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Glioblastoma is incurable and in urgent need of improved therapeutics 1 . Here we identify a small compound, gliocidin, that kills glioblastoma cells while sparing non-tumour replicative cells. Gliocidin activity targets a de novo purine synthesis vulnerability in glioblastoma through indirect inhibition of inosine monophosphate dehydrogenase 2 (IMPDH2). IMPDH2 blockade reduces intracellular guanine nucleotide levels, causing nucleotide imbalance, replication stress and tumour cell death 2 . Gliocidin is a prodrug that is anabolized into its tumoricidal metabolite, gliocidin-adenine dinucleotide (GAD), by the enzyme nicotinamide nucleotide adenylyltransferase 1 (NMNAT1) of the NAD + salvage pathway. The cryo-electron microscopy structure of GAD together with IMPDH2 demonstrates its entry, deformation and blockade of the NAD + pocket 3 . In vivo, gliocidin penetrates the blood-brain barrier and extends the survival of mice with orthotopic glioblastoma. The DNA alkylating agent temozolomide induces Nmnat1 expression, causing synergistic tumour cell killing and additional survival benefit in orthotopic patient-derived xenograft models. This study brings gliocidin to light as a prodrug with the potential to improve the survival of patients with glioblastoma., Competing Interests: Competing interests: The authors declare no competing interests., (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)

We examined whether proactive suppression can be applied on demand. A prompt cue indicated the to-be-ignored distractor color for each trial. Participants needed to use this cue to know which of two target shapes to respond to. To assess proactive suppression of the cued distractor color, we presented a probe letter recall task on a minority (25%) of the trials. A letter appeared inside each of the six shapes of the search array and participants recalled as many letters as they could. When the to-be-ignored color was fixed in Experiment 1, probe recall accuracy was lower for probe letters inside to-be-ignored-color distractors than target-color distractors, known as the probe suppression effect. However, when the prompted to-be-ignored color varied from trial to trial, the probe suppression effect disappeared, regardless of whether the prompt was a colored circle (Experiment 2) or a colored word (Experiment 3). Experiment 4 tested the search and destroy hypothesis by shortening the search display duration from 200 to 50 ms. No capture effect by the to-be-ignored color was evident, suggesting that participants did not first search for the to-be-ignored color, prior to suppressing it. We conclude that when rejection of a distractor color is required on demand, one cannot accomplish such suppression proactively but instead must deal with the distractor reactively, incurring a large cost in performance. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Does the suppression of irrelevant visual features require attentional resources? McDonald et al. (2023, Psychonomic Bulletin & Review, 30, 224-234) proposed that suppression processes are unavailable while a person is busy performing another task. They reported the absence of the P D (believed to index suppression) when two tasks were presented close together in time. We looked for converging evidence using established behavior measures of suppression. Following McDonald et al., our participants performed a rapid serial visual presentation (RSVP) task followed by a search task. For the RSVP task, participants determined whether the target digit 4 or 6 appeared within a string of other digits. The search display appeared at a lag of 2 or 8 digits after the RSVP target. Participants searched for a yellow target circle amongst nine background circles, which included a uniquely colored distractor for some trials. The main question was whether distractor suppression would occur at Lag 2, while attentional resources were still processing the RSVP target. Suppression was assessed using the capture-probe paradigm. On 30% of trials, probe letters appeared inside the colored circles and participants reported those letters. Probe recall accuracy was lower at locations with distractor colors than those with neutral colors (the baseline), suggesting proactive suppression. Critically, this difference in probe recall accuracy was similar at Lag 2 and Lag 8, suggesting that the ability to proactively suppress distractors remains intact while dual-tasking. We argue that although reactive suppression likely requires attentional resources, proactive suppression-an implicit process-does not., (© 2023. The Psychonomic Society, Inc.)

Surface-enhanced Raman scattering (SERS) is widely recognized as a highly sensitive technology for chemical detection and biological sensing. In SERS-based biomedical applications, developing highly efficient sensing platforms based on SERS plays a pivotal role in monitoring disease biomarker levels and facilitating the early detection of cancer biomarkers. Hyperuricemia, characterized by abnormally high concentrations of uric acid (UA) in the blood, was associated with a range of diseases, such as gouty arthritis, heart disease, and acute kidney injury. Recent reports have demonstrated the correlation between UA concentrations in blood and tears. In this work, we report the fabrication of SERS substrates utilizing ZnO nanocages and yolk-shell-structured plasmonic nanomaterials for the noninvasive detection of UA in tears. This innovative SERS substrate enables noninvasive and sensitive detection of UA to prevent hyperuricemia-related diseases., Competing Interests: The authors declare no competing financial interest., (© 2024 The Authors. Published by American Chemical Society.)

Hollow and porous plasmonic nanomaterials have been demonstrated for highly sensitive biosensing applications due to their distinctive optical properties. Immunosensors, which rely on antibody-antigen interactions, are essential constituents of diverse biosensing platforms owing to their exceptional binding affinity and selectivity. The majority of immunosensors and conventional bioassays needs special storage conditions and cold chain systems for transportation. Prostate-specific antigen (PSA), a serine protease, is widely employed in the diagnosis of prostate cancer. In this study, we present the successful utilization of a biopolymer-preserved plasmonic biosensor with improved environmental stability for the sensitive detection of PSA. The preserved plasmonic biosensors exhibited sustained sensitivity in the detection of PSA, achieving a limit of detection of 10 pg mL -1 . Furthermore, these biosensors exhibited remarkable stability at elevated temperatures for one week.

It has been proposed that salient objects have high potential to disrupt target performance, and so people learn to proactively suppress them, thereby preventing these salient distractors from capturing attention in the future. Consistent with this hypothesis, Gaspar et al. (Proceedings of the National Academy of Sciences, 113(13), 3693-3698, 2016) reported that the P D (believed to index suppression) was larger for high-salient color distractors than for low-salient color distractors. The present study looked for converging evidence that salience triggers suppression using established behavior measures of suppression. Following Gaspar et al., our participants searched for a yellow target circle among nine background circles, which sometimes included one circle with a unique color. The distractor was either high or low in salience with respect to the background circles. The question was whether the high-salient color would be proactively suppressed more strongly than the low-salient color. This was assessed using the capture-probe paradigm. On 33% of trials, probe letters appeared inside colored circles and participants were to report those letters. If high-salient colors are more strongly suppressed, then probe recall accuracy should be lower at locations with the high-salient color than those with the low-salient color. Experiment 1 found no such effect. A similar finding was observed in Experiment 2 after addressing possible floor effects. These findings suggest that proactive suppression is not caused by salience. We propose that the P D reflects not only proactive suppression but also reactive suppression., (© 2023. The Psychonomic Society, Inc.)

