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391 results on '"Lim, Myung-Ho"'

1. Prenatal exposure to paternal smoking and likelihood for autism spectrum disorder

Author

Kim, Bora, Ha, Mina, Kim, Young Shin, Koh, Yun-Joo, Dong, Shan, Kwon, Ho-Jang, Kim, Young-Suk, Lim, Myung-Ho, Paik, Ki-Chung, Yoo, Seung-Jin, Kim, Hosanna, Hong, Patricia S, Sanders, Stephan J, and Leventhal, Bennett L

Subjects
Biomedical and Clinical Sciences, Psychology, Behavioral and Social Science, Autism, Pediatric, Genetics, Tobacco Smoke and Health, Intellectual and Developmental Disabilities (IDD), Tobacco, Mental Health, Prevention, Brain Disorders, 2.3 Psychological, social and economic factors, 2.1 Biological and endogenous factors, Aetiology, Reproductive health and childbirth, Mental health, Autism Spectrum Disorder, Causality, Family, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Smoking, autism spectrum disorders, environmental factors, risk factor epidemiology, Specialist Studies in Education, Cognitive Sciences, Developmental & Child Psychology, Biomedical and clinical sciences
Abstract

Lay abstractWhat is Already Known about This Subject: Genetics, (including de novo mutations), environmental factors (including toxic exposures), and their interactions impact autism spectrum disorder etiology. Paternal smoking is a candidate risk for autism spectrum disorder due to biological plausibility, high prevalence, and potential intervention.What This Study Adds: This original study and its replication confirms that paternal factors can substantially contribute to autism spectrum disorder risk for their offspring. It specifically indicates that paternal smoking both before and during pregnancy contributes significantly to autism spectrum disorder risk.Implications for practice, research, or policy: Smoking prevention, especially in pregnancy planning, may decrease autism spectrum disorder risk in offspring.

Published
2021

8. The social responsiveness scale in relation to DSM IV and DSM5 ASD in Korean children

Author

Cheon, Keun‐Ah, Park, Jee‐In, Koh, Yun‐Joo, Song, Jungeun, Hong, Hyun‐Joo, Kim, Young‐Kee, Lim, Eun‐Chung, Kwon, Hojang, Ha, Mina, Lim, Myung‐Ho, Paik, Ki‐Chung, Constantino, John N, Leventhal, Bennett, and Kim, Young Shin

Subjects
Biomedical and Clinical Sciences, Applied and Developmental Psychology, Clinical and Health Psychology, Neurosciences, Psychology, Intellectual and Developmental Disabilities (IDD), Mental Health, Clinical Research, Pediatric, Behavioral and Social Science, Brain Disorders, Autism, Mental health, Autism Spectrum Disorder, Child, Child Development Disorders, Pervasive, Cross-Cultural Comparison, Diagnosis, Differential, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Male, Mass Screening, Psychometrics, Reproducibility of Results, Republic of Korea, Social Communication Disorder, Korean social responsiveness scale, validity, reliability, DSM IV PDD, DSM5 ASD, Clinical Sciences, Developmental & Child Psychology, Applied and developmental psychology, Clinical and health psychology
Abstract

The Social Responsiveness Scale (SRS) is an autism rating scales in widespread use, with over 20 official foreign language translations. It has proven highly feasible for quantitative ascertainment of autistic social impairment in public health settings, however, little is known about the validity of the reinforcement in Asia populations or in references to DSM5. The current study aims to evaluate psychometric properties and cross-cultural aspects of the SRS-Korean version (K-SRS).The study subjects were ascertained from three samples: a general sample from 3 regular education elementary schools (n=790), a clinical sample (n=154) of 6-12-year-olds from four psychiatric clinics, and an epidemiological sample of children with ASD, diagnosed using both DSM IV PDD, DSM5 ASD and SCD criteria (n=151). Their parents completed the K-SRS and the Autism Spectrum Screening Questionnaire(ASSQ). Descriptive statistics, correlation analyses and principal components analysis (PCA) were performed on the total population. Mean total scores on the K-SRS differed significantly between the three samples. ASSQ scores were significantly correlated with the K-SRS T-scores. PCA suggested a one-factor solution for the total population.Our results indicate that the K-SRS exhibits adequate reliability and validity for measuring ASD symptoms in Korean children with DSM IV PDD and DSM5 ASD. Our findings further suggest that it is difficult to distinguish SCD from other child psychiatric conditions using the K-SRS.This is the first study to examine the relationship between the SRS subscales and DSM5-based clinical diagnoses. This study provides cross-cultural confirmation of the factor structure for ASD symptoms and traits measured by the SRS. Autism Res 2016, 9: 970-980. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

