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6. Characteristics and outcomes of second cancers in patients with childhood cancer: A report from the Taiwan Pediatric Oncology Group

Author

Ho, Wan-Ling, Hung, Giun-Yi, Yen, Hsiu-Ju, Yang, Yung-Li, Chang, Hsiu-Hao, Lu, Meng-Yao, Lin, Kai-Hsin, Chen, Jiann-Shiuh, Cheng, Chao-Neng, Hung, Iou-Jih, Yang, Chao-Ping, Chen, Shih-Hsiang, Liu, Hsi-Che, Yeh, Ting-Chi, Hou, Jen-Yin, Hsiao, Chih-Cheng, Sheen, Jiunn-Ming, Chang, Tai-Tsung, Wong, Tai-Tong, Miser, James S., Liu, Yen-Lin, Chen, Rong-Long, Chen, Bow-Wen, Peng, Ching-Tien, Chang, Te-Kau, Wu, Kang-Hsi, Chang, Yu-Hsiang, Wang, Jinn-Li, Wang, Shih-Chung, Lin, Ming-Tsan, Hu, Fu-Chang, Jou, Shiann-Tarng, and Lin, Dong-Tsamn

Published
2022
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11. Treatment outcomes of pediatric acute myeloid leukemia: a retrospective analysis from 1996 to 2019 in Taiwan

Author

Yang, Yung-Li, Jaing, Tang-Her, Chen, Shih-Hsiang, Liu, Hsi-Che, Hung, Iou-Jih, Lin, Dong-Tsamn, Yang, Chao-Ping, Peng, Ching-Tien, Lin, Kai-Hsin, Hsiao, Chih-Cheng, Jou, Shiann-Tarng, Chen, Jiann-Shiuh, Lin, Ming-Tsan, Wang, Shih-Chung, Chang, Te-Kau, Huang, Fang-Liang, Cheng, Chao-Neng, Wu, Kang-Hsi, Sheen, Jiunn-Ming, Chen, Shu-Huey, Lu, Meng-Yao, Hung, Giun-Yi, Yen, Hsiu-Ju, Hsieh, Yuh-Lin, Wang, Jinn-Li, Chang, Yu-Hsiang, Chang, Hsiu-Hao, Yeh, Ting-Chi, Weng, Te-Fu, Hou, Jen-Yin, Chen, Bow-Wen, Chen, Rong-Long, Wang, Lin-Yen, Ho, Wan-Ling, Chen, Yu-Chieh, Cheng, Shin-Nan, Chao, Yu-Hua, Yang, Shang-Hsien, Huang, Ting-Huan, Chou, Shu-Wei, Lin, Chien-Yu, Chen, Hsuan-Yu, Chao, Yu-Mei Y., Liang, Der-Cherng, and Chang, Tai-Tsung

Published
2021
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13. The incidence and risk factors of hepatic veno-occlusive disease after hematopoietic stem cell transplantation in Taiwan

Author

Lee, Chien-Chang, Chang, Hsiu-Hao, Lu, Meng-Yao, Yang, Yung-Li, Chou, Shu-Wei, Lin, Dong-Tsamn, Jou, Shiann-Tarng, Yao, Ming, Li, Chi-Cheng, Yeh, Su-Peng, Chen, Mei-Hui, Gau, Jyh-Pyng, Li, Sin-Syue, Wang, Po-Nan, Liu, Yi-Chang, Wang, Tso-Fu, Tan, Tran-Der, Lee, Ming-Yang, Yu, Ming-Sun, Wang, Chuan-Cheng, Lin, Shih-Chiang, Chen, Yeu-Chin, Su, Yung-Cheng, Su, Ko-Ying, and Lin, Kai-Hsin

Published
2019
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18. Supplementary Figure 3 from β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma

Author

Chang, Hsiu-Hao, primary, Chen, Chia-Hua, primary, Chou, Chih-Hsing, primary, Liao, Yung-Feng, primary, Huang, Miao-Juei, primary, Chen, Ya-Hsin, primary, Wang, Wei-Jen, primary, Huang, John, primary, Hung, Ji-Shiang, primary, Ho, Wan-Ling, primary, Jeng, Yung-Ming, primary, Che, Mei-Ieng, primary, Lee, Hsinyu, primary, Lu, Meng-Yao, primary, Yang, Yung-Li, primary, Jou, Shiann-Tarng, primary, Lin, Dong-Tsamn, primary, Lin, Kai-Hsin, primary, Hsu, Wen-Ming, primary, and Huang, Min-Chuan, primary

