43 results on '"Lilleås F"'
Search Results
2. OMEGA-3 FATTY ACIDS TREATMENT IN RELAPSING-REMITTING MULTIPLE SCLEROSIS: SC224
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Torkildsen, Ø., Bakke, S. J., Beiske, A. G., Bjerve, K., Bjørnarå, B., Bjørnå, I., Bru, A., Dalene, F., Edland, A., Eikeland, R., Henriksen, O., Hovdal, H., Kleveland, G., Kierulf, H., Kristensen, T., Lilleås, F., Midgard, R., Olsen, I. C., Pedersen, T., Schepel, J., Wergeland, S., and Myhr, K.-M.
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- 2011
3. Nonspondylolytic lateral clefts in the lumbar vertebral arch
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Johansen, J. G., Lilleås, F. G., du Boulay, George, editor, Molyneux, Andrew, editor, and Moseley, Ivan, editor
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- 1991
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4. MR FINDINGS IN CASES OF SUSPECTED IMPACTED FRACTURE OF THE FEMORAL NECK
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Stiris, M. G. and Lilleås, F. G.
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- 1997
5. Lumbar myelography with omnipaque (iohexol)
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Lilleås, F., Bach-Gansmo, T., and Weber, H.
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- 1986
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6. Functional imaging of the thoracic outlet syndrome in an open MR scanner
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Smedby, Örjan, Rostad, H, Klaastad, Örjan, Lilleås, F, Tillung, T, Fosse, E, Smedby, Örjan, Rostad, H, Klaastad, Örjan, Lilleås, F, Tillung, T, and Fosse, E
- Abstract
Symptoms due to thoracic outlet syndrome may present only in abduction, a position that cannot be investigated in conventional MR scanners. Therefore, this study was initiated to test MRI in an open magnet as a method for diagnosis of thoracic outlet syndrome. Ten volunteers and 7 patients with a clinical suspicion of thoracic outlet syndrome were investigated at 0.5 T in an open MR scanner. Sagittal 3D SPGR acquisitions were made in 0 and 90░abduction. In the patients, a similar data set was also obtained in maximal abduction. To assess compression, the minimum distance between the first rib and the clavicle, measured in a sagittal plane, was determined. In the neutral position, no significant difference was found between patients and controls. In 90░abduction, the patients had significantly smaller distance between rib and clavicle than the controls (14 vs 29 mm, p <0.01). On coronal reformatted images, the compression of the brachial plexus could often be visualised in abduction. Functional MR examination seems to be a useful diagnostic tool in thoracic outlet syndrome. Examination in abduction, which is feasible in an open scanner, is essential for the diagnosis.
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- 2000
7. Functional imaging of thoracic outlet syndrome in an open MR scanner
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Smedby, Örjan, Rostad, H, Klaastad, O, Lilleås, F, Tillung, T, Smedby, Örjan, Rostad, H, Klaastad, O, Lilleås, F, and Tillung, T
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- 1999
8. Craniotomy in the Magnet - Preliminary Experience of Intraoperative MRI and Neuronavigation
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Smedby, Örjan, Hirschberg, H., Lilleås, F., Samset, E., Smedby, Örjan, Hirschberg, H., Lilleås, F., and Samset, E.
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- 1998
9. Palatopharyngoglossoplasty in the Treatment of Patients with Obstructive Sleep Apnea Syndrome
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Djupesland, G., primary, Schrader, H., additional, Lyberg, T., additional, Refsum, H., additional, Lilleås, F., additional, and Godtlibsen, O. B., additional
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- 1992
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10. Vitamin D and disease activity in multiple sclerosis before and during interferon-β treatment.
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Løken-Amsrud KI, Holmøy T, Bakke SJ, Beiske AG, Bjerve KS, Bjørnarå BT, Hovdal H, Lilleås F, Midgard R, Pedersen T, Benth JS, Sandvik L, Torkildsen O, Wergeland S, Myhr KM, Løken-Amsrud, Kristin I, Holmøy, Trygve, Bakke, Søren J, Beiske, Antonie Giaever, and Bjerve, Kristian S
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- 2012
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11. Interferon-alpha2a reduces MRI disease activity in relapsing-remitting multiple sclerosis. Norwegian Study Group on Interferon-alpha in Multiple Sclerosis.
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Myhr KM, Riise T, Lilleås FEG, Beiske TG, Celius EG, Edland A, Jensen D, Larsen JP, Nilsen R, Nortvedt MW, Smievoll AI, Vedeler C, Nyland HI, Norwegian Study Group on Interferon-alpha in Multiple Sclerosis, Myhr, K M, Riise, T, Green Lilleås, F E, Beiske, T G, Celius, E G, and Edland, A
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- 1999
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12. Lumbar spinal stenosis. Clinical and radiologic features.
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Amundsen T, Weber H, Lilleas F, Nordal HJ, Abdelnoor M, Magnaes B, Amundsen, T, Weber, H, Lilleås, F, Nordal, H J, Abdelnoor, M, and Magnaes, B
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- 1995
13. Interferon-α2a reduces MRI disease activity in relapsing-remitting multiple sclerosis
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Myhr, K. M., Riise, T., Lilleås, F. E. Green, Beiske, T. G., Celius, E. G., Edland, A., Jensen, D., Larsen, J. P., Nilsen, R., Nortvedt, M. W., Smievoll, A. I., Vedeler, C., and Nyland, H. I.
- Abstract
To evaluate the efficacy and safety of interferon-α2a (IFN-α2a) in relapsing-remitting MS (RRMS).
