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Fungi had been isolated from the roots and seeds of Kochia scoparia, it was found that Fusarium oxysporum was the most predominant as it was about 33 % from the whole number of other fungi (isolated from the roots) and Rhizoctonia solani (which had been isolated from seeds) by 11 %. Substituted and an substituted chalcones were prepared (1, 2, 3) and four concentrations of them were used (0,25, 0,5, 1,0, 2,0 g/l), their inhibition effects on the growth of F. oxysporum and R.solani were studied. The conc. 0,25 g/l of chalcone (1) gave an inhibition percentage of 57,3 % for the mean perpendicular diameters (MPD) for the F. oxysporum at the 7th day of incubation.The inhibition surface area (ISA) for the F. oxysporum 64 % , while the same conc. 0,25 g/l gave 100 % for the MPD on R. solani at the same period. The inhibition surface area for F. oxysporum was 97.7 % using conc. of (2 g/l), the same conc. gave 100 % inhibition for R.solani at the 7th day of incubation. The conc. 0,25 g/l of chalcone (2) causes the inhibition 7 % of F. oxysporum at the 7th day of incubation for MPD and the percentage of ISA was 14,3 %, while the same conc. 0,25 g/l manifests an inhibition of 86 % for R. solani at the 7th day of incubation for MPD, while ISA was 92,7 % . The conc. 2 g/l of chalcone (2) causes the inhibition of 92 % for MPD at 7th day for F. oxysporum , while ISA was 95,2 % , the same conc. 2 g/l displayed 100 % inhibition on R. solani for MPD and ISA. The conc. 0,25 g/l of chalcone (3) causes an inhibition of 32 % for F. oxysporum to MPD at the 7th day of incubation, the ISA was 43,3 % and the inhibition was 100 % for R. solani , while conc. of 2 g/l of chalcone (3) causes the inhibition of 100 % for F. oxysporum and R.solani at the 7th day of incubation.

We studied the sufentanil-sparing effect of diazepam for anesthesia induction and compared stress responses (hemodynamics, plasma catecholamine levels) and sufentanil and diazepam plasma levels during sufentanil anesthesia with or without diazepam. Sixteen aortocoronary bypass surgery patients were randomly assigned to receive diazepam (D) 100 micrograms/kg (Group DS) or not (Group S), then sufentanil (Sf) infused at 150 micrograms/min until unconsciousness (U). After tracheal intubation, the Sf dose for U (Sfu) was repeated, preceded in Group DS by D 150 micrograms/kg. Group DS patients require lower Sfu doses (2.01 +/- 0.23 micrograms/kg vs 4.87 +/- 0.63 micrograms/kg (P < 0.05) and plasma Sf levels (236 +/- 47 ng/100 ml vs 593 +/- 118 ng/100 ml (P < 0.01) and had similar or lower heart rate, systolic and diastolic blood pressure, rate-pressure product, and plasma norepinephrine levels than S patients. Linear regression of mean plasma norepinephrine and sufentanil levels gave correlation coefficients of -0.205 in S and -0.90 in DS (p < 0.05).

A malignant pheochromocytoma with several unique features was studied. Initially, its histological and catecholamine secretory properties and physiological effects were terminated by an infarct prior to its excision in 1973. However, in 1985 a metastasis was resected from the right atrium. Hypertensive crisis during surgery was controlled by the administration of phentolamine but not by nitroprusside. Within 2 months, it was again detected at this same site. Biochemical studies confirmed its recurrence. The tumor did not respond to chemotherapy with vincristine, cyclophosphamide and dacarbazine, but there has been physiological and biochemical improvement from inhibiting catecholamine biosynthesis with metyrosine. We recommend that both phentolamine and sodium nitroprusside be readily available during resection of a pheochromocytoma.

The purpose of this study was to evaluate epinephrine-aminophylline-induced arrhythmias during halothane anaesthesia after induction with thiopentone or midazolam. Ten mongrel dogs were studied during 1 MAC halothane and 50% N2O:O2 anaesthesia while maintaining constant acid-base status. The minimal arrhythmogenic infusion rate of epinephrine (MAIRE) and the corresponding plasma concentration of epinephrine (MAPC) required to produce ventricular arrhythmias before and after aminophylline were higher following induction of anaesthesia with midazolam than with thiopentone (P less than 0.05); the MAIREs decreased stepwise with aminophylline (P less than 0.05). The correlation coefficient between individual MAIREs and MAPCs was 0.93 (P less than 0.001). Epinephrine alone and in combination with aminophylline was less arrhythmogenic after induction with midazolam than with thiopentone.

Clamping and declamping during aortic surgery produce a hemodynamically significant myocardial stress. The cardiovascular (CV) response to this stress may be adversely altered by calcium antagonists and beta-adrenoreceptor blockade employed to control symptomatic coronary artery disease. This study evaluated the effect of verapamil (V), propranolol (P), and their combination (P + V) on the CV response to infrarenal abdominal aortic cross-clamping and declamping in anesthetized dogs. Six dogs received P as a bolus of 0.5 mg/kg 20 min before clamping. Six additional dogs received V as a 300 micrograms/kg bolus followed by a V infusion of 6 micrograms/kg/min for 20 min before clamping. A third group of six dogs received the P bolus followed 20 min later by the V regimen (P + V). In both the V and P + V groups, 6 micrograms/kg/min V was infused throughout the clamping and declamping sequence. A fourth group of six control dogs received no cardioactive drugs during the experiment. Heart rate, mean aortic blood pressure, left ventricular end-diastolic pressures, peak rate of rise of left ventricular pressure, cardiac output, and systemic vascular resistance were measured in all animals before aortic cross-clamping, at 5 and 40 min after clamping, and 5 min after declamping. The results demonstrated additive negative chronotropic and inotropic properties of P + V therapy with a more significantly adverse effect than that of either drug alone. The implications of this study warrant added caution when patients treated with these drugs undergo abdominal aortic surgery.

A patient with an unsuspected placenta percreta presented with intraperitoneal bleeding at 33 weeks' gestation. Because of the clinical picture and a lecithin/sphingomyelin ratio of 1:1, this patient was treated conservatively until 38 weeks' gestation when an L/S ratio test indicated fetal maturity. The pregnancy was successfully terminated by cesarean hysterectomy.