14 results on '"Lina Ibrahim"'
Search Results
2. Observational cohort study of perinatal outcomes of women with COVID-19
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Sami Al-Hajjar, Lina Ibrahim, Wesam Kurdi, Maha Tulbah, Maha Alnemer, Mohammed Bin Jabr, Weam Elsaidawi, Abdulaziz Binmanee, Mohanned Ali, Hanifa Bukhari, Leena Altuwaijri, Raneem Allaboon, Reem Alghamdi, Bashayer Saeed, Yasser Adi, and Fatima Alhamlan
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Coronavirus ,Pregnancy ,COVID-19 ,Neonatal ,Infectious and parasitic diseases ,RC109-216 ,Public aspects of medicine ,RA1-1270 - Abstract
Background: Understanding the impact of SARS-CoV-2 infection on pregnancy outcomes and of pregnancy on COVID-19 outcomes is critical for ensuring proper prenatal and antenatal care. No similar studies have been published in Saudi Arabia. Methods: We performed a prospective cohort study of pregnant women with confirmed SARS-CoV-2 infection who presented at King Faisal Specialist Hospital and Research Center (KFSHRC) in Riyadh, Kingdom of Saudi Arabia. COVID-19 staging was performed, pregnancy-related complications were assessed, and neonatal infection was evaluated. Results: We enrolled 81 patients (mean age 31.75 years, SD 5.25) of which there were 17 cases in the first trimester, 20 in the second trimester, and 34 in the third trimester. The distribution of COVID-19 severity was 40 patients with Stage A, 36 with Stage B, 4 with Stage C, and 1 with Stage D. Complications were pregnancy loss in 2 patients (one in each first and second trimester) and 1 fetal death after 20 weeks of pregnancy, 7 patients with fetal growth restriction, and 8 with pre-term delivery. Conclusions: We did not observe an unusual frequency of pregnancy-related complications due to SARS-CoV-2 infection in this high-risk obstetric population and there was no evidence of vertical transmission in newborns from women who delivered while positive for the virus.
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- 2022
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3. The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination
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Giovanni S. Offeddu, Cynthia Hajal, Colleen R. Foley, Zhengpeng Wan, Lina Ibrahim, Mark F. Coughlin, and Roger D. Kamm
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Biology (General) ,QH301-705.5 - Abstract
Offeddu et al. employ a microfluidic vascular model to study the effects of selective removal of glycocalyx components from cancer cells. They find that cancer-associated hyaluronic acid and CD44 mediate firm adhesion to endothelial cells and extravasation during metastasis.
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- 2021
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4. قوة الأنا وعلاقتها بإيذاء الذات لدى عينة من الأحداث المراهقين الجانحين وغير الجانحين في مدينة حمص
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Lina Ibrahim Batikh and Rania Mohamed Hilal
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History of scholarship and learning. The humanities ,AZ20-999 - Abstract
هدفت الدراسة إلى التعرف على نسبة انتشار إيذاء الذات لدى أفراد عينة البحث، والتعرف على طبيعة العلاقة بين إيذاء الذات وقوة الأنا، بالإضافة إلى تعرف الفروق في قوة الأنا وإيذاء الذات تبعاً لمتغير الإقامة (السجن المركزي-مصلحة تأهيل الأحداث- إقامة مع الأسرة)، لدى عينة تكونت من (87)حدث تراوحت أعمارهم بين (15-17 ) عاماً منهم (45) حدث جانح و(42)حدث غير جانح من طلاب ثانوية الفارابي في مدينة حمص تم اختيارهم بطريقة عشوائية. تم استخدام مقياس قوة الأنا لبارون تعريب كفافي (1982) ، واستبيان إيذاء الذات إعداد الباحثتين أظهرت نتائج الدراسة أن نسبة انتشار إيذاء الذات أعلى لدى أحداث السجن المركزي بنسبة (27.7 %). كما أظهرت النتائج وجود علاقة ارتباطية سالبة دالة إحصائياً بين درجات إيذاء الذات ودرجات قوة الأنا، وعدم وجود فروق في متوسط الدرجات على مقياس قوة الأنا وأبعاده لدى أفراد عينة الدراسة ، ووجود فروق دالة إحصائياً في متوسط درجات ايذاء الذات لصالح الاحداث في مصلحة تأهيل الاحداث الجانحين.