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- 1999
14. Arthrography of the Knee Joint with Amipaque
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Johansen, J. G., Lilleås, F. G., and Nordshus, T.
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- 1977
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15. Retrograde Pancreatography in the Pig: Comparison of Isopaque and Amipaque
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Lilleås, F. and Swensen, T.
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- 1977
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16. Interferon-α2a reduces MRI disease activity in relapsing-remitting multiple sclerosis
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Myhr, K. M., Trond Riise, Lilleås, F. E. G., Beiske, T. G., Celius, E. G., Edland, A., Jensen, D., Larsen, J. P., Nilsen, R., Nortvedt, M. W., Smievoll, A. I., Vedeler, C., and Nyland, H. I.
17. Real time MRI-guided excision and cryo-treatment of osteoid osteoma in os ischii-a case report.
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Skjeldal S, Lilleås F, Follerås G, Stenwig AE, Samset E, Tillung T, and Fosse E
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- 2000
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18. No association of tobacco use and disease activity in multiple sclerosis.
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Kvistad S, Myhr KM, Holmøy T, Benth JŠ, Løken-Amsrud KI, Wergeland S, Beiske AG, Bjerve KS, Hovdal H, Lilleås F, Midgard R, Pedersen T, Bakke SJ, and Torkildsen Ø
- Abstract
Objective: To study whether tobacco use is associated with MRI and clinical disease activity in patients with multiple sclerosis (MS)., Methods: Prospective cohort study of 87 patients with relapsing-remitting MS originally included in a randomized placebo-controlled trial of omega-3 fatty acids in MS (the OFAMS Study). Serum levels of cotinine (biomarker of tobacco use) were analyzed at baseline and every 6 months for 2 years. MRI activity was assessed at baseline and monthly for 9 months and after 12 and 24 months., Results: Fifty-three patients (61%) had serum cotinine levels ≥85 nmol/L on ≥60% of the measurements and were considered tobacco users and 34 (39%) had cotinine levels <85 nmol/L, consistent with non-tobacco use. There was no association between tobacco use and the occurrence of new gadolinium-enhancing T1 lesions, new or enlarging T2 lesions, or their aggregate (combined unique activity). Furthermore, there was no association between cotinine levels and MRI activity for the tobacco users, and tobacco users did not have more relapses or Expanded Disability Status Scale progression., Conclusion: Our results indicate that tobacco use does not directly influence MRI activity or relapse rate in MS. This may implicate that the reported association between smoking and MS disease progression could be mediated through other mechanisms.
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- 2016
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19. Body mass index influence interferon-beta treatment response in multiple sclerosis.
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Kvistad SS, Myhr KM, Holmøy T, Šaltytė Benth J, Wergeland S, Beiske AG, Bjerve KS, Hovdal H, Lilleås F, Midgard R, Pedersen T, Bakke SJ, Michelsen AE, Aukrust P, Ueland T, Sagen JV, and Torkildsen Ø
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- Adolescent, Adult, Body Mass Index, Brain pathology, Disease Progression, Double-Blind Method, Enzyme-Linked Immunosorbent Assay, Female, Humans, Inflammation etiology, Inflammation pathology, Magnetic Resonance Imaging, Male, Middle Aged, Young Adult, Immunologic Factors therapeutic use, Interferon-beta therapeutic use, Multiple Sclerosis, Relapsing-Remitting complications, Multiple Sclerosis, Relapsing-Remitting drug therapy, Multiple Sclerosis, Relapsing-Remitting pathology, Obesity complications
- Abstract
Obesity is a possible risk factor of multiple sclerosis (MS), but the association between obesity and MS disease activity has not been explored. In a cohort of 86 MS patients, 80% of overweight or obese patients (BMI≥25kg/m(2)) had MRI activity compared to 48% of the normal-weight patients (BMI<25kg/m(2)) (p=0.001) during interferon-beta treatment. NEDA-status (no evidence of disease activity) was defined as a composite that consisted of absence of any relapses, sustained disability-progression and MRI-activity. Among normal-weight patients 26% obtained NEDA-status compared to only 13% of patients with BMI >25 (p=0.05). This may indicate that BMI affects interferon-beta treatment response., (Copyright © 2015 Elsevier B.V. All rights reserved.)
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- 2015
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20. Vitamin D status and effect of interferon-β1a treatment on MRI activity and serum inflammation markers in relapsing-remitting multiple sclerosis.
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Røsjø E, Myhr KM, Løken-Amsrud KI, Bakke SJ, Beiske AG, Bjerve KS, Hovdal H, Lilleås F, Midgard R, Pedersen T, Šaltytė Benth J, Torkildsen Ø, Wergeland S, Michelsen AE, Aukrust P, Ueland T, and Holmøy T
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- Adolescent, Adult, Cytokines blood, Female, Humans, Interferon beta-1a, Longitudinal Studies, Male, Middle Aged, Norway, Regression Analysis, Retrospective Studies, Time Factors, Young Adult, Adjuvants, Immunologic therapeutic use, Interferon-beta therapeutic use, Magnetic Resonance Imaging, Multiple Sclerosis, Relapsing-Remitting blood, Multiple Sclerosis, Relapsing-Remitting drug therapy, Multiple Sclerosis, Relapsing-Remitting pathology, Vitamin D blood
- Abstract
To explore if vitamin D modulates interferon-β1a treatment effects in relapsing-remitting multiple sclerosis, we examined relationships between serum vitamin D and magnetic resonance imaging (MRI) activity and ten systemic inflammation markers in 88 patients, before and during treatment. Odds ratios for all MRI parameters were negatively associated with vitamin D levels before therapy, but converged to equally low values irrespective of vitamin D status during treatment. During therapy, similar alterations of MRI activity and inflammation markers were found across patients categorized by mean vitamin D values. This suggests that vitamin D status has no major influence on interferon-β1a treatment effects., (Copyright © 2015 Elsevier B.V. All rights reserved.)