Flexible biochips that enable sensitive detection and simultaneous quantification of biomarkers are of great importance in the field of point-of-care testing. Recently, surface-enhanced Raman scattering (SERS)-based flexible biochips have attracted a great deal of research attention for disease detection due to their rapid, sensitive, and noninvasive sensing abilities. Phenomenal progress in the synthesis of structure-controlled plasmonic nanomaterials has made SERS a powerful sensing platform for disease diagnosis and trace detection. Here, we demonstrate flexible plasmonic biochips for the SERS-based detection of uric acid (UA). Flexible strips exhibited excellent sensing performance with a detection limit of around 10 μM of UA, which is lower than the average level of UA in tears. This rapid and sensitive detection method enables the noninvasive diagnosis of gouty arthritis.

There is emerging evidence that suppressing distractors occur to prevent capture by those distractors. Theeuwes (2022) claimed that the absence of capture is not because of suppression but rather because a difficult, serial search causes salient distractors to fall outside of the attentional window. Here, we question this attentional window view by describing evidence that (a) for color singletons, capture fails to occur with an easy search, and (b) for abrupt onsets, capture does occur in a difficult search. We argue that the critical factor determining capture by salient distractors is not the attentional window or search difficulty but rather target search mode (singleton vs. nonsingleton)., Competing Interests: The authors have no competing interests to declare., (Copyright: © 2023 The Author(s).)

Visual hindsight bias, also known as the "saw-it-all-along" effect, is the tendency to overestimate one's perceptual abilities with the aid of outcome knowledge. Recently, Giroux et al. (2022, Emotion, https://doi.org/10.1037/emo0001068 ) reported robust visual hindsight bias for emotional faces except for happy. We examined whether the difficulty of emotional processing could explain their finding. As in Giroux et al., participants saw a blurred image of an emotional face (happy, angry, or neutral) that progressed to clear and were instructed to stop the clearing process when they were able to identify the emotion (foresight trials). They then were shown the clearest image of each face and determined the emotion, followed by a memory task where they were asked to adjust the blur levels to indicate the point at which they had identified the emotion earlier (hindsight trials). Experiment 1 replicated Giroux et al.'s finding, showing that participants stopped the image at a higher degree of blur during the hindsight trials than they had during the foresight trials (i.e., a visual hindsight bias) for the angry and neutral faces but not happy faces. Experiment 2 manipulated the perceptual difficulty of angry and happy faces. While the easy faces replicated the results of Experiment 1, both angry and happy faces produced strong bias when made difficult. A multinomial processing tree model suggests that visual hindsight bias for emotional faces, while robust, is sensitive to perceptual processing difficulties across emotions., (© 2022. The Psychonomic Society, Inc.)

Many studies have indicated that abrupt onsets can capture our attention involuntarily. The present study examined whether task-irrelevant onsets trigger strong suppression of their features, to reduce the ability of the onsets to capture attention. We used a capture-probe paradigm with salient abrupt onsets as precues. Participants performed a search task (70% of the trials) with occasional probe tasks mixed in (30% of the trials). In Experiment 1, two irrelevant-color distractors appeared simultaneously with the target, one of which was always precued by the abrupt onset. The question was whether an abrupt onset cue would promote suppression of the correlated color, thereby impeding recall of probe letters at a location with that color. This did not happen. The same result was obtained in Experiment 2, despite removing the target shape from the probe display to minimize floor effects and despite presenting only one distractor color per trial to further strengthen the onset-color association. In Experiment 3, one of the two irrelevant-color distractors abruptly onsetted 50 ms before the other search elements. Despite efforts to promote suppression of the cued distractor color, probe recall accuracy was again similar for the cued and non-cued distractor colors. We conclude that distractor features are suppressed but that making them especially salient does not noticeably enhance this suppression. The suppression mechanism is therefore geared towards helping observers discriminate between target features and distractor features, not towards beating down the most threatening object., (© 2022. The Psychonomic Society, Inc.)

Surface-enhanced Raman scattering (SERS) is considered to be a highly sensitive platform for chemical and biological sensing. Recently, owing to their high porosity and large surface area, metal-organic frameworks (MOFs) have attracted considerable attention in sensing applications. Porous carbon nanostructures are promising SERS substrates due to their strong broadband charge-transfer resonance and reproducible fabrication. Furthermore, an extraordinarily large enhancement of the electromagnetic field enables plasmonic nanomaterials to be ideal SERS substrates. Here, we demonstrate the porous Au@Ag nanostructure-decorated MOF-derived nanoporous carbon (NPC) for highly efficient SERS sensing. Specifically, this plasmonic nanomaterial-NPC composite offers high Raman signal enhancement with the ability to detect the model Raman reporter 2-naphthalenethiol (2-NT) at picomolar concentration levels., Competing Interests: The authors declare no competing financial interest., (© 2022 The Authors. Published by American Chemical Society.)

It is well established that attention can be captured by salient distractors. Some studies have found that action video game players were less susceptible to attention capture by irrelevant distractors than non-players. Other studies have also found that individuals with greater visual working memory capacity are less susceptible to capture by irrelevant distractors than individuals with lower visual working memory capacity. The present study examined whether action video game players were less susceptible to be captured by salient distractors and, if so, whether that relationship was due to greater visual working memory capacity. Participants completed a questionnaire reporting their video game playing experience, followed by a color change detection task assessing their visual working memory capacity. They then performed an attention capture task, where they determined the orientation of a bar within a shape singleton while attempting to ignore a color singleton distractor that appeared in 50% of the trials. Results showed that action video game players did not produce less capture effect than non-action video game players. However, high visual working memory capacity individuals produced less capture effect than low visual working memory capacity individuals regardless of their video game experience. These results suggest that the ability to resist capture by irrelevant distractors may be better explained by individual differences in visual working memory capacity than by action video game experience., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

