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3. Development of Virtual Reality Training System Based on EEG Biofeedback

Author

Lin, Pei-Jung, Lam, Man-Lai, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Nagar, Atulya K., editor, Jat, Dharm Singh, editor, Marín-Raventós, Gabriela, editor, and Mishra, Durgesh Kumar, editor

Published
2022
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16. Dementia Prevention: optimizing the use of observational data for personal, clinical, and public health decision-making.

Author

Dacks, Penny A, Andrieu, Sandrine, Blacker, Deborah, Carman, Aaron J, Green, Allan M, Grodstein, Francine, Henderson, Victor W, James, Bryan D, Lane, Rachel F, Lau, Joseph, Lin, Pei-Jung, Reeves, Barnaby C, Shah, Raj C, Vellas, Bruno, Yaffe, Kristine, Yurko-Mauro, Karin, Shineman, Diana W, Bennett, David A, and Fillit, Howard M

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Cognitive and Computational Psychology, Neurosciences, Psychology, Nutrition, Alzheimer's Disease, Brain Disorders, Dementia, Acquired Cognitive Impairment, Behavioral and Social Science, Aging, Neurodegenerative, Clinical Research, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Comparative Effectiveness Research, Prevention, Clinical Trials and Supportive Activities, 7.3 Management and decision making, Management of diseases and conditions, Neurological, Good Health and Well Being, Alzheimer’s, communication, low-risk, non-randomized studies, primary prevention, Biological psychology, Cognitive and computational psychology
Abstract

Worldwide, over 35 million people suffer from Alzheimer's disease and related dementias. This number is expected to triple over the next 40 years. How can we improve the evidence supporting strategies to reduce the rate of dementia in future generations? The risk of dementia is likely influenced by modifiable factors such as exercise, cognitive activity, and the clinical management of diabetes and hypertension. However, the quality of evidence is limited and it remains unclear whether specific interventions to reduce these modifiable risk factors can, in turn, reduce the risk of dementia. Although randomized controlled trials are the gold-standard for causality, the majority of evidence for long-term dementia prevention derives from, and will likely continue to derive from, observational studies. Although observational research has some unavoidable limitations, its utility for dementia prevention might be improved by, for example, better distinction between confirmatory and exploratory research, higher reporting standards, investment in effectiveness research enabled by increased data-pooling, and standardized exposure and outcome measures. Informed decision-making by the general public on low-risk health choices that could have broad potential benefits could be enabled by internet-based tools and decision-aids to communicate the evidence, its quality, and the estimated magnitude of effect.

Published
2014

19. Factors influencing purchase intention for online travel products : case study of Taiwanese consumers

Author

Lin, Pei-jung, Westwood, Sheena, and Jones, Eleri

Subjects
658
Abstract

The Internet has dramatically changed how people communicate, search for information, make decisions and purchase goods/services. Travel product has distinguishing features which make them particularly receptive to the Internet benefits. Although the Internet provides benefits for information searching and product purchasing, there are perceived barriers that customers may encounter while using the Internet for travel purchase, which, to some extent, impeded the growth of online travel sales. Several factors influence purchase intention for online travel products, e.g. social factors which contextualize online purchase. Trust influences consumer behaviour and is significant in e-commerce. This thesis develops a framework for investigating factors influencing Taiwanese consumers’ purchase intention for online travel products emphasizing the role of trust and providing a holistic view of online consumer purchase decision-making processes incorporating trust, culture and various supply/demand side factors and their influence on online travel purchase intention. A case study investigates Taiwanese consumers’ online travel purchase behaviour. Multi-methods enable triangulation: in-depth interviews and participant observation explore consumers’ online travel purchase experience and perceptions of travel websites; questionnaire and projective technique interviews investigate attitudes and perceptions identified in the questionnaire survey and their effect on travel purchase intention. The findings suggest trust significantly impacts online travel purchase intention. Trust cab be built by supply-side factors: vendor’s reputation and website design. If consumers feel online travel companies care about mutual benefits, trust is more likely to be forged. Cultural factors impact on consumer purchase intention. Consumers often visit and feel more comfortable purchasing from websites recommended by family and friends. This research helps understand trust by explaining factors promoting trust in online travel purchase contexts. Since perceptions of travel website information quality, vendor’s reputation, and recommendations from family and friends strongly predict trust, Taiwanese online travel companies should focus on them to increase trust and ultimately online transaction volume.