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- 2015
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21. Antibodies to Epstein-Barr virus and MRI disease activity in multiple sclerosis.
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Kvistad S, Myhr KM, Holmøy T, Bakke S, Beiske AG, Bjerve KS, Hovdal H, Løken-Amsrud KI, Lilleås F, Midgard R, Njølstad G, Pedersen T, Benth JŠ, Wergeland S, and Torkildsen O
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- Adult, Antigens, Viral immunology, Capsid Proteins immunology, Epstein-Barr Virus Nuclear Antigens immunology, Fatty Acids, Omega-3 therapeutic use, Female, Humans, Immunoglobulin G immunology, Immunoglobulin M immunology, Immunologic Factors therapeutic use, Interferon beta-1a, Interferon-beta therapeutic use, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis drug therapy, Multiple Sclerosis pathology, Prospective Studies, Severity of Illness Index, Antibodies, Viral immunology, Brain pathology, Herpesvirus 4, Human immunology, Multiple Sclerosis immunology
- Abstract
Background: Previous reports indicate an association between Epstein-Barr virus (EBV) antibody levels and multiple sclerosis (MS) disease activity, but the results have been conflicting., Objectives: The objective of this paper is to study if EBV antibody levels reflect MRI disease activity in MS and examine the potential for EBV antibody levels as biomarkers for treatment response., Methods: A total of 87 MS patients were followed for two years prior to and during interferon beta (IFNB) treatment, with MRI examinations and serum measurement of IgM and IgG antibodies to viral capsid antigen (VCA), EBV nuclear antigen 1 (EBNA-1) and early antigen (EA). Associations between EBV antibody levels and MRI activity were assessed by a logistic regression model., Results: Higher anti-EBNA-1 IgG levels were associated with increased MRI activity, OR = 2.95 (95% CI 1.07-8.10; p = 0.036) for combined unique activity (CUA; the sum of T1Gd+ lesions and new or enlarging T2 lesions). Although most patients were anti-VCA IgM negative, there was an inverse association, OR = 0.32 (95% CI 0.12-0.84; p = 0.021) with CUA during IFNB treatment., Conclusions: This study supports an association between anti-EBNA-1 IgG levels and MS disease activity. We also found an inverse association with anti-VCA IgM levels during IFNB treatment not previously described, indicating anti-VCA IgM as a possible biomarker for IFNB treatment response., (© The Author(s), 2014.)
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- 2014
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22. Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis.
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Røsjø E, Myhr KM, Løken-Amsrud KI, Bakke SJ, Beiske AG, Bjerve KS, Hovdal H, Lilleås F, Midgard R, Pedersen T, Benth JS, Torkildsen Ø, Wergeland S, Michelsen AE, Aukrust P, Ueland T, and Holmøy T
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- Adult, Biomarkers blood, C-Reactive Protein metabolism, Docosahexaenoic Acids therapeutic use, Double-Blind Method, Eicosapentaenoic Acid therapeutic use, Female, Follow-Up Studies, Humans, Immunologic Factors therapeutic use, Interferon-beta therapeutic use, Male, Middle Aged, Multiple Sclerosis drug therapy, Serum Amyloid P-Component metabolism, Time Factors, Vitamin A blood, Vitamin D blood, Vitamin E blood, Cytokines blood, Multiple Sclerosis blood, Multiple Sclerosis immunology, Vitamins blood
- Abstract
To explore the relationships between vitamin A, D and E and inflammation in relapsing remitting multiple sclerosis, we assessed their associations with 11 inflammation markers in 9 serial serum samples from 85 patients, before and during interferon-β1a treatment. A negative association was found between vitamin A and pentraxin 3 independent of interferon-β1a use, whereas positive associations between vitamin D and interleukin-1 receptor antagonist and secreted frizzled-related protein 3 were seen before, and between vitamin E and chemokine (C-X-C motif) ligand 16 during interferon-β1a treatment. These findings suggest associations with diverse inflammatory pathways, which may be differentially influenced by interferon-β1a treatment., (Copyright © 2014 Elsevier B.V. All rights reserved.)
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- 2014
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23. Inflammation markers in multiple sclerosis: CXCL16 reflects and may also predict disease activity.