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- 2020
5. Review of the Novel Agents for Hepatitis C Infection in the Emergency Department
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Alnajjar, Lina Ibrahim
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- 2018
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6. The Criteria Followed by Manufacturing Companies in Selecting Insurance Companies (An Applied Case on Industrial Companies in the Bethlehem Governorate)
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Lina Ibrahim Sajdieh and Nidal Aref Darwish
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General Earth and Planetary Sciences ,General Environmental Science - Abstract
The current study aimed to identify the criteria industrial companies follow when selecting insurance companies to purchase insurance services. The study employed the descriptive approach to achieve the study's objectives and answer its questions. Statistical analyses were used to analyze the data through the Statistical Package for Social Sciences (SPSS) program. The study population consisted of (150) factories in the Bethlehem Governorate, the possible sample (appropriate for the study) was used, and it consisted of (102) factories. The study also used the interview method to ensure that the selection criteria for companies in the questionnaire were in line with the practical reality. Four interviews were conducted with some managers who influence the purchase decision in industrial companies and managers from insurance companies. The study was concluded with several results. First. the most important criteria that affect the decision to choose the industrial companies for the insurance company when purchasing insurance services are the standards of the quality of insurance services, precisely the insurance company's credibility with compensation after the accident. Second, the price standards follow the critical quality standards, specifically the payment facilities standard. Third, the study indicates that the most important environmental factor for industrial companies is the standard of avoiding legal accountability with an arithmetic average (4.12), which suggests that industrial companies follow the laws. Finally, the religious factor has an arithmetic average of (3.27) and political conditions with an arithmetic average of (3.14) suggesting that these factors are less critical for industrial companies. The study recommends that insurance companies should keep improving the quality of insurance services they provide to industrial companies, especially the credibility of service performance. Also, insurance companies should be interested in offering payment facilities to industrial companies to encourage them to buy their services. Finally, the study recommends that industrial companies apply the selection criteria recommended by the study when choosing insurance companies to be able to select the appropriate insurance company.
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- 2022
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7. The Criteria Followed by Manufacturing Companies in Selecting Insurance Companies (An Applied Case on Industrial Companies in the Bethlehem Governorate)
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Sajdieh, Lina Ibrahim, primary and Darwish, Nidal Aref, additional
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- 2022
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8. The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination
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Cynthia Hajal, Giovanni S. Offeddu, Mark F. Coughlin, Colleen R. Foley, Roger D. Kamm, Lina Ibrahim, and Zhengpeng Wan
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0301 basic medicine ,Glycobiology ,Medicine (miscellaneous) ,Cell Communication ,Metastasis ,chemistry.chemical_compound ,0302 clinical medicine ,Lab-On-A-Chip Devices ,Hyaluronic acid ,Medicine ,Hyaluronic Acid ,Neoplasm Metastasis ,Biology (General) ,biology ,Microfluidic Analytical Techniques ,Extravasation ,Hyaluronan Receptors ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,General Agricultural and Biological Sciences ,Signal Transduction ,Endothelium ,QH301-705.5 ,Breast Neoplasms ,Glycocalyx ,Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Stroma ,Cell Line, Tumor ,Cell Adhesion ,Human Umbilical Vein Endothelial Cells ,Humans ,Neoplasm Invasiveness ,Cancer models ,business.industry ,CD44 ,Transendothelial and Transepithelial Migration ,Cancer ,medicine.disease ,Coculture Techniques ,030104 developmental biology ,chemistry ,Microvessels ,biology.protein ,Cancer research ,business - Abstract
The glycocalyx on tumor cells has been recently identified as an important driver for cancer progression, possibly providing critical opportunities for treatment. Metastasis, in particular, is often the limiting step in the survival to cancer, yet our understanding of how tumor cells escape the vascular system to initiate metastatic sites remains limited. Using an in vitro model of the human microvasculature, we assess here the importance of the tumor and vascular glycocalyces during tumor cell extravasation. Through selective manipulation of individual components of the glycocalyx, we reveal a mechanism whereby tumor cells prepare an adhesive vascular niche by depositing components of the glycocalyx along the endothelium. Accumulated hyaluronic acid shed by tumor cells subsequently mediates adhesion to the endothelium via the glycoprotein CD44. Trans-endothelial migration and invasion into the stroma occurs through binding of the isoform CD44v to components of the sub-endothelial extra-cellular matrix. Targeting of the hyaluronic acid-CD44 glycocalyx complex results in significant reduction in the extravasation of tumor cells. These studies provide evidence of tumor cells repurposing the glycocalyx to promote adhesive interactions leading to cancer progression. Such glycocalyx-mediated mechanisms may be therapeutically targeted to hinder metastasis and improve patient survival., Offeddu et al. employ a microfluidic vascular model to study the effects of selective removal of glycocalyx components from cancer cells. They find that cancer-associated hyaluronic acid and CD44 mediate firm adhesion to endothelial cells and extravasation during metastasis.
