1,892 results on '"Lin, Jessica"'
Search Results
2. Interactive Dialogue Agents via Reinforcement Learning on Hindsight Regenerations
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Hong, Joey, Lin, Jessica, Dragan, Anca, and Levine, Sergey
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computation and Language - Abstract
Recent progress on large language models (LLMs) has enabled dialogue agents to generate highly naturalistic and plausible text. However, current LLM language generation focuses on responding accurately to questions and requests with a single effective response. In reality, many real dialogues are interactive, meaning an agent's utterances will influence their conversational partner, elicit information, or change their opinion. Accounting for how an agent can effectively steer a conversation is a crucial ability in many dialogue tasks, from healthcare to preference elicitation. Existing methods for fine-tuning dialogue agents to accomplish such tasks would rely on curating some amount of expert data. However, doing so often requires understanding the underlying cognitive processes of the conversational partner, which is a skill neither humans nor LLMs trained on human data can reliably do. Our key insight is that while LLMs may not be adept at identifying effective strategies for steering conversations a priori, or in the middle of an ongoing conversation, they can do so post-hoc, or in hindsight, after seeing how their conversational partner responds. We use this fact to rewrite and augment existing suboptimal data, and train via offline reinforcement learning (RL) an agent that outperforms both prompting and learning from unaltered human demonstrations. We apply our approach to two domains that require understanding human mental state, intelligent interaction, and persuasion: mental health support, and soliciting charitable donations. Our results in a user study with real humans show that our approach greatly outperforms existing state-of-the-art dialogue agents., Comment: 23 pages, 5 figures
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- 2024
3. GDTB: Genre Diverse Data for English Shallow Discourse Parsing across Modalities, Text Types, and Domains
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Liu, Yang Janet, Aoyama, Tatsuya, Scivetti, Wesley, Zhu, Yilun, Behzad, Shabnam, Levine, Lauren Elizabeth, Lin, Jessica, Tiwari, Devika, and Zeldes, Amir
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Computer Science - Computation and Language - Abstract
Work on shallow discourse parsing in English has focused on the Wall Street Journal corpus, the only large-scale dataset for the language in the PDTB framework. However, the data is not openly available, is restricted to the news domain, and is by now 35 years old. In this paper, we present and evaluate a new open-access, multi-genre benchmark for PDTB-style shallow discourse parsing, based on the existing UD English GUM corpus, for which discourse relation annotations in other frameworks already exist. In a series of experiments on cross-domain relation classification, we show that while our dataset is compatible with PDTB, substantial out-of-domain degradation is observed, which can be alleviated by joint training on both datasets., Comment: Accepted to EMNLP 2024 (main, long); camera-ready version
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- 2024
4. RandomNet: Clustering Time Series Using Untrained Deep Neural Networks
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Li, Xiaosheng, Xi, Wenjie, and Lin, Jessica
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
Neural networks are widely used in machine learning and data mining. Typically, these networks need to be trained, implying the adjustment of weights (parameters) within the network based on the input data. In this work, we propose a novel approach, RandomNet, that employs untrained deep neural networks to cluster time series. RandomNet uses different sets of random weights to extract diverse representations of time series and then ensembles the clustering relationships derived from these different representations to build the final clustering results. By extracting diverse representations, our model can effectively handle time series with different characteristics. Since all parameters are randomly generated, no training is required during the process. We provide a theoretical analysis of the effectiveness of the method. To validate its performance, we conduct extensive experiments on all of the 128 datasets in the well-known UCR time series archive and perform statistical analysis of the results. These datasets have different sizes, sequence lengths, and they are from diverse fields. The experimental results show that the proposed method is competitive compared with existing state-of-the-art methods., Comment: 25 pages, 10 figures
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- 2024
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5. Generalized front propagation for spatial stochastic population models
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Hughes, Thomas and Lin, Jessica
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Mathematics - Probability ,60J85, 60K35, 92D25 - Abstract
We present a general framework which can be used to prove that, in an annealed sense, rescaled spatial stochastic population models converge to generalized propagating fronts. Our work is motivated by recent results of Etheridge, Freeman, and Penington [EFP2017] and Huang and Durrett [HD2021], who proved convergence to classical mean curvature flow (MCF) for certain spatial stochastic processes, up until the first time when singularities of MCF form. Our arguments rely on the level-set method and the abstract approach to front propagation introduced by Barles and Souganidis [BS1998]. This approach is amenable to stochastic models equipped with moment duals which satisfy certain general and verifiable properties. Our main results improve the existing results in several ways, first by removing regularity conditions on the initial data, and second by establishing convergence beyond the formation of singularities of MCF. In particular, we obtain a general convergence theorem which holds globally in time. This is then applied to all of the models considered in [EFP2017] and [HD2021]., Comment: 65 pages
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- 2024
6. Development of an advanced separation and characterization platform for mRNA and lipid nanoparticles using multi-detector asymmetrical flow field-flow fractionation
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Gao, Ziting, Lin, Jessica, Su, Wan-Chih, Zhang, Kelly, Gruenhagen, Jason, Zhong, Wenwan, Fan, Yuchen, and Bian, Juan
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- 2024
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7. GUMsley: Evaluating Entity Salience in Summarization for 12 English Genres
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Lin, Jessica and Zeldes, Amir
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Computer Science - Computation and Language - Abstract
As NLP models become increasingly capable of understanding documents in terms of coherent entities rather than strings, obtaining the most salient entities for each document is not only an important end task in itself but also vital for Information Retrieval (IR) and other downstream applications such as controllable summarization. In this paper, we present and evaluate GUMsley, the first entity salience dataset covering all named and non-named salient entities for 12 genres of English text, aligned with entity types, Wikification links and full coreference resolution annotations. We promote a strict definition of salience using human summaries and demonstrate high inter-annotator agreement for salience based on whether a source entity is mentioned in the summary. Our evaluation shows poor performance by pre-trained SOTA summarization models and zero-shot LLM prompting in capturing salient entities in generated summaries. We also show that predicting or providing salient entities to several model architectures enhances performance and helps derive higher-quality summaries by alleviating the entity hallucination problem in existing abstractive summarization., Comment: Camera-ready for EACL 2024
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- 2024
8. GENTLE: A Genre-Diverse Multilayer Challenge Set for English NLP and Linguistic Evaluation
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Aoyama, Tatsuya, Behzad, Shabnam, Gessler, Luke, Levine, Lauren, Lin, Jessica, Liu, Yang Janet, Peng, Siyao, Zhu, Yilun, and Zeldes, Amir
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Computer Science - Computation and Language - Abstract
We present GENTLE, a new mixed-genre English challenge corpus totaling 17K tokens and consisting of 8 unusual text types for out-of domain evaluation: dictionary entries, esports commentaries, legal documents, medical notes, poetry, mathematical proofs, syllabuses, and threat letters. GENTLE is manually annotated for a variety of popular NLP tasks, including syntactic dependency parsing, entity recognition, coreference resolution, and discourse parsing. We evaluate state-of-the-art NLP systems on GENTLE and find severe degradation for at least some genres in their performance on all tasks, which indicates GENTLE's utility as an evaluation dataset for NLP systems., Comment: Camera-ready for LAW-XVII collocated with ACL 2023
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- 2023
9. Detection of P. malariae using a new rapid isothermal amplification lateral flow assay
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Assefa, Ashenafi, Wamae, Kevin, Hennelly, Christopher M., Ngasala, Billy, Muller, Meredith, Kalonji, Albert, Phanzu, Fernandine, Cunningham, Clark H., Lin, Jessica T., and Parr, Jonathan B.