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Holmøy T, Løken-Amsrud KI, Bakke SJ, Beiske AG, Bjerve KS, Hovdal H, Lilleås F, Midgard R, Pedersen T, Saltytė Benth J, Torkildsen O, Wergeland S, Myhr KM, Michelsen AE, Aukrust P, and Ueland T
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- Biomarkers blood, Chemokine CXCL16, Dietary Supplements, Fatty Acids, Omega-3 therapeutic use, Female, Humans, Inflammation blood, Magnetic Resonance Imaging, Male, Multiple Sclerosis diet therapy, Odds Ratio, Prognosis, Chemokines, CXC blood, Multiple Sclerosis blood, Multiple Sclerosis diagnosis, Receptors, Scavenger blood
- Abstract
Background: Serum markers of inflammation are candidate biomarkers in multiple sclerosis (MS). ω-3 fatty acids are suggested to have anti-inflammatory properties that might be beneficial in MS. We aimed to explore the relationship between serum levels of inflammation markers and MRI activity in patients with relapsing remitting MS, as well as the effect of ω-3 fatty acids on these markers., Methods: We performed a prospective cohort study in 85 relapsing remitting MS patients who participated in a randomized clinical trial of ω-3 fatty acids versus placebo (the OFAMS study). During a period of 24 months 12 repeated magnetic resonance imaging (MRI) scans and nine serum samples were obtained. We measured 10 inflammation markers, including general down-stream markers of inflammation, specific markers of up-stream inflammatory pathways, endothelial action, and matrix regulation., Results: After Bonferroni correction, increasing serum levels of CXCL16 and osteoprotegerin were associated with low odds ratio for simultaneous MRI activity, whereas a positive association was observed for matrix metalloproteinase (MMP) 9. CXCL16 were also associated with low MRI activity the next month, but this was not significant after Bonferroni correction. In agreement with previously reported MRI and clinical results, ω-3 fatty acid treatment did not induce any change in the inflammation markers., Conclusions: Serum levels of CXCL16, MMP-9, and osteoprotegerin reflect disease activity in MS, but are not affected by ω-3 fatty acid treatment. CXCL16 could be a novel biomarker and potential predictor of disease activity in MS.
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- 2013
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24. Retinol levels are associated with magnetic resonance imaging outcomes in multiple sclerosis.
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Løken-Amsrud KI, Myhr KM, Bakke SJ, Beiske AG, Bjerve KS, Bjørnarå BT, Hovdal H, Lilleås F, Midgard R, Pedersen T, Benth JS, Torkildsen Ø, Wergeland S, and Holmøy T
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- Adult, Chromatography, High Pressure Liquid, Fatty Acids, Omega-3 therapeutic use, Female, Humans, Immunologic Factors therapeutic use, Interferon-beta therapeutic use, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting drug therapy, Randomized Controlled Trials as Topic, Young Adult, Multiple Sclerosis, Relapsing-Remitting blood, Multiple Sclerosis, Relapsing-Remitting pathology, Vitamin A blood
- Abstract
Background: Vitamin A has immunomodulatory properties and may regulate the transcription of genes involved in remyelination., Objective: To investigate the association between retinol and disease activity in multiple sclerosis (MS)., Methods: Cohort study of 88 relapsing-remitting MS patients, originally included in a randomised placebo-controlled trial of omega-3 fatty acids in MS (the OFAMS study), followed prospectively for 24 months with repeated assessments of serum-retinol and magnetic resonance imaging (MRI). All patients were initiated on interferon β-1a after month 6., Results: Each 1 µmol/L increase in serum-retinol reduced the odds (95% confidence interval) for new T1 gadolinium enhanced (Gd(+)) lesions by 49 (8-70)%, new T2 lesions by 42 (2-66)%, and combined unique activity (CUA) by 46 (3-68)% in simultaneous MRI scans, and 63 (25-82)% for new T1Gd(+) lesions, 49 (3-73)% for new T2 lesions and 43 (12-71)% for CUA the subsequent month. Serum-retinol also predicted new T1Gd(+) and T2 lesions six months ahead. The associations were not affected by HLA-DRB1*15, or serum levels of 25-hydroxyvitamin D, eicosapentaenoic acid or docosahexaenoic acid., Conclusion: Serum retinol is inversely associated with simultaneous and subsequent MRI outcomes in RRMS.
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- 2013
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25. Alpha-tocopherol and MRI outcomes in multiple sclerosis--association and prediction.
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Løken-Amsrud KI, Myhr KM, Bakke SJ, Beiske AG, Bjerve KS, Bjørnarå BT, Hovdal H, Lilleås F, Midgard R, Pedersen T, Benth JŠ, Torkildsen Ø, Wergeland S, and Holmøy T
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- Adult, Cohort Studies, Fatty Acids, Omega-3 metabolism, Female, Follow-Up Studies, Gadolinium, HLA-DRB1 Chains, Humans, Interferon-beta administration & dosage, Magnetic Resonance Imaging, Male, Multiple Sclerosis, Relapsing-Remitting drug therapy, Prospective Studies, Randomized Controlled Trials as Topic, Treatment Outcome, Interferon-beta adverse effects, Multiple Sclerosis, Relapsing-Remitting blood, Multiple Sclerosis, Relapsing-Remitting physiopathology, alpha-Tocopherol blood
- Abstract
Objective: Alpha-tocopherol is the main vitamin E compound in humans, and has important antioxidative and immunomodulatory properties. The aim of this study was to study alpha-tocopherol concentrations and their relationship to disease activity in Norwegian multiple sclerosis (MS) patients., Methods: Prospective cohort study in 88 relapsing-remitting MS (RRMS) patients, originally included in a randomised placebo-controlled trial of omega-3 fatty acids (the OFAMS study), before and during treatment with interferon beta. The patients were followed for two years with repeated 12 magnetic resonance imaging (MRI) scans and nine serum measurements of alpha-tocopherol., Results: During interferon beta (IFNB) treatment, each 10 µmol/L increase in alpha-tocopherol reduced the odds (CI 95%) for simultaneous new T2 lesions by 36.8 (0.5-59.8) %, p = 0.048, and for combined unique activity by 35.4 (1.6-57.7) %, p = 0.042, in a hierarchical regression model. These associations were not significant prior to IFNB treatment, and were not noticeably changed by gender, age, body mass index, HLA-DRB1*15, treatment group, compliance, or the concentrations of 25-hydroxyvitamin D, retinol, neutralising antibodies against IFNB, or the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid. The corresponding odds for having new T1 gadolinium enhancing lesions two months later was reduced by 65.4 (16.5-85.7) %, p = 0.019, and for new T2 lesions by 61.0 (12.4-82.6) %, p = 0.023., Conclusion: During treatment with IFNB, increasing serum concentrations of alpha-tocopherol were associated with reduced odds for simultaneous and subsequent MRI disease activity in RRMS patients.