Published
2023
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19. Supplementary Figure 6 from β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma

Author

Chang, Hsiu-Hao, primary, Chen, Chia-Hua, primary, Chou, Chih-Hsing, primary, Liao, Yung-Feng, primary, Huang, Miao-Juei, primary, Chen, Ya-Hsin, primary, Wang, Wei-Jen, primary, Huang, John, primary, Hung, Ji-Shiang, primary, Ho, Wan-Ling, primary, Jeng, Yung-Ming, primary, Che, Mei-Ieng, primary, Lee, Hsinyu, primary, Lu, Meng-Yao, primary, Yang, Yung-Li, primary, Jou, Shiann-Tarng, primary, Lin, Dong-Tsamn, primary, Lin, Kai-Hsin, primary, Hsu, Wen-Ming, primary, and Huang, Min-Chuan, primary

Published
2023
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20. Supplementary Figure 7 from β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma

Author

Chang, Hsiu-Hao, primary, Chen, Chia-Hua, primary, Chou, Chih-Hsing, primary, Liao, Yung-Feng, primary, Huang, Miao-Juei, primary, Chen, Ya-Hsin, primary, Wang, Wei-Jen, primary, Huang, John, primary, Hung, Ji-Shiang, primary, Ho, Wan-Ling, primary, Jeng, Yung-Ming, primary, Che, Mei-Ieng, primary, Lee, Hsinyu, primary, Lu, Meng-Yao, primary, Yang, Yung-Li, primary, Jou, Shiann-Tarng, primary, Lin, Dong-Tsamn, primary, Lin, Kai-Hsin, primary, Hsu, Wen-Ming, primary, and Huang, Min-Chuan, primary

Published
2023
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21. Supplementary Figure 9 from β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma

Author

Chang, Hsiu-Hao, primary, Chen, Chia-Hua, primary, Chou, Chih-Hsing, primary, Liao, Yung-Feng, primary, Huang, Miao-Juei, primary, Chen, Ya-Hsin, primary, Wang, Wei-Jen, primary, Huang, John, primary, Hung, Ji-Shiang, primary, Ho, Wan-Ling, primary, Jeng, Yung-Ming, primary, Che, Mei-Ieng, primary, Lee, Hsinyu, primary, Lu, Meng-Yao, primary, Yang, Yung-Li, primary, Jou, Shiann-Tarng, primary, Lin, Dong-Tsamn, primary, Lin, Kai-Hsin, primary, Hsu, Wen-Ming, primary, and Huang, Min-Chuan, primary

Published
2023
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22. Supplementary Figure 1 from β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma

Author

Chang, Hsiu-Hao, primary, Chen, Chia-Hua, primary, Chou, Chih-Hsing, primary, Liao, Yung-Feng, primary, Huang, Miao-Juei, primary, Chen, Ya-Hsin, primary, Wang, Wei-Jen, primary, Huang, John, primary, Hung, Ji-Shiang, primary, Ho, Wan-Ling, primary, Jeng, Yung-Ming, primary, Che, Mei-Ieng, primary, Lee, Hsinyu, primary, Lu, Meng-Yao, primary, Yang, Yung-Li, primary, Jou, Shiann-Tarng, primary, Lin, Dong-Tsamn, primary, Lin, Kai-Hsin, primary, Hsu, Wen-Ming, primary, and Huang, Min-Chuan, primary

Published
2023
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23. Supplementary Figure 5 from β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma

Author

Chang, Hsiu-Hao, primary, Chen, Chia-Hua, primary, Chou, Chih-Hsing, primary, Liao, Yung-Feng, primary, Huang, Miao-Juei, primary, Chen, Ya-Hsin, primary, Wang, Wei-Jen, primary, Huang, John, primary, Hung, Ji-Shiang, primary, Ho, Wan-Ling, primary, Jeng, Yung-Ming, primary, Che, Mei-Ieng, primary, Lee, Hsinyu, primary, Lu, Meng-Yao, primary, Yang, Yung-Li, primary, Jou, Shiann-Tarng, primary, Lin, Dong-Tsamn, primary, Lin, Kai-Hsin, primary, Hsu, Wen-Ming, primary, and Huang, Min-Chuan, primary

