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1. Multiple regions of Kaposi's sarcoma-associated herpesvirus ORF59 RNA are required for its expression mediated by viral ORF57 and cellular RBM15.

Author

Massimelli, Maria Julia, Majerciak, Vladimir, Kang, Jeong-Gu, Liewehr, David J, Steinberg, Seth M, and Zheng, Zhi-Ming

Subjects
Cells, Cultured, Cell Line, Humans, Herpesvirus 8, Human, Herpesviridae Infections, RNA-Binding Proteins, Viral Proteins, RNA, Viral, Protein Biosynthesis, Epistasis, Genetic, Gene Expression Regulation, Viral, Base Sequence, Response Elements, Nucleic Acid Conformation, RNA Transport, Molecular Sequence Data, Viral Regulatory and Accessory Proteins, Microbiology
Abstract

KSHV ORF57 (MTA) promotes RNA stability of ORF59, a viral DNA polymerase processivity factor. Here, we show that the integrity of both ORF59 RNA ends is necessary for ORF57-mediated ORF59 expression and deletion of both 5' and 3' regions, or one end region with a central region, of ORF59 RNA prevents ORF57-mediated translation of ORF59. The ORF59 sequence between nt 96633 and 96559 resembles other known MTA-responsive elements (MREs). ORF57 specifically binds to a stem-loop region from nt 96596-96572 of the MRE, which also binds cellular RBM15. Internal deletion of the MRE from ORF59 led to poor export, but accumulation of nuclear ORF59 RNA in the presence of ORF57 or RBM15. Despite of being translatable in the presence of ORF57, this deletion mutant exhibits translational defect in the presence of RBM15. Together, our results provide novel insight into the roles of ORF57 and RBM15 in ORF59 RNA accumulation and protein translation.

Published
2015

3. Stability of a long noncoding viral RNA depends on a 9-nt core element at the RNA 5' end to interact with viral ORF57 and cellular PABPC1.

Author

Massimelli, Maria J, Kang, Jeong-Gu, Majerciak, Vladimir, Le, Shu-Yun, Liewehr, David J, Steinberg, Seth M, and Zheng, Zhi-Ming

Subjects
Hela Cells, Humans, Herpesvirus 8, Human, Luciferases, Nucleotides, Poly(A)-Binding Protein I, RNA, Untranslated, RNA, Viral, Oligonucleotides, Blotting, Western, Blotting, Northern, Transfection, Reverse Transcriptase Polymerase Chain Reaction, DNA Mutational Analysis, Immunoprecipitation, RNA Stability, Open Reading Frames, Genetic Vectors, HEK293 Cells, E1B-AP5, KSHV, ORF57, PABPC1, PAN, RNA accumulation, RNA stability, long non-coding RNA, HeLa Cells, Blotting, Northern, Western, Herpesvirus 8, Human, RNA, Untranslated, Viral, Developmental Biology, Microbiology, Other Biological Sciences, Medical Microbiology
Abstract

Kaposi sarcoma-associated herpesvirus (KSHV) ORF57, also known as Mta (mRNA transcript accumulation), enhances viral intron-less transcript accumulation and promotes splicing of intron-containing viral RNA transcripts. In this study, we identified KSHV PAN, a long non-coding polyadenylated nuclear RNA as a main target of ORF57 by a genome-wide CLIP (cross-linking and immunoprecipitation) approach. KSHV genome lacking ORF57 expresses only a minimal amount of PAN. In cotransfection experiments, ORF57 alone increased PAN expression by 20-30-fold when compared to vector control. This accumulation function of ORF57 was dependent on a structured RNA element in the 5' PAN, named MRE (Mta responsive element), but not much so on an ENE (expression and nuclear retention element) in the 3' PAN previously reported by other studies. We showed that the major function of the 5' PAN MRE is increasing the RNA half-life of PAN in the presence of ORF57. Further mutational analyses revealed a core motif consisting of 9 nucleotides in the MRE-II , which is responsible for ORF57 interaction and function. The 9-nt core in the MRE-II also binds cellular PABPC1, but not the E1B-AP5 which binds another region of the MRE-II. In addition, we found that PAN RNA is partially exportable in the presence of ORF57. Together, our data provide compelling evidence as to how ORF57 functions to accumulate a non-coding viral RNA in the course of virus lytic infection.

