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By virtue of their green and environmentally friendly properties, photocatalysis has become one of the most ideal solutions for antibiotic pollution. Herein, a series of direct Z-scheme Zn0.5Cd0.5S/NiCo2O4 photocatalysts have been successfully fabricated. The obtained Zn0.5Cd0.5S/NiCo2O4 photocatalysts displayed outstanding photocatalytic performance for tetracycline hydrochloride (TC-HCl) degradation under the irradiation of a low-energy lamp (white LED lamp, 5 W). Compared to pure Zn0.5Cd0.5S nanoparticles and NiCo2O4 nanosheets, the Zn0.5Cd0.5S/NiCo2O4 photocatalysts exhibited significantly enhanced photocatalytic activity. This pleasantly surprised result can be attributed to the formation of Z-scheme heterojunction, which effectively inhibited the recombination of electron–hole pairs and boosted the transfer efficiency of photoinduced electrons. Moreover, anchoring Zn0.5Cd0.5S nanoparticles on the surface of NiCo2O4 nanosheets can effectively reduce the aggregation of Zn0.5Cd0.5S nanoparticles and thus increase the active site. Furthermore, free radical trapping experiments confirmed that •O2− and h+ radicals play a major role in the photocatalytic process and verified the rationality of the proposed Z-scheme mechanism. Therefore, our study provides a simple strategy for the construction of direct Z-scheme system with outstanding photocatalytic performance.

Controllable fabrication of nanomaterials with hierarchical architecture have received much attention in the field of photocatalysis due to their enhanced light-harvesting efficiency. Moreover, fabricating direct Z-scheme heterojunctions have been proven to be effective way to enhance the photocatalytic performance of photocatalysts. Herein, hierarchically hollow WO3 nanoflower was successfully synthesized by a simple hydrothermal treatment of tungsten chloride (WCl6) in ethanol solution. Decoration of the obtained WO3 with AgI nanoparticles in situ can form the Z-scheme AgI/WO3 hollow hierarchical nanoflowers (AgI/WO3 HHNFs). The AgI/WO3 HHNFs exhibited excellent photocatalytic activity and remarkable stability for the degradation of tetracycline hydrochloride (TC-HCl) and Eosin B (EB) under the irradiation of a low energy consume light (LED lamp, 5 W). Interestingly, compared to pure AgI nanoparticles, 3D hollow WO3 nanoflowers and AgI/WO3 nanosheets, the AgI/WO3 HHNFs revealed conspicuously enhanced photocatalytic activity. This phenomenon could be associated to three aspects, namely the high light-harvesting efficiency, increased light trapping and scattering capability and strongly coupled Z-scheme heterointerface, which effectively improved the photoelectron-hole sepreation efficiency. Our work therefore provide a novel insight for the fabrication of 3D hollow hierarchical structures.

The construction of noble metal-free materials with remarkable activity and high stability via a simple, green, efficient, and low-cost method remains a crucial task for addressing the problem of water contamination. Herein, ultrathin NiCo2O4 nanosheets were in situ assembled on the surface of BiOCl single-crystal nanosheets with a vertical orientation to form a well-defined hierarchically porous structure. Notably, the obtained BiOCl@NiCo2O4 nanoplates displayed outstanding catalytic activity in the reductive conversion of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP). On account of their special morphology, plentiful porosity, and good stability, the as-prepared composite could finish the reduction reaction within 280 s with a large rate constant (kapp) of 7.18 × 10−3 s−1. The BiOCl@NiCo2O4 nanoplates possessed excellent recyclability, and the original activity could be maintained even after seven consecutive cycles. Furthermore, the resultant BiOCl@NiCo2O4 could also act as a hyperactive catalyst for the reductive discoloration of organic dyes (rhodamine B, rhodamine 6G, Congo red, and methyl orange). Our strategy, therefore, promotes the development of low-cost and high-performance noble metal-free catalysts to treat water pollution.

