Search

Your search keyword '"Liikanen, Ilkka"' showing total 176 results
Start Over Author "Liikanen, Ilkka"
176 results on '"Liikanen, Ilkka"'

1. The Language of Borders

Author

Konrad, Victor, Laine, Jussi P., Liikanen, Ilkka, Scott, James W., Widdis, Randy, Brunn, Stanley D., editor, and Kehrein, Roland, editor

Published
2020
Full Text
View/download PDF

3. Introduction

Author

Laine, Jussi P., primary, Liikanen, Ilkka, additional, and Scott, James W., additional

Published
2021
Full Text
View/download PDF

5. The Language of Borders

Author

Konrad, Victor, primary, Laine, Jussi P., additional, Liikanen, Ilkka, additional, Scott, James W., additional, and Widdis, Randy, additional

Published
2019
Full Text
View/download PDF

6. The Language of Borders

Author

Konrad, Victor, primary, Laine, Jussi P., additional, Liikanen, Ilkka, additional, Scott, James W., additional, and Widdis, Randy, additional

Published
2018
Full Text
View/download PDF

7. Supplementary Figure S6. NK-cells redistribute towards tumors and draining lymph nodes after treatment with trastuzumab-coding oncolytic virus from Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer

Author

Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Guse, Kilian, primary, Gutmann, Theresia, primary, Savola, Paula, primary, Oksanen, Minna, primary, Kanerva, Anna, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

10. Supplementary Figure S1. Trastuzumab-coding oncolytic adenovirus mediates cytotoxicity in several HER2-positive and negative cancer cell lines from Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer

Author

Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Guse, Kilian, primary, Gutmann, Theresia, primary, Savola, Paula, primary, Oksanen, Minna, primary, Kanerva, Anna, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

12. Supplementary Figure S2. Oncolytic adenovirus coding for trastuzumab shows superior cell killing efficacy when dosed according to functional titers from Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer

Author

Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Guse, Kilian, primary, Gutmann, Theresia, primary, Savola, Paula, primary, Oksanen, Minna, primary, Kanerva, Anna, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

13. Supplementary Figure S4. Oncolytic adenoviruses inhibit tumor growth, while trastuzumab transgene does not add to efficacy against HER2-negative breast cancer in vivo from Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer

Author

Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Guse, Kilian, primary, Gutmann, Theresia, primary, Savola, Paula, primary, Oksanen, Minna, primary, Kanerva, Anna, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

14. Supplementary Figure 1 from Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF–Coding Oncolytic Adenovirus

Author

Kanerva, Anna, primary, Nokisalmi, Petri, primary, Diaconu, Iulia, primary, Koski, Anniina, primary, Cerullo, Vincenzo, primary, Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Oksanen, Minna, primary, Heiskanen, Raita, primary, Pesonen, Saila, primary, Joensuu, Timo, primary, Alanko, Tuomo, primary, Partanen, Kaarina, primary, Laasonen, Leena, primary, Kairemo, Kalevi, primary, Pesonen, Sari, primary, Kangasniemi, Lotta, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

15. Supplementary Figure Legend from Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF–Coding Oncolytic Adenovirus

Author

Kanerva, Anna, primary, Nokisalmi, Petri, primary, Diaconu, Iulia, primary, Koski, Anniina, primary, Cerullo, Vincenzo, primary, Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Oksanen, Minna, primary, Heiskanen, Raita, primary, Pesonen, Saila, primary, Joensuu, Timo, primary, Alanko, Tuomo, primary, Partanen, Kaarina, primary, Laasonen, Leena, primary, Kairemo, Kalevi, primary, Pesonen, Sari, primary, Kangasniemi, Lotta, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

16. Supplementary Table 3 from Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF–Coding Oncolytic Adenovirus

Author

Kanerva, Anna, primary, Nokisalmi, Petri, primary, Diaconu, Iulia, primary, Koski, Anniina, primary, Cerullo, Vincenzo, primary, Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Oksanen, Minna, primary, Heiskanen, Raita, primary, Pesonen, Saila, primary, Joensuu, Timo, primary, Alanko, Tuomo, primary, Partanen, Kaarina, primary, Laasonen, Leena, primary, Kairemo, Kalevi, primary, Pesonen, Sari, primary, Kangasniemi, Lotta, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