Published
2011

9. Supplementary Figure 3 from Immune Impact Induced by PROSTVAC (PSA-TRICOM), a Therapeutic Vaccine for Prostate Cancer

Author

Gulley, James L., primary, Madan, Ravi A., primary, Tsang, Kwong Y., primary, Jochems, Caroline, primary, Marté, Jennifer L., primary, Farsaci, Benedetto, primary, Tucker, Jo A., primary, Hodge, James W., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Heery, Christopher R., primary, and Schlom, Jeffrey, primary

Published
2023
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10. Supplementary Table 1 from Immune Impact Induced by PROSTVAC (PSA-TRICOM), a Therapeutic Vaccine for Prostate Cancer

Author

Gulley, James L., primary, Madan, Ravi A., primary, Tsang, Kwong Y., primary, Jochems, Caroline, primary, Marté, Jennifer L., primary, Farsaci, Benedetto, primary, Tucker, Jo A., primary, Hodge, James W., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Heery, Christopher R., primary, and Schlom, Jeffrey, primary

Published
2023
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11. Supplementary Table 2 from Immune Impact Induced by PROSTVAC (PSA-TRICOM), a Therapeutic Vaccine for Prostate Cancer

Author

Gulley, James L., primary, Madan, Ravi A., primary, Tsang, Kwong Y., primary, Jochems, Caroline, primary, Marté, Jennifer L., primary, Farsaci, Benedetto, primary, Tucker, Jo A., primary, Hodge, James W., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Heery, Christopher R., primary, and Schlom, Jeffrey, primary

Published
2023
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13. Supplementary Figure 2 from Immune Impact Induced by PROSTVAC (PSA-TRICOM), a Therapeutic Vaccine for Prostate Cancer

Author

Gulley, James L., primary, Madan, Ravi A., primary, Tsang, Kwong Y., primary, Jochems, Caroline, primary, Marté, Jennifer L., primary, Farsaci, Benedetto, primary, Tucker, Jo A., primary, Hodge, James W., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Heery, Christopher R., primary, and Schlom, Jeffrey, primary

Published
2023
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14. Supplementary Figure 1 from Immune Impact Induced by PROSTVAC (PSA-TRICOM), a Therapeutic Vaccine for Prostate Cancer

Author

Gulley, James L., primary, Madan, Ravi A., primary, Tsang, Kwong Y., primary, Jochems, Caroline, primary, Marté, Jennifer L., primary, Farsaci, Benedetto, primary, Tucker, Jo A., primary, Hodge, James W., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Heery, Christopher R., primary, and Schlom, Jeffrey, primary

Published
2023
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15. Supplementary Figure S2 from The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models

Author

Hebron, Katie E., primary, Wan, Xiaolin, primary, Roth, Jacob S., primary, Liewehr, David J., primary, Sealover, Nancy E., primary, Frye, William J.E., primary, Kim, Angela, primary, Stauffer, Stacey, primary, Perkins, Olivia L., primary, Sun, Wenyue, primary, Isanogle, Kristine A., primary, Robinson, Christina M., primary, James, Amy, primary, Awasthi, Parirokh, primary, Shankarappa, Priya, primary, Luo, Xiaoling, primary, Lei, Haiyan, primary, Butcher, Donna, primary, Smith, Roberta, primary, Edmondson, Elijah F., primary, Chen, Jin-Qiu, primary, Kedei, Noemi, primary, Peer, Cody J., primary, Shern, Jack F., primary, Figg, W. Douglas, primary, Chen, Lu, primary, Hall, Matthew D., primary, Difilippantonio, Simone, primary, Barr, Frederic G., primary, Kortum, Robert L., primary, Robey, Robert W., primary, Vaseva, Angelina V., primary, Khan, Javed, primary, and Yohe, Marielle E., primary

Published
2023
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16. Supplementary Data File S5 from The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models

