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1. DNA-sensing inflammasomes cause recurrent atherosclerotic stroke

Author

Cao, Jiayu, Roth, Stefan, Zhang, Sijia, Kopczak, Anna, Mami, Samira, Asare, Yaw, Georgakis, Marios K., Messerer, Denise, Horn, Amit, Shemer, Ruth, Jacqmarcq, Charlene, Picot, Audrey, Green, Jack P., Schlegl, Christina, Li, Xinghai, Tomas, Lukas, Dutsch, Alexander, Liman, Thomas G., Endres, Matthias, Wernsdorf, Saskia R., Fürle, Christina, Carofiglio, Olga, Zhu, Jie, Brough, David, Hornung, Veit, Dichgans, Martin, Vivien, Denis, Schulz, Christian, Dor, Yuval, Tiedt, Steffen, Sager, Hendrik B., Grosse, Gerrit M., and Liesz, Arthur

Published
2024
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4. Anti-PF4 immunothrombosis without proximate heparin or adenovirus vector vaccine exposure

Author

Schönborn, Linda, Esteban, Olga, Wesche, Jan, Dobosz, Paulina, Broto, Marta, Puig, Sara Rovira, Fuhrmann, Jessica, Torres, Raquel, Serra, Josep, Llevadot, Roser, Palicio, Marta, Wang, Jing Jing, Gordon, Tom Paul, Lindhoff-Last, Edelgard, Hoffmann, Till, Alberio, Lorenzo, Langer, Florian, Boehme, Christian, Biguzzi, Eugenia, Grosse, Leonie, Endres, Matthias, Liman, Thomas, Thiele, Thomas, Warkentin, Theodore E., and Greinacher, Andreas

Published
2023
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6. Stroke genetics informs drug discovery and risk prediction across ancestries

Author

Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jürgenson, Tuuli, Namba, Shinichi, Posner, Daniel C., Kamanu, Frederick K., Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K., Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C., Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R., Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V., Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Cárcel-Márquez, Jara, Nygaard, Marianne, Leonard, Hampton L., Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J., Lewis, Adam J., Judy, Renae L., Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D., Bakker, Mark K., Bartz, Traci M., Bennett, David A., Bis, Joshua C., Bordes, Constance, Børte, Sigrid, Cain, Anael, Ridker, Paul M., Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W., de Jager, Phil L., de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E., Geerlings, Mirjam I., Gasca, Natalie C., Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K., Ho, Yuk-Lam, Havulinna, Aki S., Hopewell, Jemma C., Hyacinth, Hyacinth I., Inouye, Michael, Jacob, Mina A., Jeon, Christina E., Jern, Christina, Kamouchi, Masahiro, Keene, Keith L., Kitazono, Takanari, Kittner, Steven J., Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J., Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S., Marston, Nicholas A., Meitinger, Thomas, Mitchell, Braxton D., Montellano, Felipe A., Morisaki, Takayuki, Mosley, Thomas H., Nalls, Mike A., Nordestgaard, Børge G., O’Donnell, Martin J., Okada, Yukinori, Onland-Moret, N. Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M., Rich, Stephen S., Rosand, Jonathan, Sabatine, Marc S., Sacco, Ralph L., Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L., Schmidt, Carsten O., Shimizu, Atsushi, Smith, Nicholas L., Sloane, Kelly L., Sutoh, Yoichi, Sun, Yan V., Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P., Tiwari, Hemant K., Trégouët, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjærg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S., Wiggins, Kerri L., Wennberg, Patrik, Woo, Daniel, Wilson, Peter W. F., Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Millwood, Iona Y., Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J., Jukema, J. Wouter, Rissanen, Ina L., Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna M. M., Irvin, Marguerite R., Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A., Rundek, Tatjana, Worrall, Bradford B., Lathrop, G. Mark, Riaz, Moeen, Simonsick, Eleanor M., Kõrv, Janika, França, Paulo H. C., Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, de Leeuw, Frank-Erik, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M., Heuschmann, Peter Ulrich, Longstreth, W. T., Jung, Keum Ji, Bastarache, Lisa, Paré, Guillaume, Damrauer, Scott M., Chasman, Daniel I., Rotter, Jerome I., Anderson, Christopher D., Zwart, John-Anker, Niiranen, Teemu J., Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernández-Cadenas, Israel, Walters, Robin G., Ruff, Christian T., Owolabi, Mayowa O., Huffman, Jennifer E., Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, and Debette, Stephanie