Published
2023
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24. Supplementary Figure 8 from β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma

Author

Chang, Hsiu-Hao, primary, Chen, Chia-Hua, primary, Chou, Chih-Hsing, primary, Liao, Yung-Feng, primary, Huang, Miao-Juei, primary, Chen, Ya-Hsin, primary, Wang, Wei-Jen, primary, Huang, John, primary, Hung, Ji-Shiang, primary, Ho, Wan-Ling, primary, Jeng, Yung-Ming, primary, Che, Mei-Ieng, primary, Lee, Hsinyu, primary, Lu, Meng-Yao, primary, Yang, Yung-Li, primary, Jou, Shiann-Tarng, primary, Lin, Dong-Tsamn, primary, Lin, Kai-Hsin, primary, Hsu, Wen-Ming, primary, and Huang, Min-Chuan, primary

Published
2023
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25. Supplementary Figure 4 from β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma

Author

Chang, Hsiu-Hao, primary, Chen, Chia-Hua, primary, Chou, Chih-Hsing, primary, Liao, Yung-Feng, primary, Huang, Miao-Juei, primary, Chen, Ya-Hsin, primary, Wang, Wei-Jen, primary, Huang, John, primary, Hung, Ji-Shiang, primary, Ho, Wan-Ling, primary, Jeng, Yung-Ming, primary, Che, Mei-Ieng, primary, Lee, Hsinyu, primary, Lu, Meng-Yao, primary, Yang, Yung-Li, primary, Jou, Shiann-Tarng, primary, Lin, Dong-Tsamn, primary, Lin, Kai-Hsin, primary, Hsu, Wen-Ming, primary, and Huang, Min-Chuan, primary

Published
2023
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26. Supplementary Methods and Figure Legend from β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma

Author

Chang, Hsiu-Hao, primary, Chen, Chia-Hua, primary, Chou, Chih-Hsing, primary, Liao, Yung-Feng, primary, Huang, Miao-Juei, primary, Chen, Ya-Hsin, primary, Wang, Wei-Jen, primary, Huang, John, primary, Hung, Ji-Shiang, primary, Ho, Wan-Ling, primary, Jeng, Yung-Ming, primary, Che, Mei-Ieng, primary, Lee, Hsinyu, primary, Lu, Meng-Yao, primary, Yang, Yung-Li, primary, Jou, Shiann-Tarng, primary, Lin, Dong-Tsamn, primary, Lin, Kai-Hsin, primary, Hsu, Wen-Ming, primary, and Huang, Min-Chuan, primary

Published
2023
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27. Supplementary Figure 2 from β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma

Author

Chang, Hsiu-Hao, primary, Chen, Chia-Hua, primary, Chou, Chih-Hsing, primary, Liao, Yung-Feng, primary, Huang, Miao-Juei, primary, Chen, Ya-Hsin, primary, Wang, Wei-Jen, primary, Huang, John, primary, Hung, Ji-Shiang, primary, Ho, Wan-Ling, primary, Jeng, Yung-Ming, primary, Che, Mei-Ieng, primary, Lee, Hsinyu, primary, Lu, Meng-Yao, primary, Yang, Yung-Li, primary, Jou, Shiann-Tarng, primary, Lin, Dong-Tsamn, primary, Lin, Kai-Hsin, primary, Hsu, Wen-Ming, primary, and Huang, Min-Chuan, primary

Published
2023
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28. Supplementary Table 1 from β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma

Author

Chang, Hsiu-Hao, primary, Chen, Chia-Hua, primary, Chou, Chih-Hsing, primary, Liao, Yung-Feng, primary, Huang, Miao-Juei, primary, Chen, Ya-Hsin, primary, Wang, Wei-Jen, primary, Huang, John, primary, Hung, Ji-Shiang, primary, Ho, Wan-Ling, primary, Jeng, Yung-Ming, primary, Che, Mei-Ieng, primary, Lee, Hsinyu, primary, Lu, Meng-Yao, primary, Yang, Yung-Li, primary, Jou, Shiann-Tarng, primary, Lin, Dong-Tsamn, primary, Lin, Kai-Hsin, primary, Hsu, Wen-Ming, primary, and Huang, Min-Chuan, primary

