaves and flowers, and that the citrate involved in anthocyanin synthesis mainly derived from mitochondria rather than microbodies in petunia.

We report a comprehensive study of magneto-transport properties in MoSi$_2$ bulk and thin films. Textured MoSi$_2$ thin films of around 70 nm were deposited on silicon substrates with different orientations. Giant magnetoresistance of 1000% was observed in sintered bulk samples while MoSi$_2$ single crystals exhibit a magnetoresistance (MR) value of 800% at low temperatures. At the low temperatures, the MR of the textured thin films show weak anti-localization behaviour owing to the spin orbit coupling effects. Our first principle calculation show the presence of surface states in this material. The resistivity of all the MoSi$_2$ thin films is significantly low and nearly independent of the temperature, which is important for electronic devices.

Surface morphology evolution of the trifluoroacetate metal-organic precursor for YBa2Cu3O 7−δ during pyrolysis was observed by in situ optical microscopy, and a mechanism was proposed based on an analogy to the gel-swelling-induced surface instability. The cracking and wrinkling phenomena were ascribed to the competition between reaction and diffusion. The critical condition for wrinkling was obtained, and the dependence between the heating ramp and the surface morphology was identified. Experiments showed that three types of cracks existed, and one of them exhibited healing behavior during drying. The wrinkles may exhibit healing behavior as well under certain condition. These results are believed to arise from the suppression of the precursor surface instability during pyrolysis treatment, which is relevant to the manufacturing of the coated conductor.

We study magneto-transport phenomena in two rare-earth doped topological insulators, SmxFexSb2-2xTe3 and SmxBi2-xTe2Se single crystals. The magneto-transport behaviours in both compounds exhibit a novel crossover between weak anti-localization (positive magnetoresistance) and weak localization (negative magnetoresistance) with changes in temperatures and magnetic fields. The weak localization is caused by rare-earth-doping induced magnetization, and the weak anti-localization originates from topologically protected surface states. The transition from weak localization to weak anti-localization demonstrates a gap opening at the Dirac point of the surface states in the quantum diffusive regime. This work demonstrates an effective way to manipulate the magneto-transport properties of the topological insulators by rare-earth element doping. Magnetometry measurements indicate that the Sm-dopant alone is paramagnetic, whereas the co-doped Fe-Sm state has short-range antiferromagnetic order. Our results demonstrate the potential to realize exotic topological effects and magneto-electric effects in gapped surface states of rare earth doped topological insulators.

Cytosolic acetyl-CoA is an intermediate of the synthesis of most secondary metabolites and the source of acetyl for protein acetylation. The formation of cytosolic acetyl-CoA from citrate is catalysed by ATP-citrate lyase (ACL). However, the function of ACL in global metabolite synthesis and global protein acetylation is not well known. Here, four genes, PaACLA1, PaACLA2, PaACLB1, and PaACLB2, which encode the ACLA and ACLB subunits of ACL in Petunia axillaris, were identified as the same sequences in Petunia hybrida 'Ultra'. Silencing of PaACLA1-A2 and PaACLB1-B2 led to abnormal leaf and flower development, reduced total anthocyanin content, and accelerated flower senescence in petunia 'Ultra'. Metabolome and acetylome analysis revealed that PaACLB1-B2 silencing increased the content of many downstream metabolites of acetyl-CoA metabolism and the levels of acetylation of many proteins in petunia corollas. Mechanistically, the metabolic stress induced by reduction of acetyl-CoA in PaACL-silenced petunia corollas caused global and specific changes in the transcriptome, the proteome, and the acetylome, with the effect of maintaining metabolic homeostasis. In addition, the global proteome and acetylome were negatively correlated under acetyl-CoA deficiency. Together, our results suggest that ACL acts as an important metabolic regulator that maintains metabolic homeostasis by promoting changes in the transcriptome, proteome. and acetylome.