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- 2024
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10. Perceptual correlates of comprehensibility in relation to suprasegmental features
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Gnevsheva, Ksenia and Lin, Jessica
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- 2018
11. Deep RL at Scale: Sorting Waste in Office Buildings with a Fleet of Mobile Manipulators
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Herzog, Alexander, Rao, Kanishka, Hausman, Karol, Lu, Yao, Wohlhart, Paul, Yan, Mengyuan, Lin, Jessica, Arenas, Montserrat Gonzalez, Xiao, Ted, Kappler, Daniel, Ho, Daniel, Rettinghouse, Jarek, Chebotar, Yevgen, Lee, Kuang-Huei, Gopalakrishnan, Keerthana, Julian, Ryan, Li, Adrian, Fu, Chuyuan Kelly, Wei, Bob, Ramesh, Sangeetha, Holden, Khem, Kleiven, Kim, Rendleman, David, Kirmani, Sean, Bingham, Jeff, Weisz, Jon, Xu, Ying, Lu, Wenlong, Bennice, Matthew, Fong, Cody, Do, David, Lam, Jessica, Bai, Yunfei, Holson, Benjie, Quinlan, Michael, Brown, Noah, Kalakrishnan, Mrinal, Ibarz, Julian, Pastor, Peter, and Levine, Sergey
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Computer Science - Robotics - Abstract
We describe a system for deep reinforcement learning of robotic manipulation skills applied to a large-scale real-world task: sorting recyclables and trash in office buildings. Real-world deployment of deep RL policies requires not only effective training algorithms, but the ability to bootstrap real-world training and enable broad generalization. To this end, our system combines scalable deep RL from real-world data with bootstrapping from training in simulation, and incorporates auxiliary inputs from existing computer vision systems as a way to boost generalization to novel objects, while retaining the benefits of end-to-end training. We analyze the tradeoffs of different design decisions in our system, and present a large-scale empirical validation that includes training on real-world data gathered over the course of 24 months of experimentation, across a fleet of 23 robots in three office buildings, with a total training set of 9527 hours of robotic experience. Our final validation also consists of 4800 evaluation trials across 240 waste station configurations, in order to evaluate in detail the impact of the design decisions in our system, the scaling effects of including more real-world data, and the performance of the method on novel objects. The projects website and videos can be found at \href{http://rl-at-scale.github.io}{rl-at-scale.github.io}., Comment: Published at Robotics: Science and Systems 2023
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- 2023
12. Therapy-induced APOBEC3A drives evolution of persistent cancer cells
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Isozaki, Hideko, Sakhtemani, Ramin, Abbasi, Ammal, Nikpour, Naveed, Stanzione, Marcello, Oh, Sunwoo, Langenbucher, Adam, Monroe, Susanna, Su, Wenjia, Cabanos, Heidie Frisco, Siddiqui, Faria M, Phan, Nicole, Jalili, Pégah, Timonina, Daria, Bilton, Samantha, Gomez-Caraballo, Maria, Archibald, Hannah L, Nangia, Varuna, Dionne, Kristin, Riley, Amanda, Lawlor, Matthew, Banwait, Mandeep Kaur, Cobb, Rosemary G, Zou, Lee, Dyson, Nicholas J, Ott, Christopher J, Benes, Cyril, Getz, Gad, Chan, Chang S, Shaw, Alice T, Gainor, Justin F, Lin, Jessica J, Sequist, Lecia V, Piotrowska, Zofia, Yeap, Beow Y, Engelman, Jeffrey A, Lee, Jake June-Koo, Maruvka, Yosef E, Buisson, Rémi, Lawrence, Michael S, and Hata, Aaron N
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Genetics ,Lung Cancer ,Cancer ,Lung ,Aetiology ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,2.1 Biological and endogenous factors ,Good Health and Well Being ,Humans ,Cytidine Deaminase ,DNA Breaks ,Double-Stranded ,Genomic Instability ,Lung Neoplasms ,Molecular Targeted Therapy ,Mutation ,Drug Resistance ,Neoplasm ,General Science & Technology - Abstract
Acquired drug resistance to anticancer targeted therapies remains an unsolved clinical problem. Although many drivers of acquired drug resistance have been identified1-4, the underlying molecular mechanisms shaping tumour evolution during treatment are incompletely understood. Genomic profiling of patient tumours has implicated apolipoprotein B messenger RNA editing catalytic polypeptide-like (APOBEC) cytidine deaminases in tumour evolution; however, their role during therapy and the development of acquired drug resistance is undefined. Here we report that lung cancer targeted therapies commonly used in the clinic can induce cytidine deaminase APOBEC3A (A3A), leading to sustained mutagenesis in drug-tolerant cancer cells persisting during therapy. Therapy-induced A3A promotes the formation of double-strand DNA breaks, increasing genomic instability in drug-tolerant persisters. Deletion of A3A reduces APOBEC mutations and structural variations in persister cells and delays the development of drug resistance. APOBEC mutational signatures are enriched in tumours from patients with lung cancer who progressed after extended responses to targeted therapies. This study shows that induction of A3A in response to targeted therapies drives evolution of drug-tolerant persister cells, suggesting that suppression of A3A expression or activity may represent a potential therapeutic strategy in the prevention or delay of acquired resistance to lung cancer targeted therapy.