Published
2022
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10. Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke

Author

Arends, Christopher M., Liman, Thomas G., Strzelecka, Paulina M., Kufner, Anna, Löwe, Pelle, Huo, Shufan, Stein, Catarina M., Piper, Sophie K., Tilgner, Marlon, Sperber, Pia S., Dimitriou, Savvina, Heuschmann, Peter U., Hablesreiter, Raphael, Harms, Christoph, Bullinger, Lars, Weber, Joachim E., Endres, Matthias, and Damm, Frederik

Published
2023
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12. Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries

Author

Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jürgenson, Tuuli, Namba, Shinichi, Posner, Daniel C., Kamanu, Frederick K., Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K., Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C., Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R., Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V., Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Cárcel-Márquez, Jara, Nygaard, Marianne, Leonard, Hampton L., Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J., Lewis, Adam J., Judy, Renae L., Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D., Bakker, Mark K., Bartz, Traci M., Bennett, David A., Bis, Joshua C., Bordes, Constance, Børte, Sigrid, Cain, Anael, Ridker, Paul M., Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W., de Jager, Phil L., de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E., Geerlings, Mirjam I., Gasca, Natalie C., Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K., Ho, Yuk-Lam, Havulinna, Aki S., Hopewell, Jemma C., Hyacinth, Hyacinth I., Inouye, Michael, Jacob, Mina A., Jeon, Christina E., Jern, Christina, Kamouchi, Masahiro, Keene, Keith L., Kitazono, Takanari, Kittner, Steven J., Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J., Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S., Marston, Nicholas A., Meitinger, Thomas, Mitchell, Braxton D., Montellano, Felipe A., Morisaki, Takayuki, Mosley, Thomas H., Nalls, Mike A., Nordestgaard, Børge G., O’Donnell, Martin J., Okada, Yukinori, Onland-Moret, N. Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M., Rich, Stephen S., Rosand, Jonathan, Sabatine, Marc S., Sacco, Ralph L., Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L., Schmidt, Carsten O., Shimizu, Atsushi, Smith, Nicholas L., Sloane, Kelly L., Sutoh, Yoichi, Sun, Yan V., Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P., Tiwari, Hemant K., Trégouët, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjærg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S., Wiggins, Kerri L., Wennberg, Patrik, Woo, Daniel, Wilson, Peter W. F., Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Millwood, Iona Y., Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J., Jukema, J. Wouter, Rissanen, Ina L., Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna M. M., Irvin, Marguerite R., Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A., Rundek, Tatjana, Worrall, Bradford B., Lathrop, G. Mark, Riaz, Moeen, Simonsick, Eleanor M., Kõrv, Janika, França, Paulo H. C., Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, de Leeuw, Frank-Erik, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M., Heuschmann, Peter Ulrich, Longstreth, W. T., Jung, Keum Ji, Bastarache, Lisa, Paré, Guillaume, Damrauer, Scott M., Chasman, Daniel I., Rotter, Jerome I., Anderson, Christopher D., Zwart, John-Anker, Niiranen, Teemu J., Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernández-Cadenas, Israel, Walters, Robin G., Ruff, Christian T., Owolabi, Mayowa O., Huffman, Jennifer E., Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, and Debette, Stephanie

Published
2022
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20. Cerebral small vessel disease burden and cognitive and functional outcomes after stroke: A multicenter prospective cohort study