It is commonly assumed that salient singletons generate an "attend-to-me signal" which causes suppression to develop over time, eventually preventing capture. Despite this assumption and the name "singleton suppression," a causal link between salience and suppression has not yet been clearly established. We point out the plausibility of a simple alternative mechanism: distractors might be suppressed because they are distractors rather than targets, even when non-salient. To look for evidence of salience-based suppression, we had participants search for a target shape among distractors, which sometimes included irrelevant-colored distractors. The critical manipulation was whether the irrelevant-colored distractor was salient (a color singleton) or non-salient (three non-target colored shapes; a triplet). On 30% of trials, probe letters were presented briefly inside each shape and participants were to report those letters. Probe recall below baseline indicates suppression. Experiment 1 showed that suppression was not triggered any more strongly by salient distractors (singletons) than by non-salient distractors (triplets). Experiment 2 showed that strong suppression effects developed rapidly even in the absence of salient singletons. These findings raise the thus far neglected question of whether salience plays any role in suppression., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

When letters are presented in mixed case (e.g., "PlAnE), word recognition is slowed. This case-mixing effect has been used to argue that early stages of word recognition operate holistically (on the entire visual word form) rather than merely letter-by-letter. Contrary to this holistic view, however, a masked priming study (Perea, Vergara-Martínez, & Gomez, Cognition 142:39-43, 2015) with Spanish words argued that case mixing has no effect on early stages of visual word recognition. Their participants made lexical decisions on an uppercase target (e.g., "PLANE") preceded by an identical prime (e.g., "plane") or an unrelated prime (e.g., "music"), presented in lowercase or mixed case. Because priming effects (unrelated-identical) were unaffected by case mixing, they concluded that case mixing does not impede early lexical access. We examined whether this finding applies to English words, while also including lowercase targets to prevent a strong bias against holistic word recognition. We found larger priming effects from lowercase primes than mixed-case primes regardless of target case (lowercase vs. uppercase) and whether target case was varied within blocks (Experiment 1) or between blocks (Experiment 2). Contrary to Perea et al.'s findings for Spanish, our results suggest an early locus for the case-mixing effect, consistent with the holistic view of word recognition.

We used event-related potentials to determine whether lexical access during semantic processing is achieved solely by the letter-based route, or by both a letter-based and word-based route. Participants determined whether words were related or unrelated to a prespecified category. To disrupt the word-based route (i.e., disrupt the processing of overall word shape), we manipulated case type. We measured the N170, assumed to be an index of holistic processing, and the N400, an index of semantic activation. Surprisingly, mixed-case words elicited a larger N170 effect than either consistent lowercase words (Experiment 1) or consistent uppercase words (Experiment 2). The N400, meanwhile, was unaffected by case mixing. In contrast, LEET words (e.g., T4BL3 instead of TABLE), which preserve overall word shape but distort letter shape, increased the N400 but did not reduce the N170 (Experiment 3). The results indicate that the N170 is in fact not a reliable index of holistic word processing. Implications for word recognition models are discussed.

Background : Previous studies on perceptual letter-matching have found that younger and older adults showed "fast-same" effects for response time and "false-different" effects for errors but the effects were more pronounced for older adults. According to the Noisy Operator Theory , internal noise in visual processing distorts "same" trials into appearing different whereas distortion for "different" trials does not affect performance. Older adults have a "noisier" representation of items within perceptual processing which can impact perceptual matching. However, EEG measures may provide a more direct measure of letter-matching decisions. Methods : We measured the P300 event-related potential (ERP) amplitude, an index of familiarity in stimulus categorization, and behavioral measures (response time and accuracy) to assess letter-matching performance. Results : Individuals responded faster to "same" trials than to "different" trials but were less accurate. Older adults showed similar P300 amplitudes across trial type whereas younger adults produced a larger amplitude for "same" than "different" trials, suggesting that older adults showed less familiarity for "same" trials than did younger adults - a prediction of the Noisy Operator Theory . Conclusions : These ERP results are consistent with the Noisy Operator Theory - suggesting that an age-related increase in internal noise affected letter-matching performance.

Schlaghecken, F., Blagrove, E., Mantantzis, K., Maylor, E. A., & Watson, D. G. [(2017). Look on the bright side: Positivity bias modulates interference effects in the Simon task. Journal of Experimental Psychology: General , 146 (6), 763-770] found larger spatial Simon effects for happy than sad faces. Unexpectedly, this enhancement was also observed for nonvalenced objects requiring the same response as happy faces. We examined whether the increase of the spatial Simon effect is location- or object-based. In Experiments 1 and 2, participants pressed a left/right key in response to a happy/sad face or a left-/right-pointing arrow. These stimuli appeared on the left/right side of fixation, with location being task-irrelevant. Consistent with Schlaghecken et al., the spatial Simon effect was numerically larger for happy than sad faces regardless of whether faces and arrows were presented in different blocks (Experiment 1) or intermixed within blocks (Experiment 2). However, the spatial Simon effect for arrows was not modulated by the faces' emotional valence. Similar findings were observed with pointing hands in Experiment 3. Our results imply that attentional bias is associated with specific objects (e.g. faces) not locations.

