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1. Architecture and anatomy of executive processes: evidence from verbal fluency and Trail Making Test in 2009 stroke patients

Author

Godefroy, Olivier, Weaver, Nick A., Roussel, Martine, Dorchies, Flore, Kassir, Rania, Biesbroek, J. Matthijs, Lee, Keon-Joo, Kim, Beom Joon, Bae, Hee-Joon, Lim, Jae-Sung, Lee, Minwoo, Yu, Kyung-Ho, Aben, Hugo P., de Kort, Paul L. M., Bordet, Régis, Lopes, Renaud, Dondaine, Thibaut, Biessels, Geert Jan, and Aarabi, Ardalan

Published
2024
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6. Mucosal TLR5 activation controls healthspan and longevity

Author

Lim, Jae Sung, Jeon, Eun Jae, Go, Hye Sun, Kim, Hyung-Jin, Kim, Kye Young, Nguyen, Thi Quynh Trang, Lee, Da Young, Kim, Kyu Suk, Pietrocola, Federico, Hong, Seol Hee, Lee, Shee Eun, Kim, Kyoung-Shim, Park, Tae-Shin, Choi, Dong-Hee, Jeong, Yu-Jin, Park, Jong-Hwan, Kim, Hyeon Sik, Min, Jung-Joon, Kim, Yong Sook, Park, Joon Tae, Cho, Jae-Ho, Lee, Gil-Woo, Lee, Ji Hyeon, Choy, Hyon E., Park, Sang Chul, Lee, Chul-Ho, Rhee, Joon Haeng, Serrano, Manuel, and Cho, Kyung A

Published
2024
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15. White Matter Hyperintensity Volume and Poststroke Cognition: An Individual Patient Data Pooled Analysis of 9 Ischemic Stroke Cohort Studies

Author

de Kort, Floor A.S., Coenen, Mirthe, Weaver, Nick A., Kuijf, Hugo J., Aben, Hugo P., Bae, Hee-Joon, Bordet, Régis, Cammà, Guido, Chen, Christopher P.L.H., Dewenter, Anna, Duering, Marco, Fang, Rong, van der Giessen, Ruben S., Hamilton, Olivia K.L., Hilal, Saima, Huenges Wajer, Irene M.C., Kan, Cheuk Ni, Kim, Jonguk, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L.M., Koudstaal, Peter J., Lim, Jae-Sung, Lopes, Renaud, Mok, Vincent C.T., Staals, Julie, Venketasubramanian, Narayanaswamy, Verhagen, Charlotte M., Verhey, Frans R.J., Wardlaw, Joanna M., Xu, Xin, Yu, Kyung-Ho, Biesbroek, J. Matthijs, and Biessels, Geert Jan

Published
2023
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16. The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study

Author

Weaver, Nick A, Zhao, Lei, Biesbroek, J Matthijs, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee‐Joon, Caballero, Miguel ÁA, Chappell, Francesca M, Chen, Christopher PLH, Dichgans, Martin, Duering, Marco, Georgakis, Marios K, van der Giessen, Ruben S, Gyanwali, Bibek, Hamilton, Olivia KL, Hilal, Saima, Hofe, Elise M vom, de Kort, Paul LM, Koudstaal, Peter J, Lam, Bonnie YK, Lim, Jae‐Sung, Makin, Stephen DJ, Mok, Vincent CT, Shi, Lin, Hernández, Maria C Valdés, Venketasubramanian, Narayanaswamy, Wardlaw, Joanna M, Wollenweber, Frank A, Wong, Adrian, Xin, Xu, consortium, Meta VCI Map, DeCarli, C, Fletcher, EA, Maillard, P, Barnes, J, Sudre, CH, Schott, JM, Ikram, MA, Papma, JM, Steketee, RME, Vernooij, MW, Bordet, R, Lopes, R, Huang, C‐W, Frayne, R, McCreary, CR, Smith, EE, group, Calgary Normative Study, Backes, W, Köhler, S, van Oostenbrugge, RJ, Staals, J, Verhey, F, Cheng, CY, Kalaria, RN, Werring, D, Hsu, JL, Huang, K‐L, van der Grond, J, Jukema, JW, van der Mast, RC, Nijboer, TCW, group, Framingham Heart Study, Yu, K‐H, group, The Dutch Parelsnoer Institute–Neurodegenerative diseases, Schmidt, R, Pirpamer, L, MacIntosh, BJ, Robertson, AD, de Leeuw, F‐E, Tuladhar, AM, Chaturvedi, N, Tillin, T, Brodaty, H, Sachdev, P, group, TABASCO, Barkhof, F, van der Flier, WM, Kappelle, LJ, and Biessels, Geert Jan

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Atherosclerosis, Clinical Research, Brain Disorders, Acquired Cognitive Impairment, Stroke, Neurosciences, Meta VCI Map consortium, Cerebrovascular disease, Consortium, Data harmonization, Lesion location, Lesion-symptom mapping, Small vessel disease, Support vector regression, Vascular cognitive impairment, Genetics, Biological psychology
Abstract

IntroductionThe Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies.MethodsCohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage.ResultsForty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage.DiscussionMeta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.

