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2. Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer

Author

Joanito, Ignasius, Wirapati, Pratyaksha, Zhao, Nancy, Nawaz, Zahid, Yeo, Grace, Lee, Fiona, Eng, Christine L. P., Macalinao, Dominique Camat, Kahraman, Merve, Srinivasan, Harini, Lakshmanan, Vairavan, Verbandt, Sara, Tsantoulis, Petros, Gunn, Nicole, Venkatesh, Prasanna Nori, Poh, Zhong Wee, Nahar, Rahul, Oh, Hsueh Ling Janice, Loo, Jia Min, Chia, Shumei, Cheow, Lih Feng, Cheruba, Elsie, Wong, Michael Thomas, Kua, Lindsay, Chua, Clarinda, Nguyen, Andy, Golovan, Justin, Gan, Anna, Lim, Wan-Jun, Guo, Yu Amanda, Yap, Choon Kong, Tay, Brenda, Hong, Yourae, Chong, Dawn Qingqing, Chok, Aik-Yong, Park, Woong-Yang, Han, Shuting, Chang, Mei Huan, Seow-En, Isaac, Fu, Cherylin, Mathew, Ronnie, Toh, Ee-Lin, Hong, Lewis Z., Skanderup, Anders Jacobsen, DasGupta, Ramanuj, Ong, Chin-Ann Johnny, Lim, Kiat Hon, Tan, Emile K. W., Koo, Si-Lin, Leow, Wei Qiang, Tejpar, Sabine, Prabhakar, Shyam, and Tan, Iain Beehuat

Published
2022
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3. A Randomized Phase 2 Trial of Nivolumab Versus Nivolumab-Ipilimumab Combination in EGFR-Mutant NSCLC

Author

Lai, Gillianne G.Y., Yeo, Jia Chi, Jain, Amit, Zhou, Siqin, Pang, Mengyuan, Alvarez, Jacob J.S., Sim, Ngak Leng, Tan, Aaron C., Suteja, Lisda, Lim, Tze Wei, Guo, Yu Amanda, Shen, Meixin, Saw, Stephanie P.L., Rohatgi, Neha, Yeong, Joe P.S., Takano, Angela, Lim, Kiat Hon, Gogna, Apoorva, Too, Chow Wei, Da Zhuang, Kun, Tan, Wan Ling, Kanesvaran, Ravindran, Ng, Quan Sing, Ang, Mei Kim, Rajasekaran, Tanujaa, Wang, Lanying, Toh, Chee Keong, Lim, Wan-Teck, Tam, Wai Leong, Tan, Sze Huey, Skanderup, Anders M.J., Tan, Eng-Huat, and Tan, Daniel S.W.

Published
2022
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5. Post COVID-19 Large Vessel Vasculopathy in a Previously Healthy Young Male.

Author

Fan, Bingwen Eugene, Mucheli, Shravan Sadasiv, Tang, Yee Lin, Yong, Enming, Dalan, Rinkoo, Cheung, Christine, Young, Barnaby Edward, Lye, David Chien Boon, Wang, Linfa, Tan, Chee Wah, Lim, Kiat Hon Tony, Sum, Christina Lai Lin, Gallardo, Christian Aledia, Christopher, Dheepa, Leung, Bernard PuiLam, Lim, Xin Rong, Wong, Shiun Woei, Chia, Yew Woon, and Chong, Vanessa Cui Lian

Subjects
VASCULAR cell adhesion molecule-1, SARS-CoV-2, MEDICAL personnel, CAROTID intima-media thickness, INTRAVASCULAR ultrasonography, VASCULAR diseases, COVID-19
Abstract

This article discusses a case study of a previously healthy young male who developed large vessel vasculopathy and recurrent thrombosis after recovering from COVID-19. The patient presented with acute limb pain and was found to have hypercoagulability and evidence of chronic endothelial dysfunction. Radiological and histopathological evidence showed damage to the arterial walls and thrombosis. The study suggests that persistent endothelial dysfunction and hypercoagulability may contribute to post-COVID-19 thrombosis, and further research is needed to understand the mechanisms and identify effective treatments. [Extracted from the article]