With the increasing energy and environmental crisis, exploring convenient and general strategies for constructing of highly active, stable, and cost-effective bifunctional electrocatalysts for overall water splitting are exceedingly desirable yet still challenging. Herein, 3D hierarchical mesoporous cobalt phosphide embedded N-doped carbon nanoflowers (CoP@NCNFs) are successfully constructed with ultrathin nanosheets by phosphatingof the cobalt coordination polymer nanoflowers (CoCPNFs). By virtue of their unique architecture and particular composition, the obtained CoP@NCNFs reveal extraordinary performance with ultralow overpotentials and small Tafel slopes for both OER (291 mV at 10 mA cm

Reactions of polycarboxylic acid ligands (H3cpa = 3-(4-carboxy-2-methoxyphenoxy) phthalic acid, H3cmp = 4-(4-carboxy-2-methoxyphenoxy) phthalic acid), N-containing ligand (bimp = 1,4-di(1H-imidazol-1-yl) benzene), with cobalt and cadmium salts under diverse reaction conditions have afforded two novel metal-organic frameworks: [Co3(cpa)2(bimp)2]n (1), [Cd2(cmp)(bimp)2]n (2). The V-shape organic polycarboxylic acid ligands play vital roles in determining the final structure and properties of the complexes. Complex 1 has a 3D structure constructed via bimp ligand connecting adjacent 2D layers and complex 2 has a 3D network with right-handed screw. Magnetic susceptibility measurements (χM) for complex 1 has been performed, and revealed predominant antiferromagnetic behavior. Complex 2 has been employed as a type of fluorescent probe to monitor different metal ions, and showed the obviously selective response to Fe3+ ion through luminescence quenching.

UNSTRUCTURED Internet hospitals, as a new forum for doctors to conduct diagnosis and treatment activities based on the internet, are emerging in China and have become integral to the development of the medical field in conjunction with increasing reforms and policies in China’s medical and health system. Here, we take the Internet Hospital of the First Affiliated Hospital, Zhejiang University (FAHZU Internet Hospital) as an example to discuss the operations and functional positioning of developing internet hospital medical services in relation to physical hospitals. This viewpoint considers the platform operation, management, and network security of FAHZU Internet Hospital, and summarizes the advantages and limitations in the operation to provide a reference for other areas with interest in developing internet hospitals.

Controllable fabrication of nanomaterials with hierarchical architecture have received much attention in the field of photocatalysis due to their enhanced light-harvesting efficiency. Moreover, fabricating direct Z-scheme heterojunctions havebeenproven to be effective way to enhance the photocatalytic performance of photocatalysts. Herein, hierarchically hollow WO

By virtue of their unique features, including simplicity, speed and portability, point-of-care testing (POCT) is critical for biochemical analysis in resource-limited environments. However, a single-signal readout cannot fulfil the requirements of accurate quantitative analysis due to interference from environmental factors. Hence, establishing a convenient multimodal assay method based on the concept of POCT detection is urgently desired. Herein, a novel multimode (i.e., photothermal, electrochemical, UV-Vis absorption and fluorescence) sensing strategy based on oxygen-vacancy-rich MnO2 nanosheets decorated with methylene blue (MB) is unveiled for multifunctional detection of ascorbic acid (AA). In this multimode nanosensor (MnO2@MB NSs), MnO2 nanosheets act as a photothermal agent and carrier for MB, showing an ultrasensitive response to AA, which enables photothermal signals turn “on” to “off”, and can be monitored by a thermometer. In the meantime, large amounts of MB are released to the detection solution, resulting in the absorbance, fluorescence and electrochemistry signals turning “off” to “on”. Thus, this nanosensor enables four-signal determination of AA in a supersensitive manner and exhibits a more reliable analysis result. Furthermore, MnO2@MB NSs can be even used to achieve point-of-care testing, greatly improving their application scope. Our strategy opens up a new avenue for the exploration of multistimulus-responsive nanosensors for convenient, stable, and accurate analysis of AA.

Two series of lanthanide metal organic frameworks (Ln–MOFs) [Ln(HL)(H2O)3]·H2O and [Ln(HL)(H2O)2] (Ln = Tb, 1; Er, 4; Tm, 5; Yb, 6; and Dy, 2; Ho, 3) have been successfully assembled by Ln3+ ions and asymmetric polycarboxylate ligand 3-(3′,5′-dicarboxyl-phenoxy) phthalic acid (H4L). The crystal structures, photoluminescence, and magnetic properties of these compounds have been investigated. Complexes 1, 4, 5, and 6 are isostructural and show 2D layer frameworks constructed by hydrogen bonding interactions between the coordination water molecules and the O atoms of the carboxyl group. Complexes 2 and 3 show 3D frameworks with two different interlayer channels decorated by ligands and lanthanide metals. The emission spectra show that complex 1 displays an intense green light emission and can selectively and sensitively detect for Fe3+ ion and nitromethane. In addition, near infrared (NIR) luminescence and magnetic susceptibility measurments further show that these compounds are promising functional materials.