Published
2019

18. Efficacy and safety of oxiracetam in patients with vascular cognitive impairment: A multicenter, randomized, double-blinded, placebo-controlled, phase IV clinical trial

Author

Lim, Jae-Sung, Lee, Juneyoung, Kang, Yeonwook, Park, Hyun-Tae, Kim, Dong-Eog, Cha, Jae-Kwan, Park, Tai Hwan, Heo, Jae-Hyuk, Lee, Kyung Bok, Park, Jong-Moo, Oh, Mi Sun, Kim, Eung-Gyu, Chang, Dae-Il, Heo, Sung Hyuk, Park, Man-Seok, Park, HyunYoung, Yi, SangHak, Lee, Yeong Bae, Park, Kwang-Yeol, Lee, Soo Joo, Kim, Jae Guk, Lee, Jun, Cho, Kyung-Hee, Rha, Joung-Ho, Kim, Yeong-In, Lee, Jun Hong, Choi, Jay Chol, Oh, Kyung-Mi, Kwon, Jee-Hyun, Kim, Chulho, Park, Jong-Ho, Jung, Keun-Hwa, Sung, Sang Min, Chung, Jong-Won, Lee, Yong-Seok, Kim, Hahn Young, Cho, Hyun-Ji, Park, Jeong Wook, Moon, Won-Jin, and Bae, Hee-Joon

Published
2023
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19. Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke

Author

Exalto, Lieza G., Weaver, Nick A., Kuijf, Hugo J., Aben, Hugo P., Bae, Hee-Joon, Best, Jonathan G., Bordet, Régis, Chen, Christopher P.L.H., van der Giessen, Ruben S., Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K.L., Hilal, Saima, Huenges Wajer, Irene M.C., Kim, Jonguk, Kappelle, L. Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L.M., Koudstaal, Peter J., Lim, Jae-Sung, Makin, Stephen D.J., Mok, Vincent C.T., van Oostenbrugge, Robert J., Roussel, Martine, Staals, Julie, Valdés-Hernández, Maria del C., Venketasubramanian, Narayanaswamy, Verhey, Frans R.J., Wardlaw, Joanna M., Werring, David J., Xu, Xin, van Zandvoort, Martine J.E., Biesbroek, J. Matthijs, Chappell, Francesca M., and Biessels, Geert Jan

Published
2023
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23. More Than 50 Percent Reduction in LDL Cholesterol in Patients With Target LDL <70 mg/dL After a Stroke