Published
2016

24. Theta and Gamma Activity Differences in Obsessive–Compulsive Disorder and Panic Disorder: Insights from Resting-State EEG with eLORETA.

Author

Lee, Ilju, Kim, Kyoung Min, and Lim, Myung Ho

Subjects
PANIC disorders, OBSESSIVE-compulsive disorder, PREFRONTAL cortex, ELECTROENCEPHALOGRAPHY, CINGULATE cortex
Abstract

Background: Obsessive–compulsive disorder (OCD) and panic disorder (PD) are debilitating psychiatric conditions, yet their underlying neurobiological differences remain underexplored. This study aimed to directly compare resting-state EEGs in patients with OCD and PD, without a healthy control group, using the eLORETA method. Methods: We collected retrospective EEG data from 24 OCD patients and 22 PD patients who were hospitalized due to significant impairment in daily life functions. eLORETA was used to analyze the EEG data. Results: Heightened theta activity was observed in the anterior cingulate cortex (ACC) of OCD patients compared to PD patients (PD vs. OCD, t = −2.168, p < 0.05). Conversely, higher gamma activity was found in the medial frontal gyrus (MFG) and paracentral lobule (PCL) in PD patients (PD vs. OCD, t = 2.173, p < 0.05). Conclusions: Our findings highlight neurobiological differences between OCD and PD patients. Specifically, the increased theta activity in the ACC for OCD patients and elevated gamma activity in the MFG and PCL for PD patients offer preliminary insights into the neural mechanisms of these disorders. Further studies are essential to validate these results and delve deeper into the neural underpinnings. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Unusual Removal of T-DNA in T1 Progenies of Rice after Agrobacterium-mediated CRISPR/Cas9 Editing

Author

Qin Yang, Park Tae-Sung, Lee Bumkyu, and Lim Myung-Ho

Abstract

In the present study, we attempted to knock out the bar gene selection marker in the fixed Bt- and herbicide-resistant transgenic line BT-T07 (T8 generation) to generate a marker-free Bt-resistant rice line. A binary vector containing a CRISPR/Cas9 system targeting the 108–130 bp region of bar was transformed into rice embryonic calli, and plantlets were regenerated under non-selective conditions. Three T0 plants were observed to have non-target point mutations and deletions in the targeted gene and were putatively heterozygous and chimeras. One T0 plant, 130-4, was confirmed to have a 76-nt deletion, from 140 bp to 225 bp, and it showed the segregation of bar in its T1 progenies, with 16 bar-knockout lines and seven normal bar-expressing lines. However, the CRISPR/Cas9 editing vector sequences were not detected in any of the T1 plants. In addition, unusual removal of pre-existing T-DNA was observed in all bar-knockout T1 plants. Illumina sequencing of a bar-knockout line, 130-4-36, revealed a small fraction of read residues of pre-existing T-DNA from the bar sequence to the right border at the original junction site. We speculate that this rare phenomenon might be directed by the homology between pre-existing T-DNA and CRISPR/Cas9 editing vector sequences during meiotic recombination. We report imprecise modifications and unpredictable outcomes of gene-editing techniques, providing valuable perspectives on gene-editing applications.

Published
2022

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