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7. Impact of exclusive enteral nutrition on the gut microbiome of children with medical complexity.

Author

Beauchamp‐Walters, Julia, Aleti, Gajender, Herrera, Lourdes, Debelius, Justine, Lima, Natalie, Dalal, Pritha, Hong, Suzi, Knight, Rob, and Rhee, Kyung E.

Subjects
GUT microbiome, MALNUTRITION diagnosis, ENTEROBACTERIACEAE, CHILD nutrition, FEEDING tubes
Abstract

Background: Children with medical complexity (CMC) often require enteral tube feedings to meet their nutrition needs. Many, however, experience symptoms of feeding intolerance, such as vomiting and pain. The goal of this analysis was to examine the relationship between diet and the gut microbiome, controlling for medications, among CMC receiving enteral tube feedings, CMC consuming oral nutrition, and healthy controls. Given the variety of available commercial formula preparations, we were also interested in examining the impact of different formula types on the CMC microbiome. Methods: Fecal samples from 91 children (57 CMC and 34 healthy controls) were collected and analyzed. Parents completed clinical and dietary questionnaires. 16S ribosomal RNA amplicon sequencing was completed using the QIIME2 pipeline. Results: A significant decrease in alpha diversity among CMC receiving exclusive enteral nutrition (CMC EEN) compared with healthy controls (Shannon P = 0.006 and Faith's phylogenetic distance P = 0.006) was found that was not observed between CMC receiving oral nutrition and healthy controls. Significant differences in beta diversity were also observed between CMC EEN and healthy controls, with CMC EEN having a greater relative abundance of Enterobacteriaceae and obligate anaerobes. Differences were also noted between CMC EEN and CMC receiving oral nutrition (Aitchison distance P = 0.001); however, no differences were observed between CMC receiving oral nutrition and healthy controls. Conclusion: Despite similarities in medication profiles, CMC EEN have decreased alpha diversity and differences in beta diversity compared with healthy controls not observed in CMC receiving oral nutrition, highlighting the impact of diet over medications. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Antibiotic research and development: business as usual?

Author

Harbarth, S., Theuretzbacher, U., Hackett, J., Adriaenssens, Niels, Anderson, James, Antonisse, Ad, Årdal, Christine, Baillon-Plot, Nathalie, Baraldi, Enrico, Bettiol, Esther, Bhatti, Taimur, Bradshaw, David, Brown, Nicholas, Carmeli, Yehuda, Cars, Otto, Charbonneau, Claudie, Cheng, Sue, Ciabuschi, Francesco, Cirino, Joseph, Clift, Charles, Colson, Abby, Dane, Aaron, De-Lima, Natalie, Dooa, Mindy, Drabik, Dusan, Eisenstein, Barry, Farquhar, Ronald, Fidan, Dogan, Findlay, David, Galli, Frederic, Gilchrist, Kim, Gilman, Steve, Goeschl, Timo, Goodall, Jonathan, Goossens, Herman, Gouglas, Dimitrios, Guise, Tracey, Gyssens, Inge, Hallerbäck, Peter, Heymann, David, Hoffman, Steven, Howell, Jenny, Hulscher, Marlies, Hunt, Timothy, Huttner, Benedikt, Jantarada, Fabricio, Jaquest, Dominique, Joly, Florence, Ka, Lum, Karas, Andreas, Knirsch, Charles, Kullberg, Bart-Jan, Laxminarayan, Ramanan, Le Maréchal, Marion, Legros, Stéphane, Lilliott, Nicky, Lindgren, Eva, Longshaw, Chris, Mahoney, Nicole, Mastrangelo, Dana, McDonald, John, McKeever, Steve, Mepham, Tim, Milanic, Romina, Monnier, Annelie, Morel, Chantal, Morton, Alec, Mossialos, Elias, Nolet, Brigitte, Outterson, Kevin, Payne, David, Piddock, Laura, Plahte, Jens, Potter, Danielle, Pulcini, Céline, Rex, John, Ross, Emma, Rottingen, John-Arne, Ryan, Kellie, Ryan, James, Salimi, Tehseen, Schouten, Jeroen, Schultz, Suzanne, So, Antony, Spiesser, Julie, Stålhammar, Nils-Olov, Stanic, Mirji, Tacconelli, Evelina, Temkin, Liz, Trick, Donald, Vink, Patrick, Vlahovic-Palcevski, Vera, Watt, Maureen, Wells, Marc, Wesseler, Justus, White, Alex, Wood, Susan, Zanichelli, Veronica, and Zorzet, Anna

