Search

Background Identifying the factors constraining the coupling coordination of primary medical resource allocation and high-quality economic development are essential for targeted promoting the coordinated development of the two system coupling. However, there are little research on the influencing factors that hinders the level of coordinated development of coupling. Objective To compare and analyze the coupling coordination level and its hindrance factors between primary medical resource allocation and high-quality economic development in China during the "12th Five-Year Plan" and the "13th Five-Year Plan" periods, identify barrier factors, and predict the coupling coordination trend of the two systems during the "14th Five-Year Plan". Methods The research was conducted from July 2022 to May 2023. The evaluation index system was constructed using 17 indicators, covering three dimensions from the primary medical resource allocation system (health equipment, health technicians, and healthcare funding) and five dimensions from the high-quality economic development system (innovation, coordination, openness, shared development, and green development). Data were sourced from the 2012-2021 China Statistical Yearbook and the corresponding China Health and Family Planning Statistical Yearbook. The entropy value method and comprehensive evaluation function were employed to assess the allocation of primary medical resources and economic high-quality development during the "12th Five-Year Plan" and "13th Five-Year Plan" periods. The coupling coordination model was constructed to facilitate this analysis. In order to ascertain the level of coupling coordination, an obstacle function was established in order to diagnose and identify obstacle factors affecting the coupling coordinated development. Furthermore, a grey model was employed in order to predict the trend of the coupling coordination of the two systems during the "14th Five-Year Plan" period. Results The degree of coordination between the allocation of primary medical resources and high-quality economic development in China increased from 0.15 to 0.68 between the "12th Five-Year Plan" and the "13th Five-Year Plan" periods. This overall trend was observed to be increasing year by year. However, the coupling model exhibited a low level of coordination, despite the relatively fast growth rate. The main obstacles to the coupling level of primary healthcare resource allocation and economic high-quality development binary composite system in the "12th Five-Year Plan" and "13th Five-Year Plan" periods are health equipment, health technicians, shared and green development. The modified GM (1, 1) prediction model indicates that during the "14th Five-Year Plan" period, the coupling degree of the primary medical system and the economic development level system fluctuates around 1.00, and the whole system is in the stage of the coupling degree of coordination rises from 0.73 to 1.12, indicating a rising trend in the overall situation. Furthermore, the degree of relative development is greater than 1.20, which is indicative of an oversupply state. Conclusion In order to empower the development of grass-roots medical and health systems, it is recommended that the development concept of green sharing is recommended to promote the rationalization of medical resources from three aspects from promoting coordinated development of systems, improving the conditions of grass -roots medical facilities, opening up primary medical talents, and integrating primary medical resources.

Despite fertilization efforts, phosphorus (P) availability in soils remains a major constraint to global plant productivity. Soil incorporation of biochar could promote soil P availability but its effects remain uncertain. To attain further improvements in soil P availability with biochar, we developed, characterized, and evaluated magnesium-oxide (MgO) and sepiolite (Mg4Si6O15(OH)2·6H2O)-functionalized biochars with optimized P retention/release capacity. Field-based application of these biochars for improving P availability and their mechanisms during three growth stages of maize was investigated. We further leveraged next-generation sequencing to unravel their impacts on the plant growth-stage shifts in soil functional genes regulating P availability. Results showed insignificant variation in P availability between single super phosphate fertilization (F) and its combination with raw biochar (BF). However, the occurrence of Mg-bound minerals on the optimized biochars' surface adjusted its surface charges and properties and improved the retention and slow release of inorganic P. Compared to BF, available P (AP) was 26.5% and 19.1% higher during the 12-leaf stage and blister stage, respectively, under MgO-optimized biochar + F treatment (MgOBF), and 15.5% higher under sepiolite-biochar + F (SBF) during maize physiological maturity. Cumulatively, AP was 15.6% and 13.2% higher in MgOBF and SBF relative to BF. Hence, plant biomass, grain yield, and P uptake were highest in MgOBF and SBF, respectively at harvest. Optimized-biochar amendment stimulated microbial 16SrRNA gene diversity and suppressed the expression of P starvation response and P uptake and transport-related genes while stimulating P solubilization and mineralization genes. Thus, the optimized biochars promoted P availability via the combined processes of slow-release of retained phosphates, while inducing the microbial solubilization and mineralization of inorganic and organic P, respectively. Our study advances strategies for reducing cropland P limitation and reveals the potential of optimized biochars for improving P availability on the field scale. Article Highlights: MgO and sepiolite doping optimized biochar's surface properties for phosphorus (P) retention and slow release The potential formation of Mg-PO4 phases on the optimized biochar surface regulated P retention and release MgO and sepiolite-ptimized biochars increased soil available P by promoting microbial P mineralization and solubilization. [ABSTRACT FROM AUTHOR]