Author

Georgakis, Marios K, Fang, Rong, Kerti, Lucia, Ikenberg, Benno, Bernkopf, Kathleen, Poppert, Holger, Glanz, Wenzel, Perosa, Valentina, Janowitz, Daniel, Wagner, Michael, Neumann, Katja, Speck, Oliver, Düring, Marco, Dobisch, Laura, Düzel, Emrah, Gesierich, Benno, Dewenter, Anna, Spottke, Annika, Waegemann, Karin, Görtler, Michael, Wunderlich, Silke, Endres, Matthias, Zerr, Inga, Wollenweber, Frank A, Petzold, Gabor, Dichgans, Martin, Investigators, DEMDAS, Bode, Felix J, Stoesser, Sebastian, Kindlein, Christine, Hermann, Peter, Liman, Thomas G, and Nolte, Christian H

Subjects
RESEARCH ARTICLE, RESEARCH ARTICLES, cerebral small vessel disease, cognitive impairment, functional outcome, prediction, stroke, Epidemiology, Health Policy, Magnetic Resonance Imaging, ddc, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Cognition, Developmental Neuroscience, pathology [Stroke], Humans, pathology [Cerebral Small Vessel Diseases], complications [Stroke], ddc:610, Prospective Studies, Neurology (clinical), Geriatrics and Gerontology, complications [Cognitive Dysfunction]
Abstract

It remains unknown whether the global small vessel disease (SVD) burden predicts post-stroke outcomes.In a prospective multicenter study of 666 ischemic and hemorrhagic stroke patients, we quantified magnetic resonance imaging (MRI)-based SVD markers (lacunes, white matter hyperintensities, microbleeds, perivascular spaces) and explored associations with 6- and 12-month cognitive (battery of 15 neuropsychological tests) and functional (modified Rankin scale) outcomes.A global SVD score (range 0-4) was associated with cognitive impairment; worse performance in executive function, attention, language, and visuospatial ability; and worse functional outcome across a 12-month follow-up. Although the global SVD score did not improve prediction, individual SVD markers, assessed across their severity range, improved the calibration, discrimination, and reclassification of predictive models including demographic, clinical, and other imaging factors.SVD presence and severity are associated with worse cognitive and functional outcomes 12 months after stroke. Assessing SVD severity may aid prognostication for stroke patients.In a multi-center cohort, we explored associations of small vessel disease (SVD) burden with stroke outcomes. SVD burden associates with post-stroke cognitive and functional outcomes. A currently used score of SVD burden does not improve the prediction of poor outcomes. Assessing the severity of SVD lesions adds predictive value beyond known predictors. To add predictive value in assessing SVD in stroke patients, SVD burden scores should integrate lesion severity.

Published
2022

25. Stroke induces early recurrent vascular events by inflammasome-dependent atherosclerotic plaque rupture

Author

Liesz, Arthur, primary, Cao, Jiayu, additional, Roth, Stefan, additional, Zhang, Sijia, additional, Kopczak, Anna, additional, Georgakis, Marios, additional, Li, Xinghai, additional, Dutsch, Alexander, additional, Liman, Thomas, additional, Endres, Matthias, additional, Brough, David, additional, Green, Jack, additional, Wernsdorf, Saskia, additional, Fürle, Christina, additional, Carofiglio, Olga, additional, Zhu, Jie, additional, Asare, Yaw, additional, Group, DEMDAS Study, additional, Dichgans, Martin, additional, Sager, Hendrik, additional, and Grosse, Gerrit, additional

Published
2023
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27. Heparin- and Vaccine-Independent Anti-Platelet Factor 4 Immunothrombosis