Internet hospitals, as a new forum for doctors to conduct diagnosis and treatment activities based on the internet, are emerging in China and have become integral to the development of the medical field in conjunction with increasing reforms and policies in China’s medical and health system. Here, we take the Internet Hospital of the First Affiliated Hospital, Zhejiang University (FAHZU Internet Hospital) as an example to discuss the operations and functional positioning of developing internet hospital medical services in relation to physical hospitals. This viewpoint considers the platform operation, management, and network security of FAHZU Internet Hospital, and summarizes the advantages and limitations in the operation to provide a reference for other areas with interest in developing internet hospitals.

Visible light mediated photoredox arylations can proceed under very mild conditions and have therefore become attractive. Nowadays, various metal nanomaterials and metal complexes have been developed as photocatalysts for direct arylation of heteroaromatics. These photocatalysts, however, still suffer from corrosion, high cost, aggregation or poor stability. We report the design and fabrication of a g-C3N4/rGO nanocomposite and demonstrate its excellent activity, high apparent quantum efficiency, and recyclability to catalyze the metal free direct arylation of heteroaromatics under visible light at room temperature. Moreover, the g-C3N4/rGO catalyst can be reused more than five times without significant loss of activity, confirming this catalyst's excellent stability. The present strategy to fabricate a metal-free g-C3N4/rGO nanocomposite for direct C–H arylation open a new avenue towards replacing metal-based catalysts in fine organic synthesis.

9060 Background: Dual blockade of PD-1 and CTLA-4 has shown improved overall survival (OS) in combination with a short course of chemotherapy. KN046 is a novel bispecific antibody that blocks both PD-L1 interaction with PD-1/CD80 and CTLA-4 interaction with CD80/CD86. We hypothesized that KN046 could be combined with a full course of chemotherapy and build more durable clinical benefit. Methods: This study enrolled systemic treatment naive, stage IV NSCLC patients (pts). Eligible pts received KN046 plus platinum doublet chemotherapy until progressive disease, unacceptable toxicity, withdrawal of informed consent or death. Efficacy evaluation was performed by investigators per RECIST 1.1. Safety and tolerability were assessed per NCI-CTCAE v5.0. Results: As of the Jan. 19, 2021, 87 pts [Cohort 1 (n = 51), Cohort 2 (n = 36)] have been enrolled with 83 pts having tumor PD-L1 expression data (PD-L1 ≥1%: 55.4%; PD-L1 < 1%: 44.6%). 33.3% pts remained on the study treatment and 66.7% pts discontinued treatment due to disease progression (27.6%), TEAE (13.8%), death (9.2%) and other reasons (16%). The median treatment duration of KN046 was 21 weeks (range: 1.6̃68.7 weeks). Treatment related TEAE (TRAE) occurred in 92% pts. 25.3% pts experienced Grade≥3 TRAE [diarrhoea (5.7%), alanine aminotransferase increased (4.6%), infusion related reaction (3.4%), rash (3.4%), aspartate aminotransferase increased, dermatitis allergic and immune-mediated pneumonitis (2.3%, respectively), anaphylactoid reaction, autoimmune hepatitis, back pain, bilirubin conjugated increased, hypertension, neutrophil count decreased, platelet count decreased, pneumonitis, rash maculo-papular, septic shock and white blood cell count decreased (1.1%, respectively). In 81 efficacy evaluable pts, the overall objective response rate (ORR) was 50.6% (95% CI: 39.3%,61.9%) and disease control rate (DCR) was 87.7% (95% CI: 78.5%-93.9%). The ORR and DCR in pts with non-squamous NSCLC (n = 48) were 45.8% (95% CI: 31.4%, 60.8%) and 89.6% (95% CI: 77.3%, 96.5%). The ORR and DCR in pts with squamous NSCLC (n = 33) were 57.6% (95% CI: 39.2%, 74.5%) and 84.8% (95% CI: 68.1%, 94.9). Progression free survival (PFS) and OS events have occurred in 53% and 18% patients. Median PFS was 5.9 (95%CI: 5.3, 8.7) months. Median OS was not reached. OS rate at 12 and 15 months were both 74.9%. Similar OS curves have been observed in PD-L1 ≥1% and PD-L1 < 1% pts. In PD-L1 ≥1% patients, median PFS was 6.7 months (10.8 months for PD-L1 ≥1% squamous NSCLC pts). Conclusions: KN046 combined with platinum doublet chemotherapy is tolerated and has shown promising clinical benefit as IL treatment for stage IV NSCLC particularly in PD-L1≥1% tumors and squamous histology. Pivotal Phase III trial in advanced unresectable or metastatic squamous NSCLC is currently ongoing. Clinical trial information: NCT04054531.