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- 2023
13. LB-SimTSC: An Efficient Similarity-Aware Graph Neural Network for Semi-Supervised Time Series Classification
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Xi, Wenjie, Jain, Arnav, Zhang, Li, and Lin, Jessica
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
Time series classification is an important data mining task that has received a lot of interest in the past two decades. Due to the label scarcity in practice, semi-supervised time series classification with only a few labeled samples has become popular. Recently, Similarity-aware Time Series Classification (SimTSC) is proposed to address this problem by using a graph neural network classification model on the graph generated from pairwise Dynamic Time Warping (DTW) distance of batch data. It shows excellent accuracy and outperforms state-of-the-art deep learning models in several few-label settings. However, since SimTSC relies on pairwise DTW distances, the quadratic complexity of DTW limits its usability to only reasonably sized datasets. To address this challenge, we propose a new efficient semi-supervised time series classification technique, LB-SimTSC, with a new graph construction module. Instead of using DTW, we propose to utilize a lower bound of DTW, LB_Keogh, to approximate the dissimilarity between instances in linear time, while retaining the relative proximity relationships one would have obtained via computing DTW. We construct the pairwise distance matrix using LB_Keogh and build a graph for the graph neural network. We apply this approach to the ten largest datasets from the well-known UCR time series classification archive. The results demonstrate that this approach can be up to 104x faster than SimTSC when constructing the graph on large datasets without significantly decreasing classification accuracy., Comment: Accpeted by DLG-AAAI'23
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- 2023
14. PMP: Privacy-Aware Matrix Profile against Sensitive Pattern Inference for Time Series
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Zhang, Li, Ding, Jiahao, Gao, Yifeng, and Lin, Jessica
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Computer Science - Machine Learning ,Computer Science - Cryptography and Security - Abstract
Recent rapid development of sensor technology has allowed massive fine-grained time series (TS) data to be collected and set the foundation for the development of data-driven services and applications. During the process, data sharing is often involved to allow the third-party modelers to perform specific time series data mining (TSDM) tasks based on the need of data owner. The high resolution of TS brings new challenges in protecting privacy. While meaningful information in high-resolution TS shifts from concrete point values to local shape-based segments, numerous research have found that long shape-based patterns could contain more sensitive information and may potentially be extracted and misused by a malicious third party. However, the privacy issue for TS patterns is surprisingly seldom explored in privacy-preserving literature. In this work, we consider a new privacy-preserving problem: preventing malicious inference on long shape-based patterns while preserving short segment information for the utility task performance. To mitigate the challenge, we investigate an alternative approach by sharing Matrix Profile (MP), which is a non-linear transformation of original data and a versatile data structure that supports many data mining tasks. We found that while MP can prevent concrete shape leakage, the canonical correlation in MP index can still reveal the location of sensitive long pattern. Based on this observation, we design two attacks named Location Attack and Entropy Attack to extract the pattern location from MP. To further protect MP from these two attacks, we propose a Privacy-Aware Matrix Profile (PMP) via perturbing the local correlation and breaking the canonical correlation in MP index vector. We evaluate our proposed PMP against baseline noise-adding methods through quantitative analysis and real-world case studies to show the effectiveness of the proposed method., Comment: This is a preprint. The paper has been accepted by SIAM SDM2023
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- 2023
15. Leveraging World Knowledge in Implicit Hate Speech Detection
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Lin, Jessica
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Computer Science - Computation and Language - Abstract
While much attention has been paid to identifying explicit hate speech, implicit hateful expressions that are disguised in coded or indirect language are pervasive and remain a major challenge for existing hate speech detection systems. This paper presents the first attempt to apply Entity Linking (EL) techniques to both explicit and implicit hate speech detection, where we show that such real world knowledge about entity mentions in a text does help models better detect hate speech, and the benefit of adding it into the model is more pronounced when explicit entity triggers (e.g., rally, KKK) are present. We also discuss cases where real world knowledge does not add value to hate speech detection, which provides more insights into understanding and modeling the subtleties of hate speech.
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- 2022
16. The central limit theorem via doubling of variables
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Addario-Berry, Louigi, Barill, Gavin, Beckman, Erin, and Lin, Jessica
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Mathematics - Probability ,60F05, 35K05 - Abstract
We give a new, self-contained proof of the multidimensional central limit theorem using the technique of ``doubling variables," which is traditionally used to prove uniqueness of solutions of partial differential equations (PDEs). Our technique also yields quantitative bounds for random variables with finite $2+\gamma$ moment for some $\gamma \in (0,1]$; when $\gamma=1$, this proves a version of the Berry--Esseen theorem in $\mathbb{R}^d$., Comment: 15 pages
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- 2022
17. Efficient and Accurate Similarity-Aware Graph Neural Network for Semi-supervised Time Series Classification
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Xi, Wenjie, Jain, Arnav, Zhang, Li, Lin, Jessica, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Yang, De-Nian, editor, Xie, Xing, editor, Tseng, Vincent S., editor, Pei, Jian, editor, Huang, Jen-Wei, editor, and Lin, Jerry Chun-Wei, editor
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- 2024
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18. Green function and invariant measure estimates for nondivergence form elliptic homogenization
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Armstrong, Scott, Fehrman, Benjamin, and Lin, Jessica
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Mathematics - Analysis of PDEs ,Mathematics - Probability ,35B27, 60F17, 60K37 - Abstract
We prove quantitative estimates on the the parabolic Green function and the stationary invariant measure in the context of stochasic homogenization of elliptic equations in nondivergence form. We consequently obtain a quenched, local CLT for the corresponding diffusion process and a quantitative ergodicity estimate for the environmental process. Each of these results are characterized by deterministic (in terms of the environment) estimates which are valid above a random, ``minimal'' length scale, the stochastic moments of which we estimate sharply., Comment: 60 pages
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- 2022
19. Robust Time Series Chain Discovery with Incremental Nearest Neighbors
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Zhang, Li, Zhu, Yan, Gao, Yifeng, and Lin, Jessica
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Information Retrieval - Abstract
Time series motif discovery has been a fundamental task to identify meaningful repeated patterns in time series. Recently, time series chains were introduced as an expansion of time series motifs to identify the continuous evolving patterns in time series data. Informally, a time series chain (TSC) is a temporally ordered set of time series subsequences, in which every subsequence is similar to the one that precedes it, but the last and the first can be arbitrarily dissimilar. TSCs are shown to be able to reveal latent continuous evolving trends in the time series, and identify precursors of unusual events in complex systems. Despite its promising interpretability, unfortunately, we have observed that existing TSC definitions lack the ability to accurately cover the evolving part of a time series: the discovered chains can be easily cut by noise and can include non-evolving patterns, making them impractical in real-world applications. Inspired by a recent work that tracks how the nearest neighbor of a time series subsequence changes over time, we introduce a new TSC definition which is much more robust to noise in the data, in the sense that they can better locate the evolving patterns while excluding the non-evolving ones. We further propose two new quality metrics to rank the discovered chains. With extensive empirical evaluations, we demonstrate that the proposed TSC definition is significantly more robust to noise than the state of the art, and the top ranked chains discovered can reveal meaningful regularities in a variety of real world datasets., Comment: Accepted to ICDM 2022. This is an extended version of the paper
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- 2022
20. Symmetric cooperative motion in one dimension
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Addario-Berry, Louigi, Beckman, Erin, and Lin, Jessica
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- 2024
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21. Social Determinants of Health Screening at an Urban Emergency Department Urgent Care During COVID-19
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Hong, Haeyeon, Shankar, Kalpana Narayan, Thompson, Andrew, De La Vega, Pablo Buitron, Koul, Rashmi, Manchanda, Emily Cleveland, Jaiprasert, Sorraya, Roberts, Samantha, Pina, Tyler, Anderson, Emily, Lin, Jessica, and Jacquet, Gabrielle A.