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- 2013
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26. ω-3 fatty acid treatment in multiple sclerosis (OFAMS Study): a randomized, double-blind, placebo-controlled trial.
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Torkildsen O, Wergeland S, Bakke S, Beiske AG, Bjerve KS, Hovdal H, Midgard R, Lilleås F, Pedersen T, Bjørnarå B, Dalene F, Kleveland G, Schepel J, Olsen IC, and Myhr KM
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- Adult, Dietary Supplements, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Interferon beta-1a, Interferon-beta administration & dosage, Magnetic Resonance Imaging trends, Male, Middle Aged, Multiple Sclerosis epidemiology, Treatment Outcome, Fatty Acids, Omega-3 administration & dosage, Multiple Sclerosis drug therapy, Multiple Sclerosis pathology
- Abstract
Objective: To investigate whether ω-3 fatty acids reduce magnetic resonance imaging (MRI) and clinical disease activity in patients with multiple sclerosis, both as monotherapy and in combination with interferon beta-1a treatment., Design: Multicenter, randomized, double-blind, placebo-controlled clinical trial conducted from 2004 to 2008., Setting: Thirteen public neurology departments in Norway., Participants: Patients aged 18 to 55 years with active relapsing-remitting multiple sclerosis, with a disability score equivalent to 5.0 or less on the Kurtzke Expanded Disability Status Scale. Ninety-two patients were randomized to ω-3 fatty acids (n = 46) or placebo capsules (n = 46)., Interventions: Administration of 1350 mg of eicosapentaenoic acid and 850 mg of docosahexaenoic acid daily or placebo. After 6 months, all patients in addition received subcutaneously 44 μg of interferon beta-1a 3 times per week for another 18 months., Main Outcome Measure: The primary outcome measure was MRI disease activity as measured by the number of new T1-weighted gadolinium-enhancing lesions during the first 6 months. Secondary outcome measures included MRI disease activity after 9 months and 24 months, relapse rate, disability progression, fatigue, quality of life, and safety., Results: The cumulative number of gadolinium-enhancing MRI lesions during the first 6 months were similar in the ω-3 fatty acids and placebo groups (median difference, 1; 95% CI, 0 to 3; P = .09). No difference in relapse rate was detected after 6 (median difference, 0; 95% CI, 0 to 0; P = .54) or 24 (median difference, 0; 95% CI, 0 to 0; P = .72) months. The proportion of patients without disability progression was 70% in both groups (P > .99). No differences were detected in fatigue or quality-of-life scores, and no safety concerns appeared. Serum analyses of fatty acids showed an increase in ω-3 fatty acids (mean difference, 7.60; 95% CI, 5.57 to 7.91; P < .001) in the patients treated with ω-3 fatty acids compared with the placebo group., Conclusion: No beneficial effects on disease activity were detected from ω-3 fatty acids when compared with placebo as monotherapy or in combination with interferon beta-1a. Magnetic resonance imaging disease activity was reduced as expected by interferon beta-1a. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00360906.
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- 2012
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27. Dural ectasia in Marfan syndrome: a case control study.
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Lundby R, Rand-Hendriksen S, Hald JK, Lilleås FG, Pripp AH, Skaar S, Paus B, Geiran O, and Smith HJ
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- Adult, Case-Control Studies, Comorbidity, Dilatation, Pathologic pathology, Female, Humans, Incidence, Male, Middle Aged, Norway epidemiology, Dura Mater diagnostic imaging, Dura Mater pathology, Magnetic Resonance Imaging statistics & numerical data, Marfan Syndrome diagnosis, Marfan Syndrome epidemiology, Tomography, X-Ray Computed statistics & numerical data
- Abstract
Background and Purpose: Dural ectasia (DE) is one of the major criteria of Marfan syndrome (MFS). Our aim was to establish the prevalence of DE in an adult population fulfilling the Ghent criteria for MFS and to assess definitions of DE., Materials and Methods: One hundred five adults with suspected MFS were included. MR imaging at 1.5T was performed unless contraindicated; then CT was obtained. Lumbosacral anteroposterior vertebral body diameters (VBD) and dural sac diameters (DSD) were measured. Dural sac ratios (DSR = DSD/VBD) at levels L3 through S1 were calculated. Anterior meningoceles, herniations of nerve root sleeves, and scalloping were characterized. One hundred one sex- and age-matched patients were included as controls., Results: We identified 3 patient groups: 1) fulfilling Ghent criteria independent of DE (n = 73), 2); fulfilling Ghent criteria dependent on DE (n = 14), and 3); and suspected MFS, not fulfilling Ghent criteria (n = 18). DE was found in 86% of group 1. At levels L4-S1, mean DSRs were significantly higher in group 1 than in group 3 and controls (P < .001). Herniations of the nerve root sleeves were present in 73% in group 1 versus 1% in controls. Anterior meningoceles were found in 37% and 14% in groups 1 and 2, respectively, but not in group 3 or controls., Conclusions: The diagnosis of DE on MR imaging or CT should be based on the presence of at least 1 of the following criteria: anterior meningoceles or nerve root sleeve herniation, DSD at S1 or below larger than DSD at L4, and DSR at S1 >0.59.
