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170 results on '"Lin, Xiaoxuan"'

4. FASN-mediated fatty acid biosynthesis remodels immune environment in Clonorchis sinensis infection-related intrahepatic cholangiocarcinoma

Author

Xu, Lixia, Zhang, Ying, Lin, Zhilong, Deng, Xinlang, Ren, Xiaoxue, Huang, Mingle, Li, Shangru, Zhou, Qianying, Fang, Fei, Yang, Qingxia, Zheng, Gaomin, Chen, Zebin, Wu, Zhongdao, Sun, Xi, Lin, Jie, Shen, Jingxian, Guo, Jianping, Li, Xiaoxing, Xue, Tianchen, Tan, Jing, Lin, Xiaoxuan, Tan, Li, Peng, Hong, Shen, Shunli, Peng, Sui, Li, Shaoqiang, Liang, Lijian, Cleary, James M., Lai, Jiaming, Xie, Yubin, and Kuang, Ming

Published
2024
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12. How hydrophobicity, side chains, and salt affect the dimensions of disordered proteins

Author

Baxa, Michael C., primary, Lin, Xiaoxuan, additional, Mukinay, Cedrick D., additional, Chakravarthy, Srinivas, additional, Sachleben, Joseph R., additional, Antilla, Sarah, additional, Hartrampf, Nina, additional, Riback, Joshua A., additional, Gagnon, Isabelle A., additional, Pentelute, Bradley L., additional, Clark, Patricia L., additional, and Sosnick, Tobin R., additional

Published
2024
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16. Single Cell Microgels for High‐Throughput Magnetic Sorting and Sequencing of Antigen‐Specific Antibodies.

Author

Chen, Jieru, Lin, Xiaoxuan, Sun, Fang, Wen, Huilin, Huang, Zhenxiang, Li, Wenying, Jiang, Le, Yu, Ziyi, and Hu, Chi

Subjects
*MICROGELS, *IMMUNOGLOBULINS, *PLASMA cells, *IMMUNE recognition, *CELL separation, *CELL culture, *NANORODS, *FC receptors
Abstract

Progress in the discovery of potent antibodies for therapeutic and research purposes has been accelerated by mining the antibody repertoire of plasma cells and plasmablasts. Magnetic activated cell sorting (MACS) is a well recognized method for cell sorting, however, secreted IgGs rapidly diffuse away from cells, therefore requiring specialized technique to compartmentalize individual cells and capture their secretions for MACS isolation. To this end, a scalable method to prepare hydrogel‐based microcontainers for single cell culture and subsequent sorting based on their secreted IgG products at high‐throughput level are described. In situ crosslinkable microgels featuring tunable viscosity are fabricated to act as soft compartments that accommodate delicate primary cells and capture secreted proteins, while providing solid supports after solgel transition to enable immune recognition with chemically functionalized magnetic nanorods in aqueous medium for MACS separation. Splenocytes are sorted based on antigen‐specific IgG production from mice immunized with an antibiotic target ceftriaxone sodium, enriching a population of 220 000 000 to 800 000 prevalence following sorting. This enrichment ratio is substantially higher than conventional fluorescence activated cell sorting (FACS) methods, likely due to the multivalency of the antigen‐conjugated magnetic nanorods. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Unconventional Dental Implant Placement Through an Impacted Maxillary Central Incisor in Stable Contact With Enamel and Dentin: A Case Report.

Author

Lin, Xiaoxuan, Zhang, Zhengchuan, Huang, Yaohong, Deng, Feilong, and Xu, Ruogu

Subjects
DENTIN, DENTAL implants, DENTAL enamel, INCISORS, TOOTH roots, TOOTH fractures
Abstract

When edentulism is accompanied by an impacted tooth, conventional treatment usually involves traumatic tooth extraction, which would inevitably destroy the surrounding alveolar bone and cause unfavorable esthetics, especially for anterior teeth. Recently, implant placement through the impacted tooth or residual root has been proposed as an alternative to invasive extraction. A particular type of integration has been observed between dentin/cementum and titanium implant, while enamel-implant contact has not been reported. In this article, an implant was placed through the impacted maxillary central incisor, thereby avoiding an invasive extraction surgery. The buccal section of the tooth, including crown enamel, was retained in situ for buccal alveolar ridge preservation. The follow-up results were satisfactory, and a stable enamel-implant contact was observed. Combining with previous similar studies, this technique opens intriguing possibilities and brings fresh insight for the concept of dentointegration. More histological and clinical studies with long-term follow-up are warranted before endorsing this technique in routine application. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Effect of nano-AlN, Al2O3 on friction and wear properties of copper-steel clad plate immersed in the lubricants.