Author

Amarenco, Pierre, Lavallée, Philippa C., Kim, Jong S., Labreuche, Julien, Charles, Hugo, Giroud, Maurice, Lee, Byung-Chul, Mahagne, Marie-Hélène, Meseguer, Elena, Nighoghossian, Norbert, Steg, Philippe Gabriel, Vicaut, Éric, Bruckert, Eric, Kim, Jong S, Touboul, Pierre-Jean, Leys, Didier, Béjot, Yannick, Pico, Fernando, Touzé, Emmanuel, Ducrocq, Gregory, Abtan, Jérémy, Varenne, Olivier, Touboul, Pierre-Jean, Kemmel, Agnes, Syana, Fausta, Ledra, Manele, Nagasara, Tharani, Ledjeroud, Mervette, Samia, Bahous, Hadia, Hafirassou, Hazare, Benyoub, Jaghouni, Ikrame El, Yelles, Nessima, Zemouri, Sofia, Ladjeroud, Mervette, Kerai, Salim, In, YunJeong, Hobeanu, Cristina, Guidoux, Celine, Cabrejo, Lucie, Lapergue, Bertrand, Sabben, Candice, Gonzalez-Valcarcel, Jaime, Rigual, Ricardo, Sirimarco, Gaia, Martin-Bechet, Anna, Viedma, Elena, Avram, Ioan, Samson, Yves, Rosso, Charlotte, Crozier, Sophie, Leder, Sara, Léger, Anne, Deltour, Sandrine, Mutlu, Gurkan, Yger, Marion, Zavanone, Chiara, Baronnet, Flore, Pires, Christine, Lapergue, Bertrand, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Bourdain, Frédéric, Lopez, Delphine, Pico, Fernando, de la Tour, Laetitia Bayon, Chadenat, Marie-Laure, Duong, Duc Long, Genty, Solène, Hirel, Catherine, Mutlu, Gurkan, Nifle, Chantal, Servan, Jérôme, Stanciu, Daniela, Sudacevschi, Veronica, Tir, Mélissa, Troussière, Anne-Cécile, Yeung, Jennifer, Zeghoudi, Anne-Céline, Tidafi-Bayou, Ikram, Lachaud, Sylvain, Cho, Tae-Hee, Mechtouff, Laura, Ritzenthaller, Thomas, Derex, Laurent, Albanesi, Carlo, Ong, Elodie, Benoit, Amandine, Berhoune, Nadia, Felix, Sandra, Esteban-Mader, Maud, Sibon, Igor, Kazadi, Annabelle, Rouanet, François, Renou, Pauline, Debruxelles, Sabrina, Poli, Mathilde, Sagnier, Sharmila, Mas, Jean-Louis, Domigo, Valérie, Lamy, Catherine, Bodiguel, Eric, Grimaud, Jérôme, Bohotin, Valentin, Obadia, Michael, Sabben, Candice, Morvan, Erwan, Rodier, Gilles, Vadot, Wilfried, Hénon, Hilde, Cordonnier, Charlotte, Dumont, Frédéric, Bodenant, Marie, Lucas, Christian, Moulin, Solène, Dequatre, Nelly, Alamowitch, Sonia, Muresan, Jean-Paul, Drouet, Thomas, Gallea, Magalie, Dalloz, Marie-Amélie, Delorme, Stephen, Yger, Marion, Béjot, Yannick, Loisel, Philippe, Bonnin, Carine, Bernigal, Virginie, Osseby, Guy Victor, Hervieu-BègueMarsac, Marie, Garnier, Pierre, Accassat, Sandrine, Epinat, Magali, Varvat, Jérôme, Marinescu, Doïna, Triquenot-Bagan, Aude, Ozkul- Wermester, Ozlem, Philippeau, Frédéric, Olaru, Angel, Vieillart, Anne, Lannuzel, Annie, Demoly, Alice, Wolff, Valérie, Diaconu, Mihaela, Bataillard, Marc, Montoro, Francisco Macian, Faugeras, Frédéric, Gimenez, Laeticia, Abdallah-Lebeau, Françoise, Timsit, Serge, Viakhireva-Dovganyuk, Irina, Tirel-Badets, Anne, Merrien, François-Mathias, Goas, Philippe, Rouhart, François, Jourdain, Aurore, Guillon, Benoit, Hérissson, Fanny, Sevin-Allouet, Mathieu, Nasr, Nathalie, Olivot, Jean-Marc, Lecluse, Alderic, Marc, Guillaume, Touzé, Emmanuel, de la Sayette, Vincent, Apoil, Marion, Lin, Li, Cogez, Julien, Guettier, Sophie, Godefroy, Olivier, Lamy, Chantal, Bugnicourt, Jean-Marc, Taurin, Grégory, Mérienne, Marc, Gere, Julien, Chessak, Anne-Marie, Habet, Tarik, Ferrier, Anna, Bourgois, Nathalie, Minier, Dominique, Caillier-Minier, Marie, Contégal- Callier, Fabienne, Vion, Philippe, Vaschalde, Yvan, Amrani, Mohammed El, Emilie, Zuber, Mathieu, Bruandet, Marie, Join- Lambert, Claire, Garcia, Pierre-Yves, Serre, Isabelle, Faucheux, Jean-Marc, Radji, Fatia, Leca-Radu, Elena, Debroucker, Thomas, Cumurcuc, Rodica, Cakmak, Serkan, Peysson, Stéphane, Ellie, Emmanuel, Bernady, Patricia, Moulin, Thierry, Montiel, Paola, Revenco, Eugeniu, Decavel, Pierre, Medeiros, Elisabeth, Bouveret, Myriam, Louchart, Pierre, Vaduva, Claudia, Couvreur, Grégory, Sartori, Eric, Carpentier, Alnajar, Levasseur, Michèle, Louchart, Pierre, Faucheux, Jean-Marc, Neau, Philippe, Vandamme, Xavier, Meresse, Isabelle, Stantescu, Bataillard, Marc, Ozsancak, Canan, Beauvais, Katell, Auzou, Pascal, Amevigbe, Joséphine, Vuillemet, Francis, Dugay-Arentz, Marie-Hélène, Carelli, Gabriela, Martinez, Mikel, Maillet-Vioud, Marcel, Escaillas, Jean-Pierre, Chapuis, Stéphane, Tardy, Jean, Manchon, Eric, Varnet, Olivier, Kim, Yong-Jae, Chang, Yoonkyung, Song, Tae-Jin, Kim, Jong Sung, Han, Jung-Hoon, Noh, Kyung Chul, Lee, Eun-Jae, Kang, Dong-Wha, Kwon, Sun Uck, Kwon, Boseoung, Park, Seongho, Lee, Dongwhane, Kwon, Hyuk Sung, Jeong, Daeun, Lee, MinHwan, Kim, Joonggoo, Lee, Hanbin, Nam, Hyo Jung, Lee, Sang Hun, Kim, Bum Joon, Cha, Jae-kwan, Kim, DaeHyun, Kim, Rae Young, Sohn, Sang Wuk, Shim, Dong-Hyun, Lee, Hyungjin, Nah, Hyun-Wook, Sung, Sang Min, Lee, Kyung Bok, Yoon Lee, Jeong, Yoon, Jee Eun, Kim, Eung-Gyu, Seo, Jung Hwa, Kim, Yong-Won, Hwang, Yangha, Park, Man Seok, Kim, Joon-Tae, Choi, Kang-Ho, Nam, Hyo Suk, Heo, Ji Hoe, Kim, Young Dae, Hwang, In Gun, Park, Hyung Jong, Kim, Kyoung Sub, Baek, Jang Hyun, Song, Dong Beom, Yoo, Joon Sang, Park, Jong-Moo, Kwon, Ohyun, Lee, Woong-Woo, Lee, Jung-Ju, Kang, Kyusik, Kim, Byung Kun, Lim, Jae-Sung, Oh, Mi Sun, Yu, Kyung-Ho, Hong, Bora, Jang, Mihoon, Jang, Seyoung, Jin, Jung Eun, Kim, Jei, Jeong, Hye Seon, Hong, Keun Sik, Park, Hong Kyun, Cho, Yong Jin, Bang, Oh Young, Seo, Woo-Keun, and Chung, Jongwon

Published
2023
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27. Strategic white matter hyperintensity locations associated with post-stroke cognitive impairment: A multicenter study in 1568 stroke patients.

Author

Coenen, Mirthe, de Kort, Floor AS, Weaver, Nick A, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee-Joon, Bordet, Régis, Chen, Christopher PLH, Dewenter, Anna, Doeven, Thomas, Dondaine, Thibaut, Duering, Marco, Fang, Rong, van der Giessen, Ruben S, Kim, Jonguk, Kim, Beom Joon, de Kort, Paul LM, Koudstaal, Peter J, Lee, Minwoo, and Lim, Jae-Sung

Subjects
EXECUTIVE function, COGNITIVE processing speed, COGNITION, COGNITIVE ability, WHITE matter (Nerve tissue)
Abstract