Author

Hebron, Katie E., primary, Wan, Xiaolin, primary, Roth, Jacob S., primary, Liewehr, David J., primary, Sealover, Nancy E., primary, Frye, William J.E., primary, Kim, Angela, primary, Stauffer, Stacey, primary, Perkins, Olivia L., primary, Sun, Wenyue, primary, Isanogle, Kristine A., primary, Robinson, Christina M., primary, James, Amy, primary, Awasthi, Parirokh, primary, Shankarappa, Priya, primary, Luo, Xiaoling, primary, Lei, Haiyan, primary, Butcher, Donna, primary, Smith, Roberta, primary, Edmondson, Elijah F., primary, Chen, Jin-Qiu, primary, Kedei, Noemi, primary, Peer, Cody J., primary, Shern, Jack F., primary, Figg, W. Douglas, primary, Chen, Lu, primary, Hall, Matthew D., primary, Difilippantonio, Simone, primary, Barr, Frederic G., primary, Kortum, Robert L., primary, Robey, Robert W., primary, Vaseva, Angelina V., primary, Khan, Javed, primary, and Yohe, Marielle E., primary

Published
2023
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18. Supplementary Figure 4 from Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel

Author

Noonan, Anne M., primary, Eisch, Robin A., primary, Liewehr, David J., primary, Sissung, Tristan M., primary, Venzon, David J., primary, Flagg, Thomas P., primary, Haigney, Mark C., primary, Steinberg, Seth M., primary, Figg, William D., primary, Piekarz, Richard L., primary, and Bates, Susan E., primary

Published
2023
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19. Supplementary Figure 5 from Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel

Author

Noonan, Anne M., primary, Eisch, Robin A., primary, Liewehr, David J., primary, Sissung, Tristan M., primary, Venzon, David J., primary, Flagg, Thomas P., primary, Haigney, Mark C., primary, Steinberg, Seth M., primary, Figg, William D., primary, Piekarz, Richard L., primary, and Bates, Susan E., primary

Published
2023
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20. Supplementary Figure 3 from Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel

Author

Noonan, Anne M., primary, Eisch, Robin A., primary, Liewehr, David J., primary, Sissung, Tristan M., primary, Venzon, David J., primary, Flagg, Thomas P., primary, Haigney, Mark C., primary, Steinberg, Seth M., primary, Figg, William D., primary, Piekarz, Richard L., primary, and Bates, Susan E., primary

Published
2023
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21. Supplementary Figure Legends from Profound Prevention of Experimental Brain Metastases of Breast Cancer by Temozolomide in an MGMT-Dependent Manner

Author

Palmieri, Diane, primary, Duchnowska, Renata, primary, Woditschka, Stephan, primary, Hua, Emily, primary, Qian, Yongzhen, primary, Biernat, Wojciech, primary, Sosińska-Mielcarek, Katarzyna, primary, Gril, Brunilde, primary, Stark, Andreas M., primary, Hewitt, Stephen M., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Jassem, Jacek, primary, and Steeg, Patricia S., primary

Published
2023
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22. Supplementary Figure 1 from Profound Prevention of Experimental Brain Metastases of Breast Cancer by Temozolomide in an MGMT-Dependent Manner

Author

Palmieri, Diane, primary, Duchnowska, Renata, primary, Woditschka, Stephan, primary, Hua, Emily, primary, Qian, Yongzhen, primary, Biernat, Wojciech, primary, Sosińska-Mielcarek, Katarzyna, primary, Gril, Brunilde, primary, Stark, Andreas M., primary, Hewitt, Stephen M., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Jassem, Jacek, primary, and Steeg, Patricia S., primary

Published
2023
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23. Supplementary Figure S1 from Impact of ABCB1 Allelic Variants on QTc Interval Prolongation

Author

Sissung, Tristan M., primary, Gardner, Erin R., primary, Piekarz, Richard L., primary, Howden, Reuben, primary, Chen, Xiaohong, primary, Woo, Sukyung, primary, Franke, Ryan, primary, Clark, James A., primary, Miller-DeGraff, Laura, primary, Steinberg, Seth M., primary, Venzon, David, primary, Liewehr, David, primary, Kleeberger, Steven R., primary, Bates, Susan E., primary, Price, Douglas K., primary, Rosing, Douglas R., primary, Cabell, Christopher, primary, Sparreboom, Alex, primary, and Figg, William D., primary