Published
2010
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23. Protection Schemes for Plasma Induced Damage from Well-Side Antennas

Author

Kuo, Hsi-Yu, primary, Chu, Yu-Lin, additional, Dai, Hung-Da, additional, Wang, Chun-Chi, additional, Lin, Pei-Jung, additional, Guo, Ethan, additional, Su, Yu-Ti, additional, Hsu, Chia-Lin, additional, Chen, Kuan-Hung, additional, Chen, Tsung-Yuan, additional, Lu, Ryan, additional, Liang, Victor, additional, Chen, Kuo-Ji, additional, and Xia, Kejun, additional

Published
2023
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25. Cost-effectiveness models for Alzheimer's disease and related dementias:IPECAD modeling workshop cross-comparison challenge

Author

Handels, Ron L H, Green, Colin, Gustavsson, Anders, Herring, William L, Winblad, Bengt, Wimo, Anders, Sköldunger, Anders, Karlsson, Andreas, Anderson, Robert, Belger, Mark, Brück, Chiara, Espinosa, Robert, Hlávka, Jakub P, Jutkowitz, Eric, Lin, Pei-Jung, Mendez, Mauricio Lopez, Mar, Javier, Shewmaker, Peter, Spackman, Eldon, Tafazzoli, Ali, Tysinger, Bryan, Jönsson, Linus, Handels, Ron L H, Green, Colin, Gustavsson, Anders, Herring, William L, Winblad, Bengt, Wimo, Anders, Sköldunger, Anders, Karlsson, Andreas, Anderson, Robert, Belger, Mark, Brück, Chiara, Espinosa, Robert, Hlávka, Jakub P, Jutkowitz, Eric, Lin, Pei-Jung, Mendez, Mauricio Lopez, Mar, Javier, Shewmaker, Peter, Spackman, Eldon, Tafazzoli, Ali, Tysinger, Bryan, and Jönsson, Linus

Abstract

INTRODUCTION: The credibility of model-based economic evaluations of Alzheimer's disease (AD) interventions is central to appropriate decision-making in a policy context. We report on the International PharmacoEconomic Collaboration on Alzheimer's Disease (IPECAD) Modeling Workshop Challenge.METHODS: Two common benchmark scenarios, for the hypothetical treatment of AD mild cognitive impairment (MCI) and mild dementia, were developed jointly by 29 participants. Model outcomes were summarized, and cross-comparisons were discussed during a structured workshop.RESULTS: A broad concordance was established among participants. Mean 10-year restricted survival and time in MCI in the control group ranged across 10 MCI models from 6.7 to 9.5 years and 3.4 to 5.6 years, respectively; and across 4 mild dementia models from 5.4 to 7.9 years (survival) and 1.5 to 4.2 years (mild dementia).DISCUSSION: The model comparison increased our understanding of methods, data used, and disease progression. We established a collaboration framework to assess cost-effectiveness outcomes, an important step toward transparent and credible AD models.