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Social Determinants of health ,SDOH ,Screening social determinants of health ,Screening SDOH ,Social emergency medicine ,Social EM ,COVID-19 - Abstract
Introduction: Social determinants of health (SDoH) impact patients’ health outcomes, yet screening methods in emergency departments (ED) are not consistent or standardized. The SDoH-related health disparities may have widened during the coronavirus 2019 (COVID-19) pandemic, especially among patients who primarily receive their medical care in EDs. We sought to identify SDoH among ED urgent care patients during the COVID-19 pandemic at an urban safety-net hospital, assess the impact of the pandemic on their SDoH, study the feasibility of SDoH screening and resource referrals, and identify preferred methods of resource referrals and barriers to accessing resources.Methods: Research assistants screened ED urgent care patients using a validated SDoH screener, inquiring about the impact of COVID-19 on their SDoH. A printed resource guide was provided. Two weeks later, a follow-up telephone survey assessed for barriers to resource connection and patients’ preferred methods for resource referrals. This study was deemed exempt by our institutionalreview board.Results: Of the 418 patients presented with a screener, 414 (99.0%) patients completed the screening. Of those screened, 296 (71.5%) reported at least one adverse SDoH, most commonly education (38.7%), food insecurity (35.3%), and employment (31.0%). Housing insecurity was reported by 21.0%. Over half of patients (57.0%) endorsed COVID-19 affecting their SDoH. During follow-up, 156 of 234 (67%) attempted calls were successful and 36/156 (23.1%) reported attempting to connect with a resource, with most attempts made for stable housing (11.0%) and food (7.7%). Reasons for not contacting the provided resources included lack of time (37.8%) and forgetting to do so (26.3%). Patients preferred resource guides to be printed (34.0%) and sent via text message to their mobile devices (25.6%).Conclusion: Many urgent care patients of this urban ED reported at least one adverse SDoH, the majority of which were exacerbated by the COVID-19 pandemic. This finding further emphasizes the need to allocate more resources to standardize and expand SDoH screening in EDs. Additionally, hospitals should increase availability of printed or electronic SDoH resource guides, resource navigators, and interpreters both during and after ED visits.
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- 2023
22. Analyzing U.S. Tweets for Stigma Against People Experiencing Homelessness
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Kim, Nathan J, Lin, Jessica, Hiller, Craig, Hildebrand, Chantal, and Auerswald, Colette
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Homelessness ,stigma ,homelessness ,Twitter ,Goffman ,public health - Abstract
Rising homelessness in the United States has been a considerable source of concern, with policymakers and community members calling for “solutions.” Stigma, as a societal barrier to addressing inequity, is a significant cause of morbidity and mortality for people experiencing homelessness (PEH) and presents a barrier to the proposed solutions. Given that using surveys to study stigma against PEH carries potential social desirability bias, our research team used Twitter, a microblogging platform comprised of 140-character messages (aka, tweets), to get a snapshot of how American Twitter users stigmatize PEH. We conducted a content analysis of 6,400 tweets regarding homelessness collected over 3 months. Our analysis was informed by Erving Goffman’s theoretical framework regarding stigma. Consistent with Goffman’s work, we illustrate the ways that Twitter users rationalized the situation of PEH by creating a “stigma theory,” in which they attribute undesirable characteristics to PEH, highlight the multiple ways in which they “deserve” to be homeless because of their character flaws, and emphasize their devalued “bottom of the heap” status. We describe the ways that this stigma theory of homelessness is expressed in tweets regarding interactions between PEH and housed individuals. Complementing Goffman’s work as applied to PEH, we also describe the ways in which Twitter users impute additional stigmatized identities onto PEH and the role that disgust plays in stigma against PEH. Our findings suggest the need for a multi-level response to stigma, including addressing stigma at the individual and structural levels and providing housing to PEH across communities. (PsycInfo Database Record (c) 2021 APA, all rights reserved)
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- 2023
23. Importance of Timely Sequencing, Tracking, and Surveillance of Emergent Variants
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Lin, Jessica, primary, Greenleaf, Morgan, additional, Lu, Yang, additional, Bassit, Leda, additional, Wesselman, Cassandra, additional, and Piantadosi, Anne, additional
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- 2024
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24. Symmetric cooperative motion in one dimension
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Addario-Berry, Louigi, Beckman, Erin, and Lin, Jessica
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Mathematics - Probability ,Mathematics - Analysis of PDEs ,Mathematics - Numerical Analysis ,60F05, 60K35 (Primary) 65M12, 35K61, 35K92 (Secondary) - Abstract
We explore the relationship between recursive distributional equations and convergence results for finite difference schemes of parabolic partial differential equations (PDEs). We focus on a family of random processes called symmetric cooperative motions, which generalize the symmetric simple random walk and the symmetric hipster random walk introduced in [Addario-Berry, Cairns, Devroye, Kerriou and Mitchell, arXiv:1909.07367]. We obtain a distributional convergence result for symmetric cooperative motions and, along the way, obtain a novel proof of the Bernoulli central limit theorem. In addition, we prove a PDE result relating distributional solutions and viscosity solutions of the porous medium equation and the parabolic $p$-Laplace equation, respectively, in one dimension., Comment: 33 pages, 0 figures
- Published
- 2022
25. Real-world treatment sequencing and effectiveness of second- and third-generation ALK tyrosine kinase inhibitors for ALK-positive advanced non-small cell lung cancer
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Bauman, Jessica R., Liu, Geoffrey, Preeshagul, Isabel, Liu, Stephen V., Melosky, Barbara, Abrahami, Devin, Li, Benjamin, Thomaidou, Despina, Duncan, Kirsten, Krulewicz, Stan, Rupp, Martin, and Lin, Jessica J.