17. Supplementary Figure 3 from Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF–Coding Oncolytic Adenovirus

Author

Kanerva, Anna, primary, Nokisalmi, Petri, primary, Diaconu, Iulia, primary, Koski, Anniina, primary, Cerullo, Vincenzo, primary, Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Oksanen, Minna, primary, Heiskanen, Raita, primary, Pesonen, Saila, primary, Joensuu, Timo, primary, Alanko, Tuomo, primary, Partanen, Kaarina, primary, Laasonen, Leena, primary, Kairemo, Kalevi, primary, Pesonen, Sari, primary, Kangasniemi, Lotta, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

18. Supplementary Figure 2 from Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF–Coding Oncolytic Adenovirus

Author

Kanerva, Anna, primary, Nokisalmi, Petri, primary, Diaconu, Iulia, primary, Koski, Anniina, primary, Cerullo, Vincenzo, primary, Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Oksanen, Minna, primary, Heiskanen, Raita, primary, Pesonen, Saila, primary, Joensuu, Timo, primary, Alanko, Tuomo, primary, Partanen, Kaarina, primary, Laasonen, Leena, primary, Kairemo, Kalevi, primary, Pesonen, Sari, primary, Kangasniemi, Lotta, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

19. Supplementary Table 2 from Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF–Coding Oncolytic Adenovirus

Author

Kanerva, Anna, primary, Nokisalmi, Petri, primary, Diaconu, Iulia, primary, Koski, Anniina, primary, Cerullo, Vincenzo, primary, Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Oksanen, Minna, primary, Heiskanen, Raita, primary, Pesonen, Saila, primary, Joensuu, Timo, primary, Alanko, Tuomo, primary, Partanen, Kaarina, primary, Laasonen, Leena, primary, Kairemo, Kalevi, primary, Pesonen, Sari, primary, Kangasniemi, Lotta, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

20. Supplementary Figure 4 from Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF–Coding Oncolytic Adenovirus

Author

Kanerva, Anna, primary, Nokisalmi, Petri, primary, Diaconu, Iulia, primary, Koski, Anniina, primary, Cerullo, Vincenzo, primary, Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Oksanen, Minna, primary, Heiskanen, Raita, primary, Pesonen, Saila, primary, Joensuu, Timo, primary, Alanko, Tuomo, primary, Partanen, Kaarina, primary, Laasonen, Leena, primary, Kairemo, Kalevi, primary, Pesonen, Sari, primary, Kangasniemi, Lotta, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

21. Supplementary Data from Targeted Chemotherapy for Head and Neck Cancer with a Chimeric Oncolytic Adenovirus Coding for Bifunctional Suicide Protein FCU1

Author

Dias, João D., primary, Liikanen, Ilkka, primary, Guse, Kilian, primary, Foloppe, Johann, primary, Sloniecka, Marta, primary, Diaconu, Iulia, primary, Rantanen, Ville, primary, Eriksson, Minna, primary, Hakkarainen, Tanja, primary, Lusky, Monika, primary, Erbs, Philippe, primary, Escutenaire, Sophie, primary, Kanerva, Anna, primary, Pesonen, Sari, primary, Cerullo, Vincenzo, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

22. Supplementary Figure 5 from Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF–Coding Oncolytic Adenovirus

Author

Kanerva, Anna, primary, Nokisalmi, Petri, primary, Diaconu, Iulia, primary, Koski, Anniina, primary, Cerullo, Vincenzo, primary, Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Oksanen, Minna, primary, Heiskanen, Raita, primary, Pesonen, Saila, primary, Joensuu, Timo, primary, Alanko, Tuomo, primary, Partanen, Kaarina, primary, Laasonen, Leena, primary, Kairemo, Kalevi, primary, Pesonen, Sari, primary, Kangasniemi, Lotta, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

23. Supplementary Table 1 from Antiviral and Antitumor T-cell Immunity in Patients Treated with GM-CSF–Coding Oncolytic Adenovirus