Background: Previous case-control investigations of type I Chiari malformation (CMI) have reported cognitive deficits and microstructural white matter abnormalities, as measured by diffusion tensor imaging (DTI). CMI is also typically associated with pain, including occipital headache, but the relationship between pain symptoms and microstructure is not known., Methods: Eighteen CMI patients and 18 adult age- and education-matched control participants underwent DTI, were tested using digit symbol coding and digit span tasks, and completed a self-report measure of chronic pain. Tissue microstructure indices were used to examine microstructural abnormalities in CMI as compared with healthy controls. Group differences in DTI parameters were then reassessed after controlling for self-reported pain. Finally, DTI parameters were correlated with performance on the digit symbol coding and digit span tasks within each group., Results: CMI patients exhibited greater fractional anisotropy (FA), lower radial diffusivity, and lower mean diffusivity in multiple brain regions compared with controls in diffuse white matter regions. Group differences no longer existed after controlling for self-reported pain. A significant correlation between FA and the Repeatable Battery for the Assessment of Neuropsychological Status coding performance was observed for controls but not for the CMI group., Conclusions: Diffuse microstructural abnormalities appear to be a feature of CMI, manifesting predominantly as greater FA and less diffusivity on DTI sequences. These white matter changes are associated with the subjective pain experience of CMI patients and may reflect reactivity to neuroinflammatory responses. However, this hypothesis will require further deliberate testing in future studies., (© The Author(s) 2020. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Background: Idiopathic descent of cerebellar tonsils into the cervical spine in Chiari malformation Type I (CMI) is typically associated with occipital headache. Accumulating evidence from experimental studies suggests cognitive effects of CMI. The aim of the current study was to examine the relationship between cognition and CMI using a battery of standardized neuropsychological and symptom inventory instruments., Method: Eighteen untreated adults with CMI, and 18 gender, age, and education matched healthy controls completed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and standardized measures of pain, mood, and disability. Morphometric measurements of key neural and osseous elements were also obtained from structural brain magnetic resonance images, for correlation with symptom outcomes., Results: CMI patients exhibited deficits in RBANS attention, immediate memory, delayed memory, and total score. After controlling for pain and associated affective disturbance, the significant group effect for RBANS attention remained. CMI patients also presented seven morphometric differences comprising the cerebellum and posterior cranial fossa compartment that differed from healthy controls, some of which were associated with self-reported pain and disability. Notably, group differences in tonsillar position were associated with self-reported pain, disability, and delayed memory., Conclusion: Adult CMI is associated with domain-specific cognitive change, detectable using a standard clinical instrument. The extent of cognitive impairment is independent of pain or affective symptomatology and may be related to the key pathognomonic feature of the condition. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Type I Chiari malformation (CMI) is a neurological condition in which the cerebellar tonsils descend into the cervical spinal subarachnoid space resulting in cervico-medullary compression. Early case-control investigations have indicated cognitive deficits in the areas of attention, memory, processing speed, and visuospatial function. The present study further examined cognitive and emotional processing deficits associated with CMI using a dual-task paradigm. Nineteen CMI patients were recruited during pre-surgical consultation and 19 matched control participants identified emotional expressions in separate single and asynchronous dual-task designs. To extend earlier behavioral studies of cognitive effects in CMI, we recorded event-related potentials (ERPs) in the dual-task design. Though response times were slower for CMI patients across the two tasks, behavioral and ERP analyses indicated that patients did not differ from matched controls in the ability to allocate attentional resources between the two tasks. P1 ERP component analyses provided no indication of an emotional arousal deficit in our CMI sample while P3 ERP component analyses suggested a CMI-related deficit in emotional regulation. P3 analysis also yielded evidence for a frontalization of neurophysiological activity in CMI patients. Pain and related depression and anxiety factors accounted for CMI deficits in single-task, but not dual-task, response times. Results are consistent with a dysfunctional fronto-parietal attentional network resulting from either the indirect effects of chronic pain or the direct effects of CMI pathophysiology stemming from cervico-medullary compression.

Background/Study context: Adult age differences in emotion processing have been attributed to age-related decline in earlier emotional perception and age-related bias in later emotional regulation. Yet, the relationship between the processes of early emotion perception and bias in emotional regulation and their influence on behavioral outcomes remains unclear. Event-related potentials (ERPs) have the temporal precision to allow for the online measure of neurophysiological activity and provide potential insight into the complex dynamics of emotion processing and aging., Methods: ERPs were used as the primary measure to examine the hypotheses that younger adults will differ in emotional arousal and emotional bias as represented by the early P1 waveform and later P3 waveform, respectively. Thirty-two younger and older adults (16 each) performed a facial emotion discrimination task in which they identified standardized angry, happy, or neutral expressions of faces from the NimStim database., Results: Younger adults showed a greater P1 ERP for angry faces relative to happy faces at parietal channels, while older adults did not exhibit any emotional modulation of the P1. In contrast, both younger and older adults showed a greater late P3 ERP for angry faces compared to happy faces., Conclusion: The authors' results provide evidence for an age-related deficit in early emotion perception and autonomic arousal. Younger adults, but not older adults, exhibited a pattern of neurophysiological activity believed to reflect preconscious and reflexive identification of threat. Despite these age group differences in early emotion processing, younger and older adults did not exhibit differences in neurophysiological processes believed to reflect emotion regulation.

When participants classify pictures of objects as upright or inverted with a left or right keypress, responses are faster if the response location (left/right) corresponds with the location of a handle (left/right) than if it does not. This result has typically been attributed to a grasping affordance (automatic activation of muscles associated with grasping the object with the ipsilateral hand), but several findings have indicated instead that the effect is a spatial correspondence effect, much like the Simon effect for object location. Pappas (2014) reported evidence he interpreted as showing that spatial coding predominates with silhouettes of objects, whereas photographs of objects yield affordance-based effects. We conducted two experiments similar to those of Pappas, using frying pans as stimuli, with our two experiments differing in whether the entire object was centered on the display screen or the base was centered. When the objects were centered, a positive correspondence effect relative to the handle was evident for the silhouettes but a negative correspondence effect for the photographs. When the base was centered, the handle was clearly located to the left or right side of the display, and both silhouettes and photographs produced correspondence effects of similar size relative to the handle location. Despite the main results being counter to the grasping affordance hypothesis, response-time distribution analyses suggest that, instead of activating automatically at fast responses, an effector-specific component of the hypothesized type may come into play for responses that are selected after the handle location has been identified., (Copyright © 2017 Elsevier B.V. All rights reserved.)

Previous studies on perceptual learning, acquiring a new skill through practice, appear to stimulate brain plasticity and enhance performance (Fiorentini & Berardi, 1981). The present study aimed to determine (a) whether perceptual learning can be used to compensate for age-related declines in perceptual abilities, and (b) whether the effect of perceptual learning can be transferred to untrained stimuli and subsequently improve capacity of visual working memory (VWM). We tested both healthy younger and older adults in a 3-day training session using an orientation discrimination task. A matching-to-sample psychophysical method was used to measure improvements in orientation discrimination thresholds and reaction times (RTs). Results showed that both younger and older adults improved discrimination thresholds and RTs with similar learning rates and magnitudes. Furthermore, older adults exhibited a generalization of improvements to 3 untrained orientations that were close to the training orientation and benefited more compared with younger adults from the perceptual learning as they transferred learning effects to the VWM performance. We conclude that through perceptual learning, older adults can partially counteract age-related perceptual declines, generalize the learning effect to other stimulus conditions, and further overcome the limitation of using VWM capacity to perform a perceptual task. (PsycINFO Database Record, ((c) 2017 APA, all rights reserved).)