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- 2021
9. Impact of the COVID-19 Pandemic on Identifying Exceptional Neurosurgical Residency Candidates
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Nolan J. Brown, Emily Ton, Jamie E. Clarke, Hana Sung, Lina Ibrahim, Shane Shahrestani, Alexander S. Himstead, Vera Ong, Nathan A. Shlobin, and Michael Y. Oh
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Objective A specialty with high value on reliability and accountability, aspiring neurosurgical residents have classically excelled in demonstrating these attributes through in-person engagements. Sub-internship rotations, leadership in extracurriculars, and longitudinal research endeavors have traditionally shed light on uniquely responsible and self-driven candidates. As the COVID-19 pandemic altered the paradigm for medical student engagements, our team investigated whether neurosurgical residency programs would be able to gauge candidates’ favorable attributes with the same accuracy as prior to the pandemic. Design/Setting/Participants: The PubMed/MEDLINE database was queried from inception to 2021 to determine the factors that contribute to a successful American neurosurgery residency match. Inclusion and exclusion criteria were predetermined to ensure comprehensiveness and relevance. Data from the National Residency Matching Program were also reviewed to determine significant trends in the American neurosurgery residency match. These data were then interpreted in the context of the COVID-19 pandemic to gain insight into the present-day neurosurgery match experience. Results A total of 32 studies were included in the review. Factors relevant to current neurosurgery residency match rates include the number of applicants to neurosurgery programs, quantity of research publications, quality of mentorship, interviews, letters of recommendation, standardized academic metrics, and residency program outreach. While current neurosurgery residency program directors are generally satisfied with recent match cycles, survey respondents expressed support for a more objective application review process. The transition to virtual interviews and suspension of away rotations required by the COVID-19 pandemic has raised significant student concerns related to the pandemic’s impact on the current residency recruitment process. Conclusion The neurosurgery match is influenced by multiple dynamic, varied factors that are currently impacted dramatically by the COVID-19 pandemic. While more studies focusing on refining applicant selection processes are warranted, it is imperative for neurosurgical programs to seek new surrogates for assessing favorable neurosurgery residency applicant attributes.
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- 2022
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10. Validation of the Lebanese Medication Adherence Scale among Lebanese diabetic patients
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Souheil Hallit, Lina Ibrahim, Rola Bou Serhal, Pascale Salameh, Liliane Ibrahim, Nadine Saleh, Marwan Akel, and Hala Sacre
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Pharmacology ,Response rate (survey) ,education.field_of_study ,medicine.medical_specialty ,business.industry ,Population ,Pharmaceutical Science ,Medication adherence ,Pharmacy ,Toxicology ,medicine.disease ,030226 pharmacology & pharmacy ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Scale (social sciences) ,Diabetes mellitus ,Health care ,medicine ,Pharmacology (medical) ,030212 general & internal medicine ,education ,business ,Dyslipidemia - Abstract
Background Adherence to oral antidiabetics plays a pivotal role in controlling diabetes. Healthcare workers evaluate this adherence when visited by patients. Objectives The primary objective of this study was to validate the existing LMAS-14 (Lebanese Medication Adherence Scale) in Lebanese diabetic adults. The secondary objective was to evaluate factors affecting adherence among this population. Setting The main five Lebanese governorates. Methods This study was conducted between May and September 2019, and community dwelling adult participants were enrolled using a proportionate random sample. The scale was validated using factor analysis and reliability testing, while bivariate and multivariable analyses assessed correlates of adherence. Main outcomes measures Validity of LMAS-14. Results A total of 308 participants were included, and the response rate was 91.25%. All LMAS-14 items converged over a solution of four factors, explaining a total of 64.39% of the variance (α = 0.859). The cutoff point between controlled and uncontrolled patients was set at 11. The sensitivity and specificity were good at this cutoff (71.1% and 94.74%, respectively). Results showed that 167 (57.2%) patients had good medication adherence. Advanced age (Beta = 0.046; p = 0.001) and having medical coverage (Beta = 1.452; p = 0.005) were significantly associated with higher adherence. Furthermore, adherence to oral antidiabetic drugs (Beta = 1.197; p = 0.018), female gender (Beta = 2.695; p = 0.011), and taking dyslipidemia medication (Beta = 3.527; p = 0.005) predicted higher diabetes control. Conclusion This study validated the LMAS among Lebanese adult diabetic patients taking oral antidiabetic drug. Advanced age and having medical coverage were associated with higher medication adherence. Further national studies are warranted to corroborate our findings.