Background: Post-stroke cognitive impairment (PSCI) occurs in up to 50% of stroke survivors. Presence of pre-existing vascular brain injury, in particular the extent of white matter hyperintensities (WMH), is associated with worse cognitive outcome after stroke, but the role of WMH location in this association is unclear. Aims: We determined if WMH in strategic white matter tracts explain cognitive performance after stroke. Methods: Individual patient data from nine ischemic stroke cohorts with magnetic resonance imaging (MRI) were harmonized through the Meta VCI Map consortium. The association between WMH volumes in strategic tracts and domain-specific cognitive functioning (attention and executive functioning, information processing speed, language and verbal memory) was assessed using linear mixed models and lasso regression. We used a hypothesis-driven design, primarily addressing four white matter tracts known to be strategic in memory clinic patients: the left and right anterior thalamic radiation, forceps major, and left inferior fronto-occipital fasciculus. Results: The total study sample consisted of 1568 patients (39.9% female, mean age = 67.3 years). Total WMH volume was strongly related to cognitive performance on all four cognitive domains. WMH volume in the left anterior thalamic radiation was significantly associated with cognitive performance on attention and executive functioning and information processing speed and WMH volume in the forceps major with information processing speed. The multivariable lasso regression showed that these associations were independent of age, sex, education, and total infarct volume and had larger coefficients than total WMH volume. Conclusion: These results show tract-specific relations between WMH volume and cognitive performance after ischemic stroke, independent of total WMH volume. This implies that the concept of strategic lesions in PSCI extends beyond acute infarcts and also involves pre-existing WMH. Data access statement: The Meta VCI Map consortium is dedicated to data sharing, following our guidelines. [ABSTRACT FROM AUTHOR]

Published
2024
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28. The Development of Bi-LSTM Based on Fault Diagnosis Scheme in MVDC System.

Author

Lim, Jae-Sung, Cho, Haesong, Kwon, Dohoon, and Hong, Junho

Subjects
*FAULT current limiters, *DISCRETE wavelet transforms, *DIRECT current circuits, *FAULT diagnosis, *ELECTRIC circuit breakers
Abstract

Diagnosing faults is crucial for ensuring the safety and reliability of medium-voltage direct current (MVDC) systems. In this study, we propose a bidirectional long short-term memory (Bi-LSTM)-based fault diagnosis scheme for the accurate classification of faults occurring in MVDC systems. First, to ensure stability in case a fault occurs, we modeled an MVDC system that included a resistor-based fault current limiter (R-FCL) and a direct current circuit breaker (DCCB). A discrete wavelet transform (DWT) extracted the transient voltages and currents measured using DC lines and AC grids in the frequency–time domain. Based on the digital signal normalized by the DWT, using the measurement data, the Bi-LSTM algorithm was used to classify and learn the types and locations of faults, such as DC line (PTP, P-PTG, and N-PTG) and internal inverter faults. The effectiveness of the proposed fault diagnosis scheme was validated through comparative analysis within the four-terminal MVDC system, demonstrating superior accuracy and a faster diagnosis time compared to those of the existing schemes that utilize other AI algorithms, such as the CNN and LSTM. According to the test results, the proposed fault diagnosis scheme detects MVDC faults and shows a high recognition accuracy of 97.7%. Additionally, when applying the Bi-LSTM-based fault diagnosis scheme, it was confirmed that not only the training diagnosis time (TraDT) but also the average diagnosis time (AvgDT) were 0.03 ms and 0.05 ms faster than LSTM and CNN, respectively. The results validate the superior fault clarification and fast diagnosis performance of the proposed scheme over those of the other methods. [ABSTRACT FROM AUTHOR]

Published
2024
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30. MP44-06 RENOPROTECTIVE EFFECT OF PDE5i IN A PARTIALLY NEPHRECTOMIZED RAT MODEL

Author

Lim, Jae Sung, primary, Yun, Oh Jun, additional, Kang, Jae Hoon, additional, Lee, Sang Hee, additional, Jeon, Minji, additional, Lee, Eun Hye, additional, Oh, Jeong Seok, additional, Kang, Jun-Koo, additional, Ha, Yun-Sok, additional, Choi, Seock Hwan, additional, Chun, So Young, additional, Lee, Jun Nyung, additional, Kim, Bum Soo, additional, Kim, Hyun Tae, additional, Kim, Tae-Hwan, additional, Yoo, Eun Sang, additional, Kwon, Tae Gyun, additional, and Chung, Jae-Wook, additional

Published
2024
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32. A Streamlined PENK Methylation Test in Urine DNA, EarlyTect BCD, Effectively Detects Bladder Cancer in Hematuria Patients

Author

Bang, Bo-Ram, primary, Zhong, Jin, additional, Oh, Tae Jeong, additional, Lee, Ji Yong, additional, Seo, Yangyei, additional, Woo, Min A., additional, Lim, Jae Sung, additional, Na, Yong Gil, additional, Song, Ki Hak, additional, Shin, Ju Hyun, additional, Lee, Justin Junguek, additional, Im, Chan Su, additional, Kim, Seoyong, additional, Beqaj, Safedin, additional, Shirk, Joseph D., additional, Ke, Katelyn W., additional, Vallone, John, additional, and An, Sungwhan, additional

Published
2024
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35. Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts

Author

Weaver, Nick A, Kuijf, Hugo J, Aben, Hugo P, Abrigo, Jill, Bae, Hee-Joon, Barbay, Mélanie, Best, Jonathan G, Bordet, Régis, Chappell, Francesca M, Chen, Christopher P L H, Dondaine, Thibaut, van der Giessen, Ruben S, Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kang, Yeonwook, Kappelle, L Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Kuchcinski, Gregory, Lam, Bonnie Y K, Lee, Byung-Chul, Lee, Keon-Joo, Lim, Jae-Sung, Lopes, Renaud, Makin, Stephen D J, Mendyk, Anne-Marie, Mok, Vincent C T, Oh, Mi Sun, van Oostenbrugge, Robert J, Roussel, Martine, Shi, Lin, Staals, Julie, del C Valdés-Hernández, Maria, Venketasubramanian, Narayanaswamy, Verhey, Frans R J, Wardlaw, Joanna M, Werring, David J, Xin, Xu, Yu, Kyung-Ho, van Zandvoort, Martine J E, Zhao, Lei, Biesbroek, J Matthijs, and Biessels, Geert Jan