Previous studies suggest that older adults process positive emotions more efficiently than negative emotions, whereas younger adults show the reverse effect. We examined whether this age-related difference in emotional bias still occurs when attention is engaged in two emotional tasks. We used a psychological refractory period paradigm and varied the emotional valence of Task 1 and Task 2. In both experiments, Task 1 was emotional face discrimination (happy vs. angry faces) and Task 2 was sound discrimination (laugh, punch, vs. cork pop in Experiment 1 and laugh vs. scream in Experiment 2). The backward emotional correspondence effect for positively and negatively valenced Task 2 on Task 1 was measured. In both experiments, younger adults showed a backward correspondence effect from a negatively valenced Task 2, suggesting parallel processing of negatively valenced stimuli. Older adults showed similar negativity bias in Experiment 2 with a more salient negative sound ("scream" relative to "punch"). These results are consistent with an arousal-bias competition model [Mather and Sutherland (Perspectives in Psychological Sciences 6:114-133, 2011)], suggesting that emotional arousal modulates top-down attentional control settings (emotional regulation) with age.

In 2-choice tasks, responses are faster when stimulus location corresponds to response location, even when stimulus location is irrelevant. Dolk et al. (J Exp Psychol Hum Percept Perform 39:1248-1260, 2013a) found this stimulus-response correspondence effect with a single response location in a go-nogo task when an irrelevant Japanese waving cat was present. They argued that salient objects trigger spatial coding of the response relative to that object. We examined this claim using both behavioral and lateralized readiness potential (LRP) measures. In Experiment 1 participants determined the pitch of a left- or right-positioned tone, whereas in Experiment 2 they determined the color of a dot within a centrally located hand pointing left, right, or straight ahead. In both experiments, participants performed a go-nogo task with the right-index finger and a 2-choice task with both index fingers, with a left-positioned Japanese waving cat present or absent. For the go-nogo task, the cat induced a correspondence effect on response times (RT) to the tones (Experiment 1) but not the visual stimuli (Experiment 2). For the 2-choice task, a correspondence effect was evident in all conditions in both experiments. Cat's presence/absence did not significantly modulate the effect for right and left responses, although there was a trend toward increased RT and LRP for right responses in Experiment 1. The results imply that a salient, irrelevant object could provide a reference frame for response coding when attention is available to process it, as is likely in an auditory task (Experiment 1) but not a visual task (Experiment 2).

Researchers are sharply divided regarding whether irrelevant abrupt onsets capture spatial attention. Numerous studies report that they do and a roughly equal number report that they do not. This puzzle has inspired numerous attempts at reconciliation, none gaining general acceptance. The authors propose that abrupt onsets routinely capture attention, but the size of observed capture effects depends critically on how long attention dwells on distractor items which, in turn, depends critically on search difficulty. In a series of spatial cuing experiments, the authors show that irrelevant abrupt onsets produce robust capture effects when visual search is difficult, but not when search is easy. Critically, this effect occurs even when search difficulty varies randomly across trials, preventing any strategic adjustments of the attentional set that could modulate probability of capture by the onset cue. The authors argue that easy visual search provides an insensitive test for stimulus-driven capture by abrupt onsets: even though onsets truly capture attention, the effects of capture can be latent. This observation helps to explain previous failures to find capture by onsets, nearly all of which used an easy visual search. (PsycINFO Database Record, ((c) 2016 APA, all rights reserved).)

Objective: In this study, we examined how effectively people can monitor new stimuli on a peripheral display while carrying out judgments on an adjacent central display., Background: Improved situation awareness is critical for improved operator performance in aviation and many other domains. Given the limited extent of foveal processing, acquiring additional information from peripheral vision offers high potential gains., Method: Participants carried out a sequence of central perceptual judgments while simultaneously monitoring the periphery for new stimuli. Peripheral detection was measured as a function of central-judgment difficulty, the relative timing of the two tasks, and peripheral event rate., Results: Participants accurately detected and located peripheral targets, even at the highest eccentricity explored here (~30°). Peripheral detection was not reduced by increased central-task difficulty but was reduced when peripheral targets arrived later in the processing of central stimuli and when peripheral events were relatively rare., Conclusion: Under favorable conditions-high-contrast stimuli and high event rate-people can successfully monitor peripheral displays for new events while carrying out an unrelated continuous task on an adjacent display., Application: In many fields, such as aviation, existing displays were designed with low-contrast stimuli that provide little opportunity for peripheral vision. With appropriate redesign, operators might successfully monitor multiple displays over a large visual field. Designers need to be aware of nonvisual factors, such as low event rate and relative event timing, that can lead to failures to detect peripheral stimuli., (© 2014, Human Factors and Ergonomics Society.)

Perea, Duñabeitia, and Carreiras (Journal of Experimental Psychology: Human Perception and Performance 34:237-241, 2008) found that LEET stimuli, formed by a mixture of digits and letters (e.g., T4BL3 instead of TABLE), produced priming effects similar to those for regular words. This finding led them to conclude that LEET stimuli automatically activate lexical information. In the present study, we examined whether semantic activation occurs for LEET stimuli by using an electrophysiological measure called the N400 effect. The N400 effect, also known as the mismatch negativity, reflects detection of a mismatch between a word and the current semantic context. This N400 effect could occur only if the LEET stimulus had been identified and processed semantically. Participants determined whether a stimulus (word or LEET) was related to a given category (e.g., APPLE or 4PPL3 belongs to the category "fruit," but TABLE or T4BL3 does not). We found that LEET stimuli produced an N400 effect similar in magnitude to that for regular uppercase words, suggesting that LEET stimuli can access meaning in a manner similar to words presented in consistent uppercase letters.