Author

Lin, Xiaoxuan, Sang, Xiong, Zhu, Yuyan, and Zhang, Yichen

Subjects
*MECHANICAL wear, *LUBRICATION & lubricants, *ALUMINUM oxide, *COMPOSITE plates, *FRICTION, *SCANNING electron microscopes
Abstract

Purpose: This paper aims to investigate the preparation of AlN and Al2O3, as well as the effect of nano-AlN and nano-Al2O3, on friction and wear properties of copper-steel clad plate immersed in the lubricants. Design/methodology/approach: Nano-AlN or nano-Al2O3 (0.1, 0.2, 0.3, 0.4 and 0.5 Wt.%) functional fluids were prepared. Their tribological properties were tested by an MRS-10A four-ball friction tester and a ball-on-plate configuration, and scanning electron microscope observed the worn surface of the plate. Findings: An increase in nano-AlN and Al2O3 content enhances the extreme pressure and anti-wear performance of the lubricant. The best performance is achieved at 0.5 Wt.% of nano-AlN and 0.3 Wt.% of nano-Al2O3 with PB of 834 N and 883 N, a coefficient of friction (COF) of approximately 0.07 and 0.06, respectively. Furthermore, the inclusion of nano-AlN and nano-Al2O3 particles in the lubricant enhances its extreme pressure performance and reduces wear, leading to decreased wear spot depth. The lubricating effect of the nano-Al2O3 lubricant on the surface of the copper-steel composite plate is slightly superior to that of the nano-AlN lubricant, with a COF reaching 0.07. Both lubricants effectively fill and lubricate the holes on the surface of the copper-steel composite plate. Originality/value: AlN and Al2O3 as water-based lubricants have excellent lubrication performance and can reduce the COF. It can provide some reference for the practical application of nano-water-based lubricants. Peer review: The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-08-2023-0255/ [ABSTRACT FROM AUTHOR]

Published
2024
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33. Prediction of Surgical Approach in Mitral Valve Disease by XGBoost Algorithm Based on Echocardiographic Features

Author

Lin, Xiaoxuan, primary, Chen, Lixin, additional, Zhang, Defu, additional, Luo, Shuyu, additional, Sheng, Yuanyuan, additional, Liu, Xiaohua, additional, Liu, Qian, additional, Li, Jian, additional, Shi, Bobo, additional, Peng, Guijuan, additional, Zhong, Xiaofang, additional, Huang, Yuxiang, additional, Li, Dagang, additional, Qin, Gengliang, additional, Yin, Zhiqiang, additional, Xu, Jinfeng, additional, Meng, Chunying, additional, and Liu, Yingying, additional

Published
2023
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36. Efficacy and Safety of Traditional Chinese Medicine Injection with Mecobalamin in Treating Diabetic Peripheral Neuropathy：A protocol for systematic review and meta-analysis

Author

Mai, Weihua, Wei, Aisheng, Lin, Xiaoxuan, Wang, Funeng, Ye, Jianhong, and Chen, Ping

