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Coenzyme Q10 (CoQ10) is a natural constituent of foods and is also often used in both functional foods and supplements. In addition, it is a common ingredient of cosmetics where it is believed to reduce the signs of skin ageing. However, the existing data about the effect of dietary intake of CoQ10 on skin parameters and condition are scarce. To gain an insight into this issue, we conducted a double-blind, placebo-controlled experiment with 33 healthy subjects. Our objective was to investigate the effects of 12 weeks of daily supplementation with 50 and 150 mg of CoQ10 on skin parameters and condition. Study was conducted with a water-soluble form of CoQ10 with superior bioavailability (Q10Vital® ). While the results of some previous in vitro studies showed possible protection in UVB response, we did not observe significant changes in the minimal erythema dose (MED). On the other hand, the intake of CoQ10 limited seasonal deterioration of viscoelasticity and reduced some visible signs of ageing. We determined significantly reduced wrinkles and microrelief lines, and improved skin smoothness. Supplementation with CoQ10 did not significantly affect skin hydration and dermis thickness. © 2016 BioFactors, 43(1):132-140, 2017.

This study identified sex differences in clinical presentation and survival for primary cutaneous melanoma without clinical evidence of metastasis at diagnosis from 1976 to 2008 in southern Germany. Melanoma-specific survival curves and estimated survival probabilities were generated using the Kaplan-Meier method. Multivariate survival analyses were carried out using the Cox modeling. Male patients had significantly thicker and more frequently ulcerated tumors and a lower 10-year disease-specific survival (DSS) and recurrence-free survival probability compared with females among patients of 43 years old or younger (DSS: 86.1 vs. 93.2%, P

Nodular melanoma is a rare type of cutaneous melanoma with an increased risk of death. It often mimics benign cutaneous tumors and inflammatory lesions. It has pronounced vertical growth phase and greater thickness at the time of diagnosis which caries ominous prognostic value. Nodular melanoma quickly develops metastases which are often present before the disease is clinically recognised. Here, we report a case of nodular melanoma clinically mimicking seborrheic keratosis. Therapy and 36 months follow-up after primal excision are also presented.

The clinical and histopathological characteristics that predict the outcomes of patients with melanoma have been studied for more than four decades. Increasingly more melanoma patients are being included in prospectively collected databases and our understanding of the biology of melanoma is improving. Therefore, the melanoma staging system is constantly being revised. The currently valid American Joint Committee on Cancer (AJCC) staging system for melanoma has been in place since early 2010 and is crucial for the determination of appropriate treatment, follow-up, and evaluating the risk of recurrence. Staging of a localized primary melanoma is based on the histopathological characteristics of the tumor: Breslow tumor thickness, mitotic rate, and presence or absence of ulceration. The Clark level of invasion is no longer recommended as a staging criterion. When mitotic rate is taken into consideration, it is no longer an independent prognostic factor. Other important and independent adverse predictors of primary cutaneous melanoma survival that are not part of the AJCC staging system are the age and sex of the patient and the anatomic location of the primary tumor. These factors, combined with the melanoma's histopathological features, could predict an individual patient's prognosis more precisely than the AJCC staging system currently in use.