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BackgroundGenetic-epidemiological studies that estimate the contributions of genetic factors to variation in tic symptoms are scarce. We estimated the extent to which genetic and environmental influences contribute to tics, employing various phenotypic definitions ranging between mild and severe symptomatology, in a large population-based adult twin-family sample.MethodIn an extended twin-family design, we analysed lifetime tic data reported by adult mono- and dizygotic twins (n = 8323) and their family members (n = 7164; parents and siblings) from 7311 families in the Netherlands Twin Register. We measured tics by the abbreviated version of the Schedule for Tourette and Other Behavioral Syndromes. Heritability was estimated by genetic structural equation modeling for four tic disorder definitions: three dichotomous and one trichotomous phenotype, characterized by increasingly strictly defined criteria.ResultsPrevalence rates of the different tic disorders in our sample varied between 0.3 and 4.5% depending on tic disorder definition. Tic frequencies decreased with increasing age. Heritability estimates varied between 0.25 and 0.37, depending on phenotypic definitions. None of the phenotypes showed evidence of assortative mating, effects of shared environment or non-additive genetic effects.ConclusionsHeritabilities of mild and severe tic phenotypes were estimated to be moderate. Overlapping confidence intervals of the heritability estimates suggest overlapping genetic liabilities between the various tic phenotypes. The most lenient phenotype (defined only by tic characteristics, excluding criteria B, C and D of DSM-IV) rendered sufficiently reliable heritability estimates. These findings have implications in phenotypic definitions for future genetic studies.

Many radar measurements of the atmosphere can be explained in terms of two scattering mechanisms: incoherent scattering from particles, and coherent scattering from variations in the refractive index of the air, commonly called clear-air or Bragg scattering. Spatial variations in the liquid water content of clouds may also give a coherent contribution to the radar return, but it is commonly believed that this coherent scattering from the droplets is insignificant because variations in humidity have a much larger influence on the refractive index than equal variations in liquid water content. It is argued that the fluctuations in water vapor mixing ratio in clouds can be much smaller than those in liquid water mixing ratio. In this article an expression for the strength of the coherent scattering from particles will be derived for fluctuations caused by turbulent mixing with clean (i.e., particle-free) air, where it will be assumed that the particles follow the flow, that is, their inertia is neglected. It will be shown that the coherent contribution adds to the incoherent contribution, the latter always being present. The coherent particle scattering can be stronger than the incoherent scattering, especially at longer wavelengths and high particle concentrations. Recently published dual-frequency measurements of developing cumulus clouds and smoke show a correlation for which no explanation has been found in terms of incoherent particle scattering and coherent air scattering. Scatterplots of the reflectivity factors at both frequencies show a clustering of points in between the values that correspond to pure clear-air and pure incoherent scattering. Those differences in the radar reflectivity factors could be due to a mixture of Bragg scattering and incoherent particle scattering, but then no correlation is expected, because the origin of the scattering mechanism that dominates at each wavelength is different. However, coherent scattering from the particles can cause the radar reflectivities of dual-wavelength radar measurements to become correlated with each other. It may explain the slopes and the differences seen in the scatterplots of the radar reflectivities of cloud and smoke measurements, with reasonable values of the parameters involved. However, the correlation between the radar reflectivities is very tight near the cloud top and seems to be present in adiabatic cores as well. This is an indication that, apart from mixing with environmental air, the inertia of the droplets could also be important for the creation of small-scale fluctuations in droplet concentration.