Published
2021
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36. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author

Harkness, Kirsty, Shaw, Louise, Sword, Jane, Mohd Nor, Azlisham, Sharma, Pankaj, Kelly, Deborah, Harrington, Frances, Randall, Marc, Smith, Matthew, Mahawish, Karim, Elmarim, Abduelbaset, Esisi, Bernard, Cullen, Claire, Nallasivam, Arumug, Price, Christopher, Barry, Adrian, Roffe, Christine, Coyle, John, Hassan, Ahamad, Birns, Jonathan, Cohen, David, Sekaran, Lakshmanan, Parry-Jones, Adrian, Parry, Anthea, Hargroves, David, Proschel, Harald, Datta, Prabel, Darawil, Khaled, Manoj, Aravindakshan, Burn, Mathew, Patterson, Chris, Giallombardo, Elio, Smyth, Nigel, Mansoor, Syed, Anwar, Ijaz, Marsh, Rachel, Ispoglou, Sissi, Chadha, Dinesh, Prabhakaran, Mathuri, Meenakishundaram, Sanjeevikumar, O'Connell, Janice, Scott, Jon, Krishnamurthy, Vinodh, Aghoram, Prasanna, McCormick, Michael, Sprigg, Nikola, O'Mahony, Paul, Cooper, Martin, Choy, Lillian, Wilkinson, Peter, Leach, Simon, Caine, Sarah, Burger, Ilse, Gunathilagan, Gunaratam, Guyler, Paul, Emsley, Hedley, Davis, Michelle, Manawadu, Dulka, Pasco, Kath, Mamun, Maam, Luder, Robert, Sajid, Mahmud, Okwera, James, Warburton, Elizabeth, Saastamoinen, Kari, England, Timothy, Putterill, Janet, Flossman, Enrico, Power, Michael, Dani, Krishna, Mangion, David, Suman, Appu, Corrigan, John, Lawrence, Enas, Vahidassr, Djamil, Shakeshaft, Clare, Brown, Martin, Charidimou, Andreas, Cohen, Hannah, Banerjee, Gargi, Houlden, Henry, White, Mark, Yousry, Tarek, Flossmann, Enrico, Muir, Keith, Gratz, Pascal, Mattle, Heinrich, Panos, Leonidas, Korczyn, Amos, Kliper, Efrat, Maeder, Philippe, Gass, Achim, Pachai, Chahin, Bracoub, Luc, Douste-Blazy, Marie-Yvonne, Fratacci, Marie Dominique, Vicaut, Eric, Sato, Shoichiro, Miwa, Kaori, Fujita, Kyohei, Ide, Toshihiro, Ma, Henry, Ly, John, Singhal, Shaloo, Chandra, Ronil, Slater, Lee-Anne, Soufan, Cathy, Moran, Christopher, Traenka, Christopher, Thilemann, Sebastian, Fladt, Joachim, Gensicke, Henrik, Bonati, Leo, Kim, Beom Joon, Han, Moon-Ku, Kang, Jihoon, Ko, Eunbin, Yang, Mi Hwa, Jang, Myung Suk, Murphy, Sean, Carty, Fiona, Akijian, Layan, Thornton, John, Schembri, Mark, Douven, Elles, Delgado-Mederos, Raquel, Marín, Rebeca, Camps-Renom, Pol, Guisado-Alonso, Daniel, Nuñez, Fidel, Medrano-Martorell, Santiago, Merino, Elisa, Iida, Kotaro, Ikeda, Syuhei, Irie, Hiroyuki, Demirelli, Derya Selcuk, Medanta, Jayesh Modi, Zerna, Charlotte, Hernández, Maria Valdés, Armitage, Paul, Heye, Anna, Muñoz-Maniega, Susana, Sakka, Eleni, Thrippleton, Michael, Dennis, Martin, Beigneux, Ysoline, Silva, Mauro, Venketasubramanian, Narayanaswamy, Ho, Shu Leung, Cheung, Raymond Tak Fai, Chan, Koon Ho, Teo, Kay Cheong, Hui, Edward, Kwan, Joseph Shiu Kwong, Chang, Richard, Tse, Man Yu, Hoi, Chu Peng, Chan, Chung Yan, Chan, Oi Ling, Cheung, Ryan Hoi Kit, Wong, Edmund Ka Ming, Leung, Kam Tat, Tsang, Suk Fung, Ip, Hing Lung, Ma, Sze Ho, Ma, Karen, Fong, Wing Chi, Li, Siu Hung, Li, Richard, Ng, Ping Wing, Wong, Kwok Kui, Liu, Wenyan, Wong, Lawrence, Ramos, Lino, De Schryver, Els, Jöbsis, Joost, van der Sande, Jaap, Brouwers, Paul, Roos, Yvo, Stam, Jan, Bakker, Stef, Verbiest, Henk, Schoonewille, Wouter, Linn, Cisca, Hertzberger, Leopold, van Gemert, Maarten, Berntsen, Paul, Van Dam-Nolen, Dianne, Kooi, M Eline, Van der Lugt, Aad, Koudstaal, Peter, Leff, Alexander, Ward, Nicholas, Nachev, Parashkev, Perry, Richard, Ozkan, Hatice, Mitchell, John, Best, Jonathan G, Ambler, Gareth, Wilson, Duncan, Lee, Keon-Joo, Lim, Jae-Sung, Shiozawa, Masayuki, Koga, Masatoshi, Li, Linxin, Lovelock, Caroline, Chabriat, Hugues, Hennerici, Michael, Wong, Yuen Kwun, Mak, Henry Ka Fung, Prats-Sanchez, Luis, Martínez-Domeño, Alejandro, Inamura, Shigeru, Yoshifuji, Kazuhisa, Arsava, Ethem Murat, Horstmann, Solveig, Purrucker, Jan, Lam, Bonnie Yin Ka, Wong, Adrian, Kim, Young Dae, Song, Tae-Jin, Lemmens, Robin, Eppinger, Sebastian, Gattringer, Thomas, Uysal, Ender, Tanriverdi, Zeynep, Bornstein, Natan M, Ben Assayag, Einor, Hallevi, Hen, Molad, Jeremy, Nishihara, Masashi, Tanaka, Jun, Coutts, Shelagh B, Polymeris, Alexandros, Wagner, Benjamin, Seiffge, David J, Lyrer, Philippe, Algra, Ale, Kappelle, L Jaap, Al-Shahi Salman, Rustam, Jäger, Hans R, Lip, Gregory Y H, Fischer, Urs, El-Koussy, Marwan, Mas, Jean-Louis, Legrand, Laurence, Karayiannis, Christopher, Phan, Thanh, Gunkel, Sarah, Christ, Nicolas, Abrigo, Jill, Leung, Thomas, Chu, Winnie, Chappell, Francesca, Makin, Stephen, Hayden, Derek, Williams, David J, Mess, Werner H, Nederkoorn, Paul J, Barbato, Carmen, Browning, Simone, Wiegertjes, Kim, Tuladhar, Anil M, Maaijwee, Noortje, Guevarra, Anne Cristine, Yatawara, Chathuri, Mendyk, Anne-Marie, Delmaire, Christine, Köhler, Sebastian, van Oostenbrugge, Robert, Zhou, Ying, Xu, Chao, Hilal, Saima, Gyanwali, Bibek, Chen, Christopher, Lou, Min, Staals, Julie, Bordet, Régis, Kandiah, Nagaendran, de Leeuw, Frank-Erik, Simister, Robert, Hendrikse, Jeroen, Kelly, Peter J, Wardlaw, Joanna, Soo, Yannie, Fluri, Felix, Srikanth, Velandai, Calvet, David, Jung, Simon, Kwa, Vincent I H, Engelter, Stefan T, Peters, Nils, Smith, Eric E, Hara, Hideo, Yakushiji, Yusuke, Orken, Dilek Necioglu, Fazekas, Franz, Thijs, Vincent, Heo, Ji Hoe, Mok, Vincent, Veltkamp, Roland, Ay, Hakan, Imaizumi, Toshio, Gomez-Anson, Beatriz, Lau, Kui Kai, Jouvent, Eric, Rothwell, Peter M, Toyoda, Kazunori, Bae, Hee-Joon, Marti-Fabregas, Joan, and Werring, David J

