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131 results on '"Lin, Jianjing"'

6. BlockIoT: Blockchain-based Health Data Integration using IoT Devices

Author

Shukla, Manan, Lin, Jianjing, and Seneviratne, Oshani

Subjects
Computer Science - Human-Computer Interaction
Abstract

The development and adoption of Electronic Health Records (EHR) and health monitoring Internet of Things (IoT) Devices have enabled digitization of patient records and has also substantially transformed the healthcare delivery system in aspects such as remote patient monitoring, healthcare decision making, and medical research. However, data tends to be fragmented among health infrastructures and prevents interoperability of medical data at the point of care. In order to address this gap, we introduce BlockIoT that uses blockchain technology to transfer previously inaccessible and centralized data from medical devices to EHR systems, which provides greater insight to providers who can, in turn, provide better outcomes for patients. This notion of interoperability of medical device data is possible through an Application Programming Interface (API), which serves as a versatile endpoint for all incoming medical device data, a distributed file system that ensures data resilience, and knowledge templates that analyze, identify, and represent medical device data to providers. Our participatory design survey on BlockIoT demonstrates that BlockIoT is a suitable system to supplement physicians' clinical practice and increases efficiency in most healthcare specialties, including cardiology, pulmonology, endocrinology, and primary care.

Published
2021

12. Blockchain and IoT Enhanced Clinical Workflow

Author

Shukla, Manan, Lin, Jianjing, Seneviratne, Oshani, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Michalowski, Martin, editor, Abidi, Syed Sibte Raza, editor, and Abidi, Samina, editor

Published
2022
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14. Research Progress on Injectable Microspheres as New Strategies for the Treatment of Osteoarthritis Through Promotion of Cartilage Repair.

Author

Lin, Jianjing, Jia, Shicheng, Cao, Fuyang, Huang, Jingtao, Chen, Jiayou, Wang, Juan, Liu, Peng, Zeng, Hui, Zhang, Xintao, and Cui, Wenguo

Subjects
*JOINT pain, *DRUG delivery systems, *DEGENERATION (Pathology), *MICROSPHERES, *CELL proliferation, *CARTILAGE regeneration
Abstract

Osteoarthritis (OA) is a degenerative disease caused by a variety of factors with joint pain as the main symptom, including fibrosis, chapping, ulcers, and loss of cartilage. Traditional treatment can only delay the progression of OA, and classical delivery system have many side effects. In recent years, microspheres have shown great application prospects in the field of OA treatment. Microspheres can support cells, reproduce the natural tissue microenvironment in vitro and in vivo, and are an efficient delivery system for the release of drugs or biological agents, which can promote cell proliferation, migration, and differentiation. Thus, they have been widely used in cartilage repair and regeneration. In this review, preparation processes, basic materials, and functional characteristics of various microspheres commonly used in OA treatment are systematically reviewed. Then it is introduced surface modification strategies that can improve the biological properties of microspheres and discussed a series of applications of microsphere functionalized scaffolds in OA treatment. Finally, based on bibliometrics research, the research development, future potential, and possible research hotspots of microspheres in the field of OA therapy is systematically and dynamically evaluated. The comprehensive and systematic review will bring new understanding to the field of microsphere treatment of OA. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy.

Author

Lin, Jianjing, Huang, Jingtao, Jiao, Zilu, Nian, Mengyuan, Li, Canfeng, Dai, Yali, Jia, Shicheng, and Zhang, Xintao

Subjects
*MESENCHYMAL stem cells, *OSTEOARTHRITIS, *CARTILAGE cells, *STEM cells, *EXTRACELLULAR vesicles, *CARTILAGE regeneration
Abstract

Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a huge burden on the health care system worldwide. Although traditional therapy and targeted cartilage cell therapy have made significant progress in the treatment of OA and cartilage regeneration, there are still many problems. Mesenchymal stem cells from various tissues are the most studied cell type and have been used in preclinical and clinical studies of OA, because they are more widely available, have a greater capacity for in vitro expansion, and have anti‐inflammatory and immunomodulatory properties compared to autologous chondrocytes. This article will systematically review the latest developments in these areas. It may provide new insights for improving OA and cartilage regeneration. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Latest Progress of LIPUS in Fracture Healing: A Mini‐Review.