Tremendous efforts have been made to design novel type semiconductor photocatalysts as promising candidates to solve the problem of aquatic pollution. However, the exploration of photocatalysts with high activity and stability for removing heavy metal ions and antibiotics from water through visible light photocatalysis is still a challenge. In this work, a series of Z-scheme photocatalysts X% CdS/NiCo2O4 (X = 30, 40, 50, 60, 70) have been successfully constructed by a hydrothermal method. By anchoring the CdS nanoparticles on the surface of NiCo2O4 nanosheets, the obtained CdS/NiCo2O4 exhibits the narrower bandgap energy compare to CdS nanoparticles, which can enhance the visible light harvesting efficiency and suppress the electron-hole recombination, improving the photocatalytic activity. Moreover, the introduction of NiCo2O4 nanosheets cannot only inhibit the aggregation of CdS nanoparticles and increase the stability of the composite, but also improve the adsorption of pollutants on the surface of the composite. By virtue of these advantages, the best-performing CdS/NiCo2O4 (60 % CdS/NiCo2O4) revealed outstanding visible-light driven photocatalytic activity toward the degradation of Cr (VI) and Tetracycline Hydrochloride (TC−HCl) under the irradiation of a low energy consuming light (LED lamp, 5 W). Compared with pure CdS nanopaticles, the catalytic performance of 60 % CdS/NiCo2O4 for Cr (VI) and TC−HCl increased approximately 3.9 times and 32.7 times, respectively. Furthermore, the 60 % CdS/NiCo2O4 exhibits fantastic recyclability, its catalytic activity is nearly unchanged even after six cycles. Meaningfully, as an efficient visible-light photocatalyst, 60 % CdS/NiCo2O4 can be applied to reduction of Cr (VI) and degradation of TC−HCl in natural water samples (Yellow River water, which collected in Lanzhou section), which greatly expanded its application in practice.

Precise detection and effectively eliminating mercury pollution in aqueous solutions remains an onerous task for protecting the public health and environment. In this paper, porous MoS2 composite aerogel-supported Au nanoparticles with strong mercury affinity have been fabricated to deal with this problem. Such composite aerogels are fabricated using graphene oxide (GO)-doped MoS2 sheets as the feedstock by hydrothermal assembly and then the Au and Fe3O4 nanoparticles (NPs) embed between the GO-doped MoS2 sheets through coordination. The resultant porous Au/Fe3O4/MoS2CAs aerogel not only can sensitively detect mercury(II) in aqueous solution by a colorimetric method with a low detection limit (3.279 nM) but also can exhibit a super mercury adsorption capacity (∼1527 mg g–1) and fast desorption ability. After magnetic separation, the Hg2+ levels decreased from 10 ppm to 0.11 ppb within a few minutes, which is far below 2 ppb. In addition, Au/Fe3O4/MoS2CAs could be successively recycled more than 10 times w...

The three-dimensional porous Fe3O4@Cu2-xS-MoS2 framework is reported for the first time. The as-prepared 3D framework exhibits good structural stability, high surface area, enhanced adsorption capacity to substrates, and strong absorption in the NIR range. As a result, such hybrid frameworks exhibit excellent NIR-light photocatalytic activity and stable cycling for the direct arylation of heteroaromatics at room temperature.

The fabrication of noble metal free catalysts with excellent performance and high stability by a simple, efficient, general and low-cost approach remains an urgent task for solving the problem of resource shortage. Herein, Cu-based metal organic frameworks (MOFs) immobilized on commercial filter papers were used as pyrolysis precursors to synthesize CuxO@C at various calcination temperatures. Notably, the resultant CuxO@C-400 exhibits an excellent catalytic performance toward the reaction of reducing 4-nitrophenol (4-NP) to 4-aminophenol (4-AP). By virtue of the large specific surface area, well-developed porosity, good stability and high dispersity of CuxO nanoparticles, the obtained CuxO@C-400 could complete the reduction reaction within 11 min with a large apparent rate constant κapp value (4.8 × 10-3 s-1). Our strategy therefore opens a new avenue for the preparation of low-cost and high-performance noble metal free catalysts.