Author

Schönborn, Linda, primary, Esteban, Olga, additional, Wesche, Jan, additional, Dobosz, Paulina, additional, Broto, Marta, additional, Rovira Puig, Sara, additional, Fuhrmann, Jessica, additional, Torres, Raquel, additional, Serra, Josep, additional, Llevadot, Roser, additional, Palicio, Marta, additional, Wang, Jing Jing, additional, Gordon, Tom, additional, Lindhoff-Last, Edelgard, additional, Hoffmann, Till, additional, Alberio, Lorenzo, additional, Langer, Florian, additional, Boehme, Christian, additional, Biguzzi, Eugenia, additional, Grosse, Leonie, additional, Endres, Matthias, additional, Liman, Thomas, additional, Thiele, Thomas, additional, Warkentin, Theodore, additional, and Greinacher, Andreas, additional

Published
2023
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30. Associations of clonal haematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke

Author

Arends, Christopher Maximilian, primary, Liman, Thomas G., additional, Strzelecka, Paulina M, additional, Kufner, Anna, additional, Löwe, Pelle, additional, Huo, Shufan, additional, Stein, Catarina M, additional, Piper, Sophie K., additional, Tilgner, Marlon, additional, Sperber, Pia S., additional, Dimitriou, Savvina, additional, Heuschmann, Peter, additional, Hablesreiter, Raphael, additional, Harms, Christoph, additional, Bullinger, Lars, additional, Weber, Joachim E., additional, Endres, Matthias, additional, and Damm, Frederik, additional

Published
2022
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37. Gut Microbiota–Dependent Trimethylamine N-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes

Author

Haghikia, Arash, Li, Xinmin S., Liman, Thomas G., Bledau, Nils, Schmidt, David, Zimmermann, Friederike, Kränkel, Nicolle, Widera, Christian, Sonnenschein, Kristina, Haghikia, Aiden, Weissenborn, Karin, Fraccarollo, Daniela, Heimesaat, Markus M., Bauersachs, Johann, Wang, Zeneng, Zhu, Weifei, Bavendiek, Udo, Hazen, Stanley L., Endres, Matthias, and Landmesser, Ulf

Published
2018
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38. Cerebral small vessel disease burden and cognitive and functional outcomes after stroke: A multicenter prospective cohort study.

Author

Georgakis, Marios K., Fang, Rong, Düring, Marco, Wollenweber, Frank A., Bode, Felix J., Stösser, Sebastian, Kindlein, Christine, Hermann, Peter, Liman, Thomas G., Nolte, Christian H., Kerti, Lucia, Ikenberg, Benno, Bernkopf, Kathleen, Poppert, Holger, Glanz, Wenzel, Perosa, Valentina, Janowitz, Daniel, Wagner, Michael, Neumann, Katja, and Speck, Oliver

Abstract

Introduction: It remains unknown whether the global small vessel disease (SVD) burden predicts post‐stroke outcomes. Methods: In a prospective multicenter study of 666 ischemic and hemorrhagic stroke patients, we quantified magnetic resonance imaging (MRI)–based SVD markers (lacunes, white matter hyperintensities, microbleeds, perivascular spaces) and explored associations with 6‐ and 12‐month cognitive (battery of 15 neuropsychological tests) and functional (modified Rankin scale) outcomes. Results: A global SVD score (range 0–4) was associated with cognitive impairment; worse performance in executive function, attention, language, and visuospatial ability; and worse functional outcome across a 12‐month follow‐up. Although the global SVD score did not improve prediction, individual SVD markers, assessed across their severity range, improved the calibration, discrimination, and reclassification of predictive models including demographic, clinical, and other imaging factors. Discussion: SVD presence and severity are associated with worse cognitive and functional outcomes 12 months after stroke. Assessing SVD severity may aid prognostication for stroke patients. Highlights: In a multi‐center cohort, we explored associations of small vessel disease (SVD) burden with stroke outcomes.SVD burden associates with post‐stroke cognitive and functional outcomes.A currently used score of SVD burden does not improve the prediction of poor outcomes.Assessing the severity of SVD lesions adds predictive value beyond known predictors.To add predictive value in assessing SVD in stroke patients, SVD burden scores should integrate lesion severity. [ABSTRACT FROM AUTHOR]