Published
2015
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12. Antibiotic research and development: business as usual?

Author

Harbarth, S., Theuretzbacher, U., Hackett, J., Adriaenssens, Niels, Anderson, James, Antonisse, Ad, Årdal, Christine, Baillon-Plot, Nathalie, Baraldi, Enrico, Bettiol, Esther, Bhatti, Taimur, Bradshaw, David, Brown, Nicholas, Carmeli, Yehuda, Cars, Otto, Charbonneau, Claudie, Cheng, Sue, Ciabuschi, Francesco, Cirino, Joseph, Clift, Charles, Colson, Abby, Dane, Aaron, De-Lima, Natalie, Dooa, Mindy, Drabik, Dusan, Eisenstein, Barry, Farquhar, Ronald, Fidan, Dogan, Findlay, David, Galli, Frederic, Gilchrist, Kim, Gilman, Steve, Goeschl, Timo, Goodall, Jonathan, Goossens, Herman, Gouglas, Dimitrios, Guise, Tracey, Gyssens, Inge, Hallerbäck, Peter, Heymann, David, Hoffman, Steven, Howell, Jenny, Hulscher, Marlies, Hunt, Timothy, Huttner, Benedikt, Jantarada, Fabricio, Jaquest, Dominique, Joly, Florence, Ka, Lum, Karas, Andreas, Knirsch, Charles, Kullberg, Bart-Jan, Laxminarayan, Ramanan, Le Maréchal, Marion, Legros, Stéphane, Lilliott, Nicky, Lindgren, Eva, Longshaw, Chris, Mahoney, Nicole, Mastrangelo, Dana, McDonald, John, McKeever, Steve, Mepham, Tim, Milanic, Romina, Monnier, Annelie, Morel, Chantal, Morton, Alec, Mossialos, Elias, Nolet, Brigitte, Outterson, Kevin, Payne, David, Piddock, Laura, Plahte, Jens, Potter, Danielle, Pulcini, Céline, Rex, John, Ross, Emma, Rottingen, John-Arne, Ryan, Kellie, Ryan, James, Salimi, Tehseen, Schouten, Jeroen, Schultz, Suzanne, So, Antony, Spiesser, Julie, Stålhammar, Nils-Olov, Stanic, Mirji, Tacconelli, Evelina, Temkin, Liz, Trick, Donald, Vink, Patrick, Vlahovic-Palcevski, Vera, Watt, Maureen, Wells, Marc, Wesseler, Justus, White, Alex, Wood, Susan, Zanichelli, Veronica, and Zorzet, Anna

Abstract

This article contends that poor economic incentives are an important reason for the lack of new drugs and explains how the DRIVE-AB intends to change the landscape by harnessing the expertise, motivation and diversity of its partners

Published
2017

14. Construction and validation of data collection instrument content in a neonatal intensive care unit

Author

Lima, Natalie Dantas Costa, Silva, Viviane Martins da, and Beltrão, Beatriz Amorim

Subjects
lcsh:RT1-120, Intensive Care Units, Intensive Care Units Neonatal, Data collection, lcsh:Nursing, Neonatal, Nursing diagnosis
Abstract