Objective: Our objective was to use episodic memory and executive function tests to determine whether or not Chiari Malformation Type I (CM) patients experience cognitive dysfunction., Background: CM is a neurological syndrome in which the cerebellum descends into the cervical spine causing neural compression, severe headaches, neck pain, and number of other physical symptoms. While primarily a disorder of the cervico-medullary junction, both clinicians and researchers have suspected deficits in higher-level cognitive function., Design and Methods: We tested 24 CM patients who had undergone decompression neurosurgery and 24 age- and education-matched controls on measures of immediate and delayed episodic memory, as well as three measures of executive function., Results: The CM group showed performance decrements relative to the controls in response inhibition (Stroop interference), working memory computational speed (Ospan), and processing speed (automated digit symbol substitution task), but group differences in recall did not reach statistical significance. After statistical control for depression and anxiety scores, the group effects for working memory and processing speed were eliminated, but not for response inhibition. This response inhibition difference was not due to overall general slowing for the CM group, either, because when controls' data were transformed using the linear function fit to all of the reaction time tasks, the interaction with group remained statistically significant. Furthermore, there was a multivariate group effect for all of the response time measures and immediate and delayed recall after statistical control of depression and anxiety scores., Conclusion: These results suggest that CM patients with decompression surgery exhibit cognitive dysfunction compared to age- and education-matched controls. While some of these results may be related to anxiety and depression (likely proxies for chronic pain), response inhibition effects, in particular, as well as a general cognitive deficit persisted even after control for anxiety and decompression.

Unlabelled: BACKGROUND/STUDY CONTEXT: The present study examined the effect of training on age differences in performing a highly practiced task using the psychological refractory period (PRP) paradigm (Pashler, 1984, Journal of Experimental Psychology: Human Perception and Performance, 10, 358-377). Earlier training studies have concentrated on tasks that are not already overlearned. The present question of interest is whether task dual-task integration will be more efficient when single-task performance is approaching asymptotic levels., Methods: Task 1 was red/green signal discrimination (green = "go" and red = "wait"; analogous to pedestrian signals) and Task 2 was tone discrimination (white noise vs. a horn "honk"; analogous to traffic sound). The stimulus onset asynchrony (SOA) between Task 1 and Task 2 was varied (50, 150, 600, and 1000 ms). All individuals participated in eight sessions spread over 8 weeks (one session per week). Participants completed a dual-task pretest (Week 1), followed by 6 weeks of single-task testing (Weeks 2-7), followed by a dual-task posttest (Week 8)., Results and Conclusion: Although older adults showed larger overall dual-task costs (i.e., PRP effects), they were able to reduce the costs with practice as much as younger adults. However, even when training on Task 1 results in asymptotic performance, this still did not lead to an appreciable reduction in dual-task costs. Also, older adults, but not younger adults, responded more rapidly to green stimuli than to red stimuli in the Task 1 training latency data. The authors confirmed this green/go bias using diffusion modeling, which takes into account response time and error rates at the same time. This green/go bias is potentially dangerous at crosswalks, especially when combined with large dual-task interference, and might contribute to the high rate of crosswalk accidents in the elderly.

We examined Goslin, Dixon, Fischer, Cangelosi, and Ellis's (Psychological Science 23:152-157, 2012) claim that the object-based correspondence effect (i.e., faster keypress responses when the orientation of an object's graspable part corresponds with the response location than when it does not) is the result of object-based attention (vision-action binding). In Experiment 1, participants determined the category of a centrally located object (kitchen utensil vs. tool), as in Goslin et al.'s study. The handle orientation (left vs. right) did or did not correspond with the response location (left vs. right). We found no correspondence effect on the response times (RTs) for either category. The effect was also not evident in the P1 and N1 components of the event-related potentials, which are thought to reflect the allocation of early visual attention. This finding was replicated in Experiment 2 for centrally located objects, even when the object was presented 45 times (33 more times than in Exp. 1). Critically, the correspondence effects on RTs, P1s, and N1s emerged only when the object was presented peripherally, so that the object handle was clearly located to the left or right of fixation. Experiment 3 provided further evidence that the effect was observed only for the base-centered objects, in which the handle was clearly positioned to the left or right of center. These findings contradict those of Goslin et al. and provide no evidence that an intended grasping action modulates visual attention. Instead, the findings support the spatial-coding account of the object-based correspondence effect.

As a tool of public policy making, PPGIS (public participation geographic information system) makes its biggest impact in regard to empowerment. Quite few methods are available for making a complete evaluation of the empowerment. Using the Meinong Yellow Butterfly Valley as a case study, this article analyzes how the processes and outcomes of the PPGIS make an impact on empowerment in terms of three aspects indicated by the questions: "What is empowered?" "Who are empowered?" and "How to empower?" The results show that we are able to completely grasp the impact of PPGIS empowerment by analyzing what, who and how aspects simultaneously. They also indicate that PPGIS empowerment involves mutual transfers of knowledge, capabilities and power among all of the stakeholders, which can't simply be given by outsiders., (Copyright © 2012 Elsevier Ltd. All rights reserved.)

Theeuwes (Psychonomic Bulletin & Review 11:65-70, 2004) proposed that stimulus-driven capture occurs primarily for salient stimuli that fall within the observer's attentional window, such as when performing a parallel search. This proposal, which is supported by some studies, can explain many seemingly discrepant results in the literature. The present study tested this proposal using a modified precuing paradigm. Search mode was manipulated via target-distractor similarity in color space. In the parallel search condition, the orange target "popped out" from a set of distantly colored distractors (blue and green). In the serial search condition, the orange target was more difficult to find amongst a set of similarly colored distractors (yellow and red). In Experiments 1 and 2, cue validity effects for irrelevant-color singleton cues were greater under parallel than under serial search, at least partially replicating previous studies favoring the attentional-window account (e.g., Belopolsky, Zwaan, Theeuwes, & Kramer, Psychonomic Bulletin & Review 14:934-938, 2007). We found the opposite pattern, however, for capture by abrupt onsets (Experiments 3 and 4), in which case capture effects were actually greater under serial search. In sum, parallel search appears to facilitate capture by color singletons, yet to inhibit capture by abrupt onsets.