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- 2020
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11. A robust vasculogenic microfluidic model using human immortalized endothelial cells and Thy1 positive fibroblasts
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Shun Zhang, Lina Ibrahim, Tiankun Liu, Jing Bai, Eunkyung Ko, Mark F. Coughlin, Sarah E. Shelton, Amy X. Zhong, Shriram K. Sundararaman, Marco Campisi, Zhengpeng Wan, Giovanni S. Offeddu, Roger D. Kamm, and David A. Barbie
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Stromal cell ,Angiogenesis ,Cell ,Microfluidics ,Biophysics ,Bioengineering ,urologic and male genital diseases ,Umbilical vein ,Article ,Biomaterials ,Vasculogenesis ,medicine ,Human Umbilical Vein Endothelial Cells ,Humans ,Telomerase reverse transcriptase ,Telomerase ,Cells, Cultured ,Chemistry ,fungi ,Reproducibility of Results ,Cell Differentiation ,respiratory system ,Fibroblasts ,equipment and supplies ,In vitro ,Cell biology ,Endothelial stem cell ,medicine.anatomical_structure ,Mechanics of Materials ,Ceramics and Composites ,sense organs - Abstract
Human umbilical vein endothelial cells (HUVECs) and stromal cells, such as human lung fibroblasts (FBs), have been widely used to generate functional microvascular networks (μVNs) in vitro. However, primary cells derived from different donors have batch-to-batch variations and limited lifespans when cultured in vitro, which hampers the reproducibility of μVN formation. Here, we immortalize HUVECs and FBs by exogenously expressing human telomerase reverse transcriptase (hTERT) to obtain stable endothelial cell and FB sources for μVN formation in vitro. Interestingly, we find that immortalized HUVECs can only form functional μVNs with immortalized FBs from earlier passages but not from later passages. Mechanistically, we show that Thy1 expression decreases in FBs from later passages. Compared to Thy1 negative FBs, Thy1 positive FBs express higher IGFBP2, IGFBP7, and SPARC, which are important for angiogenesis and lumen formation during vasculogenesis in 3D. Moreover, Thy1 negative FBs physically block microvessel openings, reducing the perfusability of μVNs. Finally, by culturing immortalized FBs on gelatin-coated surfaces in serum-free medium, we are able to maintain the majority of Thy1 positive immortalized FBs to support perfusable μVN formation. Overall, we establish stable cell sources for μVN formation and characterize the functions of Thy1 positive and negative FBs in vasculogenesis in vitro.
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- 2021
12. The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform
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Roger D. Kamm, Lina Ibrahim, Jean Carlos Serrano, Cynthia Hajal, and Giovanni S. Offeddu
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medicine.anatomical_structure ,Endothelium ,Chemistry ,medicine ,Cancer research ,Tissue invasion ,Tumor cells ,medicine.disease ,Process (anatomy) ,Phenotype ,Extravasation ,In vitro ,Metastasis - Abstract
Throughout the process of metastatic dissemination, tumor cells are continuously subjected to mechanical forces resulting from complex fluid flows due to changes in pressures in their local microenvironments. While these forces have been associated with invasive phenotypes in 3D matrices, their role in key steps of the metastatic cascade, namely extravasation and subsequent interstitial migration, remains poorly understood. In this study, an in vitro model of the human microvasculature was employed to subject tumor cells to physiological luminal, trans-endothelial, and interstitial flows to evaluate their effects on those key steps of metastasis. Luminal flow promoted the extravasation potential of tumor cells, possibly as a result of their increased intravascular migration speed. Trans-endothelial flow increased the speed with which tumor cells transmigrated across the endothelium as well as their migration speed in the matrix following extravasation. In addition, tumor cells possessed a greater propensity to migrate in close proximity to the endothelium when subjected to physiological flows, which may promote the successful formation of metastatic foci. These results show important roles of fluid flow during extravasation and invasion, which could determine the local metastatic potential of tumor cells.
