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21 results on '"Lin,Youting"'

6. Electrophysiological Evaluation in Identifying Unique Sleep Features Among Anti-LGI1 Encephalitis Patients During Active and Recovery Phase

Author

Liu,Xiaoyun, Yang,Liling, Han,Yuxiang, Xu,Jingjing, Pang,Zaiying, Du,Yifeng, Feng,Yabo, Lin,Youting, Liu,Xiaoyun, Yang,Liling, Han,Yuxiang, Xu,Jingjing, Pang,Zaiying, Du,Yifeng, Feng,Yabo, and Lin,Youting

Abstract

Xiaoyun Liu,1,* Liling Yang,1,* Yuxiang Han,1 Jingjing Xu,2 Zaiying Pang,1 Yifeng Du,1 Yabo Feng,1,* Youting Lin1,* 1Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan City, Shandong Province, 250021, People’s Republic of China; 2Department of Geriatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan City, Shandong Province, 250021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yabo Feng; Youting LinDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jingwu Road, Huaiyin Zone, Jinan City, Shandong Province, 250021, People’s Republic of ChinaTel/Fax +86-531‐68776354Email fyb-sd@hotmail.com; youtinglin2019@126.comObjective: The purpose of this study was to illustrate the electrophysiological features of sleep disturbances in patients with anti-leucine-rich glioma-inactivated protein 1 (anti-LGI1) encephalitis in both active and recovery stages.Methods: Retrospectively filed video electroencephalogram (VEEG) and polysomnography (PSG) data in 24 patients with anti-LGI1 encephalitis were analyzed in comparison with that in 20 individuals without sleep disorders as control group.Results: Sleep efficiency (SE) and total sleep time involving REM and NREM sleep were significantly decreased in patients with anti-LGI1 encephalitis during the active stage compared to that during the recovery stage and in the control group. Imbalanced sleep structure was found, demonstrated by elevated N1, decreased N3 and REM components, as well as abnormal N2 structure characterized with significantly lower spindle duration and density during the active stage. These findings were independent of the presence of nocturnal episodic events or sleep hyperkinetic movements (HMs). HMs were present in 11/23 patients throughout NREM and REM sleep (nonspecific in sleep stages)

Published
2021

9. HMGB1/CXCL12-Mediated Immunity and Th17 Cells Might Underlie Highly Suspected Autoimmune Epilepsy in Elderly Individuals

Author

Han,Yuxiang, Yang,Liling, Liu,Xiaoyun, Feng,Yabo, Pang,Zaiying, and Lin,Youting

Subjects
Neuropsychiatric Disease and Treatment
Abstract

Yuxiang Han, Liling Yang, Xiaoyun Liu, Yabo Feng, Zaiying Pang, Youting Lin Departments of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Ji’nan 250021, People’s Republic of ChinaCorrespondence: Youting Lin Tel/Fax +86 531 68776354Email youtinglin2019@126.ComPurpose: Late-onset epilepsy due to autoimmune dysfunction has been reported. However, definitive diagnosis requires positive antibody results. As a result, patients with negative antibody results, but presenting with classical manifestation of autoimmune epilepsy, may be managed as suspected cases. In this study, we aim to isolate and profile the concentration of cytokines/chemokines in the cerebrospinal fluid (CSF) and the serum to ascertain if they could act as alternative diagnostic biomarkers.Patients and Methods: Twenty patients aged ≥ 50 years were considered in this study. Ten patients were diagnosed with suspected autoimmune epilepsy (sAE) based on clinic manifestation, electroencephalogram, magnetic resonance imaging, and with negative antibody results of the serum and the CSF. The equivalent control group exhibited neurological disorders due to non-inflammatory pathologies. Serum and CSF were analyzed for cytokines/chemokines concentration, including interleukin (IL)-6, IL-10, IL-17, chemokine (C-X-C motif) ligand (CXCL)12 and CXCL13, as well as high-mobility group box protein 1 (HMGB1) and B cell activation factor (BAFF)).Results: The CSF levels of IL-6, IL-17, HMGB1, and CXCL12 were significantly higher in the sAE group than in the control group. There was no difference in the CSF levels of IL-10, CXCL13 and BAFF. The serum levels of HMGB1 and CXCL12 were elevated in the sAE group compared with the control group, and there was no statistical difference in the serum levels of IL-6, IL-10, IL-17, CXCL13, and BAFF between the two groups.Conclusion: Our study shows that cytokines/chemokines may act as alternative biomarkers for diagnosis of sAE. The activation of both HMGB1/CXCL12-mediated immunity and T helper cells 17 (Th17) cells may be playing a central role in the pathogenesis of sAE. We suggest that cytokines/chemokines be treated as adjuvant biomarkers, instead of solely relying on antibody screening test. However, a larger cohort in a prospective approach is required to validate our findings.Keywords: seizure, autoimmune, cytokine, chemokine, epilepsy