Published
2023

31. Derivation and Validation of a Discharge Disposition Predicting Model after Acute Stroke

Author

Jeng, Jiann-Shing, Yeh, Shin-Joe, Tsai, Li-Kai, Chiu, Hou-Chang, Lien, Li-Ming, Chen, Wei-Hung, Bai, Chyi-Huey, Huang, Tzu-Hsuan, Lau, Chi-Ieong, Wu, Ya-Ying, Yuan, Rey-Yue, Hu, Chaur-Jong, Sheu, Jau-Jiuan, Yu, Jia-Ming, Ho, Chun-Sum, Chung, Wen-Ting, Sung, Jia-Ying, Chen, Chin-I, Weng, Hsing-Yu, Han, Yu-Hsuan, Huang, Chun-Ping, Lin, Huey-Juan, Ke, Der-Shin, Chang, Chia-Yu, Yeh, Poh-Shiow, Lin, Kao-Chang, Cheng, Tain-Junn, Chou, Chih-Ho, Yang, Chun-Ming, Lo, Yuk-Keung, Lin, Yu-Te, Lin, Ching-Hwung, Lin, Jiann-Chyun, Hsu, Yaw-Don, Denq, Jong-Chyou, Peng, Giia-Sheun, Lee, Jiunn-Tay, Hsu, Chang-Hung, Lin, Chun-Chieh, Yen, Che-Hung, Cheng, Chun-An, Sung, Yueh-Feng, Chen, Yuan-Liang, Lien, Ming-Tung, Chou, Chung-Hsing, Liu, Chia-Chen, Yang, Fu-Chi, Wu, Yi-Chung, Tso, An-Chen, Lai, Yu-Hua, Chiang, Chun-I, Tsai, Chia-Kuang, Liu, Meng-Ta, Lin, Ying-Che, Hsu, Yu-Chuan, Liu, Chung-Hsiang, Tsai, Chon-Haw, Huang, Wei-Shih, Lu, Chung-Ta, Tsai, Tzung-Chang, Tseng, Chun-Hung, Lin, Kang-Hsu, Shyn, Woei-Cherng, Yang, Yu-Wan, Liu, Yen-Liang, Cho, Der-Yang, Chen, Chun-Chung, Sun, Ming-Hui, Yu, Shih-Chieh, Ke, Li-Ying, Lai, Ming-Liang, Chen, Chih-Hung, Chen, Jiunn-Rong, Tsai, Song-Yen, Chiang, Tsuey-Ru, Lee, Mei-Ching, Lin, Shinn-Kuang, Tseng, Yuan-Fu, Lee, Jing-Er, Hsiao, Cheng-Lun, Liang, Jen-Feng, Chen, Chiu-Mei, Wu, Chao-Hsin, Chen, Yu-Wei, Lee, Kuo-Ying, Lin, Yun-Yu, Li, Chen-Hua, Smith, Eric E., Tsai, Hui-Fen, Hsieh, Chuan-Fa, Yang, Chih-Dong, Liaw, Shiumn-Jen, Liao, How-Chin, Hu, Han-Hwa, Wong, Wen-Jang, Luk, Yun-On, Chern, Chang-Ming, Hsu, Li-Chi, Chung, Chih-Ping, Sun, Mu-Chien, Wu, Shey-Lin, Tseng, Hung-Pin, Liu, Chin-Hsiung, Lin, Chun-Liang, Lin, Hung-Chih, Lai, Ta-Chang, Yin, Jiu-Haw, Wang, Chung-Jen, Wang, Kai-Chen, Chen, Li-Mei, Chan, Lung, Lee, Siu-Pak, Sun, Yu, Huang, Chieh-Cheng, Liu, Chang-Hsiu, Lin, Cheng-Huai, Lu, Chien-Jung, Yeh, Shoou-Jeng, Wu, Ling-Li, Hsieh, Liang-Po, Lee, Yong-Hui, Chen, Chung-Wen, Chen, Po-Lin, Lee, Yu-Shan, Chen, Shu-Yi, Chen, Han-Jung, Hsu, Shih-Pin, Chang, Cheng-Sen, Kuo, Hung-Chang, Wu, Shu-Lung, Tsui, Huan-Wen, Tsou, Jung-Chi, Chou, Feng-Hsiung, Lin, Pei-Jung, Tung, Chin-Sung, Lu, Kan, Liliang, Po-Chou, Tsai, Yu-Duan, Liang, Cheng-Loong, Wang, Kuo-Wei, Wang, Hao-Kuang, Chen, Te-Yuan, Hsin, Yue-Loong, Lin, Chih-Yuan, Yip, Bak-Sau, Tsai, Pei-Chun, Chou, Ping-Chen, Kuo, Tsam-Ming, Lee, Yi-Chen, Chiu, Yi-Pin, Tsai, Kun-Chang, Lin, Ruey-Tay, Chen, Chun-Hung, Khor, Gim-Thean, Chao, A-Ching, Lin, Hsiu-Fen, Lin, I-Sheng, Yan, Sui-Hing, Lin, Yi-Chun, Chen, Pei-Yun, Hsiao, Sheng-Huang, Po, Helen L., Lin, Ya-Ju, Tu, Hao-Chieh, Tang, Sung-Chun, Lin, Fu-Yu, Chen, Ping-Kun, Chiu, Pai-Yi, Yip, Ping-Keung, Wang, Vin-Chi, Wang, Kaw-Chen, Tsai, Chung-Fen, Chen, Chao-Ching, Chen, Chih-Hao, Liu, Yi-Chien, Yeh, Chung-Hsin, Pan, Chou-Hsiung, Jih, Shin-Yi, Chan, Po-Chi, Hsu, Min-Hsien, Shoung, Hai-Ming, Lo, Yi-Chen, Wang, Fu-Hwa, Wei, Cheng-Yu, Lee, Jun-Yu, Lin, Ryh-Huei, Chu, Ching-Hua, Hsu, Ming-Chin, Lin, Feng-Jenq, Chen, Pi-Tzu, Mou, Chih-Hsin, Chang, Chun-Yuan, Chen, An-Chih, Hsiao, Yu-Jen, Lin, Ching-Huang, Hsu, Chung-Y., and Sung, Fung-Chang

Published
2015
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40. Association of Polymorphisms in BDNF, MTHFR, and Genes Involved in the Dopaminergic Pathway with Memory in a Healthy Chinese Population

Author

Yeh, Ting-Kuang, Hu, Chung-Yi, Yeh, Ting-Chi, Lin, Pei-Jung, Wu, Chung-Hsin, Lee, Po-Lei, and Chang, Chun-Yen