The present study examined adult age differences in processing emotional faces using a psychological refractory period paradigm. We used both behavioral and event-related potential (P1 component) measures. Task 1 was tone discrimination (fuzzy vs. pure tones) and Task 2 was emotional facial discrimination ("happy" vs. "angry" faces). The stimulus onset asynchrony (SOA) between the two tasks was 100, 300, and 900 ms. Earlier research observed larger age deficits in emotional facial discrimination for negative (angry) than for positive (happy) faces (Baena et al., 2010). Thus, we predicted that older adults would show decreased attentional efficiency in carrying out dual-task processing on the P1 (a component linked to amygdalar modulation of visual perception; Rotshtein et al., 2010). Both younger and older groups showed significantly higher P1 amplitudes at 100- and 300-ms SOAs than at the 900-ms SOA, and this suggests that both age groups could process Task 2 faces without central attention. Also, younger adults showed significantly higher P1 activations for angry than for happy faces, but older adults showed no difference. These results are consistent with the idea that younger adults exhibited amygdalar modulation of visual perception, but that older adults did not.

Do word frequency and case mixing affect different processing stages in visual word recognition? Some studies of online reading have suggested that word frequency affects an earlier, perceptual-encoding stage and that case mixing affects a later, central decision stage (e.g., Reingold, Yang, & Rayner, Journal of Experimental Psychology: Human Perception and Performance 36:1677-1683 2010); others have suggested otherwise (e.g., Allen, Smith, Lien, Grabbe, & Murphy, Journal of Experimental Psychology: Human Perception and Performance 31:713-721 2005; Besner & McCann, 1987). To determine the locus of the word frequency and case-mixing effects, we manipulated word frequency (high vs. low) and case type (consistent lower case vs. mixing case) in a lexical-decision paradigm. We measured two event-related-potential components: the N170 (an early peak occurring 140-240 ms after stimulus onset, related to structural encoding) and the P3 (a late peak occurring 400-600 ms after stimulus onset, related to stimulus categorization). The critical finding was that the N170 amplitude was sensitive to case mixing, but the P3 amplitude was sensitive to word frequency and lexicality. These results suggest that case mixing affects an earlier processing stage than does word frequency, at least with respect to lexical-decision processes.

This study compares the effectiveness of alcohol, natural drying, and salicylic sugar powder on umbilical separation time of the neonate in our high-humidity region. From September 2007 to May 2008, a total of 143 neonates in a community hospital were divided into 3 groups according to their birth month in sequence. Each umbilical care regimen was randomly assigned to a 3-month period. Data on occurrence of omphalitis and cord separation time were collected by telephone follow-up until stump separation. The salicylic sugar powder group had the lowest rates of colonization and shortest cord separation time compared with the natural drying and alcohol groups. No omphalitis developed in any of the 3 groups. Natural drying and salicylic sugar powder are safe and effective ways to care for the umbilical cord stump in high-humidity regions. Nursing professionals should consider choosing a more effective umbilical care regimen and provide mothers with thorough instruction.

The present study examined whether people become more susceptible to capture by salient objects as they age. Participants searched a target display for a letter in a specific color and indicated its identity. In Experiment 1, this target display was preceded by a non-informative cue display containing one target-color box, one ignored-color box, and two white boxes. On half of the trials, this cue display also contained a salient-but-irrelevant abrupt onset. To assess capture by the target-color cue, we used the N2pc component of the event-related potential, thought to reflect attentional allocation to the left or right visual field. The target-color box in the cue display produced a substantial N2pc effect for younger adults and, most importantly, this effect was not diminished by the presence of an abrupt onset. Therefore, the abrupt onset was unable to capture attention away from the target-color cue. Critically, older adults demonstrated the same resistance to capture by the abrupt onset. Experiment 2 extended these findings to irrelevant color singleton cues. Thus, we argue that the ability to attend to relevant stimuli and resist capture by salient-but-irrelevant stimuli is preserved with advancing age., ((c) 2011 APA, all rights reserved.)

Previous studies have disagreed about the extent to which people extract meaning from words presented outside the focus of spatial attention. The present study examined a possible explanation for such discrepancies inspired by attenuation theory: Unattended words can be read more automatically when they are expected within a given context (e.g., due to frequent repetition). We presented a brief prime word in lowercase, followed by a target word in uppercase. Participants indicated whether the target word belonged to a particular category (e.g., "sports"). When we used a visual cue to draw attention to the location of the prime word, it produced substantial priming effects on target responses (i.e., especially fast responses when the prime and target words were identical or from the same category). When prime words were not attended, however, they produced no priming effects. This finding replicated even when there were only four words, each repeated 160 times during the experiment. It appears that very little word processing is possible without spatial attention, even for words that are expected and frequently presented.

The classic theory of spatial attention hypothesized 2 modes, voluntary and involuntary. Folk, Remington, and Johnston (1992) reported that even involuntary attention capture by stimuli requires a match between stimulus properties and what the observer is looking for. This surprising conclusion has been confirmed by many subsequent studies. In these studies, however, the observer typically looks for the same property throughout an entire session. Real-world behavior, in contrast, often requires frequent shifts in attentional set. The present study examined whether such shifts weaken attentional settings, allowing task-irrelevant objects to capture attention. Surprisingly, fluctuating control settings did not increase vulnerability to capture by salient stimuli (color singletons and abrupt onsets). We conclude that the attention control system is remarkably flexible, able to rapidly and fully adopt new settings and abandon old settings.

The authors tested 18 younger adults and 18 older adults on four sessions in a psychological refractory period (PRP) paradigm, to see whether older adults can benefit as much from dual-task practice as younger adults. Task 1 involved tone discrimination and Task 2 involved simultaneous letter-matching. The stimulus onset asynchrony (SOA) between the tasks was either 50, 150, 300, or 900 ms. Although older adults showed a larger PRP effect than younger adults, there were no group differences in the practice/training benefit. These results differ from Maquestiaux, Hartley, and Bertsch (2004, Psychology and Aging, 19, 649-667, Experiment 1), who found that age differences in PRP effects became progressively larger with increased practice. These findings, along with the simultaneous-presentation, dual-task work of Kramer, Larish, and Strayer (1995, Journal of Experimental Psychology: Applied, 1, 50-76) and Bherer et al. (2005, Psychology and Aging, 20, 695-709; 2006, Acta Psychologica, 123, 261-278), suggest that older adults can benefit as much as younger adults from dual-task training.

Are emotions perceived automatically? Two psychological refractory period experiments were conducted to ascertain whether emotion perception requires central attentional resources. Task 1 required an auditory discrimination (tone vs. noise), whereas Task 2 required a discrimination between happy and angry faces. The difficulty of Task 2 was manipulated by varying the degree of emotional expression. The stimulus onset asynchrony (SOA) between Task 1 and Task 2 was also varied. Experiment 1 revealed additive effects of SOA and Task 2 emotion-perception difficulty. Experiment 2 replicated the additive relationship with a stronger manipulation of emotion-perception difficulty. According to locus-of-slack logic, our participants did not process emotional expressions while central resources were devoted to Task 1. We conclude that emotion perception is not fully automatic.