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- 2024
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26. Three-Year Overall Survival Outcomes and Correlative Analyses in Patients With NSCLC and High (50%–89%) Versus Very High (≥90%) Programmed Death-Ligand 1 Expression Treated With First-Line Pembrolizumab or Cemiplimab
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Ricciuti, Biagio, Elkrief, Arielle, Lin, Jessica, Zhang, Jianjun, Alessi, Joao V., Lamberti, Giuseppe, Gandhi, Malini, Di Federico, Alessandro, Pecci, Federica, Wang, Xinan, Makarem, Maisam, Hidalgo Filho, Cassio Murilo, Gorria, Teresa, Saini, Arushi, Pabon, Cindy, Lindsay, James, Pfaff, Kathleen L., Welsh, Emma L., Nishino, Mizuki, Sholl, Lynette M., Rodig, Scott, Kilickap, Saadettin, Rietschel, Petra, McIntyre, Debra AG., Pouliot, Jean-Francois, Altan, Mehmet, Gainor, Justin F., Heymach, John V., Schoenfeld, Adam J., and Awad, Mark M.
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- 2024
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27. Closing the Gaps in Hepatitis C Knowledge Among Internal Medicine Residents in the United States
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Li, Lucy X., Lin, Jessica S., Tackett, Sean, Bertram, Amanda, Sisson, Stephen D., Rastegar, Darius, and Buresh, Megan E.
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- 2024
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28. Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction
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Parker, Ellen, Aboghazleh, Refat, Mumby, Griffin, Veksler, Ronel, Ofer, Jonathan, Newton, Jillian, Smith, Rylan, Kamintsky, Lyna, Jones, Casey MA, O’Keeffe, Eoin, Kelly, Eoin, Doelle, Klara, Roach, Isabelle, Yang, Lynn T, Moradi, Pooyan, Lin, Jessica M, Gleason, Allison J, Atkinson, Christina, Bowen, Chris, Brewer, Kimberly D, Doherty, Colin P, Campbell, Matthew, Clarke, David B, van Hameren, Gerben, Kaufer, Daniela, and Friedman, Alon
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Brain Disorders ,Traumatic Head and Spine Injury ,Neurosciences ,Physical Injury - Accidents and Adverse Effects ,Traumatic Brain Injury (TBI) ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Animals ,Blood-Brain Barrier ,Brain ,Brain Concussion ,Humans ,Neuroimaging ,Rats ,Transforming Growth Factor beta ,concussion ,repetitive mild traumatic brain injury ,blood-brain barrier ,dynamic contrast-enhanced MRI ,biomarker ,blood–brain barrier ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery - Abstract
The mechanisms underlying the complications of mild traumatic brain injury, including post-concussion syndrome, post-impact catastrophic death, and delayed neurodegeneration remain poorly understood. This limited pathophysiological understanding has hindered the development of diagnostic and prognostic biomarkers and has prevented the advancement of treatments for the sequelae of mild traumatic brain injury. We aimed to characterize the early electrophysiological and neurovascular alterations following repetitive mild traumatic brain injury and sought to identify new targets for the diagnosis and treatment of individuals at risk of severe post-impact complications. We combined behavioural, electrophysiological, molecular, and neuroimaging techniques in a rodent model of repetitive mild traumatic brain injury. In humans, we used dynamic contrast-enhanced MRI to quantify blood-brain barrier dysfunction after exposure to sport-related concussive mild traumatic brain injury. Rats could clearly be classified based on their susceptibility to neurological complications, including life-threatening outcomes, following repetitive injury. Susceptible animals showed greater neurological complications and had higher levels of blood-brain barrier dysfunction, transforming growth factor β (TGFβ) signalling, and neuroinflammation compared to resilient animals. Cortical spreading depolarizations were the most common electrophysiological events immediately following mild traumatic brain injury and were associated with longer recovery from impact. Triggering cortical spreading depolarizations in mild traumatic brain injured rats (but not in controls) induced blood-brain barrier dysfunction. Treatment with a selective TGFβ receptor inhibitor prevented blood-brain barrier opening and reduced injury complications. Consistent with the rodent model, blood-brain barrier dysfunction was found in a subset of human athletes following concussive mild traumatic brain injury. We provide evidence that cortical spreading depolarization, blood-brain barrier dysfunction, and pro-inflammatory TGFβ signalling are associated with severe, potentially life-threatening outcomes following repetitive mild traumatic brain injury. Diagnostic-coupled targeting of TGFβ signalling may be a novel strategy in treating mild traumatic brain injury.
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- 2022
29. Utilization and Delivery of Specialty Palliative Care in the ICU: Insights from the Palliative Care Quality Network.
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Chapman, Allyson, Lin, Joseph, Cobert, Julien, Marks, Angela, Lin, Jessica, ORiordan, David, and Pantilat, Steven
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Critical care ,PCQN ,palliative medicine ,Hospice and Palliative Care Nursing ,Humans ,Intensive Care Units ,Palliative Care ,Referral and Consultation ,Retrospective Studies - Abstract
CONTEXT: Palliative care (PC) benefits critically ill patients but remains underutilized. Important to developing interventions to overcome barriers to PC in the ICU and address PC needs of ICU patients is to understand how, when, and for which patients PC is provided in the ICU. OBJECTIVES: Compare characteristics of specialty PC consultations in the ICU to those on medical-surgical wards. METHODS: Retrospective analysis of national Palliative Care Quality Network data for hospitalized patients receiving specialty PC consultation January 1, 2013 to December 31, 2019 in ICU or medical-surgical setting. 98 inpatient PC teams in 16 states contributed data. Measures and outcomes included patient characteristics, consultation features, process metrics and patient outcomes. Mixed effects multivariable logistic regression was used to compare ICU and medical-surgical units. RESULTS: Of 102,597 patients 63,082 were in medical-surgical units and 39,515 ICU. ICU patients were younger and more likely to have non-cancer diagnoses (all P < 0.001). While fewer ICU patients were able to report symptoms, most patients in both groups reported improved symptoms. ICU patients were more likely to have consultation requests for GOC, comfort care, and withdrawal of interventions and less likely for pain and/or symptoms (OR-all P < 0.001). ICU patients were less often discharged alive. CONCLUSION: ICU patients receiving PC consultation are more likely to have non-cancer diagnoses and less likely able to communicate. Although symptom management and GOC are standard parts of ICU care, specialty PC in the ICU is often engaged for these issues and results in improved symptoms, suggesting routine interventions and consultation targeting these needs could improve care.
