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18 results on '"Lim, Xinru"'

1. The Prognostic Value of CD39 as a Marker of Tumor-Specific T Cells in Triple-Negative Breast Cancer in Asian Women

Author

Meng, Jia, Tan, Jing Ying Tira, Joseph, Craig Ryan, Ye, Jiangfeng, Lim, Jeffrey Chun Tatt, Goh, Denise, Xue, Yuezhen, Lim, Xinru, Koh, Valerie Cui Yun, Wee, Felicia, Tay, Timothy Kwang Yong, Chan, Jaason Yongsheng, Ng, Cedric Chuan Young, Iqbal, Jabed, Lau, Mai Chan, Lim, Hsuen Elaine, Toh, Han Chong, Teh, Bin Tean, Dent, Rebecca Alexandra, Tan, Puay Hoon, and Yeong, Joe Poh Sheng

Published
2024
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2. Abstract P69: Immune Landscape of BRCA1/2 -mutated Breast and Ovarian Cancers in an Asian Cohort

Author

Chong, Siao Ting, primary, Wee, Felicia, additional, Ye, Jiang Feng, additional, Joseph, Craig, additional, Lim, Xinru, additional, Neo, Zhen Wei, additional, Lee, Justina Nadia, additional, Ishak, Nur Diana Binte, additional, Toh, Ming Ren, additional, Chew, Ee Ling, additional, Yeo, Claresta, additional, Chan, Sock Hoai, additional, Lim, Jeffrey, additional, Yeong, Joe, additional, and Ngeow, Joanne, additional

Published
2024
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5. The prognostic value of CD39+CD8+ T cells as a potential surrogate marker of tumor-specific T cells in Asian triple-negative breast cancer

Author

MENG, JIA, primary, Tira, Tan Jing Ying, additional, Joseph, Craig Ryan, additional, Ye, Jiangfeng, additional, Lim, Jeffrey Chun Tatt, additional, Goh, Denise, additional, Yuezhen, Xue, additional, Lim, Xinru, additional, Koh, Valerie Cui Yun, additional, Wee, Felicia, additional, Tay, Timothy Kwang Yong, additional, Chan, Jason Yongsheng, additional, Ng, Cedric Chuan Young, additional, Iqbal, Jabed, additional, Lau, Mai Chan, additional, Elaine, Lim Hsuen, additional, Chong, Toh Han, additional, Teh, Bin Tean, additional, Dent, Rebecca Alexandra, additional, Tan, Puay Hoon, additional, and Sheng, Joe Yeong Poh, additional

Published
2023
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6. Multimodal molecular landscape of response to Y90-resin microsphere radioembolization followed by nivolumab for advanced hepatocellular carcinoma

Author

Kaya, Neslihan Arife, primary, Tai, David, additional, Lim, Xinru, additional, Lim, Jia Qi, additional, Lau, Mai Chan, additional, Goh, Denise, additional, Phua, Cheryl Zi Jin, additional, Wee, Felicia Yu Ting, additional, Joseph, Craig Ryan, additional, Lim, Jeffrey Chun Tatt, additional, Neo, Zhen Wei, additional, Ye, Jiangfeng, additional, Cheung, Lawrence, additional, Lee, Joycelyn, additional, Loke, Kelvin S H, additional, Gogna, Apoorva, additional, Yao, Fei, additional, Lee, May Yin, additional, Shuen, Timothy Wai Ho, additional, Toh, Han Chong, additional, Hilmer, Axel, additional, Chan, Yun Shen, additional, Lim, Tony Kiat-Hon, additional, Tam, Wai Leong, additional, Choo, Su Pin, additional, Yeong, Joe, additional, and Zhai, Weiwei, additional

Published
2023
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7. 867 Deciphering of radiotherapy-induced immunomodulation effect synergized with immunotherapy in hepatocellular carcinoma by spatial multi-omics profiling

Author

Lau, Mai Chan, primary, Suteja, Lisda, additional, Cheung, Lawrence, additional, Lim, Jeffrey, additional, Lim, Chun Jye, additional, Lim, Xinru, additional, Kaya, Neslihan, additional, Ye, Jiang Feng, additional, Wee, Felicia, additional, Toh, Han Chong, additional, Choo, Su Pin, additional, Lee, Suat Ying, additional, Xin Lee, Joycelyn Jie, additional, Liu, Jin, additional, Hon Lim, Tony Kiat, additional, Zhai, Weiwei, additional, Tai, David, additional, and Sheng Yeong, Joe Poh, additional

Published
2022
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8. Case report: Understanding the impact of persistent tissue-localization of SARS-CoV-2 on immune response activity via spatial transcriptomic analysis of two cancer patients with COVID-19 co-morbidity