Author

Kanerva, Anna, primary, Nokisalmi, Petri, primary, Diaconu, Iulia, primary, Koski, Anniina, primary, Cerullo, Vincenzo, primary, Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Oksanen, Minna, primary, Heiskanen, Raita, primary, Pesonen, Saila, primary, Joensuu, Timo, primary, Alanko, Tuomo, primary, Partanen, Kaarina, primary, Laasonen, Leena, primary, Kairemo, Kalevi, primary, Pesonen, Sari, primary, Kangasniemi, Lotta, primary, and Hemminki, Akseli, primary

Published
2023
Full Text
View/download PDF

24. Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by [CD8.sup.+] T cells

Author

Liikanen, Ilkka, Lauhan, Colette, Quon, Sara, Omilusik, Kyla, Phan, Anthony T., Bartroli, Laura Barcelo, Ferry, Amir, Goulding, John, Chen, Joyce, Scott-Browne, James P., Yustein, Jason T., Scharping, Nicole E., Witherden, Deborah A., and Goldrath, Ananda W.

Subjects
Oncology, Experimental, T cells -- Health aspects, Immune response -- Genetic aspects, Cancer -- Care and treatment -- Research, Transcription factors -- Health aspects, Health care industry
Abstract

Adoptive T cell therapies (ACTs) hold great promise in cancer treatment, but low overall response rates in patients with solid tumors underscore remaining challenges in realizing the potential of this cellular immunotherapy approach. Promoting [CD8.sup.+] T cell adaptation to tissue residency represents an underutilized but promising strategy to improve tumor- infiltrating lymphocyte (TIL) function. Here, we report that deletion of the HIF negative regulator von Hippel-Lindau (VHL) in [CD8.sup.+] T cells induced HIF-1[alpha]/HIF-2[alpha]-dependent differentiation of tissue-resident memory-like (Trm-like) TILs in mouse models of malignancy. VHL-deficient TILs accumulated in tumors and exhibited a core Trm signature despite an exhaustion- associated phenotype, which led to retained polyfunctionality and response to [alpha]PD-1 immunotherapy, resulting in tumor eradication and protective tissue-resident memory. VHL deficiency similarly facilitated enhanced accumulation of chimeric antigen receptor (CAR) T cells with a Trm-like phenotype in tumors. Thus, HIF activity in [CD8.sup.+] TILs promotes accumulation and antitumor activity, providing a new strategy to enhance the efficacy of ACTs., Introduction Immunotherapy is evolving rapidly to provide new strategies for the treatment of cancer. Current immunotherapeutic modalities, including enhancing endogenous tumor-infiltrating lymphocytes (TILs) by checkpoint blockade or adoptive transfer of [...]

Published
2021
Full Text
View/download PDF

27. Introduction

Author

Laine, Jussi P., primary, Liikanen, Ilkka, additional, and Scott, James W., additional

Published
2018
Full Text
View/download PDF

28. Introduction

Author

Webber, Stephen, Liikanen, Ilkka, Webber, Stephen, editor, and Liikanen, Ilkka, editor

Published
2001
Full Text
View/download PDF

35. Oncolytic adenovirus decreases the proportion of TIM-3+ subset of tumor-infiltrating CD8+ T cells with correlation to improved survival in patients with cancer

Author

Liikanen, Ilkka, primary, Basnet, Saru, additional, Quixabeira, Dafne C A, additional, Taipale, Kristian, additional, Hemminki, Otto, additional, Oksanen, Minna, additional, Kankainen, Matti, additional, Juhila, Juuso, additional, Kanerva, Anna, additional, Joensuu, Timo, additional, Tähtinen, Siri, additional, and Hemminki, Akseli, additional

Published
2022
Full Text
View/download PDF

41. T-cell Subsets in Peripheral Blood and Tumors of Patients Treated With Oncolytic Adenoviruses

Author

Taipale Kristian, Ristimaki Ari, Karioja-Kallio Aila, Juhila Juuso, Liikanen Ilkka, Kanerva Anna, Vähä-Koskela Markus, Hemminki Akseli, Lundin Johan, Linder Nina, Koski Anniina, Joensuu Timo, Turkki Riku, and Oksanen Minna