Author

Guo, Xin, Lv, Maojiang, Lin, Jie, Guo, Jiang, Lin, Jianjing, Li, Shun, Sun, Yi, and Zhang, Xintao

Subjects
FRACTURE healing, ACOUSTIC radiation, BONE fractures, BONE regeneration, PATIENT compliance, STROMAL cells
Abstract

The use of low‐intensity pulsed ultrasound (LIPUS) for promoting fracture healing has been Food and Drug Administration (FDA)‐approved since 1994 due to largely its non‐thermal effects of sound flow sound radiation force and so on. Numerous clinical and animal studies have shown that LIPUS can accelerate the healing of fresh fractures, nonunions, and delayed unions in pulse mode regardless of LIPUS devices or circumstantial factors. Rare clinical studies show limitations of LIPUS for treating fractures with intramedullary nail fixation or low patient compliance. The biological effect is achieved by regulating various cellular behaviors involving mesenchymal stem/stromal cells (MSCs), osteoblasts, chondrocytes, and osteoclasts and with dose dependency on LIPUS intensity and time. Specifically, LIPUS promotes the osteogenic differentiation of MSCs through the ROCK‐Cot/Tpl2‐MEK–ERK signaling. Osteoblasts, in turn, respond to the mechanical signal of LIPUS through integrin, angiotensin type 1 (AT1), and PIEZO1 mechano‐receptors, leading to the production of inflammatory factors such as COX‐2, MCP‐1, and MIP‐1β fracture repair. LIPUS also induces CCN2 expression in chondrocytes thereby coordinating bone regeneration. Finally, LIPUS suppresses osteoclast differentiation and gene expression by interfering with the ERK/c‐Fos/NFATc1 cascade. This mini‐review revisits the known effects and mechanisms of LIPUS on bone fracture healing and strengthens the need for further investigation into the underlying mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Latest Progress of LIPUSin Fracture Healing

Author

Guo, Xin, Lv, Maojiang, Lin, Jie, Guo, Jiang, Lin, Jianjing, Li, Shun, Sun, Yi, and Zhang, Xintao

Abstract

The use of low‐intensity pulsed ultrasound (LIPUS) for promoting fracture healing has been Food and Drug Administration (FDA)‐approved since 1994 due to largely its non‐thermal effects of sound flow sound radiation force and so on. Numerous clinical and animal studies have shown that LIPUS can accelerate the healing of fresh fractures, nonunions, and delayed unions in pulse mode regardless of LIPUS devices or circumstantial factors. Rare clinical studies show limitations of LIPUS for treating fractures with intramedullary nail fixation or low patient compliance. The biological effect is achieved by regulating various cellular behaviors involving mesenchymal stem/stromal cells (MSCs), osteoblasts, chondrocytes, and osteoclasts and with dose dependency on LIPUS intensity and time. Specifically, LIPUS promotes the osteogenic differentiation of MSCs through the ROCK‐Cot/Tpl2‐MEK–ERK signaling. Osteoblasts, in turn, respond to the mechanical signal of LIPUS through integrin, angiotensin type 1 (AT1), and PIEZO1 mechano‐receptors, leading to the production of inflammatory factors such as COX‐2, MCP‐1, and MIP‐1β fracture repair. LIPUS also induces CCN2 expression in chondrocytes thereby coordinating bone regeneration. Finally, LIPUS suppresses osteoclast differentiation and gene expression by interfering with the ERK/c‐Fos/NFATc1 cascade. This mini‐review revisits the known effects and mechanisms of LIPUS on bone fracture healing and strengthens the need for further investigation into the underlying mechanisms.

Published
2024
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24. Current Strategies in Economics and Management Vol. 5

Author

Bordley, Robert, additional, Tibiletti, Luisa, additional, Aronu, C. O., additional, Ekwueme, G. O., additional, Emunefe, J. O., additional, Hazari, Bharat R., additional, Lin, Jianjing, additional, Murta, Aurélio Lamare Soares, additional, Freitas, Marcos Aurélio Vasconcelos de, additional, Surkov, Sergey A., additional, Trofimova, Ellen G., additional, Quattrocchio, Luciano, additional, Uberti, Mariacristina, additional, Nwanne, T. F. I., additional, Limone, Aquiles, additional, Marinovic, Milan, additional, Biraori, Oteki Evans, additional, Nyamasege, Ondieki John, additional, Silveira, João Serafim Tusi da, additional, Ávila, Lucas Veiga, additional, Borba, José Tavares de, additional, Juliani, Lucélia Ivonete, additional, Adis, Azaze-Azizi Abdul, additional, Pang, Yi Xuan, additional, Solomon, Kehinde, Abiodun, additional, Oluwasola, Babatunde, Taiye, additional, Johnson, Kehinde, Olujide, additional, and Omowunmi, Babatunde Oluyemisi, additional

