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Mucormycosis is an invasive opportunistic fungal infection, which may be lethal and mostly affects patients with immunodeficiency or diabetes mellitus. Among Mucorales fungi, Rhizopus spp. is the most common cause of mucormycosis, followed by genera such as Mucor and Lichtheimia. Here we report a patient with severe COVID-19 infection who developed nasal pain, facial swelling, prominent black eschar on the nasal root. CT scan revealed pansinusitis along the maxillary, ethmoidal, and sphenoid sinuses. Mixed mold infection with Rhizopus microsporus and Mucor racemosus was detected by blood metagenomics next-generation sequencing (mNGS) and later nasal mucosa histological investigation confirmed mucormycosis. Severe COVID-19 infection led to the patient's thrombocytopenia and leukopenia. Later disseminated mucormycosis aggravated the infection and sepsis eventually resulted in death.It is the first case report of mucormycosis in which R. microsporus and M. racemosus as the etiologic agents were found simultaneously in one patient. COVID-19 infection combined with disseminated mucormycosisis can be fatal and mNGS is a fast, sensitive and accurate diagnostic method for fungi detection.

The method outlined in this paper is convenient and effective for studying the thermal performance of fuel assemblies cooled with sodium fast reactors using the subchannel procedure. To initially study an optimization model for a symmetric single fuel assembly heat transfer pattern analysis in a fast sodium-cooled reactor based on subchannel calculations, this paper innovatively proposes a subchannel heat transfer analysis method with the entransy dissipation theory, which can solve the limitations and inaccuracies of the traditional entropy method such as poor applicability for heat transfer processes without functional conversion and the paradox of entropy production of heat exchangers. The symmetric distributions of the thermal-hydraulic parameters such as coolant flow rate, coolant temperature, cladding temperature, and fuel pellet temperature were calculated, and the entransy dissipation calculation method corresponding to the fuel assembly subchannels was derived based on the entransy theory. The effect of subchannel differences on the thermal-hydraulic parameters and the symmetric distribution pattern of entransy dissipation during the cooling process of the fuel assembly was analyzed and compared from the symmetrical arrangement of subchannels in the axial and radial directions.

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