Published
2021
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37. Bayesian modelling disentangles language versus executive control disruption in stroke

Author

Beeldverwerking ISI, Brain, Cancer, Circulatory Health, Structure and Connections, Opleiding Neurologie, Projectafdeling VCI, Hartwigsen, Gesa, Lim, Jae-Sung, Bae, Hee-Joon, Yu, Kyung-Ho, Kuijf, Hugo J, Weaver, Nick A, Biesbroek, J Matthijs, Kopal, Jakub, Bzdok, Danilo, Beeldverwerking ISI, Brain, Cancer, Circulatory Health, Structure and Connections, Opleiding Neurologie, Projectafdeling VCI, Hartwigsen, Gesa, Lim, Jae-Sung, Bae, Hee-Joon, Yu, Kyung-Ho, Kuijf, Hugo J, Weaver, Nick A, Biesbroek, J Matthijs, Kopal, Jakub, and Bzdok, Danilo

Published
2024

38. Strategic white matter hyperintensity locations associated with post-stroke cognitive impairment:A multicenter study in 1568 stroke patients

Author

Coenen, Mirthe, de Kort, Floor A. S., Weaver, Nick A., Kuijf, Hugo J., Aben, Hugo P., Bae, Hee-Joon, Bordet, Regis, Chen, Christopher P. L. H., Dewenter, Anna, Doeven, Thomas, Dondaine, Thibaut, Duering, Marco, Fang, Rong, van der Giessen, Ruben S., Kim, Jonguk, Kim, Beom Joon, de Kort, Paul L. M., Koudstaal, Peter J., Lee, Minwoo, Lim, Jae-Sung, Lopes, Renaud, van Oostenbrugge, Robert J., Staals, Julie, Yu, Kyung-Ho, Biessels, Geert Jan, Biesbroek, J. Matthijs, Coenen, Mirthe, de Kort, Floor A. S., Weaver, Nick A., Kuijf, Hugo J., Aben, Hugo P., Bae, Hee-Joon, Bordet, Regis, Chen, Christopher P. L. H., Dewenter, Anna, Doeven, Thomas, Dondaine, Thibaut, Duering, Marco, Fang, Rong, van der Giessen, Ruben S., Kim, Jonguk, Kim, Beom Joon, de Kort, Paul L. M., Koudstaal, Peter J., Lee, Minwoo, Lim, Jae-Sung, Lopes, Renaud, van Oostenbrugge, Robert J., Staals, Julie, Yu, Kyung-Ho, Biessels, Geert Jan, and Biesbroek, J. Matthijs