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- 2022
30. Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies
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Figueiredo, Jane C, Hirsch, Fred R, Kushi, Lawrence H, Nembhard, Wendy N, Crawford, James M, Mantis, Nicholas, Finster, Laurel, Merin, Noah M, Merchant, Akil, Reckamp, Karen L, Melmed, Gil Y, Braun, Jonathan, McGovern, Dermot, Parekh, Samir, Corley, Douglas A, Zohoori, Namvar, Amick, Benjamin C, Du, Ruofei, Gregersen, Peter K, Diamond, Betty, Taioli, Emanuela, Sariol, Carlos, Espino, Ana, Weiskopf, Daniela, Gifoni, Alba, Brien, James, Hanege, William, Lipsitch, Marc, Zidar, David A, McAlearney, Ann Scheck, Wajnberg, Ania, LaBaer, Joshua, Lewis, E Yvonne, Binder, Raquel A, Moormann, Ann M, Forconi, Catherine, Forrester, Sarah, Batista, Jennifer, Schieffelin, John, Kim, Dongjoo, Biancon, Giulia, VanOudenhove, Jennifer, Halene, Stephanie, Fan, Rong, Barouch, Dan H, Alter, Galit, Pinninti, Swetha, Boppana, Suresh B, Pati, Sunil K, Latting, Misty, Karaba, Andrew H, Roback, John, Sekaly, Rafick, Neish, Andrew, Brincks, Ahnalee M, Granger, Douglas A, Karger, Amy B, Thyagarajan, Bharat, Thomas, Stefani N, Klein, Sabra L, Cox, Andrea L, Lucas, Todd, Furr-Holden, Debra, Key, Kent, Jones, Nicole, Wrammerr, Jens, Suthar, Mehul, Wong, Serre Yu, Bowman, Natalie M, Simon, Viviana, Richardson, Lynne D, McBride, Russell, Krammer, Florian, Rana, Meenakshi, Kennedy, Joshua, Boehme, Karl, Forrest, Craig, Granger, Steve W, Heaney, Christopher D, Lapinski, Maria Knight, Wallet, Shannon, Baric, Ralph S, Schifanella, Luca, Lopez, Marcos, Fernández, Soledad, Kenah, Eben, Panchal, Ashish R, Britt, William J, Sanz, Iñaki, Dhodapkar, Madhav, Ahmed, Rafi, Bartelt, Luther A, Markmann, Alena J, Lin, Jessica T, Hagan, Robert S, Wolfgang, Matthew C, and Skarbinski, Jacek
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Biomedical and Clinical Sciences ,Clinical Sciences ,Pneumonia & Influenza ,Vaccine Related ,Emerging Infectious Diseases ,Biodefense ,Lung ,Digestive Diseases ,Infectious Diseases ,Clinical Research ,Pneumonia ,Cancer ,Pediatric ,Prevention ,Aetiology ,2.4 Surveillance and distribution ,Good Health and Well Being ,cohort ,COVID-19 ,epidemiology ,SARS-CoV-2 ,serosurveillance ,SeroNet ,Clinical sciences ,Medical microbiology - Abstract
BackgroundGlobal efforts are needed to elucidate the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the underlying cause of coronavirus disease 2019 (COVID-19), including seroprevalence, risk factors, and long-term sequelae, as well as immune responses after vaccination across populations and the social dimensions of prevention and treatment strategies.MethodsIn the United States, the National Cancer Institute in partnership with the National Institute of Allergy and Infectious Diseases, established the SARS-CoV-2 Serological Sciences Network (SeroNet) as the nation's largest coordinated effort to study coronavirus disease 2019. The network comprises multidisciplinary researchers bridging gaps and fostering collaborations among immunologists, epidemiologists, virologists, clinicians and clinical laboratories, social and behavioral scientists, policymakers, data scientists, and community members. In total, 49 institutions form the SeroNet consortium to study individuals with cancer, autoimmune disease, inflammatory bowel diseases, cardiovascular diseases, human immunodeficiency virus, transplant recipients, as well as otherwise healthy pregnant women, children, college students, and high-risk occupational workers (including healthcare workers and first responders).ResultsSeveral studies focus on underrepresented populations, including ethnic minorities and rural communities. To support integrative data analyses across SeroNet studies, efforts are underway to define common data elements for standardized serology measurements, cellular and molecular assays, self-reported data, treatment, and clinical outcomes.ConclusionsIn this paper, we discuss the overarching framework for SeroNet epidemiology studies, critical research questions under investigation, and data accessibility for the worldwide scientific community. Lessons learned will help inform preparedness and responsiveness to future emerging diseases.
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- 2022
31. Practical guidelines for eating disorder risk mitigation in patients undergoing obesity treatment for the pediatric provider
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Gordon, Katelyn, Matthews, Abigail, Zeller, Meg H., and Lin, Jessica
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- 2024
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32. WikiGUM: Exhaustive Entity Linking for Wikification in 12 Genres
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Lin, Jessica and Zeldes, Amir
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Computer Science - Computation and Language - Abstract
Previous work on Entity Linking has focused on resources targeting non-nested proper named entity mentions, often in data from Wikipedia, i.e. Wikification. In this paper, we present and evaluate WikiGUM, a fully wikified dataset, covering all mentions of named entities, including their non-named and pronominal mentions, as well as mentions nested within other mentions. The dataset covers a broad range of 12 written and spoken genres, most of which have not been included in Entity Linking efforts to date, leading to poor performance by a pretrained SOTA system in our evaluation. The availability of a variety of other annotations for the same data also enables further research on entities in context.
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- 2021
33. Associations between presenting weight and premorbid weight and the medical sequelae in hospitalized youth with anorexia nervosa or atypical anorexia nervosa
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Lin, Jessica A., Matthews, Abigail, Adhikari, Richa, Freizinger, Melissa, Richmond, Tracy K., and Jhe, Grace
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- 2024
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34. Synthesis and evaluation of a novel vancomycin-infused, biomimetic bone graft using a rat model of spinal implant-associated infection
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Rajkovic, Christian J., Tracz, Jovanna A., DeMordaunt, Trevor, Davidar, A. Daniel, Perdomo-Pantoja, Alexander, Judy, Brendan F., Zhang, Kevin Yang, Hernandez, Vaughn N., Lin, Jessica, Lazzari, Julianna L., Cottrill, Ethan, and Witham, Timothy F.
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- 2024
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35. Consolidation Osimertinib Versus Durvalumab Versus Observation After Concurrent Chemoradiation in Unresectable EGFR-Mutant NSCLC: A Multicenter Retrospective Cohort Study
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Nassar, Amin H., Kim, So Yeon, Aredo, Jacqueline V., Feng, Jamie, Shepherd, Frances, Xu, Chao, Kaldas, David, Gray, Jhanelle E., Dilling, Thomas J., Neal, Joel W., Wakelee, Heather A., Liu, Yufei, Lin, Steven H., Abuali, Tariq, Amini, Arya, Nie, Yunan, Patil, Tejas, Lobachov, Anastasiya, Bar, Jair, Fitzgerald, Bailey, Fujiwara, Yu, Marron, Thomas U., Thummalapalli, Rohit, Yu, Helena, Owen, Dwight H., Sharp, John, Farid, Saira, Rocha, Pedro, Arriola, Edurne, D’Aiello, Angelica, Cheng, Haiying, Whitaker, Ryan, Parikh, Kaushal, Ashara, Yash, Chen, Luxi, Sankar, Kamya, Harris, Jeremy P., Nagasaka, Misako, Ayanambakkam, Adanma, Velazquez, Ana I., Ragavan, Meera, Lin, Jessica J., Piotrowska, Zofia, Wilgucki, Molly, Reuss, Joshua, Luders, Heike, Grohe, Christian, Baena Espinar, Javier, Feiner, Ella, Punekar, Salman R., Gupta, Shruti, Leal, Ticiana, Kwiatkowski, David J., Mak, Raymond H., Adib, Elio, Naqash, Abdul Rafeh, and Goldberg, Sarah B.