Author

Lau, Mai Chan, primary, Yi, Yang, additional, Goh, Denise, additional, Cheung, Chun Chau Lawrence, additional, Tan, Benedict, additional, Lim, Jeffrey Chun Tatt, additional, Joseph, Craig Ryan, additional, Wee, Felicia, additional, Lee, Justina Nadia, additional, Lim, Xinru, additional, Lim, Chun Jye, additional, Leow, Wei Qiang, additional, Lee, Jing Yi, additional, Ng, Cedric Chuan Young, additional, Bashiri, Hamed, additional, Cheow, Peng Chung, additional, Chan, Chun Yip, additional, Koh, Ye Xin, additional, Tan, Thuan Tong, additional, Kalimuddin, Shirin, additional, Tai, Wai Meng David, additional, Ng, Jia Lin, additional, Low, Jenny Guek-Hong, additional, Lim, Tony Kiat Hon, additional, Liu, Jin, additional, and Yeong, Joe Poh Sheng, additional

Published
2022
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9. 626 Dissecting the spatial heterogeneity of SARS-CoV-2-infected tumour microenvironment reveals a lymphocyte-dominant immune response in a HBV-associated HCC patient with COVID-19 history

Author

Tan, Benedict, primary, Yang, Yi, additional, Lawrence Cheung, Chun Chau, additional, Goh, Denise, additional, Lau, Mai Chan, additional, Lim, Xinru, additional, Lim, Jeffrey, additional, Nadia Lee, Li Wen Justina, additional, Tien, Tracy, additional, Kalimuddin, Shirin, additional, David Tai, Wai Meng, additional, Low, Jenny, additional, Young Ng, Cedric Chuan, additional, Leow, Wei Qiang, additional, Tan, Thuan Tong, additional, Lim, Tony, additional, Liu, Jin, additional, and Yeong, Joe, additional

Published
2021
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10. Residual SARS-CoV-2 viral antigens detected in GI and hepatic tissues from five recovered patients with COVID-19

Author

Cheung, Chun Chau Lawrence, primary, Goh, Denise, additional, Lim, Xinru, additional, Tien, Tracy Zhijun, additional, Lim, Jeffrey Chun Tatt, additional, Lee, Justina Nadia, additional, Tan, Benedict, additional, Tay, Zhi En Amos, additional, Wan, Wei Yee, additional, Chen, Eileen Xueqin, additional, Nerurkar, Sanjna Nilesh, additional, Loong, Shihleone, additional, Cheow, Peng Chung, additional, Chan, Chung Yip, additional, Koh, Ye Xin, additional, Tan, Thuan Tong, additional, Kalimuddin, Shirin, additional, Tai, Wai Meng David, additional, Ng, Jia Lin, additional, Low, Jenny Guek-Hong, additional, Yeong, Joe, additional, and Lim, Kiat Hon, additional

Published
2021
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12. Residual SARS-CoV-2 viral antigens detected in gastrointestinal and hepatic tissues from two recovered COVID-19 patients

Author

Cheung, Chun Chau Lawrence, primary, Goh, Denise, additional, Lim, Xinru, additional, Tien, Tracy Zhijun, additional, Lim, Jeffrey Chun Tatt, additional, Nerurkar, Sanjna Nilesh, additional, Shihleone, Loong, additional, Cheow, Peng Chung, additional, Chan, Chung Yip, additional, Koh, Ye Xin, additional, Tan, Thuan Tong, additional, Kalimuddin, Shirin, additional, David Tai, Wai Meng, additional, Ng, Jia Lin, additional, Hong Low, Jenny Guek, additional, Yeong, Joe, additional, and Hon Lim, Tony Kiat, additional

Published
2020
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13. 475 Incidental finding of colorectal cancer in a COVID-19 patient, followed by deep profiling of SARS-CoV-2-associated immune landscape and tumour microenvironment

Author

Lawrence Cheung, Chun Chau, primary, Lim, Xinru, additional, Goh, Denise, additional, Tien, Tracy Zhijun, additional, Tatt Lim, Jeffrey Chun, additional, Tan, Thuan Tong, additional, Kalimuddin, Shirin, additional, Ng, Jia Lin, additional, Low, Jenny Guek-Hong, additional, Yeong, Joe, additional, and Lim, Kiat Hon, additional

Published
2020
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14. 825 Deep immune profiling of SARS-CoV-2 associated immune microenvironment in cancer tissues from recovered COVID-19 patients

Author

Goh, Denise, primary, Lawrence Cheung, Chun Chau, additional, Lim, Xinru, additional, Tien, Tracy Zhijun, additional, Tatt Lim, Jeffrey Chun, additional, Nerurkar, Sanjna Nilesh, additional, Shihleone, Loong, additional, Cheow, Peng Chung, additional, Chan, Chung Yip, additional, Koh, Ye Xin, additional, Tan, Thuan Tong, additional, Kalimuddin, Shirin, additional, David Tai, Wai Meng, additional, Ng, Jia Lin, additional, Low, Jenny Guek-Hong, additional, Sheng Yeong, Joe Poh, additional, and Hon Lim, Tony Kiat, additional

Published
2020
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15. Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma