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- 2009
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28. Vertebral deformities in 229 female patients with rheumatoid arthritis: associations with clinical variables and bone mineral density.
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Ørstavik RE, Haugeberg G, Uhlig T, Falch JA, Halse JI, Høiseth A, Lilleås F, and Kvien TK
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- Aged, Arthritis, Rheumatoid physiopathology, Cohort Studies, Female, Humans, Incidence, Middle Aged, Risk Factors, Spinal Diseases epidemiology, Adrenal Cortex Hormones adverse effects, Arthritis, Rheumatoid complications, Arthritis, Rheumatoid drug therapy, Bone Density, Spinal Diseases etiology
- Abstract
Objective: To examine the occurrence of vertebral deformities in female patients with rheumatoid arthritis (RA), and the relationship between vertebral deformities and bone mineral density (BMD) and between vertebral deformities and clinical variables., Methods: Lateral radiographs of the spine were obtained in 229 female patients with RA (mean age 63.4 years, range 51.4-73.6 years) recruited from a county RA register. Vertebral deformities were measured semiquantitatively by an experienced radiologist. A clinical examination including core measurements of disease activity and severity was performed, and BMD was measured at the spine (L2-L4) and hip., Results: According to the statistical analysis, 49 patients were considered to have relevant vertebral deformities. The occurrence of vertebral deformities was independently associated with age, long-term corticosteroid use, and previous nonvertebral fracture, as well as reduced BMD. Our results failed to show any independent relationship between vertebral deformities and the activity or severity of disease., Conclusion: Corticosteroid use is an important marker of established osteoporosis in patients with RA. Additionally, there seems to be a consistent relationship between BMD and vertebral deformities in this patient group.
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- 2003
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29. [Use of MR in the diagnosis of multiple sclerosis].
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Bakke SJ, Lilleås F, Smievoll AI, Myhr G, Nakstad PH, Bajic R, and Larmo A
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- Humans, Magnetic Resonance Imaging, Multiple Sclerosis pathology, Multiple Sclerosis diagnosis
- Published
- 2003
30. The clinical value of dynamic magnetic resonance imaging in normal and incontinent women--a preliminary study on micturition.
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Hedlund H, Bø K, Lilleås F, Talseth T, and Tillung T
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- Female, Humans, Magnetic Resonance Imaging, Urinary Incontinence pathology, Urination physiology, Urodynamics
- Abstract
In this preliminary study in nine volunteers and nine women with genuine stress incontinence (GSI) dynamic magnetic resonance imaging (MRI) was used to study the voiding phase in the sitting position after physiological filling of the bladder by urine. The MRI technique has been documented as being useful for this purpose, but in this small group of women it was not possible to determine any specific difference in the voiding pattern between the volunteers and the G
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- 2001
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31. Dynamic MRI of the pelvic floor muscles in an upright sitting position.
- Author
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Bø K, Lilleås F, Talseth T, and Hedland H
- Subjects
- Adult, Female, Humans, Middle Aged, Magnetic Resonance Imaging methods, Muscle, Skeletal pathology, Muscle, Skeletal physiopathology, Pelvic Floor pathology, Pelvic Floor physiopathology, Posture
- Abstract
Since the pelvic floor muscles are situated inside the pelvis, the actual function is difficult to observe. Magnetic resonance imaging (MRI) is a new method that may prove to give additional information about pelvic floor muscle function during contraction. The purpose of the present study was to assess pelvic floor muscle function during contraction and straining in an upright sitting position by use of MRI. Sixteen women, nine continent and seven with urodynamically and clinically proven genuine stress incontinence participated in the study. MRI was performed in an open-configured GE Signa SP, 0.5 T Tesla magnet. With the participants sitting in an upright position on a pelvic RF-coil, sagittal, coronal and axial T1 weighted spin echo images of the pelvic floor were obtained. During contraction and straining a scan time of 2 seconds per image for 150-250 images, was performed in a mid-sagittal plane. The results showed that the mean inward lift during contraction was 10.8 mm (SD 6.0) for all women. During straining the mean downward movement was 19.1 mm (SD 7.4). The coccyx moved in a ventral, cranial direction during contraction and was pressed in a caudal, dorsal direction during straining. It is concluded that contraction of the pelvic floor muscles is concentric, moving the coccyx in a ventral, cranial direction. The movement measured by MRI in upright sitting position is less than that concluded after clinical observation in supine position. The coccyx is pressed dorsally during straining., (Copyright 2001 Wiley-Liss, Inc.)
- Published
- 2001
- Full Text
- View/download PDF
32. [Vertebral fractures in osteoporosis--silent fractures of clinical importance].
- Author
-
Ørstavik R, Haugeberg G, Kvien TK, and Lilleås F
- Subjects
- Bone Density, Female, Humans, Male, Osteoporosis diagnosis, Osteoporosis prevention & control, Osteoporosis, Postmenopausal complications, Osteoporosis, Postmenopausal diagnosis, Osteoporosis, Postmenopausal prevention & control, Spinal Fractures diagnosis, Spinal Fractures therapy, Osteoporosis complications, Spinal Fractures etiology
- Abstract
Vertebral fractures are a common concern in patients with low bone mass. Even though less than half of these fractures are symptomatous, they represent a major health problem. This article gives a survey of vertebral fractures in osteoporosis as a "silent epidemic". They are of clinical importance for two main reasons. First, several studies have demonstrated an association between vertebral fractures and morbidity and even mortality. Second, an osteoporotic vertebral fracture dramatically increases a persons risk of suffering from further osteoporotic fractures, also non-axial ones. Vertebral deformities represent the clinical end point of large interventional studies on osteoporosis, and is used as a definition of osteoporosis in epidemiological studies. Spinal radiographs provide vertebrae in all shapes, from normal via slight reduction of height to severely crushed. There is no commonly accepted definition of when a reduction in height is defined as a vertebral fracture. This lack of standardisation complicates interpretation and comparison of different studies. During the last decade, several well documented treatments reducing the risk of further fractures have come into use. This points to the importance of discovering a vertebral fracture, so that the patient can be diagnosed as having osteoporosis and given appropriate treatment.