To allow systematic data collection, the study aimed to construct and validate a clinical evaluation instrument for neonates hospitalized in the Intensive Care Unit. A methodological study was conducted from January to June 2008, which was organi­zed into two steps: bibliographical search for subsidizing the construction of the instrument and appropriateness of content by experts from the State of Ceará. The instrument was composed of ten sections: personal data of the mother and the new­born, vital signs, physical/skin integrity, head/neck, nervous system, respiratory system, cardiovascular system, gastrointesti­nal system, urogenital system, and mother-child binomial. Relevant nursing diagnoses to each section were included. All the sections were considered by the experts to be adequate. Four sections received the maximum score of agreement: mother and newborn personal data, head/neck, cardiovascular system and genitourinary system. It is believed that the implementation of this instrument can help nurses to identify indicators that reflect possible nursing diagnoses.

Published
2012

15. Construção e validação de conteúdo de instrumento de coleta de dados em unidade neonatal

Author

Lima, Natalie Dantas Costa, Silva, Viviane Martins da, Beltrão, Beatriz Amorim, Lima, Natalie Dantas Costa, Silva, Viviane Martins da, and Beltrão, Beatriz Amorim

Abstract

Para possibilitar um levantamento de dados sistematizado, o estudo objetivou construir e validar um instrumento de avaliação clínica para neonatos internados em Unidade de Terapia Intensiva. Estudo metodológico realizado durante os meses de janeiro a junho de 2008. Este foi organizado em duas fases: levantamento bibliográfico para subsidiar a construção do instrumento e avaliação da adequação do conteúdo por especialistas do Estado do Ceará. O instrumento foi composto por dez seções: dados pessoais da mãe e recém-nascido, sinais vitais, integridade física/cutâneo-mucosa, cabeça/pescoço, avaliação dos sistemas: nervoso, respiratório, cardiovascular, gastrintestinal, geniturinário e binômio mãe-filho. Foram inclusos diagnósticos de enfermagem pertinentes para cada seção. Todas as seções foram consideradas adequadas. Quatro seções receberam escore máximo de concordância, sendo estas: dados pessoais da mãe e recém-nascido, cabeça/pescoço, sistema cardiovascular e sistema geniturinário. Acredita-se que a implementação deste instrumento poderá contribuir para que enfermeiros identifiquem indicadores que refletirão possíveis diagnósticos de enfermagem. DOI:https://doi.org/10.15253/2175-6783.20090003000012

Published
2009

21. For a Good Time, Call.

Author

Lima, Natalie

Subjects
IMAGINARY companions, HOBBIES
Abstract

On the party line, Maria and I can be anything, or anyone. But always, we're adults. [ABSTRACT FROM AUTHOR]