Published
2024
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6. Brief Report: Droplet Digital Polymerase Chain Reaction Versus Plasma Next-Generation Sequencing in Detecting Clearance of Plasma EGFR Mutations and Carcinoembryonic Antigen Levels as a Surrogate Measure

Author

Saw, Stephanie P.L., primary, Tan, Gek San, additional, Tan, Wei Chong, additional, Tan, Aaron C., additional, Lai, Gillianne G.Y., additional, Lim, Darren W.T., additional, Kanesvaran, Ravindran, additional, Tan, Wan Ling, additional, Tan, Sze Huey, additional, Lim, Kiat Hon, additional, Skanderup, Anders J., additional, and Tan, Daniel S.W., additional

Published
2023
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9. Clinical and Genomic Features of HER2 Exon 20 Insertion Mutations and Characterization of HER2 Expression by Immunohistochemistry in East Asian Non–Small-Cell Lung Cancer

Author

Tan, Aaron C., Saw, Stephanie P.L., Chen, Jianbin, Lai, Gillianne G.Y., Oo, Hlaing Nwe, Takano, Angela, Lau, Dawn P.X., Yeong, Joe P.S., Tan, Gek San, Lim, Kiat Hon, Skanderup, Anders J., Chan, Johan W.K., Teh, Yi Lin, Rajasekaran, Tanujaa, Jain, Amit, Tan, Wan Ling, Ng, Quan Sing, Kanesvaran, Ravindran, Lim, Wan-Teck, Ang, Mei-Kim, and Tan, Daniel S.W.

Published
2022
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12. Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma

Author

Hweixian Leong Penny, Je Lin Sieow, Sin Yee Gun, Mai Chan Lau, Bernett Lee, Jasmine Tan, Cindy Phua, Florida Toh, Yvonne Nga, Wei Hseun Yeap, Baptiste Janela, Dilip Kumar, Hao Chen, Joe Yeong, Justin A. Kenkel, Angela Pang, Diana Lim, Han Chong Toh, Tony Lim Kiat Hon, Christopher I. Johnson, Hanif Javanmard Khameneh, Alessandra Mortellaro, Edgar G. Engleman, Olaf Rotzschke, Florent Ginhoux, Jean-Pierre Abastado, Jinmiao Chen, and Siew Cheng Wong

Subjects
pancreatic ductal adenocarcinoma, macrophage, immunometabolism, glycolysis, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Inflammation in the tumor microenvironment has been shown to promote disease progression in pancreatic ductal adenocarcinoma (PDAC); however, the role of macrophage metabolism in promoting inflammation is unclear. Using an orthotopic mouse model of PDAC, we demonstrate that macrophages from tumor-bearing mice exhibit elevated glycolysis. Macrophage-specific deletion of Glucose Transporter 1 (GLUT1) significantly reduced tumor burden, which was accompanied by increased Natural Killer and CD8+ T cell activity and suppression of the NLRP3-IL1β inflammasome axis. Administration of mice with a GLUT1-specific inhibitor reduced tumor burden, comparable with gemcitabine, the current standard-of-care. In addition, we observe that intra-tumoral macrophages from human PDAC patients exhibit a pronounced glycolytic signature, which reliably predicts poor survival. Our data support a key role for macrophage metabolism in tumor immunity, which could be exploited to improve patient outcomes.

