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16 results on '"Ligeour, Caroline"'

1. Cibler la lectine soluble Leca de Pseudomonas aeruginosa: une approche Drug-discovery sur DDI-microarray

Author

Dupin, Lucie, Meyer, Albert, Phaner-Goutorbe, Magali, Morvan, François, Laurenceau, Emmanuelle, Vergoten, G., Vasseur, Jean-Jacques, Casoni, Francesca, Ligeour, Caroline, Darblade, B., Vidal, Olivier, Gehin, Thomas, Chevolot, Yann, INL - Chimie et Nanobiotechnologies (INL - C&N), Institut des Nanotechnologies de Lyon (INL), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École supérieure de Chimie Physique Electronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École supérieure de Chimie Physique Electronique de Lyon (CPE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Centrale de Lyon (ECL), Université de Lyon, Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Université de Lille-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.OTHE]Chemical Sciences/Other, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

2. The anti-adhesive effect of glycoclusters onPseudomonas aeruginosabacteria adhesion to epithelial cells studied by AFM single cell force spectroscopy

Author

Zuttion, Francesca, primary, Ligeour, Caroline, additional, Vidal, Olivier, additional, Wälte, Mike, additional, Morvan, François, additional, Vidal, Sébastien, additional, Vasseur, Jean-Jacques, additional, Chevolot, Yann, additional, Phaner-Goutorbe, Magali, additional, and Schillers, Hermann, additional

Published
2018
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3. Synthesis of Galactoclusters by Metal-Free Thiol 'Click Chemistry' and Their Binding Affinities for Pseudomonas aeruginosa Lectin LecA

Author

Ligeour, Caroline, Dupin, Lucie, Marra, Alberto, Vergoten, Gérard, Meyer, Albert, Dondoni, Alessandro, Souteyrand, Eliane, Vasseur, Jean-Jacques, Chevolot, Yann, Morvan, François, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), INL - Chimie et Nanobiotechnologies (INL - C&N), Institut des Nanotechnologies de Lyon (INL), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École supérieure de Chimie Physique Electronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara and Azienda Ospedaliero-Universitaria Sant'Anna Hospital of Ferrara, Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École supérieure de Chimie Physique Electronique de Lyon (CPE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Centrale de Lyon (ECL), Université de Lyon, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lille-Centre National de la Recherche Scientifique (CNRS), and Università degli Studi di Ferrara = University of Ferrara (UniFE)

Subjects
Click chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Pseudomonas aeruginosa, Oligonucleotides, Glycoclusters, Glycoconjugates
Abstract

International audience; Mannose-centered galactoclusters specific for lectin I of Pseudomonas aeruginosa (LecA) were synthesised by a combination of phosphoramidite chemistry and metal-free thiol click chemistry (i.e., thiol addition to acrylamide or nucleophilic displacement of bromine in a bromoacetamide group by a thiol function). These thiol click reactions were performed with microwave assistance in the presence of Et3N and with use of a reducing agent to avoid disulfide formation. Nine tetravalent galactoclusters containing different linkers (aliphatic, oligoethyleneglycol or aromatic) were synthesised with a DNA tag. Their binding to LecA was monitored in a DNA-based glycoarray and compared with that of a galactocluster synthesised by copper-catalyzed azide–alkyne cycloaddition. The results indicated stronger binding of all galactoclusters relative to the monovalent galactoside but slightly weaker binding than that shown by the galactocluster incorporating a triazole ring, due to a favourable interaction of the latter with proline 51 of LecA.

Published
2014
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5. Mannose-centered aromatic galactoclusters inhibit the biofilm formation of Pseudomonas aeruginosa

Author

Ligeour, Caroline, primary, Vidal, Olivier, additional, Dupin, Lucie, additional, Casoni, Francesca, additional, Gillon, Emilie, additional, Meyer, Albert, additional, Vidal, Sébastien, additional, Vergoten, Gérard, additional, Lacroix, Jean-Marie, additional, Souteyrand, Eliane, additional, Imberty, Anne, additional, Vasseur, Jean-Jacques, additional, Chevolot, Yann, additional, and Morvan, François, additional

Published
2015
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8. The influence of the aromatic aglycon of galactoclusters on the binding of LecA: a case study with O-phenyl, S-phenyl, O-benzyl, S-benzyl, O-biphenyl and O-naphthyl aglycons

Author

Casoni, Francesca, primary, Dupin, Lucie, additional, Vergoten, Gérard, additional, Meyer, Albert, additional, Ligeour, Caroline, additional, Géhin, Thomas, additional, Vidal, Olivier, additional, Souteyrand, Eliane, additional, Vasseur, Jean-Jacques, additional, Chevolot, Yann, additional, and Morvan, François, additional

Published
2014
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9. Structure Binding Relationship of Galactosylated Glycoclusters toward Pseudomonas aeruginosa Lectin LecA Using a DNA-Based Carbohydrate Microarray

Author

Gerland, Béatrice, primary, Goudot, Alice, additional, Ligeour, Caroline, additional, Pourceau, Gwladys, additional, Meyer, Albert, additional, Vidal, Sébastien, additional, Gehin, Thomas, additional, Vidal, Olivier, additional, Souteyrand, Eliane, additional, Vasseur, Jean-Jacques, additional, Chevolot, Yann, additional, and Morvan, François, additional

Published
2014
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16. The influence of the aromatic aglycon of galactoclusters on the binding of LecA: a case study with O-phenyl, S-phenyl, O-benzyl, S-benzyl, O-biphenyl and O-naphthyl aglycons.

Author

Casoni F, Dupin L, Vergoten G, Meyer A, Ligeour C, Géhin T, Vidal O, Souteyrand E, Vasseur JJ, Chevolot Y, and Morvan F

Subjects
Galactosides chemical synthesis, Adhesins, Bacterial metabolism, Azides chemistry, Biphenyl Compounds chemistry, Galactose chemistry, Galactosides chemistry, Models, Molecular, Naphthols chemistry
Abstract

A library of 24 new mannose-centered tetragalactoclusters with four different linkers (di- and triethyleneglycol with phosphodiester or phosphorothioate linkages) and six different aromatic aglycons (O-phenyl, S-phenyl, O-benzyl, S-benzyl, O-biphenyl and O-naphthyl) was synthesized. Their interactions with LecA were evaluated on a DNA Directed Immobilization (DDI) based glycocluster array allowing the determination of their IC50 against lactose and the evaluation of their dissociation constant (Kd). Finally, the docking simulations confirm the experimental results and demonstrated that the better affinity of O-biphenyl- and O-naphthyl-galactoside is due to a double interaction between the aromatic ring and the histidine 50 and proline 51 of LecA.

Published
2014
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