Published
2020

22. Antibiotic research and development: business as usual?

Author

Harbarth, S., Theuretzbacher, U., Hackett, J., Adriaenssens, Niels, Anderson, James, Antonisse, Ad, Årdal, Christine, Baillon-Plot, Nathalie, Baraldi, Enrico, Bettiol, Esther, Bhatti, Taimur, Bradshaw, David, Brown, Nicholas, Carmeli, Yehuda, Cars, Otto, Charbonneau, Claudie, Cheng, Sue, Ciabuschi, Francesco, Cirino, Joseph, Clift, Charles, Colson, Abby, Dane, Aaron, De-Lima, Natalie, Dooa, Mindy, Drabik, Dusan, Eisenstein, Barry, Farquhar, Ronald, Fidan, Dogan, Findlay, David, Galli, Frederic, Gilchrist, Kim, Gilman, Steve, Goeschl, Timo, Goodall, Jonathan, Goossens, Herman, Gouglas, Dimitrios, Guise, Tracey, Gyssens, Inge, Hallerbäck, Peter, Heymann, David, Hoffman, Steven, Howell, Jenny, Hulscher, Marlies, Hunt, Timothy, Huttner, Benedikt, Jantarada, Fabricio, Jaquest, Dominique, Joly, Florence, Ka, Lum, Karas, Andreas, Knirsch, Charles, Kullberg, Bart-Jan, Laxminarayan, Ramanan, Le Maréchal, Marion, Legros, Stéphane, Lilliott, Nicky, Lindgren, Eva, Longshaw, Chris, Mahoney, Nicole, Mastrangelo, Dana, McDonald, John, McKeever, Steve, Mepham, Tim, Milanic, Romina, Monnier, Annelie, Morel, Chantal, Morton, Alec, Mossialos, Elias, Nolet, Brigitte, Outterson, Kevin, Payne, David, Piddock, Laura, Plahte, Jens, Potter, Danielle, Pulcini, Céline, Rex, John, Ross, Emma, Rottingen, John-Arne, Ryan, Kellie, Ryan, James, Salimi, Tehseen, Schouten, Jeroen, Schultz, Suzanne, So, Antony, Spiesser, Julie, Stålhammar, Nils-Olov, Stanic, Mirji, Tacconelli, Evelina, Temkin, Liz, Trick, Donald, Vink, Patrick, Vlahovic-Palcevski, Vera, Watt, Maureen, Wells, Marc, Wesseler, Justus, White, Alex, Wood, Susan, Zanichelli, Veronica, Zorzet, Anna, Harbarth, S., Theuretzbacher, U., Hackett, J., Adriaenssens, Niels, Anderson, James, Antonisse, Ad, Årdal, Christine, Baillon-Plot, Nathalie, Baraldi, Enrico, Bettiol, Esther, Bhatti, Taimur, Bradshaw, David, Brown, Nicholas, Carmeli, Yehuda, Cars, Otto, Charbonneau, Claudie, Cheng, Sue, Ciabuschi, Francesco, Cirino, Joseph, Clift, Charles, Colson, Abby, Dane, Aaron, De-Lima, Natalie, Dooa, Mindy, Drabik, Dusan, Eisenstein, Barry, Farquhar, Ronald, Fidan, Dogan, Findlay, David, Galli, Frederic, Gilchrist, Kim, Gilman, Steve, Goeschl, Timo, Goodall, Jonathan, Goossens, Herman, Gouglas, Dimitrios, Guise, Tracey, Gyssens, Inge, Hallerbäck, Peter, Heymann, David, Hoffman, Steven, Howell, Jenny, Hulscher, Marlies, Hunt, Timothy, Huttner, Benedikt, Jantarada, Fabricio, Jaquest, Dominique, Joly, Florence, Ka, Lum, Karas, Andreas, Knirsch, Charles, Kullberg, Bart-Jan, Laxminarayan, Ramanan, Le Maréchal, Marion, Legros, Stéphane, Lilliott, Nicky, Lindgren, Eva, Longshaw, Chris, Mahoney, Nicole, Mastrangelo, Dana, McDonald, John, McKeever, Steve, Mepham, Tim, Milanic, Romina, Monnier, Annelie, Morel, Chantal, Morton, Alec, Mossialos, Elias, Nolet, Brigitte, Outterson, Kevin, Payne, David, Piddock, Laura, Plahte, Jens, Potter, Danielle, Pulcini, Céline, Rex, John, Ross, Emma, Rottingen, John-Arne, Ryan, Kellie, Ryan, James, Salimi, Tehseen, Schouten, Jeroen, Schultz, Suzanne, So, Antony, Spiesser, Julie, Stålhammar, Nils-Olov, Stanic, Mirji, Tacconelli, Evelina, Temkin, Liz, Trick, Donald, Vink, Patrick, Vlahovic-Palcevski, Vera, Watt, Maureen, Wells, Marc, Wesseler, Justus, White, Alex, Wood, Susan, Zanichelli, Veronica, and Zorzet, Anna

Abstract

This article contends that poor economic incentives are an important reason for the lack of new drugs and explains how the DRIVE-AB intends to change the landscape by harnessing the expertise, motivation and diversity of its partners

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