Author

Ng, Harry Ho Man, primary, Lee, Ren Yuan, additional, Goh, Siting, additional, Tay, Isabel Shu Ying, additional, Lim, Xinru, additional, Lee, Bernett, additional, Chew, Valerie, additional, Li, Huihua, additional, Tan, Benedict, additional, Lim, Sherlly, additional, Lim, Jeffrey Chun Tatt, additional, Au, Bijin, additional, Loh, Josh Jie Hua, additional, Saraf, Sahil, additional, Connolly, John Edward, additional, Loh, Tracy, additional, Leow, Wei Qiang, additional, Lee, Joycelyn Jie Xin, additional, Toh, Han Chong, additional, Malavasi, Fabio, additional, Lee, Ser Yee, additional, Chow, Pierce, additional, Newell, Evan W, additional, Choo, Su Pin, additional, Tai, David, additional, Yeong, Joe, additional, and Lim, Tony Kiat Hon, additional

Published
2020
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17. Residual SARS-CoV-2 viral antigens detected in GI and hepatic tissues from five recovered patients with COVID-19

Author

Cheung, Chun Chau Lawrence, Goh, Denise, Lim, Xinru, Tien, Tracy Zhijun, Lim, Jeffrey Chun Tatt, Lee, Justina Nadia, Tan, Benedict, Tay, Zhi En Amos, Wan, Wei Yee, Chen, Eileen Xueqin, Nerurkar, Sanjna Nilesh, Loong, Shihleone, Cheow, Peng Chung, Chan, Chung Yip, Koh, Ye Xin, Tan, Thuan Tong, Kalimuddin, Shirin, Tai, Wai Meng David, Ng, Jia Lin, Low, Jenny Guek-Hong, Yeong, Joe, and Lim, Kiat Hon

Published
2022
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18. Immunohistochemical scoring of LAG-3 in conjunction with CD8 in the tumor microenvironment predicts response to immunotherapy in hepatocellular carcinoma.

Author

Cheung CCL, Seah YHJ, Fang J, Orpilla NHC, Lau MC, Lim CJ, Lim X, Lee JNLW, Lim JCT, Lim S, Cheng Q, Toh HC, Choo SP, Lee SY, Lee JJX, Liu J, Lim TKH, Tai D, and Yeong J

Subjects
Humans, Tumor Microenvironment, CD8-Positive T-Lymphocytes, Immunotherapy methods, Carcinoma, Hepatocellular metabolism, Liver Neoplasms
Abstract

Introduction: Immune checkpoint blockade (ICB) is a systemic therapeutic option for advanced hepatocellular carcinoma (HCC). However, low patient response rates necessitate the development of robust predictive biomarkers that identify individuals who will benefit from ICB. A 4-gene inflammatory signature, comprising CD8 , PD-L1 , LAG-3 , and STAT1 , was recently shown to be associated with a better overall response to ICB in various cancer types. Here, we examined whether tissue protein expression of CD8, PD-L1, LAG-3, and STAT1 predicts response to ICB in HCC., Methods: HCC samples from 191 Asian patients, comprising resection specimens from 124 patients (ICB-naïve) and pre-treatment specimens from 67 advanced HCC patients treated with ICB (ICB-treated), were analyzed for CD8, PD-L1, LAG-3, and STAT1 tissue expression using multiplex immunohistochemistry followed by statistical and survival analyses., Results: Immunohistochemical and survival analyses of ICB-naïve samples showed that high LAG-3 expression was associated with shorter median progression-free survival (mPFS) and overall survival (mOS). Analysis of ICB-treated samples revealed that high proportions of LAG-3 + and LAG-3 + CD8 + cells pre-treatment were most closely associated with longer mPFS and mOS. Using a log-likelihood model, adding the total LAG-3 + cell proportion to the total CD8 + cell proportion significantly increased the predictive values for mPFS and mOS, compared with the total CD8 + cell proportion alone. Moreover, levels of CD8 and STAT1, but not PD-L1, were significantly correlated with better responses to ICB. After analyzing viral-related and non-viral HCC samples separately, only the LAG3 + CD8 + cell proportion was significantly associated with responses to ICB regardless of viral status., Conclusion: Immunohistochemical scoring of pre-treatment levels of LAG-3 and CD8 in the tumor microenvironment may help predict ICB benefits in HCC patients. Furthermore, immunohistochemistry-based techniques offer the advantage of being readily translatable in the clinical setting., Competing Interests: DT is in the advisory board in Novartis, Celgene, Sirtex, MSD, BMS, Eisai, Ipsen, and Bayer; and as research support in Novartis, Sirtex, and BMS. JJL received research funding from Bayer, has participated in the advisory boards for Eisai, Ipsen, and Bayer, and Taiho; and received honorarium from Ipsen and BMS. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be constructed as a potential conflict of interest., (Copyright © 2023 Cheung, Seah, Fang, Orpilla, Lau, Lim, Lim, Lee, Lim, Lim, Cheng, Toh, Choo, Lee, Lee, Liu, Lim, Tai and Yeong.)

Published
2023
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