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23 results on '"Liebe, Heather"'

1. Necrotizing Enterocolitis

Author

Liebe, Heather L., Ford, Henri R., Camerini, Victoria, Hunter, Catherine J., Puri, Prem, editor, and Höllwarth, Michael E., editor

Published
2023
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16. Traumatic Pediatric Fatalities: Are They Preventable?

Author

Lewis, Samara L., primary, Liebe, Heather, additional, Jeffery, Christopher, additional, Sebastian, Rohan, additional, Stewart, Kenneth E., additional, Sarwar, Zoona, additional, Gamino, Laura, additional, and Johnson, Jeremy J., additional

Published
2022
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22. Experimental Modeling of Necrotizing Enterocolitis in Human Infant Intestinal Enteroids.

Author

Buonpane, Christie, Ares, Guillermo, Yuan, Carrie, Schlegel, Camille, Liebe, Heather, and Hunter, Catherine J.

Subjects
ENTEROCOLITIS, INFANTS, PREMATURE infants, CHILD patients, TIGHT junctions
Abstract

Background: Experimental model systems are of paramount importance in advancing our understanding of human disease. There are several limitations when using a single cell culture to recapitulate the findings in a complex organism and results often vary between species, when proxy animal models are studied. Human enteroids have allowed for study of human disease in complex multicellular culture systems. Here we present the novel use of human infant enteroids generated from premature infant intestine to study necrotizing enterocolitis (NEC), which is a devastating intestinal disorder that affects our most vulnerable pediatric population. We demonstrate that NEC can be induced in premature human enteroids as supported by corresponding alterations in inflammation, apoptosis, tight junction expression, and permeability by treatment with lipopolysaccharide. [ABSTRACT FROM AUTHOR]

Published
2022
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23. A Review of the Diagnosis and Treatment of Necrotizing Enterocolitis.

Author

Cai X, Liebe HL, Golubkova A, Leiva T, and Hunter CJ

Subjects
Infant, Newborn, Humans, Biomarkers, Enterocolitis, Necrotizing diagnosis, Enterocolitis, Necrotizing therapy, Infant, Newborn, Diseases, Infant, Premature, Diseases diagnosis, Infant, Premature, Diseases therapy
Abstract

Necrotizing enterocolitis (NEC) is a devastating disease that primarily affects the gastrointestinal tract of premature neonates. The diagnosis and treatment of NEC remain challenging. New biomarkers and potential treatments for NEC have emerged in recent years, leading to the potential of earlier therapeutic intervention and improved outcomes. This paper aims to provide a review of the most recent diagnostic indicators and therapeutics of NEC along with a brief overview of future directions of research into this disease., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2023
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