Published
2023
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29. Supplementary Table 1 from Nucleophosmin Mutations in De novo Acute Myeloid Leukemia: The Age-Dependent Incidences and the Stability during Disease Evolution

Author

Chou, Wen-Chien, primary, Tang, Jih-Luh, primary, Lin, Liang-In, primary, Yao, Ming, primary, Tsay, Woei, primary, Chen, Chien-Yuan, primary, Wu, Shang-Ju, primary, Huang, Chi-Fei, primary, Chiou, Rong-Jing, primary, Tseng, Mei-Hsuan, primary, Lin, Dong-Tsamn, primary, Lin, Kai-Hsin, primary, Chen, Yao-Chang, primary, and Tien, Hwei-Fang, primary

Published
2023
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30. Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15variants

Author

Wang, Der-Shiun, Yu, Chih-Hsiang, Lin, Chien-Yu, Chang, Ya-Hsuan, Lin, Kai-Hsin, Lin, Dong-Tsamn, Jou, Shiann-Tarng, Lu, Meng-Yao, Chang, Hsiu-Hao, Lin, Shu-Wha, Chen, Hsuan-Yu, and Yang, Yung-Li

Abstract

Background: Mercaptopurine-induced neutropenia can interrupt chemotherapy and expose patients to infection during childhood acute lymphoblastic leukemia (ALL) treatment. Previously, six candidate gene variants associated with mercaptopurine intolerance were reported. Herein, we investigated the association between the mean tolerable dose of mercaptopurine and these genetic variants in Taiwanese patients. Methods: In total, 294 children with ALL were treated at the National Taiwan University Hospital from April 1997 to December 2017. Germline variants were analyzed for NUDT15, SUCLA2, TPMT, ITPA, PACSIN2, and MRP4. Mean daily tolerable doses of mercaptopurine in the continuation phase of treatment were correlated with these genetic variants. Results: Mercaptopurine intolerance was significantly associated with polymorphisms in NUDT15(Pvalue < 0.0001). Patients with SUCLA2variants received lower mercaptopurine doses (Pvalue?=?0.0119). The mean mercaptopurine doses did not differ among patients with TPMT, ITPA, MRP4, and PACSIN2polymorphisms (Pvalue?=?0.9461, 0.5818, and 0.7951, respectively). After multivariable linear regression analysis, only NUDT15variants retained their clinically significant correlation with mercaptopurine intolerance (Pvalue < 0.0001). Conclusion: In this cohort, the major genetic determinant of mercaptopurine intolerance was NUDT15in Taiwanese patients. Impact:

NUDT15causes mercaptopurine intolerance in children with ALL.

The NUDT15variant is a stronger predictor of mercaptopurine intolerance than TPMTin a Taiwanese cohort. This finding is similar with studies performed on Asian populations rather than Caucasians.

Pre-emptive genotyping of the patients’ NUDT15before administering mercaptopurine may be more helpful than genotyping TPMTin Asians.

Published
2024
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32. Clinical impact of minimal residual disease and genetic subtypes on the prognosis of childhood acute lymphoblastic leukemia

Author

Yu, Chih‐Hsiang, primary, Jou, Shiann‐Tarng, additional, Su, Ying‐Hui, additional, Coustan‐Smith, Elane, additional, Wu, Gang, additional, Cheng, Chao‐Neng, additional, Lu, Meng‐Yao, additional, Lin, Kai‐Hsin, additional, Wu, Kang‐Hsi, additional, Chen, Shu‐Huey, additional, Huang, Fang‐Liang, additional, Chang, Hsiu‐Hao, additional, Wang, Jinn‐Li, additional, Yen, Hsiu‐Ju, additional, Li, Meng‐Ju, additional, Chou, Shu‐Wei, additional, Ho, Wan‐Ling, additional, Liu, Yen‐Lin, additional, Chang, Chia‐Ching, additional, Lin, Ze‐Shiang, additional, Lin, Chien‐Yu, additional, Chen, Hsuan‐Yu, additional, Ni, Yu‐Ling, additional, Lin, Dong‐Tsamn, additional, Lin, Shu‐Wha, additional, Yang, Jun J., additional, Ni, Yen‐Hsuan, additional, Pui, Ching‐Hon, additional, Yu, Sung‐Liang, additional, and Yang, Yung‐Li, additional