Abstract

The contribution of genetic factors to the memory is widely acknowledged. Research suggests that these factors include genes involved in the dopaminergic pathway, as well as the genes for brain-derived neurotrophic factor (BDNF) and methylenetetrahydrofolate reductase (MTHFR). The activity of the products of these genes is affected by single nucleotide polymorphisms (SNPs) within the genes. This study investigates the association between memory and SNPs in genes involved in the dopaminergic pathway, as well as in the BDNF and MTHFR genes, in a sample of healthy individuals. The sample includes 134 Taiwanese undergraduate volunteers of similar cognitive ability. The Chinese versions of the Wechsler Memory Scale (WMS-III) and Wechsler Adult Intelligence Scale (WAIS-III) were employed. Our findings indicate that the BDNF Met66Val polymorphism and dopamine receptor D3 (DRD3) Ser9Gly polymorphism are associated significantly with long-term auditory memory. Further analysis detects no significant associations in the other polymorphisms and indices. Future replicated studies with larger sample sizes, and studies that consider different ethnic groups, are encouraged. (Contains 5 tables and 1 figure.)

Published
2012
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41. Cost‐effectiveness models for Alzheimer's disease and related dementias: IPECAD modeling workshop cross‐comparison challenge.

Author

Handels, Ron L.H., Green, Colin, Gustavsson, Anders, Herring, William L., Winblad, Bengt, Wimo, Anders, Sköldunger, Anders, Karlsson, Andreas, Anderson, Robert, Belger, Mark, Brück, Chiara, Espinosa, Robert, Hlávka, Jakub P., Jutkowitz, Eric, Lin, Pei‐Jung, Mendez, Mauricio Lopez, Mar, Javier, Shewmaker, Peter, Spackman, Eldon, and Tafazzoli, Ali

Abstract

Introduction: The credibility of model‐based economic evaluations of Alzheimer's disease (AD) interventions is central to appropriate decision‐making in a policy context. We report on the International PharmacoEconomic Collaboration on Alzheimer's Disease (IPECAD) Modeling Workshop Challenge. Methods: Two common benchmark scenarios, for the hypothetical treatment of AD mild cognitive impairment (MCI) and mild dementia, were developed jointly by 29 participants. Model outcomes were summarized, and cross‐comparisons were discussed during a structured workshop. Results: A broad concordance was established among participants. Mean 10‐year restricted survival and time in MCI in the control group ranged across 10 MCI models from 6.7 to 9.5 years and 3.4 to 5.6 years, respectively; and across 4 mild dementia models from 5.4 to 7.9 years (survival) and 1.5 to 4.2 years (mild dementia). Discussion: The model comparison increased our understanding of methods, data used, and disease progression. We established a collaboration framework to assess cost‐effectiveness outcomes, an important step toward transparent and credible AD models. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Alzheimer's disease medication use and adherence patterns by race and ethnicity.

Author

Olchanski, Natalia, Daly, Allan T., Zhu, Yingying, Breslau, Rachel, Cohen, Joshua T., Neumann, Peter J., Faul, Jessica D., Fillit, Howard M., Freund, Karen M., and Lin, Pei‐Jung

Abstract

Background: We examined racial and ethnic differences in medication use for a representative US population of patients with Alzheimer's disease and related dementias (ADRD). Methods: We examined cholinesterase inhibitors and memantine initiation, non‐adherence, and discontinuation by race and ethnicity, using data from the 2000–2016 Health and Retirement Study linked with Medicare and Medicaid claims. Results: Among newly diagnosed ADRD patients (n = 1299), 26% filled an ADRD prescription ≤90 days and 36% ≤365 days after diagnosis. Among individuals initiating ADRD‐targeted treatment (n = 1343), 44% were non‐adherent and 24% discontinued the medication during the year after treatment initiation. Non‐Hispanic Blacks were more likely than Whites to not adhere to ADRD medication therapy (odds ratio: 1.50 [95% confidence interval: 1.07–2.09]). Discussion: Initiation of ADRD‐targeted medications did not vary by ethnoracial group, but non‐Hispanic Blacks had lower adherence than Whites. ADRD medication non‐adherence and discontinuation were substantial and may relate to cost and access to care. HIGHLIGHTS: Initiation of anti‐dementia medications among newly diagnosed Alzheimer's disease and related dementias (ADRD) patients was low in all ethnoracial groups.ADRD medication non‐adherence and discontinuation were substantial and may relate to cost and access to care.Compared to Whites, Blacks and Hispanics had lower use, poorer treatment adherence, and more frequent discontinuation of ADRD medication, but when controlling for disease severity and socioeconomic factors, racial disparities diminish.Our findings demonstrate the importance of adjusting for socioeconomic characteristics and disease severity when studying medication use and adherence in ADRD patients. [ABSTRACT FROM AUTHOR]

Published
2023
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