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Your search keyword '"Lieberman, Eric H."' showing total 27 results
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27 results on '"Lieberman, Eric H."'

1. Quality of Life and Clinical Outcomes in Elderly Patients Treated with Ventricular Pacing as Compared with Dual-Chamber Pacing

Author

Lamas, Gervasio A, Orav, E John, Stambler, Bruce S, Ellenbogen, Kenneth A, Sgarbossa, Elena B, Huang, Shoei K Stephen, Marinchak, Roger A, Estes, NA Mark, Mitchell, Gary F, Lieberman, Eric H, Mangione, Carol M, Goldman, Lee, Griffin, John J, Maloney, James D, Rizo-Patrón, Carlos, Venditti, Ferdinand J, and Wilkoff, Bruce L

Subjects
Heart Disease, Neurosciences, Clinical Research, Cardiovascular, Aging, Bioengineering, Clinical Trials and Supportive Activities, Assistive Technology, Evaluation of treatments and therapeutic interventions, 6.3 Medical devices, Good Health and Well Being, Aged, Aged, 80 and over, Bradycardia, Cardiac Pacing, Artificial, Equipment Design, Female, Heart Block, Humans, Male, Pacemaker, Artificial, Quality of Life, Single-Blind Method, Survival Analysis, Treatment Outcome, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundStandard clinical practice permits the use of either single-chamber ventricular pacemakers or dual-chamber pacemakers for most patients who require cardiac pacing. Ventricular pacemakers are less expensive, but dual-chamber pacemakers are believed to be more physiologic. However, it is not known whether either type of pacemaker results in superior clinical outcomes.MethodsThe Pacemaker Selection in the Elderly study was a 30-month, single-blind, randomized, controlled comparison of ventricular pacing and dual-chamber pacing in 407 patients 65 years of age or older in 29 centers. Patients received a dual-chamber pacemaker that had been randomly programmed to either ventricular pacing or dual-chamber pacing. The primary end point was health-related quality of life as measured by the 36-item Medical Outcomes Study Short-Form General Health Survey.ResultThe average age of the patients was 76 years (range, 65 to 96), and 60 percent were men. Quality of life improved significantly after pacemaker implantation (P

Published
1998

6. The Mode Selection Trial (MOST) in sinus node dysfunction: design, rationale, and baseline characteristics of the first 1,000 patients

Author

Lamas, Gervasio A., Lee, Kerry, Sweeney, Michael, Leon, Angel, Yee, Raymond, Ellenbogen, Ken, Greer, Stephen, Wilber, David, Silverman, Russell, Marinchak, Roger, Bernstein, Robert, Mittleman, Robert S., Lieberman, Eric H., Sullivan, Cindi, Zorn, Lisa, Flaker, Greg, Schron, Eleanor, Orav, E. John, and Goldman, Lee

Subjects
Pacemaker, Artificial (Heart) -- Research, Arrhythmia -- Care and treatment, Health
Published
2000

12. Endothelial Function and Insights for Prevention.

Author

Cannon, Christopher P., Armani, Annemarie M., Foody, Joanne Micale, Lieberman, Eric H., Garces, Margarita R., and Lopez-Jimenez, Francisco

Abstract

When William Harvey described the circulatory system in 1628, it was believed that the endothelium was an inert organ whose mere function was to line the arteries. Extensive research, however, has demonstrated that the endothelium is one of the most sophisticated organs in the system, playing a substantial role in the homeostasis of the circulatory system (1). The endothelium serves as one of the largest paracrine organs in the body by playing a pivotal role in the regulation of such important tasks as vascular growth, vascular tone, and hemostasis. Additionally, the endothelium maintains the balance between opposing states: vasodilation vs vasoconstriction, growth promotion vs inhibition, antithrombosis vs fibrinolysis, antioxidation vs oxidation, and anti-inflammation vs proinflammation. [ABSTRACT FROM AUTHOR]

Published
2006
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13. Quality of Life and Clinical Outcomes in Elderly Patients Treated with Ventricular Pacing as Compared with Dual-Chamber Pacing

Author

LAMAS, GERVASIO A., primary, ORAV, E. JOHN, additional, STAMBLER, BRUCE S., additional, ELLENBOGEN, KENNETH A., additional, SGARBOSSA, ELENA B., additional, HUANG, SHOEI K. STEPHEN, additional, MARINCHAK, ROGER A., additional, MARK ESTES, N. A., additional, MITCHELL, GARY F., additional, LIEBERMAN, ERIC H., additional, MANGIONE, CAROL M., additional, and GOLDMAN, LEE, additional

Published
1999
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21. Flow-induced vasodilation of the human brachial artery is impaired in patients <40 years of age...

Author

Lieberman, Eric H. and Gerhard, Marie D.

Subjects
*CORONARY disease, *VASODILATION
Abstract

Determines coronary artery disease in young patients by abnormal flow-induced endothelium-dependent vasodilation in the human brachial artery. Nitric oxide-synthase inhibition and flow-mediated vasodilation; Mechanism of flow-mediated, endothelium-dependent vasodilation; Associated with coronary artery disease.

Published
1996
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23. Noninvasive Assessment of Endothelium-Dependent Flow-Mediated Dilation of the Brachial Artery

Author

Uehata, Akimi, Lieberman, Eric H, Gerhard, Marie D, Anderson, Todd J, Ganz, Peter, Polak, Joseph F, Creager, Mark A, and Yeung, Alan C

Abstract

Coronary atherosclerosis is characterized by an early loss of endothelium-dependent vasodilation. However, the methods of assessing coronary endothelial function are invasive and difficult to repeat over time. Recently, a noninvasive ultrasound method has been widely used to measure flow-mediated dilation in the brachial artery as a surrogate test for endothelial function. We seek to further validate this method of measuring vascular function.The brachial artery diameters and blood flow of 20 normal volunteers (10 males and 10 females) were measured using high resolution (7.5 MHz) ultrasound and strain gauge plethysmography. Flow-mediated endothelium-dependent vasodilation was measured in the brachial artery during reactive hyperemia after 5 minutes of cuff occlusion in the upper arm. The brachial artery diameter increased maximally by 9.7 ± 4.3% from baseline at 1 min after cuff release and blood flow increased by 1002 ± 376%. Five min of cuff occlusion was sufficient to achieve 97 ± 6% of maximal brachial artery dilation and degree of dilation was not different whether the cuff was inflated proximally or distally to the image site. The intraobserver variability in measuring brachial diameters was 2.9 % and the variability of the hyperemic response was 1.4%. In young, healthy men and women, the baseline brachial artery diameter was the only factor that was predictive of the flow-mediated vasodilation response.The brachial noninvasive technique has been further validated by the determination of flow-mediated dilation. This method of assessing endothelial function may help to determine the importance of vasodilator dysfunction as a risk factor in the development of atherosclerosis.

Published
1991
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