Subjects
Oncolytic adenovirus, Lymphocyte, medicine.medical_treatment, T cell, 03 medical and health sciences, 0302 clinical medicine, Immune system, Drug Discovery, Genetics, medicine, Molecular Biology, 030304 developmental biology, Pharmacology, 0303 health sciences, business.industry, Melanoma, Immunotherapy, medicine.disease, 3. Good health, Oncolytic virus, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Immunology, Molecular Medicine, business, CD8
Abstract

The quality of the antitumor immune response is decisive when developing new immunotherapies for cancer. Oncolytic adenoviruses cause a potent immunogenic stimulus and arming them with costimulatory molecules reshapes the immune response further. We evaluated peripheral blood T-cell subsets of 50 patients with refractory solid tumors undergoing treatment with oncolytic adenovirus. These data were compared to changes in antiviral and antitumor T cells, treatment efficacy, overall survival, and T-cell subsets in pre- and post-treatment tumor biopsies. Treatment caused a significant ( P + cells, and decrease of CD4 + cells. Concomitant treatment with cyclophosphamide and temozolomide resulted in less CD4 + decrease ( P = 0.041) than cyclophosphamide only. Interestingly, we saw a correlation between T-cell changes in peripheral blood and the tumor site. This correlation was positive for CD8 + and inverse for CD4 + cells. These findings give insight to the interconnections between peripheral blood and tumor-infiltrating lymphocyte (TIL) populations regarding oncolytic virotherapy. In particular, our data suggest that induction of T-cell response is not sufficient for clinical response in the context of immunosuppressive tumors, and that peripheral blood T cells have a complicated and potentially misleading relationship with TILs.

Published
2015

44. The EU's Eastern Neighbourhood

Author

Liikanen, Ilkka, Scott, James, and Sotkasiira, Tiina

Subjects
Anaïs Marin, european, Furugzod Usmonov, federation, free, Ihor Markov, James Wesley Scott, James W. Scott, Joni Virkkunen, Larissa Titarenko, labour, migration, Octavian Ţîcu, Oleksii Pozniak, Olga Brednikova, Olga Davydova-Minguet, Olga Filippova, Olga Tkach, Paul Fryer, policies, policy, regime, russian, Sergei Riazantsev, Sergey Rumyantsev, Tiina Sotkasiira, Valeriu Mosneaga, Volodymyr Kravchenko, visa, bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSL Ethnic studies, bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTB Regional studies
Abstract

The collapse of the Soviet Union has had profound and long-lasting impacts on the societies of Eastern Europe, the South Caucasus and Central Asia, impacts which are not yet fully worked through: changes in state-society relations, a comprehensive reconfiguration of political, economic and social ties, the resurgence of regional conflicts "frozen" during the Soviet period, and new migration patterns both towards Russia and the European Union. At the same time the EU has emerged as an important player in the region, formulating its European Neighbourhood Policy, and engaging neighbouring states in a process of cross-border regional co-operation. This book explores a wide range of complex and contested questions related to borders, security and migration in the emerging "European Neighbourhood" which includes countries of the Caucasus and Central Asia as well as the countries which immediately border the EU. Issues discussed include new forms of regional and cross-border co-operation, new patterns of migration, and the potential role of the EU as a stabilizing external force.

Published
2016
Full Text
View/download PDF

50. Chronic Activation of Innate Immunity Correlates With Poor Prognosis in Cancer Patients Treated With Oncolytic Adenovirus

Author

Taipale, Kristian, primary, Liikanen, Ilkka, additional, Juhila, Juuso, additional, Turkki, Riku, additional, Tähtinen, Siri, additional, Kankainen, Matti, additional, Vassilev, Lotta, additional, Ristimäki, Ari, additional, Koski, Anniina, additional, Kanerva, Anna, additional, Diaconu, Iulia, additional, Cerullo, Vincenzo, additional, Vähä-Koskela, Markus, additional, Oksanen, Minna, additional, Linder, Nina, additional, Joensuu, Timo, additional, Lundin, Johan, additional, and Hemminki, Akseli, additional

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results