Published
2022
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33. A microRNA signature for clinical outcomes of pediatric ALL patients treated with TPOG protocols

Author

Chang, Ya-Hsuan, Jou, Shiann-Tarng, Yen, Ching-Tzu, Lin, Chien-Yu, Yu, Chih-Hsiang, Chang, Sheng-Kai, Lu, Meng-Yao, Chang, Hsiu-Hao, Pai, Chen-Hsueh, Hu, Chung-Yi, Lin, Kai-Hsin, Lin, Shu-Rung, Lin, Dong-Tsamn, Chen, Hsuan-Yu, Yang, Yung-Li, Lin, Shu-Wha, and Yu, Sung-Liang

Subjects
Original Article
Abstract

MicroRNA (miRNA) expression is reportedly associated with clinical outcomes in childhood acute lymphoblastic leukemia (ALL). Here, we aimed at investigating whether miRNA expression is associated with clinical outcomes in pediatric ALL patients treated with the Taiwan Pediatric Oncology Group (TPOG) protocols. The expression of 397 miRNAs was measured using stem-loop quantitative real-time polymerase chain reaction miRNA arrays in 60 pediatric ALL patients treated with TPOG-ALL-93 or TPOG-ALL-97 VHR (very high-risk) protocols. In order to identify prognosis-related miRNAs, original cohort was randomly split into the training and testing cohort in a 2:1 ratio, and univariate Cox proportional hazards regression was applied to identify associations between event-free survival (EFS) and expressions of miRNAs. Four prognosis-related miRNAs were selected and validated in another independent cohort composed of 103 patients treated with the TPOG-ALL-2002 protocol. Risk score, including the impact of four prognosis-related miRNAs, was calculated for each patients, followed by grouping patients into the high or low risk-score groups. Irrespective of the training, testing, or validation cohort, risk-score group was significantly associated with EFS and overall survival (OS). Risk-score group combining with clinical characteristics including the age onset (≥10 years), white blood cell counts (≥100 × 10(9)/L), cell type (T- or B-cell), sex, and risk groups of the treatment protocols were used as predictors of EFS using the multivariate Cox proportional hazards regression. Results showed that the risk-score group was the strongest predictor. In the validation cohort, hazard ratios (HRs) of the risk-score group were 7.06 (95% CI=1.93-25.84, p-value =0.003) and 14.03 (95% CI=3.34-59.04, p-value =0.003) for EFS and OS, respectively. High risk-score group had higher risk of having poor prognosis and risk of death than that in the low risk group. Accuracy of the prediction model for 5-year EFS could reach 0.76. For the prediction of 5-year OS, accuracy was 0.75. In conclusion, a miRNA signature was associated with clinical outcomes in childhood ALL patients treated with TPOG protocols and might be a suitable prognostic biomarker.

Published
2022

34. Sequential Approach to Improve the Molecular Classification of Childhood Acute Lymphoblastic Leukemia

Author

Yu, Chih-Hsiang, primary, Wu, Gang, additional, Chang, Chia-Ching, additional, Jou, Shiann-Tarng, additional, Lu, Meng-Yao, additional, Lin, Kai-Hsin, additional, Chen, Shu-Huey, additional, Wu, Kang-Hsi, additional, Huang, Fang-Liang, additional, Cheng, Chao-Neng, additional, Chang, Hsiu-Hao, additional, Hedges, Dale, additional, Wang, Jinn-Li, additional, Yen, Hsiu-Ju, additional, Li, Meng-Ju, additional, Chou, Shu-Wei, additional, Hung, Chen-Ting, additional, Lin, Ze-Shiang, additional, Lin, Chien-Yu, additional, Chen, Hsuan-Yu, additional, Ni, Yu-Ling, additional, Hsu, Yin-Chen, additional, Lin, Dong-Tsamn, additional, Lin, Shu-Wha, additional, Yang, Jun J., additional, Pui, Ching-Hon, additional, Yu, Sung-Liang, additional, and Yang, Yung-Li, additional