Published
2023
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24. Supplemental Appendix 1, Supplementary Tables 1-5 from Pediatric PK/PD Phase I Trial of Pexidartinib in Relapsed and Refractory Leukemias and Solid Tumors Including Neurofibromatosis Type I–Related Plexiform Neurofibromas

Author

Boal, Lauren H., primary, Glod, John, primary, Spencer, Melissa, primary, Kasai, Miki, primary, Derdak, Joanne, primary, Dombi, Eva, primary, Ahlman, Mark, primary, Beury, Daniel W., primary, Merchant, Melinda S., primary, Persenaire, Christianne, primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Widemann, Brigitte C., primary, and Kaplan, Rosandra N., primary

Published
2023
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25. Supplementary Figure 1 from Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel

Author

Noonan, Anne M., primary, Eisch, Robin A., primary, Liewehr, David J., primary, Sissung, Tristan M., primary, Venzon, David J., primary, Flagg, Thomas P., primary, Haigney, Mark C., primary, Steinberg, Seth M., primary, Figg, William D., primary, Piekarz, Richard L., primary, and Bates, Susan E., primary

Published
2023
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26. Supplementary Data File from Alterations in Pericyte Subpopulations Are Associated with Elevated Blood–Tumor Barrier Permeability in Experimental Brain Metastasis of Breast Cancer

Author

Lyle, L. Tiffany, primary, Lockman, Paul R., primary, Adkins, Chris E., primary, Mohammad, Afroz Shareef, primary, Sechrest, Emily, primary, Hua, Emily, primary, Palmieri, Diane, primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Kloc, Wojciech, primary, Izycka-Swieszewska, Ewa, primary, Duchnowska, Renata, primary, Nayyar, Naema, primary, Brastianos, Priscilla K., primary, Steeg, Patricia S., primary, and Gril, Brunilde, primary

Published
2023
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27. Supplementary Figure 8 from Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel

Author

Noonan, Anne M., primary, Eisch, Robin A., primary, Liewehr, David J., primary, Sissung, Tristan M., primary, Venzon, David J., primary, Flagg, Thomas P., primary, Haigney, Mark C., primary, Steinberg, Seth M., primary, Figg, William D., primary, Piekarz, Richard L., primary, and Bates, Susan E., primary

Published
2023
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28. Supplementary Figure 2 from Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel

Author

Noonan, Anne M., primary, Eisch, Robin A., primary, Liewehr, David J., primary, Sissung, Tristan M., primary, Venzon, David J., primary, Flagg, Thomas P., primary, Haigney, Mark C., primary, Steinberg, Seth M., primary, Figg, William D., primary, Piekarz, Richard L., primary, and Bates, Susan E., primary

Published
2023
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29. Data from Impact of ABCB1 Allelic Variants on QTc Interval Prolongation

Author

Sissung, Tristan M., primary, Gardner, Erin R., primary, Piekarz, Richard L., primary, Howden, Reuben, primary, Chen, Xiaohong, primary, Woo, Sukyung, primary, Franke, Ryan, primary, Clark, James A., primary, Miller-DeGraff, Laura, primary, Steinberg, Seth M., primary, Venzon, David, primary, Liewehr, David, primary, Kleeberger, Steven R., primary, Bates, Susan E., primary, Price, Douglas K., primary, Rosing, Douglas R., primary, Cabell, Christopher, primary, Sparreboom, Alex, primary, and Figg, William D., primary

Published
2023
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30. Supplementary Figure 3 from Profound Prevention of Experimental Brain Metastases of Breast Cancer by Temozolomide in an MGMT-Dependent Manner

Author

Palmieri, Diane, primary, Duchnowska, Renata, primary, Woditschka, Stephan, primary, Hua, Emily, primary, Qian, Yongzhen, primary, Biernat, Wojciech, primary, Sosińska-Mielcarek, Katarzyna, primary, Gril, Brunilde, primary, Stark, Andreas M., primary, Hewitt, Stephen M., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Jassem, Jacek, primary, and Steeg, Patricia S., primary