- Published
- 2000
33. A magnetic resonance imaging study of modifications to the infraclavicular brachial plexus block.
- Author
-
Klaastad O, Lilleås FG, Røtnes JS, Breivik H, and Fosse E
- Subjects
- Adult, Arm anatomy & histology, Clavicle, Female, Humans, Male, Middle Aged, Needles, Nerve Block instrumentation, Pectoralis Muscles anatomy & histology, Pleura injuries, Pneumothorax etiology, Pneumothorax prevention & control, Posture, Punctures, Risk Factors, Scapula anatomy & histology, Subclavian Artery anatomy & histology, User-Computer Interface, Brachial Plexus anatomy & histology, Magnetic Resonance Imaging, Nerve Block methods
- Abstract
A previously described infraclavicular brachial plexus block may be modified by using a more lateral needle insertion point, while the patient abducts the arm 45 degrees or 90 degrees. In performing the modified block on patients abducting 45 degrees, we often had problems finding the cords of the brachial plexus. Therefore, we designed an anatomic study to describe the ability of the recommended needle direction to consistently reach the cords. Additionally, we assessed the risk of penetrating the pleura by the needle. Magnetic resonance images were obtained in 10 volunteers. From these images, a virtual reality model of each volunteer was created, allowing precise positioning of a simulated needle according to the modified block, without exposing the volunteers to actual needle placement. In both arm positions, the recommended needle angle of 45 degrees to the skin was too shallow to reach a defined target on the cords. Comparing the two arm positions, target precision and risk of contacting the pleura were more favorable with the greater arm abduction. We conclude that when the arm is abducted to 90 degrees, a 65 degrees -needle angle to the skin appears optimal for contacting the cords, still with a minimal risk of penetrating the pleura. However, this needs to be confirmed by a clinical study.
- Published
- 2000
- Full Text
- View/download PDF
34. [Villonodular synovitis--a rare cause of knee joint locking].
- Author
-
Lilleås FG and Stiris M
- Subjects
- Humans, Knee Joint diagnostic imaging, Knee Joint pathology, Radiography, Synovitis, Pigmented Villonodular diagnostic imaging, Synovitis, Pigmented Villonodular pathology, Knee Joint physiopathology, Synovitis, Pigmented Villonodular physiopathology
- Published
- 1999
35. Magnetic resonance imaging demonstrates lack of precision in needle placement by the infraclavicular brachial plexus block described by Raj et al.
- Author
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Klaastad O, Lilleås FG, Røtnes JS, Breivik H, and Fosse E
- Subjects
- Adult, Clavicle innervation, Female, Humans, Male, Middle Aged, Nerve Block adverse effects, Nerve Block instrumentation, Brachial Plexus anatomy & histology, Clavicle anatomy & histology, Magnetic Resonance Imaging methods, Needles adverse effects, Nerve Block methods
- Abstract
Unlabelled: The infraclavicular brachial plexus block first described by Raj et al. was supposed to anesthetize all the main peripheral nerves of the brachial plexus without the risk of pneumothorax. However, in performing the block, we have had difficulties finding the nerves at the cord level. Therefore, we questioned whether the recommended needle direction (the "Raj line") guides the needle close enough to the cords. We therefore designed an anatomic study to answer this question and to assess the risks of entering the pleura and axillary vein. Ten volunteers were examined noninvasively in an open model magnetic resonance scanner. The Raj line deviated greatly from a defined location on the cords by a mean of 26 (range 14-39) mm, always caudad, and posterior to the target in nine cases. Further, the needle trajectory's shortest distance to the pleura was only 10 (0-27) mm, and in one case, it hit the pleura. Finally, the Raj line's distance to the axillary vein was also short, 11 (0-18) mm. We conclude that a modification of the method is necessary to guide the needle closer to the cords and further away from the pleura and the axillary vein. A more lateral needle insertion seems beneficial., Implications: Using a magnetic resonance scanner, the anatomical basis of Raj's infraclavicular method for brachial plexus blockade was examined in volunteers. The results show that the method should be modified to make it more precise and to provide less risk of complications.
- Published
- 1999
- Full Text
- View/download PDF
36. [The intervention center at the Rikshospital. Experiences from the first year of activity].
- Author
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Fosse E, Lilleås F, Røtnes JS, Edwin B, Tønnessen TI, Hafsahl G, and Laerum F
- Subjects
- Evaluation Studies as Topic, Humans, Interdepartmental Relations, Norway, Research, Workforce, Centralized Hospital Services organization & administration, Centralized Hospital Services standards, Laparoscopy, Radiography, Interventional methods
- Abstract
In order to co-ordinate and promote the development of new clinical applications by structuring collaboration and communication across traditional specialty boundaries, a first of its kind hospital department was opened at Rikshospitalet in June 1996. The Interventional Centre is a multidisciplinary centre for research and development, teaching and quality management of imaging-guided minimally invasive therapy, endoscopic surgery and interventional radiology. The department is a full fusion of state-of-the art operating theatre with an advanced radiology department and with fully up-to-date ultrasound and endoscopy facilities for integrated use in the treatment of the patient. The department is cross-disciplinary organised. A small staff of 14 persons are responsible for the day-to-day running of the centre. Specialists from other hospital departments work together with the centre's permanent staff to develop new procedures. During the first year, 19 research projects were started and a total of 510 procedures performed within the fields of Radiology, Neurosurgery, Gastroenterology, Cardiology, Cardiovascular surgery and Paediatric cardiology, and also within the fields of image processing and telecommunication.