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- 2024
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36. Lorlatinib and capmatinib in a ROS1-rearranged NSCLC with MET-driven resistance: tumor response and evolution
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Schneider, Jaime L., Shaverdashvili, Khvaramze, Mino-Kenudson, Mari, Digumarthy, Subba R., Do, Andrew, Liu, Audrey, Gainor, Justin F., Lennerz, Jochen K., Burns, Timothy F., and Lin, Jessica J.
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- 2023
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37. Epidemiology of Plasmodium malariae and Plasmodium ovale spp. in Kinshasa Province, Democratic Republic of Congo
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Sendor, Rachel, Banek, Kristin, Kashamuka, Melchior M., Mvuama, Nono, Bala, Joseph A., Nkalani, Marthe, Kihuma, Georges, Atibu, Joseph, Thwai, Kyaw L., Svec, W. Matthew, Goel, Varun, Nseka, Tommy, Lin, Jessica T., Bailey, Jeffrey A., Emch, Michael, Carrel, Margaret, Juliano, Jonathan J., Tshefu, Antoinette, and Parr, Jonathan B.
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- 2023
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38. Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients With NTRK Fusion-Positive Solid TumorsEntrectinib in NTRK+ Solid Tumors: Updated Efficacy/Safety
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Demetri, George D, De Braud, Filippo, Drilon, Alexander, Siena, Salvatore, Patel, Manish R, Cho, Byoung Chul, Liu, Stephen V, Ahn, Myung-Ju, Chiu, Chao-Hua, Lin, Jessica J, Goto, Koichi, Lee, Jeeyun, Bazhenova, Lyudmila, John, Thomas, Fakih, Marwan, Chawla, Sant P, Dziadziuszko, Rafal, Seto, Takashi, Heinzmann, Sebastian, Pitcher, Bethany, Chen, David, Wilson, Timothy R, and Rolfo, Christian
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Cancer ,Clinical Trials and Supportive Activities ,Brain Disorders ,Neurosciences ,Clinical Research ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Adult ,Benzamides ,Carcinoma ,Non-Small-Cell Lung ,Child ,Humans ,Indazoles ,Lung Neoplasms ,Protein-Tyrosine Kinases ,Proto-Oncogene Proteins ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
PurposeEntrectinib potently inhibits tropomyosin receptor kinases (TRKAs)/B/C and ROS1, and previously induced deep [objective response rate (ORR) 57.4%] and durable [median duration of response (DoR) 10.4 months] responses in adults with NTRK fusion-positive solid tumors from three phase I/II trials. This article expands prior reports with additional patients and longer follow-up.Patients and methodsPatients with locally advanced/metastatic NTRK fusion-positive solid tumors and ≥12 months' follow-up were included. Primary endpoints were ORR and DoR by blinded independent central review (BICR); secondary endpoints included progression-free survival (PFS), intracranial efficacy, and safety. The safety-evaluable populations included all patients who had received ≥1 entrectinib dose.ResultsAt clinical cut-off (August 31, 2020), the efficacy-evaluable population comprised 121 adults with 14 tumor types and ≥30 histologies. Median follow-up was 25.8 months; 61.2% of patients had a complete (n = 19) or partial response (n = 55). Median DoR was 20.0 months [95% confidence interval (CI), 13.0-38.2]; median PFS was 13.8 months (95% CI, 10.1-19.9). In 11 patients with BICR-assessed measurable central nervous system (CNS) disease, intracranial ORR was 63.6% (95% CI, 30.8-89.1) and median intracranial DoR was 22.1 (95% CI, 7.4-not estimable) months. The safety profile of entrectinib in adults and pediatric patients was aligned with previous reports. Most treatment-related adverse events (TRAEs) were grade 1/2 and manageable/reversible with dose modifications. TRAE-related discontinuations occurred in 8.3% of patients.ConclusionsWith additional clinical experience, entrectinib continues to demonstrate durable systemic and intracranial responses and can address the unmet need of a CNS-active treatment in patients with NTRK fusion-positive solid tumors.
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- 2022
39. Similar Prevalence of Plasmodium falciparum and Non-P. falciparum Malaria Infections among Schoolchildren, Tanzania
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Sendor, Rachel, Mitchell, Cedar L., Chacky, Frank, Mohamed, Ally, Mhamilawa, Lwidiko E., Molteni, Fabrizio, Nyinondi, Ssanyu, Kabula, Bilali, Mkali, Humphrey, Reaves, Erik J., Serbantez, Naomi, Kitojo, Chonge, Makene, Twilumba, Kyaw, Thwai, Muller, Meredith, Mwanza, Alexis, Eckert, Erin L., Parr, Jonathan B., Lin, Jessica T., Juliano, Jonathan J., and Ngasala, Billy
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Elementary school students -- Statistics -- Health aspects ,Malaria -- Statistics -- Risk factors -- Causes of ,Pediatric research ,Health - Abstract
Sub-Saharan Africa harbors 95% of the global malaria burden (1). National surveys conducted by ministries of health throughout Africa regularly assess Plasmodium falciparum prevalence (2); however, little is known about [...]
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- 2023
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40. Comparison of RT-PCR and antigen test sensitivity across nasopharyngeal, nares, and oropharyngeal swab, and saliva sample types during the SARS-CoV-2 omicron variant
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Damhorst, Gregory L., Lin, Jessica, Frediani, Jennifer K., Sullivan, Julie A., Westbrook, Adrianna, McLendon, Kaleb, Baugh, Tyler J., O'Sick, William H., Roback, John D., Piantadosi, Anne L., Waggoner, Jesse J., Bassit, Leda, Rao, Anuradha, Greenleaf, Morgan, O'Neal, Jared W., Swanson, Seegar, Pollock, Nira R., Martin, Greg S., Lam, Wilbur A., and Levy, Joshua M.