Published
2023
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32. Supplementary Methods from Impact of ABCB1 Allelic Variants on QTc Interval Prolongation

Author

Sissung, Tristan M., primary, Gardner, Erin R., primary, Piekarz, Richard L., primary, Howden, Reuben, primary, Chen, Xiaohong, primary, Woo, Sukyung, primary, Franke, Ryan, primary, Clark, James A., primary, Miller-DeGraff, Laura, primary, Steinberg, Seth M., primary, Venzon, David, primary, Liewehr, David, primary, Kleeberger, Steven R., primary, Bates, Susan E., primary, Price, Douglas K., primary, Rosing, Douglas R., primary, Cabell, Christopher, primary, Sparreboom, Alex, primary, and Figg, William D., primary

Published
2023
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33. Supplementary Results from Impact of ABCB1 Allelic Variants on QTc Interval Prolongation

Author

Sissung, Tristan M., primary, Gardner, Erin R., primary, Piekarz, Richard L., primary, Howden, Reuben, primary, Chen, Xiaohong, primary, Woo, Sukyung, primary, Franke, Ryan, primary, Clark, James A., primary, Miller-DeGraff, Laura, primary, Steinberg, Seth M., primary, Venzon, David, primary, Liewehr, David, primary, Kleeberger, Steven R., primary, Bates, Susan E., primary, Price, Douglas K., primary, Rosing, Douglas R., primary, Cabell, Christopher, primary, Sparreboom, Alex, primary, and Figg, William D., primary

Published
2023
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34. Supplementary Figure Legends from Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel

Author

Noonan, Anne M., primary, Eisch, Robin A., primary, Liewehr, David J., primary, Sissung, Tristan M., primary, Venzon, David J., primary, Flagg, Thomas P., primary, Haigney, Mark C., primary, Steinberg, Seth M., primary, Figg, William D., primary, Piekarz, Richard L., primary, and Bates, Susan E., primary

Published
2023
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35. Supplementary Figure 6 from Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel

Author

Noonan, Anne M., primary, Eisch, Robin A., primary, Liewehr, David J., primary, Sissung, Tristan M., primary, Venzon, David J., primary, Flagg, Thomas P., primary, Haigney, Mark C., primary, Steinberg, Seth M., primary, Figg, William D., primary, Piekarz, Richard L., primary, and Bates, Susan E., primary

Published
2023
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36. Supplementary Tables 1 - 2 from Profound Prevention of Experimental Brain Metastases of Breast Cancer by Temozolomide in an MGMT-Dependent Manner

Author

Palmieri, Diane, primary, Duchnowska, Renata, primary, Woditschka, Stephan, primary, Hua, Emily, primary, Qian, Yongzhen, primary, Biernat, Wojciech, primary, Sosińska-Mielcarek, Katarzyna, primary, Gril, Brunilde, primary, Stark, Andreas M., primary, Hewitt, Stephen M., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Jassem, Jacek, primary, and Steeg, Patricia S., primary

Published
2023
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37. Supplementary Figure 2 from Profound Prevention of Experimental Brain Metastases of Breast Cancer by Temozolomide in an MGMT-Dependent Manner

Author

Palmieri, Diane, primary, Duchnowska, Renata, primary, Woditschka, Stephan, primary, Hua, Emily, primary, Qian, Yongzhen, primary, Biernat, Wojciech, primary, Sosińska-Mielcarek, Katarzyna, primary, Gril, Brunilde, primary, Stark, Andreas M., primary, Hewitt, Stephen M., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Jassem, Jacek, primary, and Steeg, Patricia S., primary

Published
2023
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38. Supplementary Statistical Section from Pediatric PK/PD Phase I Trial of Pexidartinib in Relapsed and Refractory Leukemias and Solid Tumors Including Neurofibromatosis Type I–Related Plexiform Neurofibromas

Author

Boal, Lauren H., primary, Glod, John, primary, Spencer, Melissa, primary, Kasai, Miki, primary, Derdak, Joanne, primary, Dombi, Eva, primary, Ahlman, Mark, primary, Beury, Daniel W., primary, Merchant, Melinda S., primary, Persenaire, Christianne, primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Widemann, Brigitte C., primary, and Kaplan, Rosandra N., primary