Abstract

Background: Post-stroke cognitive impairment (PSCI) occurs in up to 50% of stroke survivors. Presence of pre-existing vascular brain injury, in particular the extent of white matter hyperintensities (WMH), is associated with worse cognitive outcome after stroke, but the role of WMH location in this association is unclear.Aims: We determined if WMH in strategic white matter tracts explain cognitive performance after stroke.Methods: Individual patient data from nine ischemic stroke cohorts with magnetic resonance imaging (MRI) were harmonized through the Meta VCI Map consortium. The association between WMH volumes in strategic tracts and domain-specific cognitive functioning (attention and executive functioning, information processing speed, language and verbal memory) was assessed using linear mixed models and lasso regression. We used a hypothesis-driven design, primarily addressing four white matter tracts known to be strategic in memory clinic patients: the left and right anterior thalamic radiation, forceps major, and left inferior fronto-occipital fasciculus.Results: The total study sample consisted of 1568 patients (39.9% female, mean age = 67.3 years). Total WMH volume was strongly related to cognitive performance on all four cognitive domains. WMH volume in the left anterior thalamic radiation was significantly associated with cognitive performance on attention and executive functioning and information processing speed and WMH volume in the forceps major with information processing speed. The multivariable lasso regression showed that these associations were independent of age, sex, education, and total infarct volume and had larger coefficients than total WMH volume.Conclusion: These results show tract-specific relations between WMH volume and cognitive performance after ischemic stroke, independent of total WMH volume. This implies that the concept of strategic lesions in PSCI extends beyond acute infarcts and also involves pre-existing WMH.Data access stat

Published
2024

39. Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA:A Pooled Analysis

Author

Best, Jonathan G., Ambler, Gareth, Wilson, Duncan, Du, Houwei, Lee, Keon Joo, Lim, Jae Sung, Teo, Kay Cheong, Mak, Henry, Kim, Young Dae, Song, Tae Jin, Selcuk Demirelli, Derya, Nishihara, Masashi, Yoshikawa, Masaaki, Kubacka, Marta, Zietz, Annaelle, Al-Shahi Salman, Rustam, Jäger, Hans Rolf, Lip, Gregory Y.H., Panos, Leonidas, Goeldlin, Martina B., Slater, Lee Anne, Karayiannis, Christopher Charles, Phan, Thanh G., Bellut, Maximilian, Abrigo, Jill, Cheng, Cyrus, Leung, Thomas W., Chu, Winnie, Chappell, Francesca, Makin, Stephen D.J., Van Dam-Nolen, Dianne H.K., Kooi, M. Eline, Köhler, Sebastian, Staals, Julie, Kuchcinski, Grégory, Bordet, Régis, Dubost, Florian, Wardlaw, Joanna M., Soo, Yannie O.Y., Fluri, Felix, Srikanth, Velandai K., Jung, Simon, Peters, Nils, Hara, Hideo, Yakushiji, Yusuke, Necioglu Orken, Dilek, Heo, Ji Hoe, Lau, Gary Kui Kai, Bae, Hee Joon, Werring, David J., Best, Jonathan G., Ambler, Gareth, Wilson, Duncan, Du, Houwei, Lee, Keon Joo, Lim, Jae Sung, Teo, Kay Cheong, Mak, Henry, Kim, Young Dae, Song, Tae Jin, Selcuk Demirelli, Derya, Nishihara, Masashi, Yoshikawa, Masaaki, Kubacka, Marta, Zietz, Annaelle, Al-Shahi Salman, Rustam, Jäger, Hans Rolf, Lip, Gregory Y.H., Panos, Leonidas, Goeldlin, Martina B., Slater, Lee Anne, Karayiannis, Christopher Charles, Phan, Thanh G., Bellut, Maximilian, Abrigo, Jill, Cheng, Cyrus, Leung, Thomas W., Chu, Winnie, Chappell, Francesca, Makin, Stephen D.J., Van Dam-Nolen, Dianne H.K., Kooi, M. Eline, Köhler, Sebastian, Staals, Julie, Kuchcinski, Grégory, Bordet, Régis, Dubost, Florian, Wardlaw, Joanna M., Soo, Yannie O.Y., Fluri, Felix, Srikanth, Velandai K., Jung, Simon, Peters, Nils, Hara, Hideo, Yakushiji, Yusuke, Necioglu Orken, Dilek, Heo, Ji Hoe, Lau, Gary Kui Kai, Bae, Hee Joon, and Werring, David J.

Abstract

Background and Objectives: Visible perivascular spaces are an MRI marker of cerebral small vessel disease and might predict future stroke. However, results from existing studies vary. We aimed to clarify this through a large collaborative multicenter analysis. Methods: We pooled individual patient data from a consortium of prospective cohort studies. Participants had recent ischemic stroke or transient ischemic attack (TIA), underwent baseline MRI, and were followed up for ischemic stroke and symptomatic intracranial hemorrhage (ICH). Perivascular spaces in the basal ganglia (BGPVS) and perivascular spaces in the centrum semiovale (CSOPVS) were rated locally using a validated visual scale. We investigated clinical and radiologic associations cross-sectionally using multinomial logistic regression and prospective associations with ischemic stroke and ICH using Cox regression. Results: We included 7,778 participants (mean age 70.6 years; 42.7% female) from 16 studies, followed up for a median of 1.44 years. Eighty ICH and 424 ischemic strokes occurred. BGPVS were associated with increasing age, hypertension, previous ischemic stroke, previous ICH, lacunes, cerebral microbleeds, and white matter hyperintensities. CSOPVS showed consistently weaker associations. Prospectively, after adjusting for potential confounders including cerebral microbleeds, increasing BGPVS burden was independently associated with future ischemic stroke (versus 0-10 BGPVS, 11-20 BGPVS: HR 1.19, 95% CI 0.93-1.53; 21+ BGPVS: HR 1.50, 95% CI 1.10-2.06; p = 0.040). Higher BGPVS burden was associated with increased ICH risk in univariable analysis, but not in adjusted analyses. CSOPVS were not significantly associated with either outcome. Discussion: In patients with ischemic stroke or TIA, increasing BGPVS burden is associated with more severe cerebral small vessel disease and higher ischemic stroke risk. Neither BGPVS nor CSOPVS were independently associated with future ICH.