Published
2023
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41. High-Sensitivity Cardiac Troponin T and Cognitive Decline in Older Adults: Results of the Berlin Aging Study II

Author

von Rennenberg, Regina, primary, Liman, Thomas, additional, Nolte, Christian H., additional, Nave, Alexander H., additional, Scheitz, Jan F., additional, Düzel, Sandra, additional, Regitz-Zagrosek, Vera, additional, Gerstorf, Denis, additional, Steinhagen-Thiessen, Elisabeth, additional, Demuth, Ilja, additional, and Endres, Matthias, additional

Published
2022
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44. High-Sensitivity Cardiac Troponin T and Cognitive Decline in Older Adults: Results of the Berlin Aging Study II.

Author

von Rennenberg, Regina, Liman, Thomas, Nolte, Christian H., Nave, Alexander H., Scheitz, Jan F., Düzel, Sandra, Regitz-Zagrosek, Vera, Gerstorf, Denis, Steinhagen-Thiessen, Elisabeth, Demuth, Ilja, and Endres, Matthias

Subjects
*OLDER people, *COGNITION disorders, *COGNITIVE processing speed, *TROPONIN, *COGNITIVE testing
Abstract

Introduction: There is evidence of an association between markers of cardiac injury and cognition in patients with cardiovascular disease. We hypothesized that levels of high-sensitivity cardiac troponin T (hs-cTnT) are associated with cognitive performance and cognitive decline in a population of predominantly healthy older adults. Methods: We included 1,226 predominantly healthy adults ≥60 years from the Berlin Aging Study II. Participants were recruited from the general population of the Berlin metropolitan area from 2009 to 2014. At baseline, participants underwent measurement of hs-cTnT and cognitive testing using the extended Consortium to Establish a Registry for Alzheimer's Disease (CERAD-Plus) battery. In addition, the Digit Symbol Substitution Test (DSST) was performed at baseline and at follow-up (7.3 ± 1.4 years after the baseline visit). The CERAD test results were summarized into four cognitive domains (processing speed, executive function, visuo-construction, and memory). After summing-up the respective raw scores, we calculated standardized z scores. We performed unadjusted and adjusted linear regression models to assess links between hs-cTnT and cognitive domains. We used linear mixed models to analyze associations between hs-cTnT and cognitive decline according to changes in DSST scores over time. Results: The mean age of study participants at baseline was 68.5 (±3.6) years, 49% were female, and median hs-cTnT levels were 6 ng/L (IQR 4–8 ng/L). We detected no significant association between hs-cTnT and different cognitive domains at baseline after adjustment for age, sex, education, and cardiovascular risk factors. Hs-cTnT was associated with cognitive decline, which remained statistically significant after full adjustment (adjusted beta-coefficient −0.82 (−1.28 to −0.36), p = 0.001). After stratification for sex, the association with hs-cTnT remained statistically significant in men but not in women. Conclusion: Higher hs-cTnT levels in older men are associated with cognitive decline measured with the DSST. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Stroke genetics informs drug discovery and risk prediction across ancestries