Published
2021
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15. Supplementary Figures 1-6 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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18. Supplementary Table 5 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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20. Supplementary Methods and Supplementary Figure and Table Legends from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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21. Supplementary Table 4 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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22. Supplementary Table 2 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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24. Supplementary Table 1 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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25. Supplementary Table 3 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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29. Data from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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30. Supplementary Data from Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities

Author

Chua, Khi Pin, primary, Teng, Yvonne H.F., primary, Tan, Aaron C., primary, Takano, Angela, primary, Alvarez, Jacob J.S., primary, Nahar, Rahul, primary, Rohatgi, Neha, primary, Lai, Gillianne G.Y., primary, Aung, Zaw Win, primary, Yeong, Joe P.S., primary, Lim, Kiat Hon, primary, Naeini, Marjan Mojtabavi, primary, Kassam, Irfahan, primary, Jain, Amit, primary, Tan, Wan Ling, primary, Gogna, Apoorva, primary, Too, Chow Wei, primary, Kanesvaran, Ravindran, primary, Ng, Quan Sing, primary, Ang, Mei Kim, primary, Rajasekaran, Tanujaa, primary, Anantham, Devanand, primary, Phua, Ghee Chee, primary, Tan, Bien Soo, primary, Lee, Yin Yeng, primary, Wang, Lanying, primary, Teo, Audrey S.M., primary, Khng, Alexis Jiaying, primary, Lim, Ming Jie, primary, Suteja, Lisda, primary, Toh, Chee Keong, primary, Lim, Wan-Teck, primary, Iyer, N. Gopalakrishna, primary, Tam, Wai Leong, primary, Tan, Eng-Huat, primary, Zhai, Weiwei, primary, Hillmer, Axel M., primary, Skanderup, Anders J., primary, and Tan, Daniel S.W., primary

Published
2023
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31. Supplementary Figure from Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer

Author

Seeber, Andreas, primary, Battaglin, Francesca, primary, Zimmer, Kai, primary, Kocher, Florian, primary, Baca, Yasmine, primary, Xiu, Joanne, primary, Spizzo, Gilbert, primary, Novotny-Diermayr, Veronica, primary, Rieder, Dietmar, primary, Puccini, Alberto, primary, Swensen, Jeff, primary, Ellis, Michelle, primary, Goldberg, Richard M., primary, Grothey, Axel, primary, Shields, Anthony F., primary, Marshall, John L., primary, Weinberg, Benjamin A., primary, Sackstein, Paul E., primary, Lim, Kiat Hon, primary, Tan, Gek San, primary, Nabhan, Chadi, primary, Korn, W. Michael, primary, Amann, Arno, primary, Trajanoski, Zlatko, primary, Berger, Martin D., primary, Lou, Emil, primary, Wolf, Dominik, primary, and Lenz, Heinz-Josef, primary

Published
2023
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32. Supplementary Table from Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer

Author

Seeber, Andreas, primary, Battaglin, Francesca, primary, Zimmer, Kai, primary, Kocher, Florian, primary, Baca, Yasmine, primary, Xiu, Joanne, primary, Spizzo, Gilbert, primary, Novotny-Diermayr, Veronica, primary, Rieder, Dietmar, primary, Puccini, Alberto, primary, Swensen, Jeff, primary, Ellis, Michelle, primary, Goldberg, Richard M., primary, Grothey, Axel, primary, Shields, Anthony F., primary, Marshall, John L., primary, Weinberg, Benjamin A., primary, Sackstein, Paul E., primary, Lim, Kiat Hon, primary, Tan, Gek San, primary, Nabhan, Chadi, primary, Korn, W. Michael, primary, Amann, Arno, primary, Trajanoski, Zlatko, primary, Berger, Martin D., primary, Lou, Emil, primary, Wolf, Dominik, primary, and Lenz, Heinz-Josef, primary

Published
2023
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34. GATA4 loss of function in liver cancer impedes precursor to hepatocyte transition

Author

Enane, Francis O., Shuen, Wai Ho, Gu, Xiaorong, Quteba, Ebrahem, Przychodzen, Bartlomiej, Makishima, Hideki, Bodo, Juraj, Ng, Joanna, Chee, Chit Lai, Ba, Rebecca, Koh, Lip Seng, Lim, Janice, Cheong, Rachael, Teo, Marissa, Hu, Zhenbo, Ng, Kwok Peng, Maciejewski, Jaroslaw, Radivoyevitch, Tomas, Chung, Alexander, Ooi, London Lucien, Tan, Yu Meng, Cheow, Peng-Chung, Chow, Pierce, Chan, Chung Yip, Lim, Kiat Hon, Yerian, Lisa, Hsi, Eric, Toh, Han Chong, and Saunthararajah, Yogen