Published
2020
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33. Global research trends in extracellular vesicles based on stem cells from 1991 to 2021: A bibliometric and visualized study

Author

Lin, Jianjing, Yang, Zhen, Wang, Li, Xing, Dan, and Lin, Jianhao

Subjects
Histology, Biomedical Engineering, Bioengineering, Biotechnology
Abstract

Objective: With the development of extracellular vesicles (EVs) based on stem cells research all over the world, our present study was aiming to discover the global trends in this field.Methods: All publications related to EVs based on stem cells from 1991 to 2021 were collected from the Science Citation Index-Expanded of Web of Science Subsequently, the data were evaluated using the bibliometric methodology. In terms of visualized study, the VOS viewer software was performed to investigate the bibliographic coupling, co-citation, co-authorship, and co-occurrence trends, and last for the publication’s trends involved in the field of EVs based on stem cells.Results: A total of 8,208 publications were retrieved and the relative number of global publications and research interests were increasing every year especially in recent 5 years. China rank top one in terms of total publications, prolific authors, and funds, whereas the USA made the greatest contributions with the most total citations and highest H-index to the global research. Stem cell research therapy contributed the highest publications, whereas the journal of PLOS ONE showed the best total link strength. The Shanghai Jiao Tong University, University of California System, and Harvard University were the most contributive institutions. The global studies could be divided into six clusters as follows: cancer research, musculoskeletal system research, respiratory system research, urinary system and endocrine system research, nerve system research, and cardiovascular system research. All the directions were predicted to still hotspots in near future researches in this field.Conclusion: The total number of publications about EVs based stem cells would be increasing according to the current global trends. China and the USA was the largest contributors in this field. Further efforts should be put in the directions of cancer research, musculoskeletal system research, respiratory system research, urinary system and endocrine system research, nerve system research, as well was cardiovascular system research in this field of EVs based stem cells.

Published
2022

36. Magnesium Oxide Nanoparticle Coordinated Phosphate-Functionalized Chitosan Injectable Hydrogel for Osteogenesis and Angiogenesis in Bone Regeneration

Author

Chen, Yingqi, primary, Sheng, Weibei, additional, Lin, Jianjing, additional, Fang, Chongzhou, additional, Deng, Jiapeng, additional, Zhang, Peng, additional, Zhou, Meng, additional, Liu, Peng, additional, Weng, Jian, additional, Yu, Fei, additional, Wang, Deli, additional, Kang, Bin, additional, and Zeng, Hui, additional

Published
2022
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47. Biomimetic matrix fabricated by LMP-1 gene-transduced MC3T3-E1 cells for bone regeneration

Author

Ma, Junxuan, primary, Guo, Wei, additional, Gao, Manman, additional, Huang, Baoding, additional, Qi, Qihua, additional, Ling, Zemin, additional, Chen, Yan, additional, Hu, Hao, additional, Zhou, Hailian, additional, Yu, Fei, additional, Chen, Ke, additional, Richards, Geoff, additional, Lin, Jianjing, additional, Zhou, Zhiyu, additional, Xiao, Deming, additional, and Zou, Xuenong, additional

Published
2017
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50. GW26-e0740 Safety and Efficacy of IntraCoronary Hypoxia-precondItioned Bone Marrow MonoNuclear Cell Administration for Acute Myocardial Infarction Patients: The CHINA-AMI Randomized Controlled Trial

Author

Hu, Xinyang, primary, Huang, Xin, additional, Yang, Qian, additional, Wang, Lihua, additional, Sun, Jianzhong, additional, Zhan, Hongwei, additional, Lin, Jianjing, additional, Pu, Zhaoxia, additional, Jiang, Jun, additional, Sun, Yong, additional, Xiang, Meixiang, additional, Liu, Xianbao, additional, Xie, Xiaojie, additional, Yu, Xia, additional, and Chen, Zexin, additional

Published
2015
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