Published
2024

42. Deep learning-based automatic classification of ischemic stroke subtype using diffusion-weighted images

Author

Ryu, Wi-Sun, primary, Schellingerhout, Dawid, additional, Lee, Hoyeon, additional, Lee, Keon-Joo, additional, Kim, Chi Kyung, additional, Kim, Beom Joon, additional, Chung, Jong-Won, additional, Lim, Jae-Sung, additional, Kim, Joon-Tae, additional, Kim, Dae-Hyun, additional, Cha, Jae-Kwan, additional, Sunwoo, Leonard, additional, Kim, Dongmin, additional, Suh, Sang-il, additional, Bang, Oh Young, additional, Bae, Hee-Joon, additional, and Kim, Dong-Eog, additional

Published
2024
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44. Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA

Author

Best, Jonathan G., primary, Ambler, Gareth, additional, Wilson, Duncan, additional, Du, Houwei, additional, Lee, Keon-Joo, additional, Lim, Jae-Sung, additional, Teo, Kay Cheong, additional, Mak, Henry, additional, Kim, Young Dae, additional, Song, Tae-Jin, additional, Selcuk Demirelli, Derya, additional, Nishihara, Masashi, additional, Yoshikawa, Masaaki, additional, Kubacka, Marta, additional, Zietz, Annaelle, additional, Al-Shahi Salman, Rustam, additional, Jäger, Hans Rolf, additional, Lip, Gregory Y.H., additional, Panos, Leonidas, additional, Goeldlin, Martina B., additional, Slater, Lee-Anne, additional, Karayiannis, Christopher Charles, additional, Phan, Thanh G., additional, Bellut, Maximilian, additional, Abrigo, Jill, additional, Cheng, Cyrus, additional, Leung, Thomas W., additional, Chu, Winnie, additional, Chappell, Francesca, additional, Makin, Stephen D.J., additional, van Dam-Nolen, Dianne H.K., additional, Kooi, M. Eline, additional, Köhler, Sebastian, additional, Staals, Julie, additional, Kuchcinski, Grégory, additional, Bordet, Régis, additional, Dubost, Florian, additional, Wardlaw, Joanna M., additional, Soo, Yannie O.Y., additional, Fluri, Felix, additional, Srikanth, Velandai K., additional, Jung, Simon, additional, Peters, Nils, additional, Hara, Hideo, additional, Yakushiji, Yusuke, additional, Necioglu Orken, Dilek, additional, Heo, Ji-Hoe, additional, Lau, Gary Kui Kai, additional, Bae, Hee-Joon, additional, and Werring, David J., additional

Published
2024
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45. Factors associated with caregiver burden in early onset dementia: the LEAF study

Author

Lee, Sun Min, primary, Kim, Hee Jin, additional, Jung, Na‐Yeon, additional, Park, Kee Hyung, additional, Cho, Hanna, additional, Kim, Yeshin, additional, Jang, Jae‐Won, additional, Kang, Heeyoung, additional, Lee, Jin San, additional, Kang, Sung Hoon, additional, Yoon, Soo Jin, additional, Kim, Hang‐Rai, additional, Park, Kyung Won, additional, Chung, Eunjoo, additional, Park, Young Ho, additional, Jang, Hyemin, additional, Lim, Jae Sung, additional, Kim, Geon Ha, additional, Jeong, Jee Hyang, additional, Choi, Seong Hye, additional, Cho, Su Hyun, additional, Kim, Seung Joo, additional, Kwon, Jay Cheol, additional, Lee, Juyoun, additional, Kang, Kyunghun, additional, Kim, Jaeho, additional, Kim, Hee‐Jin, additional, Kim, Si Eun, additional, Yi, Hyon‐Ah, additional, Park, Ji Yoon, additional, Kim, Eun‐Joo, additional, and Moon, So Young, additional

Published
2023
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47. Baseline demographic and clinical characteristics of Longitudinal study of Early onset dementia And Family members

Author

Jung, Na‐Yeon, primary, Kim, Hee Jin, additional, Lee, Sun Min, additional, Park, Kee Hyung, additional, Cho, Hanna, additional, Kim, Yeshin, additional, Jang, Jae‐Won, additional, Kang, Heeyoung, additional, Lee, Jin San, additional, Kang, Sung Hoon, additional, Yoon, Soo Jin, additional, Kim, Hang‐Rai, additional, Park, Kyung Won, additional, CHUNG, EUNJOO, additional, Park, Young Ho, additional, Jang, Hyemin, additional, Lim, Jae‐Sung, additional, Kim, Geon Ha, additional, Jeong, Jee Hyang, additional, Choi, Seong Hye, additional, Cho, Su Hyun, additional, Kim, Seung Joo, additional, Kwon, Jay Cheol, additional, Lee, Juyoun, additional, Kang, Kyunghun, additional, Kim, Jaeho, additional, Kim, Hee‐Jin, additional, Kim, Si Eun, additional, Yi, Hyon‐Ah, additional, Park, Ji Yoon, additional, Moon, So Young, additional, and Kim, Eun‐Joo, additional

Published
2023
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