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- 2020
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13. The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform
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Roger D. Kamm, Jean Carlos Serrano, Lina Ibrahim, Giovanni S. Offeddu, and Cynthia Hajal
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Endothelium ,Hydrostatic pressure ,Biophysics ,Cell Count ,Bioengineering ,Tumor cells ,02 engineering and technology ,Article ,Metastasis ,Biomaterials ,03 medical and health sciences ,Cell Line, Tumor ,medicine ,Humans ,Process (anatomy) ,Mechanical Phenomena ,030304 developmental biology ,0303 health sciences ,Chemistry ,021001 nanoscience & nanotechnology ,medicine.disease ,Phenotype ,Extravasation ,In vitro ,medicine.anatomical_structure ,Mechanics of Materials ,Microvessels ,Ceramics and Composites ,Cancer research ,0210 nano-technology - Abstract
Throughout the process of metastatic dissemination, tumor cells are continuously subjected to mechanical forces resulting from complex fluid flows due to changes in pressures in their local microenvironments. While these forces have been associated with invasive phenotypes in 3D matrices, their role in key steps of the metastatic cascade, namely extravasation and subsequent interstitial migration, remains poorly understood. In this study, an in vitro model of the human microvasculature was employed to subject tumor cells to physiological luminal, trans-endothelial, and interstitial flows to evaluate their effects on those key steps of metastasis. Luminal flow promoted the extravasation potential of tumor cells, possibly as a result of their increased intravascular migration speed. Trans-endothelial flow increased the speed with which tumor cells transmigrated across the endothelium as well as their migration speed in the matrix following extravasation. In addition, tumor cells possessed a greater propensity to migrate in close proximity to the endothelium when subjected to physiological flows, which may promote the successful formation of metastatic foci. These results show important roles of fluid flow during extravasation and invasion, which could determine the local metastatic potential of tumor cells.
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- 2021
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14. Posaconazole treatment of extensive skin and nail dermatophytosis due to autosomal recessive deficiency of CARD9
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Jean-David Bouaziz, Fanny Lanternier, Lina Ibrahim, Marie Jachiet, Martine Bagot, Anne Puel, Jean-Laurent Casanova, and Michel Rybojad
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Adult ,Male ,medicine.medical_specialty ,Posaconazole ,Pathology ,Biopsy ,DNA Mutational Analysis ,Genes, Recessive ,Dermatology ,Disease ,Trichophyton rubrum ,Dermis ,Tinea ,medicine ,Humans ,Skin ,biology ,medicine.diagnostic_test ,business.industry ,Deep dermatophytosis ,Triazoles ,biology.organism_classification ,medicine.disease ,CARD Signaling Adaptor Proteins ,medicine.anatomical_structure ,Phenotype ,Nails ,Mutation ,Nail (anatomy) ,Terbinafine ,business ,medicine.drug ,Follow-Up Studies - Abstract
Importance Deep dermatophytosis is a disease that involves dermatophytic infection of the dermis and/or lymph nodes and sometimes the central nervous system. Autosomal recessive deficiency of the CARD9 (caspase recruitment domain 9) protein has been described in 17 patients with deep dermatophytosis from Algeria, Tunisia, and Morocco. Observations We report a case of extensive dermatophytosis due to autosomal recessive CARD9 deficiency in a patient of Egyptian origin. This patient had extensive superficial Trichophyton rubrum infection of the skin and nails without significant visceral involvement. Treatment with posaconazole was well tolerated and induced a complete clinical remission within 3 months that continued for 8 months of follow-up. Conclusions and Relevance This case report underlines the phenotypic variability of dermatophytic infection in patients with CARD9 deficiency and the potential efficacy of posaconazole for this indication.
- Published
- 2014
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