Published
2020

14. Subtypes evaluation of motor dysfunction in Parkinson’s disease using neuromelanin-sensitive magnetic resonance imaging

Author

Xiang, Yuanyuan, primary, Gong, Tao, additional, Wu, Junwei, additional, Li, Jifeng, additional, Chen, Yan, additional, Wang, Yongxiang, additional, Li, Shan, additional, Cong, Lin, additional, Lin, Youting, additional, Han, Yuxiang, additional, Yin, Ling, additional, Wang, Guangbin, additional, and Du, Yifeng, additional

Published
2017
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21. Reduced serum neurotrophic factors and monoamine neurotransmitters in epilepsy patients with comorbid depression.

Author

Sun S, Han Y, Liu X, Yang L, Han T, Lin Y, and Feng Y

Abstract

Objective: This study aimed to investigate the roles of neurotrophic factors (NTFs), monoamine neurotransmitters, and inflammatory processes in the pathophysiology of the comorbidity of epilepsy and depression., Methods: A retrospective analysis was conducted with 57 epilepsy patients (PWE), 50 patients with epilepsy and comorbid depression (PWECD), and 47 healthy controls (HC) admitted between June 2020 and June 2024. Serum levels of brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), 5-hydroxytryptamine (5-HT), norepinephrine (NE), dopamine (DA), interleukin-1β (IL-1β), and interleukin-6 (IL-6) were measured using enzyme-linked immunosorbent assay (ELISA). Additionally, BDNF and GDNF levels in cerebrospinal fluid (CSF) samples were analyzed from selected patients in the PWE and PWECD groups., Results: Serum BDNF levels were significantly lower in both PWE and PWECD groups compared to HC, while no differences between the former two groups. GDNF levels were lower in PWECD compared to HC, but not between PWE and HC. Serum 5-HT was significantly reduced in PWECD compared to both HC and PWE groups. No significant differences were observed in serum DA, NE, and IL-6 levels across the groups. Serum IL-1β levels were elevated in the PWECD group compared to the HC group. The Self-Rating Depression Scale (SDS) score negatively correlated with serum 5-HT and GDNF levels. In terms of predictive ability, serum BDNF demonstrated higher accuracy for the diagnosis of epilepsy [area under the curve, AUC = 0.701, 95% confidence intervals (95% CI) 0.601 ~ 0.801], while serum 5-HT was the best marker for predicting the development of depression in epilepsy patients (AUC = 0.727, 95% CI 0.632 ~ 0.821). No significant correlation was found between serum and CSF BDNF levels within the same subject ( r  = 0.155; p  = 0.221; Spearman correlation), and CSF GDNF levels were too low to be clinically informative., Conclusion: The findings suggest the involvement of NTFs, monoamine neurotransmitters, and inflammatory processes in the pathogenesis of epilepsy and depression. Decreased serum BDNF levels correlate with epilepsy but not necessarily with comorbid depression, while serum GDNF and 5-HT show potential clinical value in diagnosing this comorbidity. However, the deficient levels of NTFs in CSF suggest a need for more sensitive detection methods., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Sun, Han, Liu, Yang, Han, Lin and Feng.)

Published
2024
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