Subjects
Liver cancer -- Physiological aspects, Hepatocytes -- Health aspects, Health care industry
Abstract

The most frequent chromosomal structural loss In hepatocellular carcinoma (HCC) Is of the short arm of chromosome 8 (8p). Genes on the remaining homologous chromosome, however, are not recurrently mutated, and the identity of key 8p tumor-suppressor genes (TSG) is unknown. In this work, analysis of minimal commonly deleted 8p segments to identify candidate TSG implicated GATA4, a master transcription factor driver of hepatocyte epithelial lineage fate. In a murine model, liver-conditional deletion of 1 Gata4 allele to model the haploinsufficiency seen in HCC produced enlarged livers with a gene expression profile of persistent precursor proliferation and failed hepatocyte epithelial differentiation. HCC mimicked this gene expression profile, even in cases that were morphologically classified as well differentiated. HCC with intact chromosome 8p also featured GATA4 loss of function via GATA4 germline mutations that abrogated GATA4 interactions with a coactivator, MED12, or by inactivating mutations directly in GATA4 coactivators, including ARID1A. GATA4 reintroduction into GATA4-haploinsufficient HCC cells or ARID1A reintroduction into ARID1A-mutant/GATA4-intact HCC cells activated hundreds of hepatocyte genes and quenched the proliferative precursor program. Thus, disruption of GATA4-mediated transactivation in HCC suppresses hepatocyte epithelial differentiation to sustain replicative precursor phenotype., Introduction Hepatocellular carcinoma (HCC) is the world's second leading cause of cancer death. In the effort to understand the molecular mechanisms of HCC genesis, a relevant lead is that the [...]

Published
2017
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38. Thyroid Hormone Decreases Hepatic Steatosis, Inflammation, and Fibrosis in a Dietary Mouse Model of Nonalcoholic Steatohepatitis

Author

Zhou, Jin, primary, Tripathi, Madhulika, additional, Ho, Jia Pei, additional, Widjaja, Anissa Anindya, additional, Shekeran, Shamini Guna, additional, Camat, Macalinao Dominique, additional, James, Anne, additional, Wu, Yajun, additional, Ching, Jianhong, additional, Kovalik, Jean-Paul, additional, Lim, Kiat-Hon, additional, Cook, Stuart Alexander, additional, Bay, Boon-Huat, additional, Singh, Brijesh Kumar, additional, and Yen, Paul Michael, additional

Published
2022
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40. Sa1088: DISCOVERY OF NOVEL PROGNOSTIC BIOMARKERS IN ASCITES OF PATIENTS WITH PERITONEAL CARCINOMATOSIS OF GASTROINTESTINAL ORIGIN

Author

Liu, Ying, primary, Hendrikson, Josephine, additional, Ng, Wai Har, additional, Tan, Qiu Xuan, additional, Tan, Joey Wee-Shan, additional, Ng, Gillian, additional, Shannon, Nicholas B., additional, Lim, Weng Khong, additional, Lim, Kiat Hon, additional, Tu, Irene W., additional, Ong, Xing-Yi Sarah, additional, Lim, Hui Jun, additional, Wong, Jolene S., additional, So, Jimmy B., additional, Chia, Claramae S., additional, and Ong, Chin-Ann Johnny, additional

Published
2022
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44. Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer

Author

Seeber, Andreas, primary, Battaglin, Francesca, additional, Zimmer, Kai, additional, Kocher, Florian, additional, Baca, Yasmine, additional, Xiu, Joanne, additional, Spizzo, Gilbert, additional, Novotny-Diermayr, Veronica, additional, Rieder, Dietmar, additional, Puccini, Alberto, additional, Swensen, Jeff, additional, Ellis, Michelle, additional, Goldberg, Richard M., additional, Grothey, Axel, additional, Shields, Anthony F., additional, Marshall, John L., additional, Weinberg, Benjamin A., additional, Sackstein, Paul E., additional, Lim, Kiat Hon, additional, Tan, Gek San, additional, Nabhan, Chadi, additional, Korn, W. Michael, additional, Amann, Arno, additional, Trajanoski, Zlatko, additional, Berger, Martin D., additional, Lou, Emil, additional, Wolf, Dominik, additional, and Lenz, Heinz-Josef, additional

Published
2022
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46. Detection of IDH mutations in cerebrospinal fluid: A discussion of liquid biopsy in neuropathology

Author

Tham Chee Kian, Lee Ming, Tan Gek San, and Tony Lim Kiat-Hon

Subjects
Pathology, medicine.medical_specialty, Cerebrospinal fluid, business.industry, medicine, General Medicine, Neuropathology, Liquid biopsy, business
Abstract

Isocitrate dehydrogenase (IDH) mutations are a common event in secondary glioblastoma multiforme and lower-grade adult infiltrative astrocytomas and independently confer a better prognosis [1,2]. These are highly conserved mutations during glioma progression and thus also a useful diagnostic marker amenable to modern molecular sequencing methods. These mutations can even be detected in sites distant from the primary tumour. We use an illustrative case of a patient with radiologically suspected recurrent astrocytoma and negative histology, but positive IDH-mutated tumour DNA detected within CSF. Our results demonstrated the usefulness of liquid biopsy for recurrent glioma within the context of equivocal or negative histopathological results, whilst also showing the ability to detect a de-novo IDH-2 mutation not present in the previous resection. Building on this ‘proof-of-concept’ result, we also take the opportunity to briefly review the current literature describing the various liquid biopsy substrates available to diagnose infiltrative gliomas, namely the study of circulating tumour DNA, circulating tumour cells, and extracellular vesicles. We outline the current challenges and prospects of liquid biopsies in these tumours and suggest that more studies are required to overcome these challenges and harness the potential benefits of liquid biopsies in guiding our management of gliomas.

Published
2020

49. Recommended testing algorithms for NTRK gene fusions in pediatric and selected adult cancers: Consensus of a Singapore Task Force

Author

Lim, Kiat Hon Tony, primary, Kong, Hwai Loong, additional, Chang, Kenneth Tou En, additional, Tan, Daniel Shao Weng, additional, Tan, Iain Bee Huat, additional, Mohamad, Farid, additional, Soh, Shui Yen, additional, Pang, Brendan Nghee‐Kheem, additional, Soo, Ross Andrew, additional, Choo, Su Pin, additional, Hsieh, Wen‐Son, additional, and Aung, LeLe, additional

Published
2021
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50. Association of Clinicopathologic and Molecular Tumor Features With Recurrence in Resected Early-Stage Epidermal Growth Factor Receptor–Positive Non–Small Cell Lung Cancer

Author

Saw, Stephanie P. L., primary, Zhou, Siqin, additional, Chen, Jianbin, additional, Lai, Gillianne, additional, Ang, Mei-Kim, additional, Chua, Kevin, additional, Kanesvaran, Ravindran, additional, Ng, Quan Sing, additional, Jain, Amit, additional, Tan, Wan Ling, additional, Rajasekaran, Tanujaa, additional, Lim, Darren W. T., additional, Tan, Aaron, additional, Fong, Kam Weng, additional, Takano, Angela, additional, Cheng, Xin Ming, additional, Lim, Kiat Hon, additional, Koh, Tina, additional, Ong, Boon-Hean, additional, Tan, Eng Huat, additional, Toh, Chee Keong, additional, Skanderup, Anders J., additional, Tan, Sze Huey, additional, and Tan, Daniel S. W., additional

Published
2021
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