Published
2022
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35. High frequency of heat shock protein 27 overexpression is a highly effective, high‐coverage marker for minimal residual disease detection in children with B‐cell acute lymphoblastic leukemia

Author

Chou, Shu‐Wei, primary, Su, Ying‐Hui, additional, Lu, Meng‐Yao, additional, Chang, Hsiu‐Hao, additional, Yang, Yung‐Li, additional, Lin, Dong‐Tsamn, additional, Lin, Kai‐Hsin, additional, Coustan‐Smith, Elaine, additional, and Jou, Shiann‐Tarng, additional

Published
2022
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37. Treatment for childhood acute lymphoblastic leukemia in Taiwan: Taiwan Pediatric Oncology Group ALL‐2002 study emphasizing optimal reinduction therapy and central nervous system preventive therapy without cranial radiation

Author

Li, Meng‐Ju, Liu, Hsi‐Che, Yen, Hsiu‐Ju, Jaing, Tang‐Her, Lin, Dong‐Tsamn, Yang, Chao‐Ping, Lin, Kai‐Hsin, Hung, Iou‐Jih, Jou, Shiann‐Tarng, Lu, Meng‐Yao, Hsiao, Chih‐Cheng, Peng, Ching‐Tien, Chang, Tai‐Tsung, Wang, Shih‐Chung, Lin, Ming‐Tsan, Chen, Jiann‐Shiuh, Chang, Te‐Kau, Hung, Giun‐Yi, Wu, Kang‐Hsi, Yang, Yung‐Li, Chang, Hsiu‐Hao, Chen, Shih‐Hsiang, Yeh, Ting‐Chi, Cheng, Chao‐Neng, Lin, Pei‐Chin, Chiou, Shyh‐Shin, Sheen, Jiunn‐Ming, Cheng, Shin‐Nan, Chen, Shu‐Huey, Chang, Yu‐Hsiang, Ho, Wan‐Ling, Chao, Yu‐Hua, Chen, Rong‐Long, Chen, Bow‐Wen, Wang, Jinn‐Li, Hsieh, Yuh‐Lin, Liao, Yu‐Mei, Yang, Shang‐Hsien, Chang, Wan‐Hui, Chao, Yu‐Mei Y., and Liang, Der‐Cherng

Published
2017
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39. Integration of immunohistochemistry, RNA sequencing, and multiplex ligation‐dependent probe amplification for molecular classification of pediatric medulloblastoma

Author

Huang, Hsin‐Yi, primary, Yu, Chih‐Hsiang, additional, Yang, Yung‐Li, additional, Chang, Ya‐Hsuan, additional, Jou, Shiann‐Tarng, additional, Lin, Kai‐Hsin, additional, Lu, Meng‐Yao, additional, Chang, Hsiu‐Hao, additional, Chou, Shu‐Wei, additional, Ni, Yu‐Ling, additional, Lin, Dong‐Tsamn, additional, Chen, Hsuan‐Yu, additional, Peng, Steven Shinn‐Forng, additional, Kuo, Meng‐Fai, additional, and Yang, Shih‐Hung, additional

Published
2022
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41. Surgical treatment confers prognostic significance in pediatric malignant mediastinal germ cell tumors.

Author

Huang, Ting‐Huan, Hung, Giun‐Yi, Weng, Te‐Fu, Wang, Fu‐Mien, Lee, Chih‐Ying, Lin, Dong‐Tsamn, Chen, Bow‐Wen, Lin, Kai‐Hsin, Wu, Kang‐Hsi, Liu, Hsi‐Che, Chen, Jiann‐Shiuh, Jou, Shiann‐Tarng, Hou, Jen‐Yin, Yang, Yung‐Li, Chen, Shih‐Hsiang, Chang, Hsiu‐Hao, Chiou, Shyh‐Shin, Lin, Pei‐Chin, Chen, Rong‐Long, and Hsiao, Chih‐Cheng

