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3 results on '"Light-activated ion channels"'

1. Optogenetics Comes of Age: Novel Inhibitory Light-Gated Anionic Channels Allow Efficient Silencing of Neural Function

Author

Alex Perálvarez-Marín, Pere Garriga, Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, and Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial

Subjects
0301 basic medicine, Cellular signal transduction, Light, Light-activated ion channels, Nanotechnology, Brain function, Optogenetics, Signal transduction, Inhibitory postsynaptic potential, Biochemistry, Ion Channels, 03 medical and health sciences, 0302 clinical medicine, Neurobiology, Rhodopsins, Microbial, Gene silencing, Humans, Rhodopsins, Molecular Biology, Ion channel, Chemistry, Organic Chemistry, Transducció de senyal cel·lular, Brain, 030104 developmental biology, Neural function, Molecular Medicine, Neuroscience, 030217 neurology & neurosurgery, Neurobiologia, Enginyeria química::Química orgànica::Bioquímica [Àrees temàtiques de la UPC], Signal Transduction
Abstract

This is the peer reviewed version of the following article: A. Peralvárez-Marín, P. Garriga, Optogenetics Comes of Age: Novel Inhibitory Light-Gated Anionic Channels Allow Efficient Silencing of Neural Function. ChemBioChem 2016, 17, 204-206, which has been published in final form at http://dx.doi.org/10.1002/cbic.201500608. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving Optogenetics, the developing field of research that uses light-switchable biochemical tools in a sophisticated technological approach to monitor or control neural function, is rapidly evolving with the discovery and development of novel microbial rhodopsins. Light-absorbing membrane proteins, as tools for brain research, are promoting new applications within the discipline of optogenetics. Light-gated rhodopsin ion channels with better intrinsic light sensitivity and improved resolution are needed to overcome some of the current limitations of existing molecules. The recent discovery of light-gated inhibitory anion channels opens new opportunities for studying physiological neural processes and, at the same time, represent a powerful approach for elucidating the mechanisms of neurological and mental disorders that could benefit from this approach.

Published
2015

2. Optogenetics comes of age: novel inhibitory light-gated anionic channels allow efficient silencing of neural function

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial, Peralvarez Marin, Alex, Garriga Solé, Pere, Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial, Peralvarez Marin, Alex, and Garriga Solé, Pere

Abstract

This is the peer reviewed version of the following article: A. Peralvárez-Marín, P. Garriga, Optogenetics Comes of Age: Novel Inhibitory Light-Gated Anionic Channels Allow Efficient Silencing of Neural Function. ChemBioChem 2016, 17, 204-206, which has been published in final form at http://dx.doi.org/10.1002/cbic.201500608. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving, Optogenetics, the developing field of research that uses light-switchable biochemical tools in a sophisticated technological approach to monitor or control neural function, is rapidly evolving with the discovery and development of novel microbial rhodopsins. Light-absorbing membrane proteins, as tools for brain research, are promoting new applications within the discipline of optogenetics. Light-gated rhodopsin ion channels with better intrinsic light sensitivity and improved resolution are needed to overcome some of the current limitations of existing molecules. The recent discovery of light-gated inhibitory anion channels opens new opportunities for studying physiological neural processes and, at the same time, represent a powerful approach for elucidating the mechanisms of neurological and mental disorders that could benefit from this approach., Peer Reviewed, Postprint (published version)

Published
2016

3. Optogenetics Comes of Age: Novel Inhibitory Light-Gated Anionic Channels Allow Efficient Silencing of Neural Function.

Author

Peralvárez-Marín A and Garriga P

Subjects
Brain metabolism, Humans, Light, Rhodopsins, Microbial metabolism, Signal Transduction, Ion Channels metabolism, Optogenetics
Abstract

Optogenetics, the developing field of research that uses light-switchable biochemical tools in a sophisticated technological approach to monitor or control neural function, is rapidly evolving with the discovery and development of novel microbial rhodopsins. Light-absorbing membrane proteins, as tools for brain research, are promoting new applications within the discipline of optogenetics. Light-gated rhodopsin ion channels with better intrinsic light sensitivity and improved resolution are needed to overcome some of the current limitations of existing molecules. The recent discovery of light-gated inhibitory anion channels opens new opportunities for studying physiological neural processes and, at the same time, represent a powerful approach for elucidating the mechanisms of neurological and mental disorders that could benefit from this approach., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2016
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