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2. Coexistence of two distinct G-quadruplex conformations in the hTERT promoter

Author

Kah Wai Lim, Lacroix, Laurent, Yue, Doris Jia En, Lim, Joefina Kim Cheow, Lim, Jocelyn Mei Wen, and Phan, Anh Tuan

Subjects
G proteins -- Structure, G proteins -- Chemical properties, Nuclear magnetic resonance spectroscopy -- Usage, Promoters (Genetics) -- Research, Telomerase -- Structure, Telomerase -- Chemical properties, Chemistry
Abstract

The NMR solution structures of two G-quadruplex conformations in potassium solution: a (3 + 1) and a parallel-stranded G-quadruplexes were explored to understand their coexistance in guanine-rich stretches of human telomerase, hTERT promoter. The findings from a combination of NMR and CD techniques, complemented with sequence modifications and variations of experimental condition provide better insight into the coexistence of the two G-quadruplex conformations in equilibrium and the way different structural elements adapt to favor a particular form.

Published
2010

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