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1,956 results on '"Lin, M C"'

4. EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis

Author

Shih, C-H, Chang, Y-J, Huang, W-C, Jang, T-H, Kung, H-J, Wang, W-C, Yang, M-H, Lin, M-C, Huang, S-F, Chou, S-W, Chang, E, Chiu, H, Shieh, T-Y, Chen, Y-J, Wang, L-H, and Chen, L

Subjects
Orphan Drug, Lung, Cancer, Genetics, Dental/Oral and Craniofacial Disease, Lung Cancer, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Animals, Biomarkers, Tumor, Carcinoma, Squamous Cell, Cell Line, Tumor, Cell Proliferation, Chemokine CXCL1, Down-Regulation, Enhancer of Zeste Homolog 2 Protein, ErbB Receptors, Gene Expression Regulation, Neoplastic, Histones, Humans, Lung Neoplasms, Male, Methylation, Mice, Molecular Targeted Therapy, Mouth Neoplasms, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, STAT1 Transcription Factor, Up-Regulation, Xenograft Model Antitumor Assays, Zinc Finger Protein GLI1, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Current anti-epidermal growth factor receptor (EGFR) therapy for oral cancer does not provide satisfactory efficacy due to drug resistance or reduced EGFR level. As an alternative candidate target for therapy, here we identified an oncogene, ROS1, as an important driver for oral squamous cell carcinoma (OSCC) metastasis. Among tumors from 188 oral cancer patients, upregulated ROS1 expression strongly correlated with metastasis to lung and lymph nodes. Mechanistic studies uncover that the activated ROS1 results from highly expressed ROS1 gene instead of gene rearrangement, a phenomenon distinct from other cancers. Our data further reveal a novel mechanism that reduced histone methyltransferase EZH2 leads to a lower trimethylation of histone H3 lysine 27 suppressive modification, relaxes chromatin, and promotes the accessibility of the transcription factor STAT1 to the enhancer and the intron regions of ROS1 target genes, CXCL1 and GLI1, for upregulating their expressions. Down-regulation of ROS1 in highly invasive OSCC cells, nevertheless, reduces cell proliferation and inhibits metastasis to lung in the tail-vein injection and the oral cavity xenograft models. Our findings highlight ROS1 as a candidate biomarker and therapeutic target for OSCC. Finally, we demonstrate that co-targeting of ROS1 and EGFR could potentially offer an effective oral cancer therapy.

Published
2017

6. Numerical modeling of a table-top tunable Smith-Purcell Terahertz free-electron laser operating in the super-radiant regime

Author

Prokop, C., Piot, P., Lin, M. -C., and Stoltz, P.

Subjects
Physics - Accelerator Physics
Abstract

Terahertz (THz) radiation occupies a very large portion of the electromagnetic spectrum and has generated much recent interest due to its ability to penetrate deep into many organic materials without the damage associated with ionizing radiation such as x-rays. One path for generating copious amount of tunable narrow-band THz radiation is based on the Smith-Purcell free-electron laser (SPFEL) effect. In this Letter we propose a simple concept for a compact two-stage tunable SPFEL operating in the superradiant regime capable of radiating at the grating's fundamental bunching frequency. We demonstrate its capabilities and performances via computer simulation using the conformal finite-difference time-domain electromagnetic solver {\sc vorpal}., Comment: 4 pages, 5 figures, accepted for publication in Applied Physics Letters

Published
2010
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17. LBA8 Nivolumab (NIVO) + chemotherapy (chemo) vs chemo in patients (pts) with EGFR-mutated metastatic non-small cell lung cancer (mNSCLC) with disease progression after EGFR tyrosine kinase inhibitors (TKIs) in CheckMate 722

Author

Mok, T.S.K., primary, Nakagawa, K., additional, Park, K., additional, Ohe, Y., additional, Girard, N., additional, Kim, H.R., additional, Wu, Y-L., additional, Gainor, J., additional, Lee, S-H., additional, Chiu, C-H., additional, Sang-We, K., additional, Cheng-Ta, Y., additional, Liang, W., additional, Wu, L., additional, Lin, M-C., additional, Samol, J., additional, Zhang, X., additional, Sylvester, J., additional, Li, S., additional, and Yang, J.C-H., additional

Published
2022
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18. Silicon-Based Nano Devices for Detection of DNA Molecules

Author

Lin, M. C., Chu, C. J., Liu, C. J., Wu, Y. P., Wu, C. S., Chen, C. D., Cheng, I. C., Tsai, L. C., Lin, H. Y., Wu, Ya-Na, Shieh, Dar-Bin, Wu, H. C., Chen, Y. T., Wang, Zhiming M., editor, Waag, Andreas, editor, Salamo, Gregory, editor, Kishimoto, Naoki, editor, Tang, Zikang, editor, and Sheng, Ping, editor

Published
2008
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