Subjects
GERM cell tumors, PEDIATRIC oncology, YOLK sac, TREATMENT effectiveness, PROGNOSIS, CHORIOCARCINOMA
Abstract

Background: Primary malignant mediastinal germ cell tumors (GCTs) are rare pediatric tumors that have a poorer prognosis compared to GCTs occurring elsewhere in the body. The current study aimed to assess the prognostic factors and treatment outcomes of children with primary malignant mediastinal GCT in Taiwan. Methods: The authors retrospectively reviewed children 0–18 years old who were newly diagnosed with primary malignant mediastinal GCT between January 1, 2005 and December 31, 2019 and were registered in the Taiwan Pediatric Oncology Group patient registry. The impact of presenting characteristics, including sex, age, tumor stage, histology subtype, surgical treatment, and chemotherapy regimens of the patients were analyzed. Results: This study enrolled 52 children with malignant mediastinal GCT who had a median age of 16.0 (range, 6.0–17.9) years at diagnosis. The most common histological subtypes were mixed GCTs (n = 20) and yolk sac tumors (n = 15). Advanced disease stage and choriocarcinoma histology subtype were associated inferior outcomes. Children who received surgical treatment exhibited better outcomes compared to those who did not (5‐year overall survival, 78% vs. 7%, p <.001). After comparing patients who received first‐line cisplatin‐ and carboplatin‐based chemotherapy, no difference in treatment outcomes was observed. Multivariate analysis showed that surgical management was the only independent predictor for superior OS. Conclusions: Surgical treatment is recommended for mediastinal GCT. Cisplatin‐based chemotherapy was not superior to carboplatin‐based chemotherapy as first‐line treatment and may be avoided due to toxicity concerns. Surgical treatment is recommended for pediatric malignant mediastinal germ cell tumors. Cisplatin‐based chemotherapy was not superior to carboplatin‐based chemotherapy as first‐line treatment. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Characteristics and outcomes of second cancers in patients with childhood cancer: A report from the Taiwan Pediatric Oncology Group

Author

Ho, Wan-Ling, primary, Hung, Giun-Yi, additional, Yen, Hsiu-Ju, additional, Yang, Yung-Li, additional, Chang, Hsiu-Hao, additional, Lu, Meng-Yao, additional, Lin, Kai-Hsin, additional, Chen, Jiann-Shiuh, additional, Cheng, Chao-Neng, additional, Hung, Iou-Jih, additional, Yang, Chao-Ping, additional, Chen, Shih-Hsiang, additional, Liu, Hsi-Che, additional, Yeh, Ting-Chi, additional, Hou, Jen-Yin, additional, Hsiao, Chih-Cheng, additional, Sheen, Jiunn-Ming, additional, Chang, Tai-Tsung, additional, Wong, Tai-Tong, additional, Miser, James S., additional, Liu, Yen-Lin, additional, Chen, Rong-Long, additional, Chen, Bow-Wen, additional, Peng, Ching-Tien, additional, Chang, Te-Kau, additional, Wu, Kang-Hsi, additional, Chang, Yu-Hsiang, additional, Wang, Jinn-Li, additional, Wang, Shih-Chung, additional, Lin, Ming-Tsan, additional, Hu, Fu-Chang, additional, Jou, Shiann-Tarng, additional, and Lin, Dong-Tsamn, additional

Published
2021
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48. The Different Impacts of an MRD-Guided Protocol on Relapse of Childhood Acute Lymphoblastic Leukemia: The Report of Taiwan Pediatric Oncology Group (TPOG)-ALL-2013

Author

Liu, Hsi-Che, Jou, Shiann-Tarng, Chen, Shih-Hsiang, Jaing, Tang-Her, Yeh, Ting-Chi, Chen, Jiann-Shiuh, Wu, Kang-Hsi, Wang, Shih-Chung, Hsiao, Chih-Cheng, Chang, Te-Kau, Lu, Meng-Yao, Yen, Hsiu-Ju, Huang, Fang-Liang, Chen, Shu-Huey, Yang, Shang-Hsien, Liu, Yen-Lin, Chiou, Shyh-Shin, Yang, Chao-Ping, Shih, Lee-Yung, and Lin, Dong-Tsamn

Published
2023
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