Published
2023
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39. Supplementary Data from Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks

Author

Palmieri, Diane, primary, Lockman, Paul R., primary, Thomas, Fancy C., primary, Hua, Emily, primary, Herring, Jeanne, primary, Hargrave, Elizabeth, primary, Johnson, Matthew, primary, Flores, Natasha, primary, Qian, Yongzhen, primary, Vega-Valle, Eleazar, primary, Taskar, Kunal S., primary, Rudraraju, Vinay, primary, Mittapalli, Rajendar K., primary, Gaasch, Julie A., primary, Bohn, Kaci A., primary, Thorsheim, Helen R., primary, Liewehr, David J., primary, Davis, Sean, primary, Reilly, John F., primary, Walker, Robert, primary, Bronder, Julie L., primary, Feigenbaum, Lionel, primary, Steinberg, Seth M., primary, Camphausen, Kevin, primary, Meltzer, Paul S., primary, Richon, Victoria M., primary, Smith, Quentin R., primary, and Steeg, Patricia S., primary

Published
2023
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40. Supplementary Figure 7 from Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel

Author

Noonan, Anne M., primary, Eisch, Robin A., primary, Liewehr, David J., primary, Sissung, Tristan M., primary, Venzon, David J., primary, Flagg, Thomas P., primary, Haigney, Mark C., primary, Steinberg, Seth M., primary, Figg, William D., primary, Piekarz, Richard L., primary, and Bates, Susan E., primary

Published
2023
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41. Supplementary Figure 1 from Opposing Effects of Pigment Epithelium–Derived Factor on Breast Cancer Cell versus Neuronal Survival: Implication for Brain Metastasis and Metastasis-Induced Brain Damage

Author

Fitzgerald, Daniel P., primary, Subramanian, Preeti, primary, Deshpande, Monika, primary, Graves, Christian, primary, Gordon, Ira, primary, Qian, Yongzhen, primary, Snitkovsky, Yeva, primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Paltán-Ortiz, José D., primary, Herman, Mary M., primary, Camphausen, Kevin, primary, Palmieri, Diane, primary, Becerra, S. Patricia, primary, and Steeg, Patricia S., primary

Published
2023
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42. Supplementary Figure 5 from Opposing Effects of Pigment Epithelium–Derived Factor on Breast Cancer Cell versus Neuronal Survival: Implication for Brain Metastasis and Metastasis-Induced Brain Damage

Author

Fitzgerald, Daniel P., primary, Subramanian, Preeti, primary, Deshpande, Monika, primary, Graves, Christian, primary, Gordon, Ira, primary, Qian, Yongzhen, primary, Snitkovsky, Yeva, primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Paltán-Ortiz, José D., primary, Herman, Mary M., primary, Camphausen, Kevin, primary, Palmieri, Diane, primary, Becerra, S. Patricia, primary, and Steeg, Patricia S., primary

Published
2023
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43. Supplementary Methods from Opposing Effects of Pigment Epithelium–Derived Factor on Breast Cancer Cell versus Neuronal Survival: Implication for Brain Metastasis and Metastasis-Induced Brain Damage

Author

Fitzgerald, Daniel P., primary, Subramanian, Preeti, primary, Deshpande, Monika, primary, Graves, Christian, primary, Gordon, Ira, primary, Qian, Yongzhen, primary, Snitkovsky, Yeva, primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Paltán-Ortiz, José D., primary, Herman, Mary M., primary, Camphausen, Kevin, primary, Palmieri, Diane, primary, Becerra, S. Patricia, primary, and Steeg, Patricia S., primary

Published
2023
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44. Data from Opposing Effects of Pigment Epithelium–Derived Factor on Breast Cancer Cell versus Neuronal Survival: Implication for Brain Metastasis and Metastasis-Induced Brain Damage

Author

Fitzgerald, Daniel P., primary, Subramanian, Preeti, primary, Deshpande, Monika, primary, Graves, Christian, primary, Gordon, Ira, primary, Qian, Yongzhen, primary, Snitkovsky, Yeva, primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Paltán-Ortiz, José D., primary, Herman, Mary M., primary, Camphausen, Kevin, primary, Palmieri, Diane, primary, Becerra, S. Patricia, primary, and Steeg, Patricia S., primary