Author

Debette, Stéphanie, primary, Mishra, Aniket, additional, Malik, Rainer, additional, Hachiya, Tsuyoshi, additional, Jürgenson, Tuuli, additional, Namba, Shinichi, additional, Koido, Masaru, additional, Grand, Quentin Le, additional, Kamanu, Frederick, additional, Shi, Mingyang, additional, He, Yunye, additional, Georgakis, Marios, additional, Caro, Ilana, additional, Krebs, Kristi, additional, Vaura, Felix, additional, Habib, Naomi, additional, Winsvold, Bendik, additional, Jee, Yon Ho, additional, Thomassen, Jesper Qvist, additional, Abedi, Vida, additional, Cárcel-Márquez, Jara, additional, Lin, Kuang, additional, Nygaard, Marianne, additional, Chauhan, Ganesh, additional, Leonard, Hampton, additional, Yang, Chaojie, additional, Yonova-Doing, Ekaterina, additional, Knol, Maria, additional, Ago, Tetsuro, additional, Amouyel, Philippe, additional, Anderson, Christopher, additional, Armstrong, Nicole, additional, Bakker, Mark, additional, Bartz, Traci, additional, Bis, Joshua, additional, Bordes, Constance, additional, Borte, Sigrid, additional, Cain, Anael, additional, Ridker, Paul, additional, Chen, Zhengming, additional, Chong, Michael, additional, Cole, John, additional, de Cid, Rafael, additional, Endres, Matthias, additional, Ferreira, Leslie, additional, Gasca, Natalie, additional, Gudnason, Vilmundur, additional, Hata, Jun, additional, Havulinna, Aki, additional, Hopewell, Jemma, additional, Hyacinth, Hyacinth, additional, Inouye, Michael, additional, Jacob, Mina, additional, Jeon, Christina , additional, Jern, Christina, additional, Kamouchi, Masahiro, additional, Keene, Keith, additional, Kitazono, Takanari, additional, Kittner, Steven, additional, Konuma, Takahiro, additional, Kumar, Amit, additional, Lacaze, Paul, additional, Launer, Lenore, additional, Lepik, Kaido, additional, Li, Jiang, additional, Li, Liming, additional, Manichaikul, Ani, additional, Markus, Hugh, additional, Marston, Nicholas, additional, Meitinger, Thomas, additional, Mitchell, Braxton, additional, Montellano, Felipe, additional, Morisaki, Takayuki, additional, Mosley, Thomas, additional, Nalls, Mike, additional, Nordestgaard, Børge, additional, O'Donnell, Martin, additional, Okada, Yukinori, additional, Pare, Guillaume, additional, Peters, Annette, additional, Psaty, Bruce, additional, Rich, Stephen, additional, Rosand, Jonathan, additional, Sabatine, Marc, additional, Sacco, Ralph, additional, Saleheen, Danish, additional, Sandset, Else Charlotte, additional, Sargurupremraj, Muralidharan, additional, Sasaki, Makoto, additional, Satizabal, Claudia, additional, Schmidt, Carsten, additional, Shimizu, Atsushi, additional, Smith, Nicholas, additional, Strbian, Daniel, additional, Sutoh, Yoichi, additional, Tanno, Kozo, additional, Tiedt, Steffen, additional, Torres-Aguila, Nuria, additional, Trégouët, David-Alexandre, additional, Trompet, Stella, additional, Tuladhar, Anil, additional, Tybjærg-Hansen, Anne, additional, Vugt, Marion van, additional, Vibo, Riina, additional, Wiggins, Kerri, additional, Woo, Daniel, additional, Xu, Huichun, additional, Yang, Qiong, additional, Lathrop, Mark, additional, Millwood, Iona, additional, Gieger, Christian, additional, Ninomiya, Toshiharu, additional, Grabe, Hans, additional, Jukema, J Wouter, additional, Rissanen, Ina, additional, Seshadri, Sudha, additional, Longstreth, William, additional, Chasman, Daniel, additional, Howson, Joanna, additional, Irvin, Marguerite, additional, Adams, Hieab, additional, Wasssertheil-Smoller, Sylvia, additional, Christensen, Kaare, additional, Ikram, M. Arfan, additional, Rundek, Tatjana, additional, Rotter, Jerome, additional, Riaz, Moeen, additional, Simonsick, Eleanor, additional, Kõrv, Janika, additional, França, Paulo, additional, Fornage, Myriam, additional, Zand, Ramin, additional, Prasad, Kameshwar, additional, Frikke-Schmidt, Ruth, additional, de Leeuw, Frank-Erik, additional, Liman, Thomas, additional, Haeusler, Karl Georg, additional, Ruigrok, Ynte, additional, Heuschmann, Peter, additional, Jung, Keum, additional, Zwart, John-Anker, additional, Niiranen, Teemu, additional, Ruff, Christian, additional, Fernández-Cadenas, Israel, additional, Walters, Robin, additional, Milani, Lili, additional, Kamatani, Yoichiro, additional, and Dichgans, Martin, additional