Abstract

Background: Diabetic peripheral neuropathy is a common complication of diabetes and the main cause of disability. At present, there is no specific therapeutic regimen. Mecobalamin is often used as a neurotrophic drug, and its long-term effects are not satisfactory when used alone. Clinical practice indicates that traditional Chinese medicine injection with mecobalamin has a therapeutic advantage in treating diabetic peripheral neuropathy while it lacks evidence-based medicine. In this scheme, the efficacy and safety of traditional Chinese medicine injection with mecobalamin in treating diabetic peripheral neuropathy has been studied. Methods：Computers were used to search the English database（PubMed, the Cochrane Library, Embase, Web of Science）and Chinese database（CNKI, Wanfang, CBMDISC, VIP）. Besides, manual searching was conducted to search for Baidu Scholar, CHICTR, Google Scholar. During the establishment of the database to November 2020, a randomized controlled trial on traditional Chinese medicine injection with mecobalamin in treating diabetic peripheral neuropathy was conducted. There were two researchers independently conducting data extraction and quality evaluation of literature on the included studies, RevMan5.3 was performed for Meta-analysis on the included literature. Results：In this study, the efficacy and safety of traditional Chinese medicine injection with mecobalamin in treating diabetic peripheral neuropathy was evaluated by the total effective rate, motor nerve conduction velocity, sensory nerve conduction velocity, adverse reactions and glucose metabolism level. Conclusion：This study can provide an evidence-based basis on the clinical applications of traditional Chinese medicine injection with mecobalamin in the treatment of diabetic peripheral neuropathy.

Published
2022
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44. Efficacy Comparison of Repeated Low-Level Red Light and Low-Dose Atropine for Myopia Control: A Randomized Controlled Trial

Author

Chen, Yanxian, Xiong, Ruilin, Chen, Xu, Zhang, Jian, Bulloch, Gabriella, Lin, Xiaoxuan, Wu, Xiaoman, Li, Jinying, Chen, Yanxian, Xiong, Ruilin, Chen, Xu, Zhang, Jian, Bulloch, Gabriella, Lin, Xiaoxuan, Wu, Xiaoman, and Li, Jinying

Abstract

Purpose: To compare the treatment efficacy between repeated low-level red light (RLRL) therapy and 0.01% atropine eye drops for myopia control. Methods: A single-masked, single-center, randomized controlled trial was conducted on children 7 to 15 years old with cycloplegic spherical equivalent refraction (SER) ≤ -1.00 diopter (D) and astigmatism ≤ 2.50 D. Participants were randomly assigned to the RLRL group or low-dose atropine (LDA, 0.01% atropine eye drops) group and were followed up at 1, 3, 6, and 12 months. RLRL treatment was provided by a desktop light therapy device that emits 650-nm red light. The primary outcome was the change in axial length (AL), and the secondary outcome was the change in SER. Results: Among 62 eligible children equally randomized to each group (31 in the RLRL group, 31 in the LDA group), 60 children were qualified for analysis. The mean 1-year change in AL was 0.08 mm (95% confidence interval [CI], 0.03-0.14) in the RLRL group and 0.33 mm (95% CI, 0.27-0.38) in the LDA group, with a mean difference (MD) of -0.24 mm (95% CI, -0.32 to -0.17; P < 0.001). The 1-year change in SER was -0.03 D (95% CI, -0.01 to -0.08) in the RLRL group and -0.60 D (95% CI, -0.7 to -0.48) in the LDA group (MD = 0.57 D; 95% CI, 0.40-0.73; P < 0.001). The progression of AL < 0.1 mm was 53.2% and 9.7% (P < 0.001) in the RLRL and LDA groups, respectively. For AL ≥ 0.36 mm, progression was 9.7% and 50.0% (P < 0.001) in the RLRL and LDA groups, respectively. Conclusions: In this study, RLRL was more effective for controlling AL and myopia progression over 12 months of use compared with 0.01% atropine eye drops. Translational Relevance: RLRL therapy significantly slows axial elongation and myopia progression compared with 0.01% atropine; thus, it is an effective alternative treatment for myopia control in children.

Published
2022

49. Intestinal strictures in Crohn’s disease: a 2021 update

Author

Lin, Xiaoxuan, primary, Wang, Yu, additional, Liu, Zishan, additional, Lin, Sinan, additional, Tan, Jinyu, additional, He, Jinshen, additional, Hu, Fan, additional, Wu, Xiaomin, additional, Ghosh, Subrata, additional, Chen, Minhu, additional, Liu, Fen, additional, and Mao, Ren, additional

Published
2022
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