Published
2023
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45. Supplementary Figure 4 from Opposing Effects of Pigment Epithelium–Derived Factor on Breast Cancer Cell versus Neuronal Survival: Implication for Brain Metastasis and Metastasis-Induced Brain Damage

Author

Fitzgerald, Daniel P., primary, Subramanian, Preeti, primary, Deshpande, Monika, primary, Graves, Christian, primary, Gordon, Ira, primary, Qian, Yongzhen, primary, Snitkovsky, Yeva, primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Paltán-Ortiz, José D., primary, Herman, Mary M., primary, Camphausen, Kevin, primary, Palmieri, Diane, primary, Becerra, S. Patricia, primary, and Steeg, Patricia S., primary

Published
2023
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46. Supplementary Figure 2 from Opposing Effects of Pigment Epithelium–Derived Factor on Breast Cancer Cell versus Neuronal Survival: Implication for Brain Metastasis and Metastasis-Induced Brain Damage

Author

Fitzgerald, Daniel P., primary, Subramanian, Preeti, primary, Deshpande, Monika, primary, Graves, Christian, primary, Gordon, Ira, primary, Qian, Yongzhen, primary, Snitkovsky, Yeva, primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Paltán-Ortiz, José D., primary, Herman, Mary M., primary, Camphausen, Kevin, primary, Palmieri, Diane, primary, Becerra, S. Patricia, primary, and Steeg, Patricia S., primary

Published
2023
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47. Supplementary Figure 3 from Opposing Effects of Pigment Epithelium–Derived Factor on Breast Cancer Cell versus Neuronal Survival: Implication for Brain Metastasis and Metastasis-Induced Brain Damage

Author

Fitzgerald, Daniel P., primary, Subramanian, Preeti, primary, Deshpande, Monika, primary, Graves, Christian, primary, Gordon, Ira, primary, Qian, Yongzhen, primary, Snitkovsky, Yeva, primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Paltán-Ortiz, José D., primary, Herman, Mary M., primary, Camphausen, Kevin, primary, Palmieri, Diane, primary, Becerra, S. Patricia, primary, and Steeg, Patricia S., primary

Published
2023
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48. Flow cytometric differentiation of abnormal and normal plasma cells in the bone marrow in patients with multiple myeloma and its precursor diseases

Author

Tembhare, Prashant R., Yuan, Constance M., Venzon, David, Braylan, Raul, Korde, Neha, Manasanch, Elisabet, Zuchlinsky, Diamond, Calvo, Katherine, Kurlander, Roger, Bhutani, Manisha, Tageja, Nishant, Maric, Irina, Mulquin, Marcia, Roschewski, Mark, Kwok, Mary, Liewehr, David, Landgren, Ola, and Stetler-Stevenson, Maryalice

Published
2014
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50. Local Data Journalism in Germany: Data-driven Reporting Amidst Local Communities and Authorities.

Author

Stalph, Florian, Hahn, Oliver, and Liewehr, David

Subjects
JOURNALISM, ONLINE journalism, SEMI-structured interviews, JOURNALISTS
Abstract

This study explores data journalism within local and regional news organisations in Germany. Findings were drawn from nine semi-structured in-depth interviews with journalists working with local and regional dailies. Weischenberg's model of contextual layers of journalism provides theoretical underpinnings to capture normative, structural, and functional insights as well as data journalists' role conceptions. Results show that viable data is scarce at a local level and data journalists actively seek to maintain good relationships with local authorities to be granted access to data. The practice of data journalism at the local level depends on a few data journalism advocates who institutionalise the practice in their local newsrooms and take training on their own initiative. Local data journalists face similar constraints to their colleagues working for national organisations. Data-driven newswork is carried out in addition to regular duties, and collaboration with specialist correspondents who work on-site is widely reported. We find that the combination of traditional shoe-leather epistemologies of on-site reporting with data-driven practices can add to the independence and neutrality of local journalism. [ABSTRACT FROM AUTHOR]

Published
2023
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