- Published
- 1997
37. [Percutaneous automated lumbar nucleotomy. Patient selection, practical performance and clinical results].
- Author
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Dullerud R, Johansen JG, Lilleås FG, Rasmussen F, Amundsen T, Lie H, and Magnaes B
- Subjects
- Adult, Aged, Diskectomy, Percutaneous instrumentation, Female, Humans, Intervertebral Disc Displacement diagnosis, Intervertebral Disc Displacement diagnostic imaging, Lumbar Vertebrae diagnostic imaging, Magnetic Resonance Imaging, Male, Middle Aged, Patient Satisfaction, Prognosis, Tomography, X-Ray Computed, Diskectomy, Percutaneous methods, Intervertebral Disc Displacement surgery, Lumbar Vertebrae surgery
- Abstract
Percutaneous nucleotomy is designed to treat small and medium-sized contained disk hernias. It is offered to patients who have not responded to conservative treatment for three months or more. The nucleotomy procedure is well tolerated by a majority of patients and the rate of complications is low. The patients can be treated as out-patients. Among a total material of 130 patients, a primary good response to the treatment was observed in 81 (62%). However, owing to recurrencies the success rate had fallen to 52% at 12-39 months (mean 22 months) after nucleotomy. In selected patients with symptoms from one disk level only, and with no evidence of spinal stenosis, or of osteophyte formation or a narrowing of the disk space by more than 25%, the results were better. Here the success rate was 61% (70% in males and 50% in females).
- Published
- 1994
38. Cavernous hemangioma of the middle ear.
- Author
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Mair IW, Roald B, Lilleås F, and Olsholt R
- Subjects
- Adult, Hearing Loss, Sensorineural etiology, Hearing Loss, Sensorineural pathology, Hemangioma, Cavernous complications, Humans, Immunohistochemistry, Male, Microscopy, Electron, Tomography, X-Ray Computed, Ear Neoplasms diagnosis, Ear Neoplasms pathology, Ear, Middle pathology, Hemangioma, Cavernous diagnosis, Hemangioma, Cavernous pathology
- Abstract
A case of an accidentally discovered, nonsymptomatic cavernous angioma of the middle ear in a 29-year-old white male Caucasian is presented together with a review of the relevant literature. The lesion is documented with computer tomography, light microscopy, and immunohistochemistry.
- Published
- 1994
39. Septic complications to sphenoidal sinus infection.
- Author
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Oktedalen O and Lilleås F
- Subjects
- Adult, Cellulitis etiology, Female, Humans, Male, Meningitis etiology, Orbital Diseases etiology, Sepsis etiology, Sphenoid Sinusitis diagnostic imaging, Tomography, X-Ray Computed, Sphenoid Sinusitis complications
- Abstract
Sphenoid sinusitis is an uncommon infection, but an early diagnosis and appropriate treatment is important because of its serious complications. We report 4 patients (28, 28, 37 and 28 years old) admitted to a department of infectious diseases with meningitis, sepsis and orbital cellulitis as complications of acute sphenoidal cavity infection. The cases illustrate the value of computed tomography (CT) scan of the sphenoid sinus in the evaluation of patients with clinical features suspicious of sphenoid sinusitis.
- Published
- 1992
- Full Text
- View/download PDF
40. [Discography].
- Author
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Lie H and Lilleås F
- Subjects
- Back Pain diagnosis, Diagnosis, Differential, Humans, Radionuclide Imaging, Tomography, X-Ray Computed, Intervertebral Disc diagnostic imaging, Spinal Diseases diagnostic imaging
- Abstract
Discography means imaging of the intervertebral discs by intradiscal contrast injections. Discography with a combined CT/discography allows a more detailed classification of annular disruption and degeneration. Combined with a pain response registration, discography can be of value in the diagnosis of chronic low back pain with signs of sciatica in cases where other x-ray modalities have failed to explain the source of pain. Among 20 discography examinations there was a correlation between radicular symptoms and annular disruption with contrast leakage to the epidural space, and disc protrusion on CT scanning.
- Published
- 1990
41. [Plain X-ray examination of the lumbo-sacral spine in patients with low back pain and sciatica].
- Author
-
Lie H and Lilleås FE
- Subjects
- Adolescent, Adult, Female, Humans, Male, Middle Aged, Radiography, Spine diagnostic imaging, Back Pain diagnostic imaging, Sciatica diagnostic imaging
- Published
- 1984
42. [Use of computer tomography in stroke].
- Author
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Landmark K, Aursnes I, Lilleås FG, and Eldevik P
- Subjects
- Acute Disease, Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Tomography, X-Ray Computed, Cerebrovascular Disorders diagnostic imaging
- Published
- 1988
43. [Computerized tomography in severe head injuries. 1-year case material from Ullevål Hospital].
- Author
-
Lilleås FG, Syvertsen A, and Kollevold T
- Subjects
- Adolescent, Adult, Aged, Cerebral Angiography, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Retrospective Studies, Craniocerebral Trauma diagnostic imaging, Tomography, X-Ray Computed
- Published
- 1980
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