Unlike monolayer Fe-Chalcogenide (Fe-Ch)/SrTiO3 (STO), which possesses the potential for high-temperature superconductivity (HTS), a regular Fe-Ch thin film grown on a non-STO substrate by the pulsed laser deposition method shows totally different superconducting behavior and a different mechanism. Although regular Fe-Ch thick films grown on CaF2 generally show the highest superconducting transition temperature (Tc) compared with any other substrates, the disappearance of superconductivity always takes place when the thickness of the Fe-Ch film is reduced to a critical value (∼20nm for Fe-Se and ∼30nm for Fe-Se-Te) with the reason still under debate. Here, we report an enhanced Tc≈17.6K in a 7-nm-FeTe/7-nm-FeSe bilayer heterostructure grown on CaF2 substrate. Generally, the Fe-Ch film on CaF2 is supposed to be one order of magnitude greater in thickness to achieve similar performance. Hall measurements manifest the dominant nature of hole-type carriers in the films in this work, which is similar to the case of a pressurized bulk FeSe single crystal, while in sharp contrast to heavily electron-doped HTS Fe-Ch systems. According to the electron energy loss spectroscopy results, we observed direct evidence of nanoscale phase separation in the form of a fluctuation of the Fe-L3/L2 ratio near the FeTe/FeSe interface. In detail, a several-unit-cell-thick Fe(Se,Te) diffusion layer shows a higher Fe-L3/L2 ratio than either an FeTe or an FeSe layer, indicating low Fe 3d electron occupancy, which is, to some extent, consistent with the hole-dominant scenario obtained from the Hall results. It also implies a possible relationship between the state of Fe 3d electron occupancy and the enhanced Tc in this work. Our work clarifies the importance of the FeTe/FeSe interface in reviving the superconductivity in Fe-Ch ultrathin films, contributing to a more unified understanding of unconventional Fe-Ch superconductivity.

Halogen doped Fe(Se, Te) superconducting materials were successfully synthesized through the eutectic transformation method. Both the distribution and morphology of the secondary hexagonal phase were tuned accordingly by substituting halogen elements. The morphology of the hexagonal phase was transformed from plate-like lamellar to agglomerated dots or bulk precipitates as the doping elements changed from F to Cl and Br. Moreover, the flux pinning mechanism, which represents the ability of materials to trap the penetrating magnetic field, was observed to change from Δκ to point pinning when doped by elements with heavier atomic mass. As a result, tremendous optimization of the critical current, upper critical field, and thermally activated flux flow activation energy were achieved in the as-prepared samples, with a specific value of 7 times, 2 times, and 3 times, respectively, in FeSe0.45Te0.5F0.05 compared with the values for the undoped sample. Our results reveal that the light-halogen element doping is a promising way to optimize the superconductivities in the Fe(Se, Te) systems and inspire us to manipulate the morphology of secondary phase to boost the superconductivities in iron-based superconductors.

Similar to DNA methylation modifications, N6-methyladenine (m6A) has been identified as a dynamic and reversible modification in messenger RNA (mRNA), regulated by m6A methyltransferases and demethylases. m6A modifications regulate gene expressions and play vital roles in many life processes. Some proteins serve as m6A-binding proteins to perform the m6A-modified biological functions. Recently, m6A modifications have been reported to play critical roles in human cancers, including lung cancer, brain tumor, leukemia, and many others. In this comprehensive review, we have described the roles played by m6A modifications of mRNA in the development of cancers. These modifications appear to have an oncogenic role in some cancers while a tumor-suppressor role in others. Therefore, it would be of great significance to study the biological functions of genes regulated by m6A in different cancers and identify the key m6A target genes to understand the potential mechanism underlying the pathogenesis of cancer.

The investigations into the interfaces in iron selenide (FeSe) thin films on various substrates have manifested the great potential of showing high-temperature-superconductivity in this unique system. In present work, we obtain FeSe thin films with a series of thicknesses on calcium fluoride (CaF

We have carried out a detailed investigation of the magnetism, valence state, and magnetotransport in VSe

We have carried out a detailed investigation of the magnetism, valence state, and magnetotransport in VSe2 bulk single crystals, as well as in laminates obtained by mechanical exfoliation. In sharp contrast to the ferromagnetic behavior reported previously, here, no ferromagnetism could be detected for VSe2 single crystal and laminate from room temperature down to 2 K. Neither did we find the Curie paramagnetism expected due to the 3d 1 odd-electronic configuration of covalent V4+ ions. Rather, intrinsic VSe2 is a non-magnetic alloy without local moment. Only a weak paramagnetic contribution introduced by defects is noticeable below 50 K. A weak localization effect due to defects was also observed in VSe2 single crystals for the first time.

Thick high-Tc superconducting films consisting of a YBa2Cu3O7−δ/GdBa2Cu3O7−δ periodic architecture are developed on oxid-buffered Hastelloy tapes using a pulsed laser deposition process. It is revealed that multilayer intermittent structures for superconducting layers are effective to avoid the presence of a-axis grains and microcracks that occur with increasing thickness, which are frequently observed in monolayer films of REBa2Cu3O7−δ (RE = Y, Gd, or other rare earths), such grains and cracks being the significant challenge for obtaining high critical current in coated conductors. Presently, the thicknesses of multilayer films vary from 0.5 μm to 3 μm and, based on the SEM images and x-ray φ-scans, hardly show the influences on the microstructures and grain orientation of the c-axis. Also, the characteristic Raman spectrum patterns and their shifting with increasing the thickness of YBCO/GdBCO imply that the superior texture is obtained due to the evolution of stress dominated by the compressive stress rather than tensile stress.