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As a result of global climate change and human production activities, algal blooms are occurring in aquatic environments. The problem of eutrophication in water bodies is becoming increasingly severe, affecting the safety of drinking water sources. In this study, an algal bloom risk index model combining the Improved Fuzzy Analytic Hierarchy Process (IFAHP), Entropy Weight Method (EWM), and Game Theory (GT) was proposed for the Shanxi Reservoir based on the TOPSIS method. After the seasonal and spatial variability in algal bloom risk from 2022 to 2023 was analyzed, an adaptive simplification of the algal bloom risk index calculation was proposed to optimize the model. To enhance its practical applicability, this study proposed an adaptive simplification of the algal bloom risk index calculation based on an improved TOPSIS approach. The error indexes R2 for the four seasons and the annual analysis were 0.9884, 0.9968, 0.9906, 0.9946, and 0.9972, respectively. Additionally, the RMSE, MAE, and MRE values were all below 0.035, indicating the method's high accuracy. Using the adaptively simplified risk index, a risk grading and a spatial delineation of risk areas in Shanxi Reservoir were conducted. A comparison with traditional risk classification methods showed that the error in the risk levels did not exceed one grade, demonstrating the effectiveness of the proposed calculation model and risk grading approach. This study provides valuable guidance for the prevention and control of algal blooms in reservoir-type drinking water sources, contributing to the protection of drinking water sources and public health. [ABSTRACT FROM AUTHOR]

In view of problems of DC side overvoltage, grid-connected current distortion and grid-connected power fluctuation existed in grid-connected operation of direct-drive wind power system under asymmetric grid voltage sag, superconducting magnetic energy storage was connected in parallel at DC side of grid-connected converter. Meanwhile, positive and negative sequence current control to suppress the grid-connected power fluctuation was used to improve control strategy for grid side converter based on analysis of mathematical model of the grid side converter under asymmetric grid voltage sag, so as to stabilize DC side voltage, improve grid-connected current quality and suppress grid-connected power fluctuation. The simulation result verifies correctness and effectiveness of the control strategy.

Background: Lung adenocarcinoma (LUAD) incidence and mortality take the leading place of most malignancies. Previous studies have revealed the regulator of chromosome condensation 1 (RCC1) family members played an essential role during tumorigenesis. However, its biological functions in LUAD still need further investigation. Methods: Several databases were applied to explore potential effects of RCC1 family members on LUAD, such as Oncomine, GEPIA, and cBioPortal. Real-time PCR and immunohistochemistry were used to verify the expression of RCC2 in stage I LUAD. H1975 and A549 were selected to explore the biological function of RCC2 in cellular malignant phenotype. Results: The expressions of RCC1 and RCC2 showed marked differences in malignant tissue compared to lung tissue. The higher the expression levels of RCC1 or RCC2 in LUAD patients, the shorter their overall survival (OS). In normal lung tissues, RCC1 expression was highly enriched in alveolar cells and endothelial cells. Compare with RCC1, RCC2 expression in normal lung tissue was significantly enriched in macrophages, B cells and granulocytes. Additionally, RCC2 expression level was correlated with multiple immune cell infiltration in LUAD. Moreover, the mutation or different sCNA status of RCC2 exerted influence on multiple immune cell infiltration distribution. We found that the upregulation of RCC1 and RCC2 were obviously related to TP53 mutation. GSEA analysis revealed that RCC2 was involved in the process of DNA replication, nucleotide excision repair and cell cycle, which might affect tumor progression through P53 signaling pathway. We further elucidated that downregulation of RCC2 could dramatically repress the migration and invasion of LUAD cells. Conclusions: The study demonstrated that RCC1 and RCC2 expression were markedly increased in early-stage of LUAD. Patients with high expression of RCC1 or RCC2 had a worse prognosis. Based on our analysis, RCC1 and RCC2 might exert influence on LUAD process through DNA replication, nucleotide excision repair and cell cycle, as well as cells migration and invasion. Different from RCC1, RCC2 also involved in immune infiltration. These analyses provided a novel insight into the identification of diagnostic biomarker., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)

Immune checkpoint inhibitors (ICIs) have been established as the cornerstone for advanced non-small cell lung cancer, while thyroid adverse events (AEs) associated with ICIs have not been systematically documented. Therefore, we performed a meta-analysis to evaluate the effect of ICI applications on the thyroid of patients with non-small cell lung cancer. We performed a systematic search of PubMed, the Cochrane Library, Web of Science, and Embase for eligible randomized controlled trials up to December 2021. Clinical trials reporting thyroid AEs including hypothyroidism, hyperthyroidism, and thyroiditis were enrolled. The I 2  statistic was also calculated to quantify the heterogeneity. Data were evaluated as risk ratio (RR) and corresponding 95%CIs. A total of 10 randomized clinical trials involving 6154 patients were included in this meta-analysis. ICI application was found to have a statistically significant higher risk of all grade hypothyroidism (RR, 7.03; P < 0.0001), hyperthyroidism (RR, 4.88; P < 0.0001), and thyroiditis (RR, 6.58; P = 0.0014) compared with the chemotherapy group. Moreover, we demonstrated that second-line therapy significantly increased the risk of all-grade hypothyroidism (RR, 7.03 [95%CI, 4.69-10.55]) and hyperthyroidism (RR, 4.88 [95%CI, 3.11-7.65]). Our meta-analysis manifested that regimens with ICIs may significantly increase all grades of hypothyroidism, hyperthyroidism, and thyroiditis. ICIs may induce the occurrence and exacerbation of endocrine AEs compared with chemotherapy., (© 2022, The American College of Clinical Pharmacology.)