Fluorescent chemosensors for detecting single anions have been largely synthesized. However, the simultaneous detection and degradation of multiple anions remain a major challenge. Herein we report the synthesis of a white emission nanoprobe on the basis of a Coumarin-Rhodamine CR1-Eu complex coordinated to dipicolinic acid (dpa)-PEG-Fe3O4 nanoparticles for the selective detection of ClO(-) and SCN(-) ions on controlling by a logic gate. The obtained nanoprobe exhibits three individual primary colors (blue, green, and red) as well as white emission at different excitation energies. Interestingly, this nanoprobe shows a marked rose red to violet emission color change in response to ClO(-), a reversible violet to rose red emission color change in response to SCN(-), and high ClO(-) and SCN(-) selectivity and sensitivity with a detection limit of 0.037 and 0.250 nM, respectively. Furthermore, the SCN(-) and ClO(-) can degrade simultaneously through the redox reaction between ClO(-) and SCN(-).

The development of sensitive and reliable methods to monitor the presence of mercuric ions in cells and organisms is of great importance to biological research and biomedical applications. In this work, we propose a strategy to construct a solar-driven nanoprobe using a 3D Au@MoS2 heterostructure as a photocatalyst and rhodamine B (RB) as a fluorescent and color change reporter molecule for monitoring Hg2+ in living cells and animals. The sensing mechanism is based on the photoinduced electron formation of gold amalgam in the 3D Au@MoS2 heterostructure under visible light illumination. This formation is able to remarkably inhibit the photocatalytic activity of the heterostructure toward RB decomposition. As a result, “OFF–ON” fluorescence and color change are produced. Such characteristics enable this new sensing platform to sensitively and selectively detect Hg2+ in water by fluorescence and colorimetric methods. The detection limits of the fluorescence assay and colorimetric assay are 0.22 and 0.038 nM ...

An improved solid-state reaction route has been employed to synthesize Mg2+-doped LiFePO4/C nanocomposite cathode by calcining the precursor obtained via evaporating the mixture of ascorbic acid, LiCH3COO·2H2O, Mg(CH3COO)2·4H2O, and amorphous FePO4 nanoparticles in anhydrous ethanol under continuous stirring. Ascorbic acid used here acted as both reducing agent and carbon source. The amorphous FePO4 was pre-prepared via a simple and fast oxidic precipitation method. Electrochemical tests showed that the final product exhibited good rate and cycling performance, with discharge capacities of 145.2 mAh g−1 at 0.2 C, 129.8 mAh g−1 at 1 C, 107.6mAh g−1 at 5 C, and 81.4 mAh g−1 at 20 C, respectively. The Mg2+-doped LiFePO4/C showed enhanced charge–discharge performance compared with undoped LiFePO4/C, especially at high rates. The enhanced electrochemical performance of the composite could be attributed to a combination result of the fine particle size with narrow particle size distribution, homogeneous carbon coating on the surface of the particles, and magnesium ion doping.

Fe(3)O(4) nanoparticles (NPs) decorated with rhodamine 6G Schiff base, which exhibit high selectivity and sensitivity toward Al(3+) over other common metal ions in aqueous media under a physiological pH window via a 1:1 binding mode, have been synthesized and characterized. The resulting conjugate renders the rhodamine 6G Schiff base unit more water soluble, and the detection limit reaches 0.3 ppb in water. Moreover, can detect Al(3+) in a wide pH span (5.0-11.0) and enrich/remove excess Al(3+) in water via an external magnetic field, which indicates that it has more potential and further practical applications for biology and toxicology. Furthermore, provides good fluorescent imaging of Al(3+) in living cells.

Fe3O4 nanoparticles (NPs) decorated with rhodamine 6G Schiff base, which exhibit high selectivity and sensitivity toward Al3+ over other common metal ions in aqueous media under a physiological pH window via a 1 : 1 binding mode, have been synthesized and characterized. The resulting conjugate 1c renders the rhodamine 6G Schiff base unit more water soluble, and the detection limit reaches 0.3 ppb in water. Moreover, 1c can detect Al3+ in a wide pH span (5.0–11.0) and enrich/remove excess Al3+ in water via an external magnetic field, which indicates that it has more potential and further practical applications for biology and toxicology. Furthermore, 1c provides good fluorescent imaging of Al3+ in living cells.