Four experiments are reported that test a multistream model of visual word recognition, which associates letter-level and word-level processing channels with three known visual processing streams isolated in macaque monkeys: the magno-dominated (MD) stream, the interblob-dominated (ID) stream, and the blob-dominated (BD) stream (Van Essen & Anderson, 1995). We show that mixing the color of adjacent letters of words does not result in facilitation of response times or error rates when the spatial-frequency pattern of a whole word is familiar. However, facilitation does occur when the spatial-frequency pattern of a whole word is not familiar. This pattern of results is not due to different luminance levels across the different-colored stimuli and the background because isoluminant displays were used. Also, the mixed-case, mixed-hue facilitation occurred when different display distances were used (Experiments 2 and 3), so this suggests that image normalization can adjust independently of object size differences. Finally, we show that this effect persists in both spaced and unspaced conditions (Experiment 4)--suggesting that inappropriate letter grouping by hue cannot account for these results. These data support a model of visual word recognition in which lower spatial frequencies are processed first in the more rapid MD stream. The slower ID and BD streams may process some lower spatial frequency information in addition to processing higher spatial frequency information, but these channels tend to lose the processing race to recognition unless the letter string is unfamiliar to the MD stream--as with mixed-case presentation.

This study looked for evidence of task-set inhibition in a voluntary task-switching paradigm. Participants performed one of three tasks on a digit: parity (even or odd), size (less than or greater than 5), or distance (near or far from 5). On each trial, they were allowed to choose which task to perform, with encouragement to perform each task equally often overall and in a random sequence. The question was whether participants would avoid performing a task that they had recently switched away from (e.g., the task performed on trial n-2), because the task set was still inhibited. Results confirmed that participants strongly avoided performing the n-2 task (e.g., ABA) in favor of performing other tasks (e.g., ABC). This occurred both when participants were required to switch tasks every trial (Experiment 1) and when they were allowed to repeat tasks (Experiment 2). The results suggest that a task set is inhibited during switching to a new task, reducing the likelihood that this task will be selected in the near future.

One of the most robust findings in attention research is that the time to name a color is lengthened markedly in the presence of an irrelevant word that spells a different color name: the Stroop effect. The Stroop effect is found even when the word is physically separated from the color, apparently indicating that words can be read outside the focus of spatial attention. The present study critically evaluated this claim. We employed several stringent measures within a Stroop paradigm to prevent participants from attending to the irrelevant words (e.g., limiting exposure duration to prevent attention capture). Nonetheless, residual Stroop effects were obtained for both color words and semantic associates (e.g., sky to blue). These data suggest that lexical processing can sometimes occur outside the focus of spatial attention.

Theories of attentional control are divided over whether the capture of spatial attention depends primarily on stimulus salience or is contingent on attentional control settings induced by task demands. The authors addressed this issue using the N2-posterior- contralateral (N2pc) effect, a component of the event-related brain potential thought to reflect attentional allocation. They presented a cue display followed by a target display of 4 letters. Each display contained a green item and a red item. Some participants responded to the red letter and others to the green letter. Converging lines of evidence indicated that attention was captured by the cues with the same color as the target. First, these target-color cues produced a cuing validity effect on behavioral measures. Second, distractors appearing in the cued location produced larger compatibility effects. Third, the target-color cue produced a robust N2pc effect, similar in magnitude to the N2pc effect to the target itself. Furthermore, the target-color cue elicited a similar N2pc effect regardless of whether it competed with a simultaneous abrupt onset. The findings provide converging evidence for attentional capture contingent on top-down control settings.

The present study used event-related potentials (ERPs) to determine the degree to which people can process words while devoting central attention to another task. Experiments 1-4 measured the N400 effect, which is sensitive to the degree of mismatch between a word and the current semantic context. Experiment 5 measured the P3 difference between low- and high-frequency words. Because these effects can occur only if a word has been identified, both ERP components index word processing. The authors found that the N400 effect (Experiments 1, 3, and 4) and the P3 difference (Experiment 5) were strongly attenuated for Task 2 words presented nearly simultaneously with Task 1. No such attenuation was found when the Task 1 stimulus was presented but required no response (Experiment 2). Strong attenuation was also evident when the Task 2 word was presented before the Task 1 stimulus (Experiment 4), suggesting that central resources are not allocated to stimuli first-come, first-served but rather are strategically locked to Task 1. The authors conclude that visual word processing is not fully automatic but rather requires access to limited central attentional resources.

The present study tested the hypothesis that older adults establish a weaker task set than younger adults and therefore rely more on stimulus-triggered activation of task sets. This hypothesis predicts that older adults should have difficulty with task switches, especially when the stimuli-responses are associated with multiple, competing tasks. Weak task preparation, however, could actually benefit older adults when performing an unexpected task. The authors tested this prediction in Experiment 1 using a repeating AABB task sequence, with univalent and bivalent stimuli intermixed. On some univalent trials, participants received an unexpected task. Contrary to the authors' predictions, expectancy costs were not smaller for older adults. Similar findings were obtained in Experiments 2 and 3, in which the authors used a task-cueing paradigm to more strongly promote deliberate task preparation. The authors found no disproportionate age effects on switch costs but did find age effects on bivalence costs and mixing costs. The authors conclude that older adults do experience extra difficulty dealing with stimuli associated with 2 active tasks but found no evidence that the problem specifically stems from an increased reliance on bottom-up task activation rather than top-down task preparation.

The present study examined individual differences in the automaticity of visual word recognition. Specifically, we examined whether people can recognize words while central attention is devoted to another task and how this ability depends on reading skill. A lexical-decision Task 2 was combined with either an auditory or visual Task 1. Regardless of the Task 1 modality, Task 2 word recognition proceeded in parallel with Task 1 central operations for individuals with high Nelson-Denny reading scores, but not for individuals with low reading scores. We conclude that greater lexical skill leads to greater automaticity, allowing better readers to more efficiently perform lexical processes in parallel with other attention-demanding tasks.