Background: Whether the relationship of intracerebral bleeding risk with lipid profile may vary by sex remains unclear. This study aims to investigate potential sex differences in the association between lipid profile and the risk of symptomatic intracerebral hemorrhage (sICH) in patients with acute ischemic stroke (AIS) who received intravenous thrombolysis using recombinant tissue plasminogen activator (r-tPA). Methods: This multicenter retrospective observational study analyzed patients with AIS treated with intravenous r-tPA. sICH was defined as a worsening of 4 or higher points in the National Institutes of Health Stroke Scale (NIHSS) score within 36 hours after intravenous thrombolysis in any hemorrhage subtype. We assessed the odds ratio (OR) with 95% confidence interval (CI) of lipid profile for sICH for each sex using logistic regression models adjusted for potential confounding factors. Results: Of 957 participants (median age 68 (interquartile range, 59–75), men 628 (65.6%)), 56 sICH events (36 (5.7%) in men and 20 (6.1%) in women) were observed. The risk of sICH in men decreased with increasing serum levels of triglyceride after adjustment for confounding factors (vs lowest tertile, medium tertile OR 0.39, 95% CI [0.17–0.91], top tertile OR 0.33, 95% CI [0.13–0.84], overall p = 0.021; per point increase, adjusted OR 0.29, 95% CI [0.13–0.63], p = 0.002). Neither serum levels of total cholesterol nor low-density lipoprotein (LDL) was associated with sICH in men. In women, there was no association between any of the lipid levels and the risk of sICH. Conclusions: This study indicated that the association between serum levels of triglyceride and sICH may vary by sex. In men, increased triglyceride levels decrease the risk of sICH; in women, this association was lost. Further studies on the biological mechanisms for sex differences in stroke risk associated with triglyceride are needed. [ABSTRACT FROM AUTHOR]

Objective: Following tonsillectomy, postoperative pain and hemorrhage from the tonsillar bed are causes of significant morbidity. Intracapsular tonsillectomy with Coblation is suggested to minimize such morbidity while remaining efficacious in long‐term outcomes. This systematic review and meta‐analysis assessed short‐term morbidity and long‐term outcomes from intracapsular tonsillectomy with Coblation, focusing primarily on posttonsillectomy hemorrhage. Data Sources: Medline, Embase, and the Cochrane Library. Review Methods: Guided by PRISMA guidelines, studies on intracapsular tonsillectomy with Coblation published between December 2002 and July 2022 evaluating frequency of posttonsillectomy hemorrhage were screened. Studies without primary data were excluded. Meta‐analysis was conducted using the random‐effect model. The primary outcome was the proportion of patients who experienced posttonsillectomy hemorrhage. The secondary outcomes were posttonsillectomy pain, the proportion requiring revision tonsillectomy, and severity of sleep‐disordered breathing measured by polysomnography outcomes. Results: From 14 studies there were 9821 patients. The proportion of total posttonsillectomy hemorrhage was 1.0% (95% confidence interval [CI] 0.5%‐1.6%, n = 9821). The proportion experiencing primary hemorrhage, secondary hemorrhage, and those requiring further tonsil surgery were 0.1% (95% CI 0.0%‐0.1%; study n = 7), 0.8% (95% CI 0.2%‐1.4%; study n = 7), and 1.4% (95% CI 0.6%‐2.2%; study n = 6), respectively. Mean reduction in apnea‐hypopnea index was –16.0 events per hour (95% CI −8.8 to −23.3, study n = 3) and mean increase in oxygen nadir was 5.9% (95% CI 2.6%‐9.1%, study n = 3). Conclusion: Intracapsular tonsillectomy with Coblation has been demonstrated to have a low rate of posttonsillectomy hemorrhage. Data regarding long‐term tonsil regrowth and need for reoperation were encouraging of the efficacy of this technique. [ABSTRACT FROM AUTHOR]

To determine the effect of a 6-month traditional Chinese mind-body Baduanjin exercise intervention on cognitive ability in older people with Mild cognitive impairment (MCI). A total of 135 community-dwelling seniors with MCI were randomized into either the Baduanjin group (BDJ), the brisk walking group (BWK) or the usual physical activity control group (UPA). Cognitive ability was assessed at baseline, 2, 4 and 6 months post-intervention, and 3 months after the intervention ended. After 6 months of intervention, the MoCA score of the BDJ group was significantly higher than that of the UPA group (P < 0.05), The Go/No-go correct numbers of the BDJ group and BWK group were significantly higher than those of the UPA group (P < 0.05). There was no statistical difference in other outcomes, or there were only a tiny effect size. Three months after the intervention, there was no significant difference between the primary and secondary outcomes(P > 0.05). The 6-month period of Baduanjin training has positive benefits on global cognitive function and attention function in community-dwelling elderly individuals with MCI. The effect seems to have been transient and needs to be confirmed by additional studies. [ABSTRACT FROM AUTHOR]

Perillae Fructus oil has an important function in relieving cold stress. However, its application in this aspect has still been restricted because of instability and low bioavailability. In this study, Perillae Fructus oil was extracted through Soxhlet extraction, analyzed through gas chromatography–mass spectrometry (GC–MS), and nanopackaged into a yeast shell for the preparation of nanoparticles for oral administration. The characteristics of the nanoparticles were investigated using a Malvern zeta‐size nanoinstrument, scanning electron microscopy (SEM), and high‐performance liquid chromatography (HPLC). Then, the roles of orally administered nanoparticles in relieving cold stress were evaluated by investigating blood physiological and biochemical indexes in mice. The results showed that the oil yield from Perillae Fructus and shell yield from yeast cells were ~48.37% and ~16.87%, respectively. Approximately 89.21% of the added oil was packaged into the yeast shell to form nanoparticles with an average diameter of 316.74 nm and a surface charge of +2.9 mV. The nanoparticles were stable in simulated gastric acid and could be effectively released in simulated intestinal fluid with an efficiency of ~91.34%. After oral administration of nanoparticles, the mouse blood indexes of white blood cells (WBCs), superoxide dismutase (SOD) activity, and malonaldehyde (MDA) content were recovered compared to those in model mice, with a more remarkable effect than oral administration of free Perillae Fructus oil. Overall, the stability and bioavailability were improved by packaging Perillae Fructus oil into a yeast shell. These nanoparticles are a new agent for the prevention of cold stress. [ABSTRACT FROM AUTHOR]