Published
2022
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48. High‐Sensitivity Cardiac Troponin T and Recurrent Vascular Events After First Ischemic Stroke

Author

Scheitz, Jan F., Lim, Jess, Broersen, Leonie H. A., Ganeshan, Ramanan, Huo, Shufan, Sperber, Pia S., Piper, Sophie K., Heuschmann, Peter U., Audebert, Heinrich J., Nolte, Christian H., Siegerink, Bob, Endres, Matthias, and Liman, Thomas G.

Subjects
Male, blood [Troponin T], blood [Ischemic Stroke], survival, trends [Survival Rate], Brain Ischemia, Troponin T, Risk Factors, mortality [Ischemic Stroke], ischemic stroke, Humans, mortality/survival, ddc:610, trends [Cause of Death], Prospective Studies, Aged, Original Research, blood [Biomarkers], troponin, Incidence, vascular disease, Middle Aged, epidemiology [Berlin], Prognosis, etiology [Vascular Diseases], mortality, epidemiology [Vascular Diseases], methods [Risk Assessment], blood [Vascular Diseases], Stroke, complications [Ischemic Stroke], Cardiovascular Diseases, Heart Disease Risk Factors, Female, epidemiology, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Biomarkers, Follow-Up Studies
Abstract

Background Recent evidence suggests cardiac troponin levels to be a marker of increased vascular risk. We aimed to assess whether levels of high-sensitivity cardiac troponin T (hs-cTnT) are associated with recurrent vascular events and death in patients with first-ever, mild to moderate ischemic stroke. Methods and Results We used data from the PROSCIS-B (Prospective Cohort With Incident Stroke Berlin) study. We computed Cox proportional hazards regression analyses to assess the association between hs-cTnT levels upon study entry (Roche Elecsys, upper reference limit, 14 ng/L) and the primary outcome (composite of recurrent stroke, myocardial infarction, and all-cause death). A total of 562 patients were analyzed (mean age, 67 years [SD 13]; 38.6% women; median National Institutes of Health Stroke Scale=2; hs-cTnT above upper reference limit, 39.2%). During a mean follow-up of 3 years, the primary outcome occurred in 89 patients (15.8%), including 40 (7.1%) recurrent strokes, 4 (0.7%) myocardial infarctions, and 51 (9.1%) events of all-cause death. The primary outcome occurred more often in patients with hs-cTnT above the upper reference limit (27.3% versus 10.2%; adjusted hazard ratio, 2.0; 95% CI, 1.3-3.3), with a dose-response relationship when the highest and lowest hs-cTnT quartiles were compared (15.2 versus 1.8 events per 100 person-years; adjusted hazard ratio, 4.8; 95% CI, 1.9-11.8). This association remained consistent in sensitivity analyses, which included age matching and stratification for sex. Conclusions Hs-cTnT is dose-dependently associated with an increased risk of recurrent vascular events and death within 3 years after first-ever, mild to moderate ischemic stroke. These findings support further studies of the utility of hs-cTnT for individualized risk stratification after stroke. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT01363856.

Published
2021

49. High‐Sensitivity Cardiac Troponin T and Recurrent Vascular Events After First Ischemic Stroke

Author

Scheitz, Jan F., primary, Lim, Jess, additional, Broersen, Leonie H. A., additional, Ganeshan, Ramanan, additional, Huo, Shufan, additional, Sperber, Pia S., additional, Piper, Sophie K., additional, Heuschmann, Peter U., additional, Audebert, Heinrich J., additional, Nolte, Christian H., additional, Siegerink, Bob, additional, Endres, Matthias, additional, and Liman, Thomas G., additional

Published
2021
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