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- 2024
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41. Efficacy and Safety of Dose-Escalated Alectinib in Patients With Metastatic ALK-Positive NSCLC and Central Nervous System Relapse on Standard-Dose Alectinib
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Cheung, Justin M., Kang, Jiyoon, Yeap, Beow Y., Peterson, Jennifer L., Do, Andrew, Gainor, Justin F., Digumarthy, Subba R., and Lin, Jessica J.
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- 2024
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42. Asymmetric cooperative motion in one dimension
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Addario-Berry, Louigi, Beckman, Erin, and Lin, Jessica
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Mathematics - Probability ,Mathematics - Analysis of PDEs ,Mathematics - Numerical Analysis ,Primary: 60F05, 60K35, Secondary: 65M12, 35F21, 35F25 - Abstract
We prove distributional convergence for a family of random processes on $\mathbb{Z}$, which we call asymmetric cooperative motions. The model generalizes the "totally asymmetric hipster random walk" introduced in [Addario-Berry, Cairns, Devroye, Kerriou and Mitchell, 2020]. We present a novel approach based on connecting a temporal recurrence relation satisfied by the cumulative distribution functions of the process to the theory of finite difference schemes for Hamilton-Jacobi equations [Crandall and Lyons, 1984]. We also point out some surprising lattice effects that can persist in the distributional limit, and propose several generalizations and directions for future research., Comment: 28 pages, to appear in Transactions of the AMS
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- 2021
43. Nanoparticle seeded glancing-angle deposition of tip-handle heterostructures for manipulation of individual nanoparticles
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Trepka, Kai, Bindra, Govind, Langan, Haley, Lin, Jessica, Linko, Kristina, Tsang, Henry, Janvelyan, Nare, Hiebel, Fanny, and Tao, Ye
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
The controllable handling of an arbitrary single particle of matter with sub-100 nanometer (nm) dimensions is an essential but unsolved scientific challenge. We demonstrate nanoparticle-seeded glancing angle deposition using 10-100 nm diameter nanoparticle seeds (Er2O3, Fe@C, and Fe). The products are nanoparticle-nanowire heterostructures composed of arbitrary nanoscale tips attached to micron-length nanowire handles. Optical micromanipulation of the micron-scale handles enables concurrent manipulation of the attached nanoscale particles of matter., Comment: 8 pages, 2 figures, 3 tables, updated reference DOIs and fixed typos and formatting issues
- Published
- 2020
44. ALK-positive lung cancer: a moving target
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Schneider, Jaime L., Lin, Jessica J., and Shaw, Alice T.
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- 2023
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45. Anisotropic Surface Tensions for Phase Transitions in Periodic Media
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Choksi, Rustum, Fonseca, Irene, Lin, Jessica, and Venkatraman, Raghavendra
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Mathematics - Analysis of PDEs ,Mathematical Physics ,Mathematics - Metric Geometry - Abstract
This paper establishes bounds on the homogenized surface tension for a heterogeneous Allen-Cahn energy functional in a periodic medium. The approach is based on relating the homogenized energy to a purely geometric variational problem involving the large scale behaviour of the signed distance function to a hyperplane in periodic media. Motivated by this, a homogenization result for the signed distance function to a hyperplane in both periodic and almost periodic media is proven., Comment: Fixed an error in an earlier version and other revisions. 40 pages
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- 2020
46. Barycentric Brownian Bees
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Addario-Berry, Louigi, Lin, Jessica, and Tendron, Thomas
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Mathematics - Probability ,60K35, 60J70, 60J65, 82C22 - Abstract
We establish an invariance principle for the barycenter of a Brunet-Derrida particle system in $d$ dimensions. The model consists of $N$ particles undergoing dyadic branching Brownian motion with rate $1$. At a branching event, the number of particles is kept equal to $N$ by removing the particle located furthest away from the barycenter. To prove the invariance principle, a key step is to establish Harris recurrence for the process viewed from its barycenter., Comment: 36 pages. This version incorporates useful feedback from an anonymous referee. To appear in Annals of Applied Probability
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- 2020
47. Semantic Discord: Finding Unusual Local Patterns for Time Series
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Zhang, Li, Gao, Yifeng, and Lin, Jessica
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Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Finding anomalous subsequence in a long time series is a very important but difficult problem. Existing state-of-the-art methods have been focusing on searching for the subsequence that is the most dissimilar to the rest of the subsequences; however, they do not take into account the background patterns that contain the anomalous candidates. As a result, such approaches are likely to miss local anomalies. We introduce a new definition named \textit{semantic discord}, which incorporates the context information from larger subsequences containing the anomaly candidates. We propose an efficient algorithm with a derived lower bound that is up to 3 orders of magnitude faster than the brute force algorithm in real world data. We demonstrate that our method significantly outperforms the state-of-the-art methods in locating anomalies by extensive experiments. We further explain the interpretability of semantic discord., Comment: Accepted by SDM 2020
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- 2020
48. Ensemble Grammar Induction For Detecting Anomalies in Time Series
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Gao, Yifeng, Lin, Jessica, and Brif, Constantin
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Computer Science - Machine Learning ,Computer Science - Databases ,Statistics - Machine Learning - Abstract
Time series anomaly detection is an important task, with applications in a broad variety of domains. Many approaches have been proposed in recent years, but often they require that the length of the anomalies be known in advance and provided as an input parameter. This limits the practicality of the algorithms, as such information is often unknown in advance, or anomalies with different lengths might co-exist in the data. To address this limitation, previously, a linear time anomaly detection algorithm based on grammar induction has been proposed. While the algorithm can find variable-length patterns, it still requires preselecting values for at least two parameters at the discretization step. How to choose these parameter values properly is still an open problem. In this paper, we introduce a grammar-induction-based anomaly detection method utilizing ensemble learning. Instead of using a particular choice of parameter values for anomaly detection, the method generates the final result based on a set of results obtained using different parameter values. We demonstrate that the proposed ensemble approach can outperform existing grammar-induction-based approaches with different criteria for selection of parameter values. We also show that the proposed approach can achieve performance similar to that of the state-of-the-art distance-based anomaly detection algorithm., Comment: 12 pages
- Published
- 2020
49. Associations between nutritional intake, stress and hunger biomarkers, and anxiety and depression during the treatment of anorexia nervosa in adolescents and young adults
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Lin, Jessica A., Stamoulis, Catherine, and DiVasta, Amy D.
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- 2023
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50. Speech disturbances in schizophrenia: Assessing cross-linguistic generalizability of NLP automated measures of coherence
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Parola, Alberto, Lin, Jessica Mary, Simonsen, Arndis, Bliksted, Vibeke, Zhou, Yuan, Wang, Huiling, Inoue, Lana, Koelkebeck, Katja, and Fusaroli, Riccardo
- Published
- 2023
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